腹主动脉瘤开腹手术与腔内修复术后心肌损伤比较

目的：比较腹主动脉瘤开腹手术与腔内修复术后心肌损伤程度.方法：收集75例腹主动脉瘤开腹切除手术和67例腔内修复手术患者的临床资料,根据患者冠状动脉CT造影（CTA）检查结果所示狭窄程度将所有病例分为轻、中、重三组,CTA示至少一处≥75％狭窄者为重度狭窄组,至少一处≥50％狭窄者为中度狭窄组,狭窄均＜50％者为轻度狭窄组.以肌钙蛋白I（cTnI） ≥0.01 μg/L为升高.每组进行两种术式病史资料及术后24h cTnI升高情况的比较.结果：中度狭窄组腔内介入13例,共6例术后cTnI升高,发生率46％；开腹手术15例中13例术后cTnI升高,发生率87％,两者比较,差异有统计学意义（P =0.042）.轻度狭窄及重度狭窄组腔内介入与开腹手术术后cTnI升高发生率差异无统计学意义（P＞0.05）.结论：冠状动脉中度狭窄患者腔内修复术较开腹手术术后心肌损伤发生率低.     

静息心电图 ST-T 改变及静息心率与冠心病严重程度的相关性

目的探讨静息心电图ST-T改变及静息心率与冠心病(CHD)严重程度的相关性。方法通过回顾性病例对照研究方法,采集508例CHD患者为病例组,410例非CHD患者为对照组,采用多因素Logistic回归分析及决策树方法,分析影响CHD严重程度的因素,并比较两种模型的优劣。结果①静息心电图ST-T改变与冠状动脉造影在CHD中的诊断阳性率差异有统计学意义(P0.05),心电图诊断的敏感性为65.4%,特异性为44.5%,但不同CHD严重程度在心电图ST-T改变率上差异有统计学意义(P0.028),说明血管病变数量越多,出现心电图ST-T改变的可能性越大。②静息时最大心率与有无患CHD疾病的差异有统计学意义(P0.05),但在不同CHD血管病变严重程度之间,尚不能发现有统计学差异(P0.205)。③经多因素Logistic回归结果显示年龄(OR=1.027)、性别(OR=4.098)、心绞痛类型(OR=2.208)、心电图ST-T改变(OR=1.315)、静息时最大心率(OR=1.015)、运动型心绞痛(OR=2.032)、ST斜率(OR=0.793)和病变血管数量(OR=1.235)为是否患CHD的主要影响因素;决策树分析CHD影响因素主要为心绞痛类型、ST段斜率、病变血管数量、运动型心绞痛和静息时最大心率。④两模型均较好地拟合了数据模型,但决策树模型判别效果(AUC=0.82)比Logistic回归模型[受试者工作特征曲线下面积(AUC)=0.78]要优。结论与传统的Logistic回归比较,决策树方法具有较高的预测效果,同时通过监测静息心电图结果、静息心率等指标并结合患者个体特征对CHD的严重程度具有一定的预测价值。     

