西比灵与天舒胶囊合用治疗紧张性头痛的疗效观察

我们自2000—2004年3月采用西比灵与天舒胶囊治疗紧张型头痛(TH)120例，取得较好效果。现报告如下。     

头痛宁胶囊治疗紧张性头痛疗效观察

紧张性头痛或肌收缩性疼痛是一种头部的紧缩、受压或钝痛感,约占头痛患者的40%,多与日常生活应激有关.我院2010-03-2012-10采用头痛宁胶囊治疗紧张性头痛126例,现将结果报告如下.     

丹珍头痛胶囊治疗慢性紧张性头痛疗效观察

目的观察丹珍头痛胶囊治疗慢性紧张性头痛的疗效。方法将我院2014-06-2015-03门诊就诊的120例慢性紧张性头痛患者随机分为对照组和治疗组,分别给予氟哌噻吨美利曲辛片和丹珍头痛胶囊治疗并观察4周。评估2组临床疗效,使用Hamilton抑郁量表和Hamilton焦虑量表评估抑郁、焦虑情况。结果治疗组总有效率93.33%,对照组为50%,2组相比差异有统计学意义(P0.05)。治疗组治疗后14d、28dHAMD评分、HAMA评分均较治疗前降低,与对照组在各个时间点相比,差异有统计学意义(P0.05)。结论丹珍头痛胶囊可明显改善慢性紧张性头痛患者的头痛程度及焦虑、抑郁障碍。     

天舒胶囊治疗偏头痛的疗效观察

本研究应用天舒胶囊治疗偏头痛患者51例,取得明显疗效.现报告如下.     

西比灵、全天麻胶囊联合治疗紧张性头痛远期疗效观察

紧张性头痛虽很少有严重的病例,且不需要紧急处理,但其迁延难愈的特点在很大程度上影响了患者的生活质量,病程长者还会损害患者心理健康。传统药物治疗常用镇静抗抑郁剂及止痛剂,但远期疗效不满意,且止痛剂的长期应用又成为某些头痛的常见促发因素。笔者用西比灵加全天麻胶囊治疗紧张性头痛33例,远期疗效较好,未见不良反应,总结如下。     

天舒胶囊合用妥泰治疗偏头痛的疗效观察

目的 观察天舒胶囊合用妥泰对偏头痛的治疗作用.方法 50例偏头痛患者同时服用天舒胶囊4粒,3次/d,妥泰片25mg,2次/d,疗程一个月,观察治疗前后头痛发作的程度、头痛发作的频率及头痛持续时间的变化.结果 治疗前后上述各项指标均有改善,评分差值均有统计学意义(P＜0.05).结论 天舒胶囊合用妥泰对偏头痛发作的程度、频率及持续时间均有较好治疗作用.     

天舒胶囊治疗偏头痛50例疗效分析

近年来,偏头痛在人群中发病率有逐年增高趋势,严重影响患者的工作和生活。我科自2010年来应用天舒胶囊治疗偏头痛取得较好疗效,现报告如下。1资料与方法1.1一般资料入选的100例偏头痛患者均来自我院2010年门诊和住院患者,均符合国际头痛协会偏头痛诊断标准,并经多项检查排除脑血管疾病、癫、颅内占位性病变、颅内感染、眼科疾病及全身性疾病引起的头痛。随机分为2组各50例,治疗组(天舒胶囊组)中男21例,女29例,年     

西比灵与天舒胶囊合用治疗紧张性头痛的疗效观察

我们自2000-2004年3月采用西比灵与天舒胶囊治疗紧张 型头痛(TH)120例,取得较好效果。现报告如下。 1 资料和方法 1.1 对象 本文所述的病例是按国际头痛协会(1988)将TH 分为四类,有严格的诊断标准:①发作性TH:要求发作至 少10次以上,头痛时间<180d/年,<15d/月;②有颅周肌肉 疾病的发作性TH:有颅周骨和肌肉触痛和EMG活动增加;③ 无颅周肌肉疾病的发作性TH:无肌肉触痛和EMG改变;④慢 性TH:头痛时间≥180d/年,≥15d/月,神经系统检查,头颅     

