Cardiovascular reactivity of younger and older adults to positive-, negative-, and mixed-emotion cognitive challenge

Although aging is associated with progressive increases in blood pressure level, previous research has been inconsistent as to whether older adults show greater or lesser cardiovascular reactivity (CVR) to emotion than do younger adults. There is reason to believe that these inconsistencies could be clarified by examining age-related differences in hemodynamic profile revealed by measuring the pattern of cardiac output and total peripheral resistance associated with changes in blood pressure reactivity. Accordingly, the present study examined the performance, CVR, and hemodynamic profile of younger and older adults during encoding and recognition of word pairs involving four valence types: positive, negative, mixed (positive/negative), and neutral word pairs. Results revealed higher baseline blood pressure, increased CVR characterized by a vascular hemodynamic profile, and more rapid recovery (especially during encoding) for older than for younger participants. Results are discussed in light of research and theory on the relationship between aging and cardiovascular health.     

Vitamin K status and cognitive function in healthy older adults

Evidence is accumulating that vitamin K could have a role in cognition, especially in aging. Using data from the Québec Longitudinal Study on Nutrition and Successful Aging (NuAge), a cross-sectional analysis was conducted to examine the associations between vitamin K status, measured as serum phylloquinone concentrations, and performance in verbal and non-verbal episodic memory, executive functions, and speed of processing. The sample included 320 men and women aged 70 to 85 years who were free of cognitive impairment. After adjustment for covariates, higher serum phylloquinone concentration (log-transformed) was associated with better verbal episodic memory performances (F = 2.43, p = 0.048); specifically with the scores (Z-transformed) on the second (β = 0.47; 95% confidence interval [CI] = 0.13–0.82), third (β = 0.41; 95% CI = 0.06–0.75), and 20-minute delayed (β = 0.47; 95% CI = 0.12–0.82) free recall trials of the RL/RI-16 Free and Cued Recall Task. No associations were found with non-verbal episodic memory, executive functions, and speed of processing. Our study adds evidence to the possible role of vitamin K in cognition during aging, specifically in the consolidation of the memory trace.     

Association between subjective social status and facets of depression self-stigma

Individuals with depressive symptoms frequently experience stigma, which may lower self-esteem and increase social withdrawal, further exacerbating symptoms. The association between depressive symptoms and subjective social status (SSS; perceived standing within one's community) have previously been identified. However, no work has connected the constructs of SSS and self-stigma among people with depression. Participants (N = 230) who screened positive for current major depressive episode via a self-report completed an online survey. A significant negative association between SSS and overall stigma (p = .024) was observed, which was largely explained by general self-stigma (p = .016) and stigmatizing experiences (p = .015) subscales. The results offer preliminary evidence that SSS may be associated with negative social consequences of stigmatizing health conditions.     

The effects of social stress and cortisol responses on the preconscious selective attention to social threat

The purpose of the present study was to investigate the effects of social stress and stress-induced cortisol on the preconscious selective attention to social threat. Twenty healthy participants were administered a masked emotional Stroop task (comparing color-naming latencies for angry, neutral and happy faces) in conditions of rest and social stress. Stress was induced by means of the Trier social stress test. Based on the stress-induced increase in cortisol levels, participants were allocated post hoc (median-split) to a high and low responders group. In contrast to low responders, high responders showed a negative or avoidant attentional bias to threat (i.e. shorter latencies for angry than neutral faces) in the rest condition. Most importantly, although low responders became avoidant, the high responders became vigilant to the angry faces after stress induction. There were no such effects for happy faces. Our findings are in line with previous studies in both animals and humans, that associate high glucocorticoid stress-responsiveness with diminished avoidance and prolonged freezing reactions during stress.     

Cardiovascular and cortisol reactions to acute psychological stress and cognitive ability in the Dutch Famine Birth Cohort Study

Given evidence linking blunted cardiovascular and cortisol reactions to acute stress and a range of adverse behavioral outcomes, the present study examined the associations between cardiovascular and cortisol reactivity and cognitive ability measured independently of the stress task exposure. Cognitive ability was assessed using the Alice Heim-4 test of general intelligence and two memory tasks in 724 men and women who were part of the Dutch Famine Birth Cohort Study. Blood pressure and heart rate, as well as cortisol reactivity, were measured to a battery of three standard acute stress tasks. Poorer cognitive ability was associated with lower cardiovascular reactions to stress and lower cortisol area under the curve. Our results are consistent with recent findings implicating low physiological stress reactivity in a range of adverse behavioral and health outcomes.     