中国农村高血压人群心电图非特异性ST-T改变的流行病学调查

目的总结中国农村高血压人群心电图非特异性ST-T改变的流行病学特点及相关影响因素。方法数据来源于中国脑卒中一级预防研究(CSPPT),于2008年5月19日至2013年8月24日共纳入20 702例来自江苏省及安徽省32个社区中年龄45~75岁的高血压患者,行血压、脉率、体质量指数(BMI)、血脂等测定,记录合并使用降压药物情况,同时行十二导联心电图。心电图采用明尼苏达编码的方法进行分析。最终入组15 038例患者,分析统计总体及不同性别非特异性ST-T改变的发生率。并根据心电图分为ST-T正常组和ST-T改变组,分析年龄、空腹血糖、吸烟、饮酒等危险因素与非特异性ST-T改变的关系。结果中国农村高血压人群心电图非特异性ST-T改变的发生率为8.5%,其中男性为5.7%,女性为10.3%,女性高于男性(P0.05)。Logistics回归分析显示:女性(OR=2.07,95%CI1.68~2.54)、高龄(55~65岁组OR=1.28,95%CI1.10~1.49;65~75岁组OR=1.64,95%CI1.39~1.93)、高收缩压(160~180 mm Hg组OR=1.62,95%CI 1.18~2.24;≥180 mm Hg组OR=2.20,95%CI 1.59~3.04)、高胆固醇血症(OR=1.14,95%CI 1.01~1.29)及口服利尿剂(OR=1.69,95%CI1.20~2.37)是非特异性ST-T改变发生的危险因素(均P0.05);而口服血管紧张素转换酶抑制剂(ACEI)为非特异性ST-T改变发生的保护因素(OR=0.68,95%CI0.54~0.86,P0.05)。结论在中国农村高血压人群中,心电图非特异性ST-T改变较常见,总体发生率为8.5%,其危险因素为女性、高龄、高收缩压、高胆固醇血症及口服利尿剂,其保护因素为口服ACEI。     

非ST段抬高型急性冠状动脉综合征患者入院肌酸激酶同工酶与肌钙蛋白Ⅰ检测一致性分析

目的:评价肌酸激酶同工酶(CK-MB)与肌钙蛋白I(cTnI)在非ST段抬高型急性冠状动脉综合征(NSTE-ACS)患者早期危险分层及处理中的作用及二者结果一致性的意义。方法:1 074例NSTE-ACS患者,入院早期(<48 h)行冠状动脉造影检查并采集症状发作至入院36 h内cTnI和CK-MB检测结果。以>1×正常值上限(ULN)作为阳性结果,以≤1×ULN作为阴性结果,将入选患者分为4组:CK-MB、cTnI均阴性组(CK-MB-/cTnI-组),CK-MB阳性、cTnI阴性组(CK-MB /cTnI-组),CK-MB阴性、cTnI阳性组(CK-MB-/cTnI 组),CK-MB、cTnI均阳性组(CK-MB /cTnI 组)。评价组间结果一致与不一致的发生率及早期侵入性检查(<48 h)应用情况,统计各组院内主要不良心脏事件(MACE)。结果:1 074例NSTE-ACS患者在CK-MB-/cTnI-组、CK-MB /cTnI-组、CK-MB-/cTnI 组、CK-MB /cTnI 组中分别为664例、90例、54例、266例。cTnI 318例,CK-MB 356例;CK-MB与cTnI结果一致者共930例(CK-MB-/cTnI-组664例,CK-MB /cTnI 组266例);CK-MB与cTnI结果不一致者144例(CK-MB /cTnI-组90例,CK-MB-/cTnI 组54例)。CK-MB-/cT-nI 组与CK-MB /cTnI-组在冠状动脉病变支数、SCAI分型及院内MACE比较差异无统计学意义(P>0.05)。Logistic回归分析结果显示:冠状动脉病变SCAI分型、cTnI是CK-MB升高的危险因素;冠状动脉病变SCAI分型、冠状动脉病变支数、CK-MB是cTnI升高的危险因素。同时发现,在4组间存在风险逐渐上升的倾向。与CK-MB-/cTnI-组院内MACE进行比较,CK-MB /cTnI-组(OR=2.07,95%CI:1.04~4.84)、CK-MB-/cT-nI 组(OR=3.57,95%CI:2.41~6.14)、CK-MB /cTnI 组(OR=4.12,95%CI:2.98~8.32)院内风险有逐级升高趋势。结论:在NSTE-ACS患者,cTnI升高能够独立预测患者院内风险,CK-MB 的预测价值与cTnI 比较无明显差异。     

冠状动脉旁路移植术后主动脉内球囊反搏应用的危险因素分析及预测模型的构建

目的：探讨冠状动脉旁路移植术（coronary artery bypass grafting,CABG）后应用主动脉内球囊反搏（intra-aortic balloon pump,IABP）的危险因素,构建预测CABG术后应用IABP风险的列线图模型。方法：回顾性收集2020年3月至2022年9月,在河南省人民医院心脏中心行CABG手术的161例冠心病患者的临床资料,根据CABG术后是否应用IABP将患者分为IABP组（58例）和非IABP组（103例）。通过单因素及多因素Logistic回归分析筛选影响CABG术后应用IABP的危险因素,应用R软件建立预测IABP应用风险的列线图模型,利用ROC曲线下面积（AUC）、校准曲线和Hosmer-Lemeshow拟合优度检验评估列线图预测模型。结果：多因素Logistic回归分析显示：术前NT-proBNP(OR=1.288,95%CI:1.063～1.560,P=0.010)升高、术前肌钙蛋白T(TnT)(OR=2.460,95%CI:1.079～5.383,P=0.032)升高、术前LVEF(OR=0.873,95%CI:0.830～0...     

基于形态学的腹主动脉瘤破裂风险评估研究

目的:以计算机断层扫描血管造影(CTA)为基础分析除最大直径以外的其他影响腹主动脉瘤破裂的形态学指标。方法:通过性别,年龄(±3岁),最大瘤体直径(±2.5 mm)进行破裂腹主动脉瘤(破裂组)与稳定腹主动脉瘤(稳定组)的1:1匹配,收集2组患者的临床基线资料与腹主动脉瘤解剖形态信息,通过单因素统计检验以及多元回归分析比较二者间的差异,分析影响动脉瘤破裂的危险因素。结果:破裂组(39例)与稳定组(39例)的临床基线情况无差异,破裂组的平均瘤颈长度明显短于稳定组[(25.26±17.99) mm vs(36.19±19.40) mm,P=0.013],双侧髂总动脉近端直径明显小于稳定组[(右侧：(18.21±7.84) mm vs(21.73±8.27) mm,P=0.030;左侧：(16.28±5.23) mm vs(19.00±5.80) mm,P=0.048]。Logistic回归分析结果显示,瘤颈长度<12 mm(OR=7.28,95%CI:1.47～36.04,P=0.015)、双侧髂总动脉近端直径之和与腹主动脉瘤最大直径之比<0.56(OR=3.67,95%CI:1...     

血浆同型半胱氨酸水平与腹主动脉瘤的相关性研究

目的探讨血浆同型半胱氨酸(Hcy)水平与腹主动脉瘤的相关性。方法回顾性分析2011年7月²012年7月入住我院血管外科经CT诊断为腹主动脉瘤患者(病例组)58例,另选健康体检者63例为对照组。常规检测血生化指标,采用循环酶法检测Hcy水平。结果与对照组比较,病例组高同型半胱氨酸血症(HHcy)发生率明显升高(65.5%vs 27.0%,P<0.01),Hcy水平明显升高[(19.02±9.80)μmol/L vs(13.37±4.54)μmol/L,P<0.01]。多元logistic回归分析显示,HHcy较非HHcy发生腹主动脉瘤的风险增加4.12倍(OR=5.12,95%CI:2.332012年7月入住我院血管外科经CT诊断为腹主动脉瘤患者(病例组)58例,另选健康体检者63例为对照组。常规检测血生化指标,采用循环酶法检测Hcy水平。结果与对照组比较,病例组高同型半胱氨酸血症(HHcy)发生率明显升高(65.5%vs 27.0%,P<0.01),Hcy水平明显升高[(19.02±9.80)μmol/L vs(13.37±4.54)μmol/L,P<0.01]。多元logistic回归分析显示,HHcy较非HHcy发生腹主动脉瘤的风险增加4.12倍(OR=5.12,95%CI:2.33¹1.27,P=0.00)。调整相关危险因素后,未明显改变相关结果(OR=3.35,95%CI:1.1411.27,P=0.00)。调整相关危险因素后,未明显改变相关结果(OR=3.35,95%CI:1.14⁹.80,P=0.03)。病例组HHcy患者与Hcy水平正常者腹主动脉瘤最大直径比较,差异无统计学意义[(5.66±1.49)cmvs(5.11±0.98)cm,P=0.18],年龄与腹主动脉瘤最大直径不相关(r=0.09,P=0.48)。结论 HHcy患者发生腹主动脉瘤的风险更大。降低Hcy水平可能有助于减缓腹主动脉瘤的发展。     

冠心病病人经皮冠状动脉支架植入后的心电图分析

目的观察静息状态下冠心病病人心电图ST-T的水平及冠状动脉支架植入术后心电图ST—T、QT间期离散度的变化。评价心电图ST-T、QT间期离散度的变化与冠状动脉狭窄程度的关系。方法依据冠状动脉造影结果将冠心病病人心电图有无持续性ST—T改变分为ST-T正常组与ST-T异常组，观察冠状动脉植入支架术后心电图ST-T的变化及QT间期离散度的变化。结果两组在冠状动脉支架植入后心电图ST-T无变化。QT间期离散度比较有统计学意义（P〈0．05）。结论静息状态下心电图持续性ST—T改变与冠状动脉狭窄无相关性，QT间期离散度与冠状动脉是否狭窄有关。     

急性冠脉综合征病人aVL导联T波倒置预测左前降支中段病变的临床意义

目的研究急性冠脉综合征(ACS)病人心电图aVL导联T波倒置与左前降支中段病变的关系。方法将241例ACS病人按照入院心电图aVL导联T波形态分为T波倒置组(95例)和T波非倒置组(146例),比较两组临床资料以及冠状动脉病变情况。分析T波倒置对左前降支中段病变的预测价值。结果T波倒置组左前降低中段狭窄程度明显高于T波非倒置组(P<0.01)。多元Logistic回归分析显示,左前降低中段狭窄程度是aVL导联T波倒置的独立危险因素[OR=1.028,95%CI(1.019,1.036),P<0.01];一致性检验中,aVL导联T波倒置预测AMI病人左前降低中段狭窄程度≥50%与冠状动脉造影呈中等程度相关(Kappa=0.558,P<0.01)。结论aVL导联T波倒置与左前降支中段狭窄相关,可作为预测左前降支中段病变的方法之一。     

术前血浆D-二聚体含量对择期经皮冠状动脉介入治疗术后心肌损伤的预测价值

目的:探讨经皮冠状动脉介入治疗术前血浆D-二聚体含量对术后心肌损伤的预测价值.方法:68例择期行经皮冠状动脉介入治疗的患者,根据术后12～24 h肌钙蛋白Ⅰ(cTnI)是否≥1.0 ng/ml而分为肌钙蛋白阳性组及肌钙蛋白阴性组.采用酶联免疫吸附法测定手术前、后血浆D-二聚体含量,并进行两组间的比较.结果:肌钙蛋白阳性组血浆D-二聚体含量术后即刻及术后12～24 h均高于术前(P＜0.05),在各时间点的血浆D-二聚体含量均高于肌钙蛋白阴性组(P＜0.05).多变量逐步Logistic回归分析表明术前及术后即刻血浆D-二聚体含量、术前血管狭窄程度是术后cTnI升高的独立预测指标(P＜0.05).ROC曲线分析显示预测术后cTnI升高的最佳界值为术前血浆D-二聚体含量≥0.345 mg/L.结论:术前血浆D-二聚体含量是术后心肌损伤的独立预测因素,术前血浆D-二聚体含量≥0.345 mg/L者应视为术后cTnI升高的高危患者.     

冠心病患者心电图和冠脉CT检查结果分析

目的探讨冠心病患者心电图和冠脉CT检查的相关性及其临床意义。方法对诊断明确的冠心病患者行心电图和冠脉CT检查,分析其相关性。结果心电图检查均有ST—T改变者,冠脉CT9例有血管病变,血管狭窄程度为50％-70％,1例为冠状动脉血管均纤细（各支血管管腔内未见斑块形成和血管狭窄）,6例为冠状动脉前降支肌桥。结论心电图和冠脉CT检查均可作为判定病变程度的重要指标。     

Aortic stenosis: an underestimated risk factor for perioperative complications in patients undergoing noncardiac surgery

PURPOSE: To determine the incidence of perioperative events in patients with aortic stenosis undergoing noncardiac surgery. METHODS: We studied 108 patients with moderate (mean gradient, 25 to 49 mm Hg) or severe (mean gradient, > or =50 mm Hg) aortic stenosis and 216 controls who underwent noncardiac surgery between 1991 and 2000 at Erasmus Medical Center. Controls were selected based on calendar year and type of surgery. Details of clinical risk factors, type of surgery, and perioperative management were retrieved from medical records. The main outcome measure was the composite of perioperative mortality and nonfatal myocardial infarction. RESULTS: There was a significantly higher incidence of the composite endpoint in patients with aortic stenosis than in patients without aortic stenosis (14% [15/108] vs. 2% [4/216], P <0.001). This rate of perioperative complications was also substantially higher in patients with severe aortic stenosis compared with patients with moderate aortic stenosis (31% [5/16] vs. 11% [10/92], P = 0.04). After adjusting for cardiac risk factors, aortic stenosis remained a strong predictor of the composite endpoint (odds ratio = 5.2; 95% confidence interval: 1.6 to 17.0). CONCLUSION: Aortic stenosis is a risk factor for perioperative mortality and nonfatal myocardial infarction, and the severity of aortic stenosis is highly predictive of these complications.     

不稳定性心绞痛心电图预测左前降支病变部位的价值

目的 探讨12导联常规心电图表现在预测冠状动脉(冠脉)左前降支(LAD)病变部位中的价值.方法 选择临床诊断为不稳定性心绞痛(UAP)患者70例,冠脉造影结果显示罪犯血管为LAD.入院后完成12导联常规心电图检查,监测心肌损伤标志物变化,择期行冠脉造影术.分析UAP患者胸痛时心电图表现与LAD病变部位的关系.结果 96.7%的LAD近段狭窄患者,V3导联ST段压低伴V1、V2导联T波低平或倒置;7.5%的LAD中段狭窄患者,V3导联有相同改变(P＜0.05).V4导联ST-T段改变差异有显著性(P＜0.05);V5、V6导联ST-T段改变差异无显著性(P＞0.05).经多因素logistic回归分析显示,V3导联ST段压低是否伴V1、V2导联T波低平或倒置对LAD病变部位有明显的独立预测价值[OR(95%CI)为33.119),P＜0.001].结论 UAP患者胸痛时,12导联常规心电图表现可以用于初步判定LAD近段或中段狭窄部位.     

胸腹降主动脉置换术后发生脊髓损伤危险因素分析

目的 研究胸腹降主动脉置换术后发生脊髓损伤的围术期风险因素.方法 收集2013年3月至2018年9月130例行胸腹降主动脉置换术患者的临床资料.对所有变量进行单因素Logistic回归,将P＜0.2的变量及临床中认为可能影响术后脊髓缺血的因素纳入多因素Logistic回归模型中进行逐步剔除法建立方程.结果 体质量指数(...     