中药静痛灵胶囊双盲交叉法治疗紧张性头痛的疗效观察

52例紧张性头痛病人服用静痛灵胶囊和安慰剂进行双盲自身交叉法治疗,同时观察服药前后病人血浆血栓烷(TXB_2)含量及颈动脉多普勒超声脑血流图各项指标的变化。结果发现用静痛灵治疗组效果显著优于安慰剂组,并观察到静痛灵组血浆TXB_2含量明显减低及颈动脉血流量明显增加,据此推断了该药可能的作用。     

天舒胶囊治疗偏头痛疗效的Meta分析

目的评价天舒胶囊治疗偏头痛的疗效和安全性。方法检索公开发表关于天舒胶囊治疗偏头痛的随机对照试验的文献,通过Cochrane系统评价方法对所纳入文献进行质量评价,采用Revman 5.2软件进行统计分析。结果将对照组仅为氟桂利嗪、结局指标为总有效率的7篇文献进行Meta分析显示,天舒胶囊组疗效显著优于氟桂利嗪组(OR=2.92,95%CI:1.89~4.49,Z=4.87,P0.00001);选取其中3个剂量及疗程相同的研究做亚组分析发现,治疗组与对照组疗效差异有统计学意义(OR=4.21,95%CI:2.21~8.02,Z=4.37,P0.0001),与整体分析结果一致。对另4篇因对照组药物不同及结局指标无法合并的文献进行描述性分析发现,天舒胶囊治疗偏头痛的疗效优于奥卡西平(P=0.007),且奥卡西平更易发生肝功能异常;治疗前后头痛发作频率、头痛持续时间差异均有统计学意义(均P0.05)。8篇文献以胃部不适、女性月经过多为主要不良反应,未见严重不良反应。结论天舒胶囊治疗偏头痛的疗效优于氟桂利嗪、奥卡西平、传统中成药元胡止痛胶囊、丹参胶囊,且不良反应少。     

西酞普兰治疗紧张性头痛的疗效观察

目的探讨西酞普兰治疗紧张性头痛的临床疗效。方法入选92例病人,随机分为治疗组48例,对照组44例,2组病人的一般情况及病情程度等比较差异无统计学意义(P>0.05),具有可比性。对照组给予布洛芬300 mg,1次/d,疗程8周;治疗组(西太普兰组)在对照组基础上给予西酞普兰片20 mg,1次/d,疗程6周。6周后观察临床疗效。结果西酞普兰组疗效明显优于单用布洛芬组。结论治疗紧张性头痛西酞普兰效果满意,有应用价值     

养血清脑颗粒与罗痛定治疗紧张性头痛及对血小板聚合的影响

目的 研究养血清颗粒治疗紧张性头痛的疗效，探讨对血小板聚集的影响及紧张性头痛可能的发病机制。方法 对紧张性头痛患者随机分组，治疗组用养血清脑颗粒，对照组用罗痛定片，2周为一疗程，分别判定治疗前后2组患者疗效。测定血小板聚集率的变化。结果 养血清脑颗粒治疗紧张性头痛的有效率95．5％，对血小板聚集率有明显的影响。结论 养血清脑颗粒治疗紧张性头痛有效，其发病机制有待进一步探讨。     

养血清脑颗粒与罗痛定治疗紧张性头痛及对血小板聚合的影响

目的 研究养血清颗粒治疗紧张性头痛的疗效,探讨对血小板聚集的影响及紧张性头痛可能的发病机制.方法 对紧张性头痛患者随机分组,治疗组用养血清脑颗粒,对照组用罗痛定片,2周为一疗程,分别判定治疗前后2组患者疗效.测定血小板聚集率的变化.结果 养血清脑颗粒治疗紧张性头痛的有效率95.5%,对血小板聚集率有明显的影响.结论 养血清脑颗粒治疗紧张性头痛有效,其发病机制有待进一步探讨.     