The relation of hydration status to cognitive performance in healthy older adults.

Little is known about the relation of hydration status to cognitive performance in older adults, who may be more vulnerable to poor hydration and cognitive impairment. We examined whether hydration status was related to cognitive functioning in 28 healthy community-dwelling older adults. Hierarchical regression models demonstrated that lower hydration status was related to slowed psychomotor processing speed and poorer attention/memory performance, after controlling for demographic variables and blood pressure.     

Pupillometry as a measure of cognitive effort in younger and older adults

Two experiments examined the effectiveness of the pupillary response as a measure of cognitive load in younger and older adults. Experiment 1 measured the change in pupil size of younger and older adults while they listened to spoken digit lists that varied in length and retained them briefly for recall. In Experiment 2 changes in relative pupil size were measured while younger and older adults listened to sentences for later recall that varied in syntactic complexity and sentence length. Both age groups' pupil sizes were sensitive to the size of the memory set in Experiment 1 and sentence length in Experiment 2, with the older adults showing a larger effect of the memory load on a normalized measure of pupil size relative to the younger adults. By contrast, only the younger adults showed a difference in the pupillary response to a change in syntactic complexity, even with an adjustment for the reduced reactivity of the older pupil.     

Blunted cardiovascular and cortisol reactivity to acute psychological stress: A summary of results from the Dutch Famine Birth Cohort Study

The Dutch Famine Birth Cohort Study is a large population based study of late middle aged, overall healthy men and women whose health has been followed from 50 to 65 years of age. In a sample of 725 cohort members, an extensive psychological stress protocol was performed during which cardiovascular and cortisol responses were measured. In line with many previous studies, results showed that increased blood pressure responsiveness to the stress protocol was associated with an increased risk for hypertension 5 years later. However, decreased cardiovascular and/or cortisol stress reactivity were associated with obesity and the risk of becoming obese, symptoms of depression and anxiety, a poor self-reported health, poor lung function, and poor cognitive function (all p for statistical tests < 0.05). These associations generally survived adjustment for a range of potential confounders, including resting cardiovascular and cortisol activity, commitment to the stress tasks, sex, age, smoking and use of medication. Results from these studies agree with recent evidence that low biological reactivity to acute psychological stress may not always be beneficial for health but instead seems to be a marker for a range of negative health outcomes. Future studies have to point out whether low stress reactivity precedes or follows these negative health outcomes.     

Cortisol response to challenge involving low controllability: The role of control beliefs and age

Cortisol responses are typically more pronounced under low controllability conditions, yet little is known about the role of individual differences. This study examined whether cortisol response to a situation with low controllability differs as a function of preexisting control beliefs and age. We manipulated level of controllability using a driving simulator. Control beliefs were assessed prior to the lab session. Salivary cortisol was measured before and after the driving simulation. Participants were 152 adults aged 22–84 from a Boston area sample. In comparison to the normal controllability condition, those in the low controllability condition reported less perceived control over driving, supporting the effectiveness of the manipulation. In the low controllability condition those with higher control beliefs showed a greater cortisol response than those with low control beliefs. Older adults showed a greater cortisol response than younger adults during the challenge. Implications of acute cortisol responses for performance outcomes are discussed.     

Heterogeneity in the social networks of young and older adults: prediction of mental health and cardiovascular reactivity during acute stress

We examined the utility of a broad framework that separated positive, negative, and ambivalent social network members. One hundred thirty-three young and older participants completed the social relationships index, measures of mental health, and a cardiovascular reactivity protocol. Results replicated prior research on the beneficial influence of positive (supportive) ties on psychological outcomes. More important, analyses also revealed that the number of ambivalent network ties predicted age-related differences in depression and sympathetic control of heart rate reactivity during stress. The statistical interactions between age and ambivalent ties on cardiovascular responses during stress were not changed when statistically controlling for other social network categories, demographic variables, and various personality factors. These data suggest that social network ambivalence was a relatively unique predictor of cardiovascular reactivity and highlight the utility of separating the variance due to positive, negative, and ambivalent network ties. Implications for the study of social relationships, physiological processes, and health outcomes are also discussed.     

Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis

AimsTo systematically review the literature on outcomes for individuals with subjective cognitive decline (SCD) with concurrent affective symptoms. To conduct a meta-analysis to establish whether either higher depressive symptoms or higher levels of anxiety increased the risk of progression SCD to mild cognitive impairment (MCI) or dementia.MethodsFive databases were searched from inception to February 2021 for longitudinal studies of older adults with SCD, reporting depressive and anxiety symptoms at baseline and risk of MCI or dementia at follow-up. Data were extracted and pooled using a random-effects meta-analysis.ResultsTwelve studies were identified. Pooled effect sizes indicated higher depressive symptoms did not increase risk of clinical progression to either MCI (RR = 0.98; 95 % CI: 0.75–1.26) or dementia (RR = 0.69; 95 % CI: 0.27–1.79). However, presence of anxiety or SCD-related worry did significantly increase risk of progression from subjective to objective cognitive impairment by 40 % (RR = 1.40; 95 % CI:1.20 – 1.63).ConclusionsAffective symptoms in the form of anxiety, but not depressive symptoms, increase the risk of progression to objective cognitive impairment in individuals with SCD. Further research should focus on establishing whether psychological interventions aimed at reducing anxiety and worry also reduce the risk of clinical progression.     

中、老龄男性血清睾酮和皮质醇含量变化规律的研究

目的：研究中老年男性血清睾酮和皮质醇含量变化及规律。方法：５８１例４０岁以上健康男性以每１０年为一年龄组,分为４组。以２０～３９岁健康男性１１０例作为对照组。均于上午８～１０时静脉采血,分离血清,应用放免分析方法检测血清睾酮和皮质醇含量。结果：（１）４０岁以上各组血清睾酮含量与年轻组比较明显下降（Ｐ＜００１）,血清皮质醇含量逐渐增加,与对照组比较均差异显著（Ｐ＜００１）;（２）血清睾酮与皮质醇含量呈显著负相关（ｒ＝－０．３０９６,Ｐ＜００１）。结论：随增龄睾丸的内分泌功能逐渐下降,而肾上腺皮质功能则发生与之相反的变化     

Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs

ObjectiveTo examine the dose-response relationship between overall and specific types of exercise with cognitive function in older adults.DesignSystematic Review and Bayesian Model-Based Network Meta-Analysis.Data sourcesSystematic search of MEDLINE, Web of Science, Scopus, PsycINFO and SPORTDiscus.Eligibility criteria for selecting studiesRandomized controlled trials of exercise interventions in participants aged 50 years or over, and that reported on at least one global cognition outcome.ResultsThe search returned 1998 records, of which 44 studies (4793 participants; 102 different effect sizes) were included in this review with meta-analysis. There was a non-linear, dose-response association between overall exercise and cognition. We found no minimal threshold for the beneficial effect of exercise on cognition. The estimated minimal exercise dose associated with clinically relevant changes in cognition was 724 METs-min per week, and doses beyond 1200 METs-min per week provided less clear benefits. We also found that the dose-response association was exercise type dependent, and our results show that clinically important effects may occur at lower doses for many types of exercise. Our findings also highlighted the superior effects of resistance exercises over other modalities.ConclusionsIf provided with the most potent modalities, older adults can get clinical meaningful benefits with lower doses than the WHO guidelines. Findings support the WHO recommendations to emphasise resistance training as a critical component of interventions for older adults.     

Social influences on circulating levels of cortisol and prolactin in male talapoin monkeys

Three captive groups of adult talapoin monkeys (Miopithecus talapoin), each with four males and four or five ovariectomized, estrogen-treated females, were observed. Behavioral interactions were recorded and levels of cortisol and prolactin were measured. In each group, males formed a linear dominance order, determined by the direction of spontaneous aggression; highest male rank was associated with frequent socio-sexual interactions and lowest rank with infrequent socio-sexual behavior. The first study compared males' cortisol and prolactin titers when all males were either housed with estrogen-treated females, or singly caged. The two lowest-ranking males of each group had elevated cortisol levels when group-housed; prolactin levels did not reflect these changes. In the second study, males of one group interacted with females when only the lowest-ranking, or the highest-ranking, female was made attractive (i.e., received estradiol), while the other females were present, but not estradiol-treated. Across these conditions (1) frequencies of some socio-sexual and aggressive behaviors changed, (2) cortisol levels increased in all males, and (3) prolactin levels decreased in three of four males. Dissociation of changes in cortisol and prolactin titers suggests that these hormones may be differentially responsive to social modifications, not simply reflecting a single intervening variable, such as "stress."     

The effects of socioeconomic status and short stature on overweight,obesity and the risk of metabolic complications in adults

Objective:

to observe the relationship between socioeconomic status, height and nutritional problems related to obesity, overweight and risk of metabolic complications in men and women of Medellin (Colombia).

Methods:

cross-sectional study with a sample of 5556 adults between 18 and 69 years of age. We assessed weight, height and waist circumference. Socioeconomic variables were evaluated by family income, socioeconomic stratum and academic level achieved.

Results:

we found that in men and women the height reached in adulthood is associated with socioeconomic conditions as measured by the socioeconomic strata and family income. In women, height, age, and socioeconomic strata are associated with obesity, overweight and risk of obesity, and risk of metabolic complications.

Conclusion:

These results are not only from individual unhealthy habits, such as eating patterns based on high density foods combined with low energy expenditure, but also from the cumulative effect of food deprivation throughout life. Therefore, policies intended to prevent them should take a preventive approach that begins before birth and continues during childhood and adulthood.     

The relation between subjective well-being and career aspirations amongst a sample of adolescents in low socioeconomic status communities in Cape Town

The study aimed to determine the relation between adolescents’ subjective well-being and career aspirations. The study further aimed to determine the extent to which social support mediates this relation. The sample comprised 1082 adolescents in Grades 8–11, selected from schools located in low socioeconomic status communities in Cape Town, South Africa. The overall model demonstrated a nonsignificant relation between adolescents’ subjective well-being and career aspirations. Across gender, the results indicated a significant relation between subjective well-being and career aspirations for the male group, but not for females. The results further indicate that social support did not mediate the relation between adolescents’ subjective well-being and career aspirations for the pooled sample. However, for females, the study found a significant negative relation between social support and aspirations. We recommend targeting interventions at an institutional level, inclusive of challenging gender roles and providing information about educational and career opportunities for young people.     

Type D personality and cardiovascular reactivity to acute stress: The mediating effects of social support and negative social relationships

Type D personality has been consistently associated with adverse cardiovascular health with atypical cardiovascular reactions to psychological stress one potential underlying mechanism. As Type D individuals have been noted to report lower social support and greater perceptions of negativity in social interactions, this study examined if the association between Type D personality and cardiovascular reactivity was mediated by these social relationships. A sample of 195 undergraduate students (138 female) participated in this observational study, where they completed measures assessing Type D personality (DS14), social support, and perceptions of negative social relationships (National Institute of Health social relationship scales), before undergoing a traditional cardiovascular reactivity protocol. Systolic and diastolic blood pressure (SBP; DBP), heart rate (HR), cardiac output (CO), and total peripheral resistance (TPR) were monitored throughout. ANCOVAs and regressions indicated that Type D personality was associated with lower cardiovascular reactivity to a mental arithmetic stressor. Furthermore, mediation analyses (process macro) indicated that the relationship between Type D personality and cardiovascular reactivity was mediated via increased perceptions of negative social relationships, as well as lower levels of social support. Apart from a significant association between Type D personality and increased HR reactivity, all results failed to withstand adjustment for the individual effects of negative affect (NA) and social inhibition (SI) in controlled analyses. Overall, these findings suggest that the predictive utility of Type D personality on cardiovascular reactivity above and beyond the individual effects of NA and SI is limited, and may vary depending on the cardiovascular parameter of focus.     

APOE-epsilon4 and aging of medial temporal lobe gray matter in healthy adults older than 50 years

Atrophy of the hippocampus and surrounding temporal regions occurs in Alzheimer's disease (AD). APOE ε4, the major genetic risk factor for late-onset AD, has been associated with smaller volume in these regions before amyloidosis can be detected by AD biomarkers. To examine APOE ε4 effects in relation to aging, we performed a longitudinal magnetic resonance imaging study involving cognitively normal adults (25 APOE ε4 carriers and 31 ε3 homozygotes), initially aged 51–75 years. We used growth curve analyses, which can provide information about APOE ε4-related differences initially and later in life. Hippocampal volume was the primary outcome; nearby medial temporal regions were secondary outcomes. Brain-derived neurotrophic factor, val66met was a secondary covariate. APOE ε4 carriers had significantly smaller initial hippocampal volumes than ε3 homozygotes. Rate of hippocampal atrophy was not greater in the APOE ε4 group, although age-related atrophy was detected in the overall sample. The findings add to the growing evidence that effects of APOE ε4 on hippocampal size begin early in life, underscoring the importance of early interventions to increase reserve.