血液透析患者血清铁调素与颈动脉粥样硬化的关系

目的:探讨维持性血液透析(MHD)患者血清铁调素(hepcidin)水平的变化及与颈动脉粥样硬化的相关性。方法:选择维持性血液透析患者93例和健康对照组40例为研究对象,采用ELISA法测定hepcidin、IL-6及TNF-α水平,高分辨二维超声对双侧颈总动脉内膜中膜厚度(IMT)及颈动脉粥样斑块进行测量,分析hepcidin水平与颈动脉病变及炎症因子之间的关系。结果:MHD组患者血清hepcidin水平(139.04±77.91)μg/L显著高于健康对照组(51.13±22.01)μg/L;MHD组CRP、IL-6、TNF-α水平均显著高于健康对照组(P0.05或P0.01)。MHD组IMT值为(1.15±0.21)mm、斑块形成率(59.2%)、颈动脉硬化的患病率(77.6%)均显著高于健康对照组的(0.78±0.28)mm和2.5%与10%(均P0.05)。直线相关分析显示MHD组血清hepcidin水平与CRP、IL-6、TNF-α、IMT及斑块形成、颈动脉硬化率的患病率均呈正相关;与SBP、DBP、年龄亦呈正相关(P0.05或P0.01)。多元逐步回归分析显示,hepcidin、CRP、SBP和年龄是MHD颈动脉病变的独立危险因素。结论:MHD患者血清hepcidin水平显著升高,其可能通过促进CRP、IL-6等炎症因子的产生,参与MHD患者动脉粥样硬化的形成。     

老年骨质疏松与颈动脉硬化的相关性研究

目的探讨研究老年骨质疏松与颈动脉硬化的相关性。方法将随机抽取的236名60岁以上的体检者作为研究对象,采用双能X线骨密度仪测定腰椎(L_(1-4))及股骨颈、Word’s三角、大转子的骨密度(bone mineral density,BMD)。采用高分辨率彩色超声探查颈动脉内中膜厚度(intima-media thickness,IMT)及斑块的情况。同时收集研究对象的基本资料,包括年龄、身高、体重、血钙、血脂等生化结果。将入选对象分为骨质疏松组和非骨质疏松组,颈动脉有斑块组和颈动脉无斑块组。结果在骨质疏松组(114例)中,存在内膜增厚94例(82.46%),粥样斑块73例(64.04%),与非骨质疏松组(122名)比较,骨质疏松组在颈动脉内中膜增厚(IMT≥0.9 mm)及粥样斑块的发生率上均明显升高(P0.05);IMT增厚及斑块形成与骨量逐渐减少呈正相关,IMT、年龄、体重指数(body mass index,BMI)与骨质疏松发生显著相关(P0.05);性别分组比较得出,女性骨质疏松患者在颈动脉斑块中的发病率明显高于男性和非骨质疏松患者,其对比差异具有统计学意义(P0.05)。结论老年骨质疏松与动脉硬化存在密切联系;骨质疏松人群较非骨质疏松人群更易发生动脉粥样硬化病变,且女性骨质疏松患者的颈动脉硬化患病率明显高于男性。     

血液透析患者血浆FGF23水平与颈动脉粥样硬化关系的研究

目的:探讨血液透析(HD)患者血浆成纤维细胞生长因子(FGF23)浓度与颈动脉粥样硬化程度的关系。方法:采用酶联免疫法(ELISA)检测186例维持性血透患者血浆FGF23浓度,高分辨二维超声技术测量颈动脉内膜-中层厚度(IMT)及粥样硬化斑块。结果:IMT增厚组及颈动脉斑块组血浆FGF23浓度明显高于颈动脉正常组(3.12±0.23vs2.67±0.21,P<0.01)。FGF23浓度与IMT存在显著正相关(r=0.496P=0.000),多因素逐步回归分析,FGF23浓度是血液透析患者IMT增加的独立危险因素。结论:血液透析患者动脉粥样硬化病变与FGF23有关,FGF23在血液透析患者颈动脉粥样硬化的发生发展中起着重要作用。     

代谢综合征与狼疮性肾炎患者的颈动脉粥样硬化相关

目的:探讨狼疮性肾炎(lupus nephritis,LN)患者代谢综合征(metabolic syndrome,MS)的发病情况及与颈动脉粥样硬化的相关性。方法:入选我院肾脏科LN患者共210例,计算MS的发生率,以颈动脉超声检测斑块和内膜中层厚度(IMT),分析MS与颈动脉粥样硬化的关系。结果:本组LN患者中MS的发生率为41.90%。存在MS的患者颈动脉斑块比例(28.41%vs 17.21%,P0.05)和IMT值[(0.74±0.25)mm vs(0.64±0.18)mm,P0.01]显著升高。随着MS组成病种数的增加,颈动脉IMT水平呈逐渐增高趋势(P0.01)。逐步多元线性回归进一步证实年龄(β=0.026,P=0.033)、病程(β=0.057,P=0.025)和MS(β=0.074,P0.001)是影响颈动脉IMT值的独立危险因素。结论:LN患者中MS的发生率较高,且与颈动脉粥样硬化显著相关,提示筛查MS对于LN患者动脉粥样硬化病变的防治可能具有重要的临床价值。     

慢性肾脏病非透析患者脑钠素与动脉粥样硬化及心功能的关系

目的 研究脑钠素（BNP）与慢性肾脏病（CKD）非透析患者动脉粥样硬化及心功能不全的关系。 方法 采用双抗夹心免疫荧光法检测203例CKD非透析患者与16例高血压患者对照组全血BNP水平，分析其与颈动脉超声结果、心脏彩超结果及既往心血管疾病史的关系。 结果 CKD非透析患者BNP水平与对照组相比显著升高[M（范围）：54.40(15.10～ 173.00) ng/L比9.35(7.35～15.00) ng/L，P < 0.01]。Spearman相关分析显示CKD患者BNP与颈动脉内膜中层厚度（IMT）、左室心肌重量指数（LVMI）等呈正相关。存在颈动脉斑块、左室肥厚或既往发生过心血管事件的患者血BNP水平显著增高。多元回归分析显示LVMI、既往心血管事件均是影响BNP水平的独立因素。 结论 CKD非透析患者BNP水平和动脉粥样硬化性疾病、左室肥厚及心功能不全相关，提示BNP水平可作为一项评价CKD非透析患者心功能及动脉粥样硬化的敏感生物学指标。     

老年人骨密度测定在颈动脉硬化随访观察中的意义

目的研究老年人骨质疏松与颈动脉粥样硬化的相关性,给出颈动脉内中膜厚度(IMT)、粥样斑块直径与骨密度T值之间联系。方法研究对象为第二人民医院老年科门诊和住院患者100例,采用双能X线吸收法(DXA)测定腰椎骨和股骨区的骨密度(BMD);同时采用彩超探查颈总及颈内动脉IMT及粥样斑块的情况。根据颈动脉病变程度分为3组:A组(无病变组)、B组(轻度病变组)和C组(中重度病变组)。结果 C组甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、骨碱性磷酸酶(BALP)水平明显低于A组,总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)明显高于A组,差异均有统计学意义(P0.05)。B组BALP水平明显低于A组,差异有统计学意义(P0.05)。C组BALP水平明显低于B组,差异有统计学意义(P0.05)。C组第2-4腰椎及股骨颈BMD水平均明显低于A组,C组股骨颈BMD水平明显低于B组,B组股骨颈BMD水平亦明显低于A组,差异均有统计学意义(P0.01)。结论老年颈动脉粥样硬化病变程度严重者,骨密度较正常及轻度者偏低。对有颈动脉粥样硬化的老年人随访及体检时加强骨密度检测可能有积极意义。     

维持性血液透析患者动脉粥样硬化的早期诊断及相关因素研究

显著的影响.MHD患者桡动脉内膜厚度显著厚于对照组(P＜0.05),与颈动脉IMT呈正相关(P＜0.01).有斑块患者IMT及心血管并发症的发生率高于无斑块患者(P＜0.01).结论 MHD患者颈动脉粥样硬化发生率高,微炎症状态是其发生的重要影响因素.     

慢性肾脏病患者血栓调节蛋白与动脉粥样硬化的相关性

目的 探讨慢性肾脏病(CKD)患者血栓调节蛋白（Tm）水平与动脉粥样硬化（AS）的相关性。 方法 以北京朝阳医院肾内科住院的96例CKD患者为对象,其中血液透析32例,非透析64例;30例健康志愿者为对照。参试者均于清晨空腹采静脉血,分别测定Scr、胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、C反应蛋白、血红蛋白及血栓调节蛋白。应用彩色多普勒超声检测颈动脉内膜中层厚度（IMT）。对血栓调节蛋白与IMT及相关参数进行相关分析。 结果 CKD患者血栓调节蛋白为（12.15±3.04） mg/L,显著高于健康对照组的（3.12±0.23） mg/L（P < 0.01）。血液透析组血栓调节蛋白为（16.89±3.35） mg/L,显著高于非透析组的（9.78±2.49） mg/L（P < 0.01）。血液透析组IMT值为（1.13±0.31） mm,斑块检出率为48.5%,均显著高于非透析治疗组的（0.95±0.33） mm和28.7%（均P < 0.05）。96例CRF患者的Tm水平与IMT呈正相关（r = 0.335,P < 0．01）。动脉病变程度越重者,血浆Tm水平越高。多元逐步回归分析结果显示,Tm（OR=1.13,95%CI 1.010~1.121）、SBP（OR=1.09,95%CI 1.009~1.114）、CRP（OR=1.22,95%CI 1.216~2.007）分别与CKD患者IMT独立相关。 结论 CKD患者Tm水平与IMT独立相关。血管内皮细胞损伤与CKD患者动脉粥样硬化并发症密切相关。Tm有可能成为血管内皮细胞损伤或功能紊乱的标志物。     

老年人动脉硬化与骨质疏松关系的初步研究

目的 探讨老年患者动脉硬化与骨质疏松的关系。方法对106例老年患者进行超声波颈动脉内中膜厚度(IMT)检测及双能X线吸收法(DEXA)骨密度(BMD)测定,并对界值上下两组患者临床数据及骨密度进行比较。另外,所有患者再分为骨质疏松组与非骨质疏松组,比较两组的IMT结果。结果 IMT≥0.8 mm组的松质骨T值明显降低(P<0.01),有斑块组BMD未明显低于无斑块组,骨质疏松组与非骨质疏松组比较,IMT无明显升高,骨密度与年龄及IMT。呈负相关(P<0.01)。结论 老年人动脉硬化可能与骨质疏松有关,但是颈动脉超声检查IMT不能作为很好反映动脉硬化与骨质疏松关系的指标。二者的明确因果关系有待于进一步研究。     

2型糖尿病患者颈动脉粥样硬化与骨密度的相关性研究

目的探讨2型糖尿病(T2DM)患者颈动脉粥样硬化(CA)与骨密度(BMD)的相关性。方法选取T2DM患者201例,根据颈动脉内膜中层厚度(IMT)分为正常组和动脉粥样硬化组。测量血压、身高、体重,并检测生化指标,采用彩色多谱勒超声测定颈动脉IMT,双能X线吸收仪(DXA)测定腰椎1-4、股骨颈、股骨转子、ward’s和全髋部的骨密度。结果男性T2DM患者动脉粥样硬化组L1、Ward’s骨密度均低于正常组,差异均有统计学意义(P0.05)。女性T2DM患者动脉粥样硬化组L1、L2、L3、L1-4、Ward’s、全髋部的骨密度均低于正常组,差异均有统计学意义(P0.05)。Pearson相关分析显示T2DM患者颈动脉IMT与各部位骨密度均成负相关。结论 T2MD患者颈动脉粥样硬化与骨密度密切相关。     

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Abstract

Background and aim: Omentin-1 is suggested to affect inversely atherosclerosis (AS). Data about omentin-1 is limited to chronic kidney disease (CKD). Our aim was to examine omentin-1 in non-diabetic CKD patients who are not dialyzed and investigate its relationships with inflammation and carotid AS. Materials and Methods: We performed a cross-sectional study in 55 non-diabetic CKD patients and 30 healthy controls. Baseline clinical and laboratory data were obtained for all participants. Serum omentin-1 and interleukin-6 (IL-6) levels were measured according to the manufacturer’s instructions. Carotic plaque and intima-media thickness (IMT) were assessed by carotid ultrasonography. The homeostasis model assessment of insulin resistance index (HOMA-IR) was used to assess IR. Results: Omentin-1 and IL-6 levels in the patient group were found to be higher than the control group; the differences were statistically significant (p?=?0.01 and p?=?0.04, respectively). Carotid IMT(mean) was significantly higher in the patient group (p?=?0.01). Omentin-1 did not correlate with IL-6 and IMT in the patient group (p?=?0.51 and p?=?0.76, respectively). In subgroup analysis, omentin-1 levels in patients with carotid plaque were lower than those without carotid plaque (179.5?±?88.1?ng/ml and 185.9?±?67.8?ng/ml, respectively). However, the difference was not statistically significant (p?=?0.47). Conclusion: We conclude that omentin-1 is higher in not dialyzed non-diabetic CKD and there is no correlation between omentin-1 and IL-6 or carotid IMT(mean).     

Asymptomatic atherosclerosis and hypertension in nondiabetic patients with chronic kidney disease

Abstract:  Atherosclerosis is accelerated in dialysis patients, but less is known about asymptomatic atherosclerosis and major risk factors in patients with different stages of chronic kidney disease (CKD). We compared intima media thickness (IMT) and plaque occurrence in the carotid arteries in 104 nondiabetic patients (stages 1–5 of CKD; mean age: 51.6 years) with those in 40 healthy control subjects. The IMT values (0.69 vs. 0.59 mm; P  < 0.002) were higher in patients. More patients had plaques (46.2 vs. 17.5%; P  < 0.002), and number of plaques was higher ( P  < 0.003). Negative correlation between IMT ( P  < 0.0001), presence of plaques ( P  < 0.0001), their number ( P  < 0.040), and chromium 51-labeled ethylenediaminetetraacetate (⁵¹Cr-EDTA) clearance were found in patients. With multiple regression analysis, relationship between IMT and ⁵¹Cr-EDTA clearance ( P  < 0.001) and presence of hypertension ( P  < 0.001) was found. Nondiabetic patients with CKD showed advanced atherosclerosis and IMT, plaque occurrence, and number increased directly with the level of renal dysfunction. Another important risk factor was hypertension.       

Bone Mineral Density,Carotid Artery Intimal Medial Thickness,and the Vitamin D Receptor <Emphasis Type="Italic">Bsm</Emphasis>I Polymorphism in Mexican American Women

Low bone mineral density (BMD) is a predictor of cardiovascular mortality, suggesting that osteoporosis and cardiovascular disease may share common risk factors. We assessed the relationship between BMD and intimal medial thickening (IMT) of the common carotid artery, a marker of sub-clinical atherosclerosis, in 471 women examined as part of the San Antonio Family Osteoporosis Study, a population-based study of osteoporosis risk conducted in Mexican American families. Because of the documented role of vitamin D metabolism in bone metabolism and its possible role in cardiovascular function, we further evaluated whether allelic variation at the vitamin D receptor locus (VDR) influenced joint variation in BMD and IMT. The association of BMD with IMT depended on age, with low BMD being correlated with high IMT in older women, but with low IMT in younger women [age by IMT interaction effects significant at the spine (P = 0.042), radius ultradistal (P = 0.010), and hip (P = 0.006)]. In all women, the VDR BsmI BB genotype was associated with significantly higher forearm BMD (P = 0.005 for both radius ultradistal and midpoint), higher IMT (P = 0.05), and higher spine BMD in older women (P = 0.06), but not with hip BMD. The association of the VDR genotype with IMT was independent of its association with BMD. Although a functional consequence of the BsmI polymorphism on vitamin D metabolism has not been established, these findings support a possible biological relationship among VDR, bone metabolism, and atherosclerosis. We conclude that VDR polymorphisms may be one of multiple factors influencing the joint risk of atherosclerosis and osteoporosis.     

中晚期CKD患者腹主动脉钙化发生情况及危险因素分析

目的：分析中晚期CKD患者腹主动脉钙化的发生情况和危险因素。方法：63例透析及非透析CKD患者进行腹部侧位片的检查,分析腹主动脉钙化发生情况及影响因素。结果：中晚期CKD患者腹主动脉钙化发生率为54%;腹主动脉钙化与年龄、血磷水平、钙磷乘积和低密度脂蛋白水平呈正相关（P〈0.05）。结论：中晚期CKD患者腹主动脉钙化高发,远端起病,年龄、血脂、钙磷水平影响其程度。     

Vitamin D deficiency, CD4+CD28null cells and accelerated atherosclerosis in chronic kidney disease

Aim: Cardiovascular disease (CVD) is the leading cause of death among chronic kidney disease (CKD) patients. The role of vitamin D remains controversial in this process. We evaluated the relationship between 25‐hydroxyvitamin D, abnormal T helper cells (CD4+CD28null cells), systemic inflammation and atherosclerosis in CKD patients. Methods: A total of 101 stage 4–5 non‐dialysis CKD patients and 40 healthy controls were studied. Common carotid artery intima media thickness (CCA‐IMT) was measured with an ultrasound system. 25(OH) vitamin D and highly sensitive C‐reactive protein (hsCRP) were measured in serum by enzyme linked immunosorbent assay. The frequency of circulating CD4+CD28null cells was evaluated by flowcytometry. Results: CKD subjects exhibited higher CCA‐IMT (0.71 ± 0.01 vs 0.56 ± 0.01 mm, P < 0.0001), hsCRP (90.7 ± 5.8 vs 50.1 ± 8.6 µg/mL, P < 0.0001), CD4+CD28null cell frequency (9.1 ± 0.9 vs 3.6 ± 0.5%, P < 0.0001) and lower 25(OH) vitamin D levels (17.9 ± 1.9 vs 26.9 ± 3.5 ng/mL, P < 0.0001). In CKD subjects, serum 25 (OH) vitamin D level showed a strong inverse correlation with CCA‐IMT (r = ?0.729, P < 0.0001) and correlated with CD4+CD28null cell frequency (r = ?0.249, P = 0.01) and hsCRP (r = ?0.2, P = 0.047). We also noted correlation of IMT with patient age (r = 0.291, P = 0.004) and CD4+CD28null cells (r = 0.34, P = 0.001). On multiple regression analysis, 25(OH) vitamin D level, diabetic status and CD4+CD28null cell frequency exhibited independent association with IMT in CKD subjects. Conclusions: Vitamin D deficiency, inflammatory activation and higher frequency of CD4+CD28null T lymphocyte population correlate with preclinical atherosclerotic changes in CKD population. These findings suggest possible linkage between vitamin D metabolism and T cell modulation – abnormalities that may contribute to development of atherosclerosis in CKD.     

Tight relations between coronary calcification and atherosclerotic lesions in the carotid artery in chronic dialysis patients

Aim: Both vascular calcification and atherosclerosis are highly prevalent in patients with end‐stage renal disease (ESRD) and have been associated with increased cardiovascular morbidity. Because those two phenomena might be only coincidentally related in chronic haemodialysis (HD) patients, in this study, coronary artery calcification (CAC), common carotid artery intima media thickness (CCA‐IMT) and thickness of atherosclerotic plaques in the carotid artery were simultaneously measured. Methods: In a cross‐sectional study of 47 HD patients (31 male, mean age 56.8 ± 11.4 years, and 16 female, mean age 56.0 ± 7.5 years) without history of major cardiovascular complications. CCA‐IMT and presence and thickness of atherosclerotic plaques were measured with ultrasound and CAC with multidetector computed tomography. Results: The CAC were present in 70.2% of patients. The mean CAC was 1055 ± 232, the mean CCA‐IMT was 0.96 ± 0.21. The atherosclerotic plaques in the common carotid arteries were visualized in 38 patients (80.1%), the mean thickness of the atherosclerotic plaque was 1.61 ± 0.8 mm. We found a significant positive correlation between CAC and CCA‐IMT (r = 0.70, P < 0.001). The thickness of atherosclerosis plaque positively correlated with CAC as well as with CCA‐IMT (r = 0.60, P < 0.001 and r = 0.7, P < 0.003, respectively). Conclusion: The study revealed close relationships between CAC, intima media thickness and the thickness of atherosclerotic plaques in dialysis patients. It may indicate that both vascular calcification and atherosclerotic lesions frequently coexist in patients with ESRD and that the intima media thickness could serve as a surrogate marker of vascular calcification.     

Relationship between insulin resistance and increased carotid artery intima-media thickness in non-diabetic kidney disease patients