Aneurysmal subarachnoid hemorrhage in patients with migraine and tension headache: A cohort comparison study

Migraine headache is a common condition with an estimated lifetime prevalence of greater than 20%. While it is a well-established risk factor for cardiovascular disease and ischemic stroke, its association with subarachnoid hemorrhage is largely unexplored. We sought to compare the incidence of aneurysmal subarachnoid hemorrhage in a cohort of migraine patients with a cohort of patients with tension headache. A cohort comparison study utilizing the MarketScan insurance claims database compared patients diagnosed with migraine who were undergoing treatment with abortive or prophylactic pharmacotherapy (treatment cohort) and patients diagnosed with tension headache who had never been diagnosed with a migraine and who were naïve to migraine pharmacotherapy (control cohort). Patients with major pre-existing risk factors for aSAH were excluded from the study, and minor risk factors such as smoking status and hypertension were accounted for using coarsened exact matching (CEM) and subsequent cox proportional-hazards (CPH) regression. More than 679,000 patients (~125,000 treatment and ~ 550,000 control) with an average follow-up of more than three years were analyzed for aneurysmal subarachnoid hemorrhage. CPH regression on matched data showed that treated migraine patients had a significantly lower hazard of aneurysmal subarachnoid hemorrhage compared with tension headache patients (HR = 0.40, 95% CI: 0.19 – 0.86, p = 0.02). This large cohort comparison study, analyzing more than 679,000 patients, demonstrated that migraine patients undergoing pharmacologic treatment had a lower hazard of aneurysmal subarachnoid hemorrhage than patients diagnosed with tension headaches. Future work specifically focusing on migraine medications may identify the mechanisms underlying this association.     

天舒胶囊对偏头痛动物模型血浆一氧化氮、一氧化氮合酶、降钙素基因相关肽含量及血流动力学的影响

目的 研究天舒胶囊对偏头痛动物模型血浆及脑组织血管活性物质及血流动力学的影响.方法 皮下注射硝酸甘油分别制作大鼠和兔偏头痛模型.给予天舒胶囊后用放免法和分光光度法测大鼠血浆一氧化氮(NO)和一氧化氮合酶(NOS)、降钙素基因相关肽(CGRP)含量;通过免疫组织化学染色观察三叉神经脊束核神经元型NOS(NOS1)和CGRP表达;用经颅多普勒检测兔颈内动脉血流速度改变.结果 模型组大鼠血浆NO、NOS和CGRP较对照组明显升高;经不同剂量天舒胶囊灌胃后大鼠血浆NO、NOS和CGRP的增加受到抑制,尤以中、高剂量组明显(P<0.05～0.01).模型组兔颈内动脉收缩期峰值流速明显下降,经中剂量天舒胶囊干预后流速下降也受到抑制 (P<0.05).免疫组织化学染色发现灌胃天舒胶囊后,偏头痛大鼠三叉神经脊束核NOS1和CGRP表达增加的程度减小(均P<0.05).结论 天舒胶囊可改善偏头痛发作时血管活性物质和神经递质水平失常,从而缓解偏头痛症状.     

The prevalence of migraine and tension headache in Saudi Arabia: a community-based study

The prevalence of migraine and tension headache was determined in a 2-stage, door-to-door community survey in Thugbah, Saudi Arabia. Out of 22630 subjects surveyed, 2742 individuals had headaches thus yielding a crude prevalence of 12.1% (95% CI = 11.7–12.5%) and with age-adjustment, it rose to 15.9% (95% CI = 15.4–16.4%). There was female preponderance overall and the peak frequency was in the 3rd decade. The age-specific rates rose from 2.4% in the first decade to 37.2% in the 7th decade. The prevalence of tension-type headache (PR 9.5%; 95% CI = 9.1–9.9%) was higher than migraine (PR = 5.0%; 95% CI = 4.7-5.3%). The low headache prevalence in this community compared to findings in western countries could be ascribed to the young age of the population and/or could possibly reflect the influence of traditional life styles and cultural factors in the Kingdom.     

Emotional and behavioral problems in pediatric patients with migraine and tension-type headache

ObjectiveThis study aimed to investigate the associations between psychopathological characteristics of children and adolescents with primary headache, as measured by the Strengths and Difficulties Questionnaire (SDQ), and treatment outcomes.MethodsA cohort study was conducted on 124 pediatric patients with primary headache. At the first consultation, the SDQ was completed by the parents. The analysis of treatment efficacy was conducted on 90 patients with a follow-up period of at least one year. Treatment responders were defined as those who showed 50% reduction in the headache frequency. First, an analysis of the SDQ total scores and five subscales, among the migraine and tension-type headache groups, was conducted for 124 participants. Second, the association between the SDQ scores and treatment outcomes in the groups with periods of improvement of less than three months and three months or more were analyzed in 90 patients.ResultsMigraine patients displayed more difficulties than strengths in terms of the total score (p = .004) and in the emotional symptoms subscale (p = .012) compared with tension-type headache patients. Migraine patients who required more than three months to show improvement displayed more peer problems (p = .020), while tension-type headache patients who required more than three months to show improvement displayed fewer conduct problems (p = .007).ConclusionEvaluation of patient characteristics using the SDQ at first consultation can predict the treatment outcome. Moreover, it can help provide appropriate initial treatment and improve outcome of primary headache in children.     

乌灵胶囊联合帕罗西汀治疗卒中后抑郁疗效观察

目的观察乌灵胶囊联合帕罗西汀治疗卒中后抑郁患者的疗效。方法将180例卒中后抑郁患者随机分为2组,实验组即乌灵胶囊联合帕罗西汀组92例,对照组即单用帕罗西汀组88例,疗程3个月。分别在治疗前和疗程结束后应用汉密尔顿抑郁量表(hamilton rating scale for depression,HAMD)评分来评估抑郁症状的改善情况,应用TESS不良反应量表(treatment emergent symptom scale,TESS)评估药物不良反应。结果实验组汉密尔顿抑郁量表评分较对照组明显降低,差异有统计学意义(P<0.05);2组TESS不良反应量表评分差异无统计学意义(P>0.05)。结论乌灵胶囊联合帕罗西汀治疗卒中后抑郁安全有效。     

Tension type headache: a neuropsychological and neurophysiological study

Characteristic personality profiles of patients suffering from either migraine headache (MH) or tension type headache (TTH) have been described in the light of Minnesota Multiphasic Personality Inventory (MMPI). In the present study we evaluated personality profile changes following modifications of the painful symtoms after treatment, through the administration of the MMPI to MH and TTH patients. In TTH patients with no clinical improvement the depression scale scores were higher after 6 months of treatment, whereas in MH patients similar scores were observed before and after therapy, thus suggesting a primary role of depression in the onset of pain in the latter patients. Computerized EMG recording of the neck muscle activity showed different patterns of muscle contraction in resting condition and during stress or maximal muscular activity in patients suffering from TTH as compared to MH patients and normal subjects.

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Somario Il Minnesota Multiphasic Personality Inventory (MMPI) ha permesso di tracciare profili di personalità caratteristici di pazienti affetti da emicrania (migraine headache, MH) o cefalea di tipo tensivo (tension type headache, TTH). Nel presente studio abbiamo valutato le modificazioni dei profili di personalità da noi ottenuti nei suddetti pazienti in relazione alla presenza o meno di miglioramento clinico valutato dopo sei mesi di terapia. Nei pazienti con TTH in cui la terapia non ha indotto alcun miglioramento clinico, il punteggio ottenuto nella scale della depressione è risultato più alto rispetto a quello ottenuto prima della terapia. Al contrario, in pazienti con MH il punteggio della depressione non si è modificato dopo terapia. Questi dati suggeriscono che la depressione ha un ruolo di primaria importanza nello svilupparsi della sintomatologia algica nei pazienti con MH.La registrazione elettromiografica dell'attività dei muscoli nucali a riposo non ha messo in evidenza differenze significative tra i due gruppi di pazienti, mentre in condizioni di sforzo muscolare massimo o durante uno stimolo stressante nei pazienti con TTH era evidente una attività muscolare significativamente maggiore rispetto a pazienti con MH.