Incidence de l’hypertension artérielle dans la population française de plus de 60 ans

ObjectiveTo evaluate incidence and determinants of arterial hypertension after 60 years.MethodsFour thousand nine hundred and forty one subjects aged 60 years or above (2505 men: 64.2 ± 4.2 years; 2436 women: 64.8 ± 4.3 years) were explored two times at the IPC center, Paris, between 1992 and 2007, and were normotensive at the first visit (V1): systolic BP (SBP) less than 140 mmHg and diastolic BP (DBP) less than 90 mmHg without treatment. The delay between the two visits was 5.8 ± 2.2 years. At the second visit, population was analysed as normotensives and hypertensives. An age-adjusted Anova compared groups.ResultsIn men, incidence of hypertension is 41.5% and 25.9% for isolated systolic hypertension. In women, incidences were 37.8% and 27.8% respectively. Baseline characteristics for V2-hypertensives showed higher SBP, DBP, BMI, heart rate, glycemia, ECG abnormalities thanV2-normotensives but they had lower physical activity. The determinants of hypertension were: SBP, age, BMI, DBP, glycemia, and lack of physical activity for this age class.ConclusionFrom 60 years old, 6-year incidence of hypertension is about 40% and 26% for isolated systolic hypertension, this latter being higher in women. Regular physical activity is protective.     

Surdité sous-hydroxychloroquine : premier cas de réintroduction positive et analyse de la base française de pharmacovigilance

Introduction

Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated.