ASO Author Reflections: Psychosocial Outcomes After Breast Cancer Treatment

Annals of Surgical Oncology -     

Pretreatment Primary Tumor Stage is a Risk Factor for Recurrence in Patients with Esophageal Squamous Cell Carcinoma Who Achieve Pathological Complete Response After Neoadjuvant Chemoradiotherapy

Annals of Surgical Oncology - Although pathological complete response (pCR) after multimodal treatment for esophageal cancer is associated to the best prognosis, recurrence may occur in...     

ASO Author Reflections: Undertreatment of Early-Stage Breast Cancer in Elderly Women Undergoing Lumpectomy Without Radiotherapy Increases the Risk of Locoregional Recurrence

Annals of Surgical Oncology -     

ASO Author Reflections: Role of Local Treatment for Oligometastatic Esophagogastric Cancer

Annals of Surgical Oncology -     

ASO Author Reflections: Robust Prediction Models for Colon Cancer in Asian Patients

Annals of Surgical Oncology -     

ASO Author Reflections: Modern-Day Implementation of Robotic Esophagogastric Cancer Surgery

Annals of Surgical Oncology -     

ASO Author Reflections: Clinical Importance of Histologic Subtype for Metaplastic Breast Cancer

Annals of Surgical Oncology -     

ASO Author Reflections: Routine Radiologic Staging of Distant Metastases Must Be Recommended as a Binding Guideline After Diagnosis of Local Breast Cancer Recurrence

Annals of Surgical Oncology -     

ASO Author Reflections: Contemporary Analysis of Impact of Lymphadenectomy on Survival in Nonmetastatic Gallbladder Cancer

Annals of Surgical Oncology -     

Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer Decreases Distant Recurrence and Could Eradicate Local Recurrence

Background

The aim of this study was to evaluate the clinical implications of pathologic complete response (pCR) (i.e., T0N0M0) after neoadjuvant chemoradiation and radical surgery in patients with locally advanced rectal cancer.

Materials and Methods

A single-center, prospectively maintained colorectal cancer database was queried for patients with primary cII and cIII rectal cancer staged by CT and ERUS/MRI undergoing long-course neoadjuvant chemoradiation followed by proctectomy with curative intent between 1997 and 2007. Patients were stratified into pCR and no-pCR groups and compared with respect to demographics, tumor and treatment characteristics, and oncologic outcomes. Outcomes evaluated were 5-year overall survival, disease-free survival, disease-specific mortality, local recurrence, and distant recurrence.

Results

The query returned 238 patients (73% male), with a median age of 57 years and median follow-up of 54 months. Of these, 58 patients achieved pCR. Patients with pCR vs no-pCR were statistically comparable with respect to demographics, chemoradiation regimens, tumor distance from anal verge, clinical stage, surgical procedures performed, and follow-up time. No patient with pCR had local recurrence. Overall survival and distant recurrence were also significantly improved for patients achieving pCR.

Conclusions

Achievement of pCR after neoadjuvant chemoradiation is associated with greatly improved cancer outcomes in locally advanced rectal cancer. Future studies should evaluate the relationship between increases in pCR rates and improvements in cancer outcomes in this population.     

ASO Author Reflections: Failing to Adhere to Treatment Guidelines in Gallbladder Cancer

Annals of Surgical Oncology -     

ASO Author Reflections: Breast-Specific Sensuality in the Sexually Inactive Breast Cancer Survivor

Annals of Surgical Oncology -     

ASO Visual Abstract: Nodal Pathologic Complete Response Rates in Luminal Breast Cancer Vary by Genomic Risk

Annals of Surgical Oncology -     

ASO Author Reflections: Rare Breast Cancer Subtypes and the Role for Precision Oncology

Annals of Surgical Oncology -     

ASO Author Reflections: Neutrophil-to-Lymphocyte Ratio Predicts Recurrence Pattern in Patients with Resectable Colorectal Liver Metastases

Annals of Surgical Oncology -     

ASO Author Reflections: Clinical Implications of Circulating Tumor DNA in Pancreatic Cancer Patients

Annals of Surgical Oncology -     

ASO Author Reflections: Preoperative Prediction of Postmastectomy Radiation Therapy After Neoadjuvant Systemic Therapy

Annals of Surgical Oncology -