Objective To evaluate the relationship of insulin resistance (IR) and carotid artery intima-media thickness (CA-IMT), plaque status in non-diabetic non-dialysis chronic kidney disease (CKD) patients with different stages. Methods One hundred and seventeen non-diabetes non-dialysis CKD patients were enrolled into this cross-sectional observational study. Insulin resistance index (HOME-IR) was assessed by the homeostasis model assessment. Patients with HOME-IR≥1.73 were defined as insulin resistance. And patients with CA-IMT≥0.9 mm were defined as thickening. The blood pressure measurement, heart Doppler ultrasound, bilateral carotid artery ultrasound examination, blood biochemistry and urine protein test were performed, eGFR was calculated by EPI formula. Results The prevalence of IR was 47.01% in 117 non-diabetic non-dialysis CKD patients, and it was 35.71%, 50.00% and 54.55% in eGFR≥60ml•min-1•(1.73 m2)-1 group, 30≤eGFR＜60ml•min-1•(1.73 m2)-1 group, and eGFR＜30ml•min-1•(1.73 m2)-1 group separately. In eGFR＜30ml•min-1•(1.73 m2)-1 group, cystain C, homocysteine, parathyroid hormone, Scr, BUN, uric acid, interventricular septal thickness, left ventricular dimension, left ventricular posterior wall thickness were significantly higher than that in the other two groups (P＜0.01), while the level of hemoglobin was significantly lower (P＜0.01); then the levels of serum albumin and systolic pressure were higher than that in the eGFR≥60ml•min-1•(1.73 m2)-1 group, however, the levels of total cholesterol and low-density lipoprotein-cholesterol were lower than that in the eGFR≥60ml•min-1•(1.73 m2)-1 group. Correlation analysis showed that insulin resistance index was significantly correlated with CA-IMT (r=0.444, P=0.006）in the eGFR＜30ml•min-1•(1.73 m2)-1 group, however, there wasn’t correlation in other two groups. And although insulin resistance wasn’t correlated with soft plaque, it was significantly correlated with hard plaque (χ2=6.476, P=0.011) in the eGFR＜30ml•min-1•(1.73 m2)-1 group. The Logistic regression analysis results displayed aging increase was the independent risk factor of the CA-IMT thickening for non-diabetes non-dialysis CKD patients but not insulin resistance. Conclusions HOMA-IR is correlated with CA-IMT and hard plaque when eGFR＜30ml•min-1•(1.73 m2)-1 in non-diabetes non-dialysis CKD patients. However, the insulin resistance isn’t the independent risk factor of the CA-IMT thickening for non-diabetes non-dialysis CKD patients.     

老年男性糖尿病患者骨质疏松与动脉硬化的相关性研究

目的 探讨老年男性糖尿病人群骨质疏松与动脉硬化的相关性。方法 测定226例老年男性糖尿病患者的股骨近端骨密度（BMD）,将其分为骨质疏松组和非骨质疏松组,分别比较两组的一般情况,同时采用动脉硬化检测仪进行测定其踝肱指数（ABI）和脉搏波传导速度（PWV）。结果 骨质疏松组患者的吸烟比例较非骨质疏松组高,差异有显著性（P<0.05）。骨质疏松组患者的ABI显著低于非骨质疏松组,PWV高于骨质疏松组,两组比较差异有显著性（P<0.05）。随BMD水平下降,所有患者的PWV水平升高,ABI降低,提示动脉硬化程度加重。结论 老年男性糖尿病骨质疏松患者更易并发动脉粥样硬化病变,治疗和预防时应采取系统性的措施。     

Risk factors of bone density disorder and vascular calcification in non-dialysis chronic kidney disease patients

Objective To explore the risk factors of bone density disorder and vascular calcification in non-dialysis chronic kidney disease (CKD) patients. Methods Clinical data of non-dialysis CKD patients who were admitted to the First Affiliated Hospital of Fujian Medical University between January 2013 and June 2014 were retrospectively analyzed. Using dual energy X-ray absorptiometry to evaluate their bone mineral density (BMD) and T value. Patients were divided into normal BMD group (T≥-1), osteopenia group (-2.5＜T＜-1) and osteoporosis group (T≤-2.5). The vascular calcification was evaluated by pectoral computed tomography. Multi-factor stepwise logistic regression analysis was used to assess the risk factors for low bone density and vascular calcification in non-dialysis CKD patients. Results A total of 337 non-dialysis CKD patients were enrolled. There were 110 (32.6%) patients with normal BMD, and 146(43.3%) patients with osteopenia, and 81(24.0%) patients with osteoporosis. Gender, history of hypertension, 25-hydroxy vitamin D and N-terminal osteocalcin shown statistical differences among three groups (all P＜0.05). The incidence rate of 25-hydroxy vitamin D deficiency shown statistical difference among three groups (P=0.012). Further, the rates were increased with the decreased bone mass (χ2=7.100, P=0.008). The other mineral bone disorders, such as hypocalcemia, hyperphosphatemia, low intact parathyroid hormone (iPTH) and high iPTH had no statistical difference among three groups (all P＞0.05). Multi-factor stepwise logistic regression analysis revealed that increased iPTH (OR=1.938), and low bone density (OR=1.724) were independent risk factors for CKD patients with vascular calcification (all P＜0.05), while women (OR=3.312) and vascular calcification (OR=1.742) were independent risk factors for CKD patients with low bone density (all P＜0.05). Conclusion Increased iPTH and low bone density are independent risk factors for non-dialysis CKD patients with vascular calcification, while women and vascular calcification are independent risk factors for non-dialysis CKD patients with low bone density.