持续性ST-T改变对慢性心肌缺血诊断价值的探讨

目的 探讨静息心电图持续性ST—T改变与慢性冠状动脉供血不足之间的关系。方法 观察168例持续性ST-T改变患者选择性冠状动脉造影术和活动平板运动试验等结果。结果 34例(20．2％)造影发现有冠状动脉狭窄，其中活动平板运动试验阳性者32例，占冠状动脉狭窄病例的94．1％。运动试验阳性者42例中冠状动脉狭窄者32例(76．2％)。结论 静息心电图持续性ST—T改变不是慢性心肌缺血的特异性改变，绝大多数(79．8％)并非由冠状动脉狭窄引起，应努力寻找其他原因。     

Cardiopulmonary complications of ERCP in older patients

BACKGROUND: Biochemical markers of ERCP-related myocardial injury have not previously been investigated. OBJECTIVE: To evaluate ERCP-related cardiac troponin I (cTnI) release, myocardial ischemia, hemodynamic changes, and arterial hypoxemia in a series of consecutive patients according to age and to determine their relationship to preexisting cardiovascular risk factors (RF) and the development of post-ERCP pancreatitis. DESIGN: Prospective cohort study. SETTING: Tertiary teaching hospital, Canberra, Australia. PATIENTS: Data were collected on 130 consecutive ERCPs performed on 100 unselected patients (aged 18-93 years) by one endoscopist. Patients were divided into two groups: 65 years of age and older (group 1, n = 53; 27 women) and less than 65 years of age (group 2, n = 47; 33 women). INTERVENTIONS: ERCP. MAIN OUTCOME MEASUREMENTS: Cardiovascular RFs were identified, and electrocardiogram (ECG), cTnI, creatine kinase (CK), amylase, and lipase were measured before and 24 hours after ERCP. Oxygen saturation (SpO(2)), heart rate (HR), blood pressure (BP), and ECG were monitored continuously during each procedure. RESULTS: New ECG changes (ischemia, arrhythmias) occurred in 24% of procedures in group 1 and in 9.3% in group 2 (p = 0.168), and episodic arterial hypoxemia (SpO(2) < 90%) in 16.2% (group 1) and 21.4% (group 2) (p = 0.596). A post-ERCP rise in cTnI levels was documented in 6 patients in the older group. Two of these patients died: one from acute myocardial infarction and one from undiagnosed ascending aortic aneurysm. A cTnI rise was not related to any comorbid conditions, total number of RFs, hemodynamic or ECG changes, or arterial desaturation. In patients with a new cTnI rise, the duration of ERCP was significantly longer (59.5 vs. 26.4 minutes, p = 0.026), being 30 minutes or longer in 5 of 6 patients. Post-ERCP pancreatitis was associated with desaturation (relative risk [RR] = 5.9; 95% confidence interval [CI] [1.2, 32.0], p = 0.027) and myocardial ischemia/injury (RR = 4.4; 95% CI [1.4, 7.8]; p = 0.009). CONCLUSIONS: Although the majority of older patients tolerated ERCP well, in 8% of procedures, most of which were prolonged (>30 minutes), myocardial injury, as defined by the release of cTnI, occurred. Desaturation and myocardial ischemia/injury were associated with post-ERCP pancreatitis.     

Comparison of computed tomographic angiography versus rubidium-82 positron emission tomography for the detection of patients with anatomical coronary artery disease

BACKGROUND: The present study compared computed tomographic coronary angiography (CTA) and positron emission tomography (PET) for the detection of significant anatomical coronary artery stenosis as defined by conventional invasive coronary angiography (CICA). METHODS: The study protocol was approved by the local ethics board, and informed consent was obtained from all patients. Of the 26 patients (mean age 57+/-9 years, 18 men) who prospectively underwent CTA and rubidium-82 PET before CICA, 24 patients had a history of chest pain. Images were interpreted by expert readers and assessed for the presence of anatomically significant coronary stenosis (50% luminal diameter stenosis or greater) or myocardial perfusion defects. Diagnostic test characteristics were analyzed using patient-based, territory-based, vessel-based and segment-based analyses. RESULTS: In the 24 patients referred for chest pain, CTA had similar sensitivity to PET, but was more specific (sensitivity 95% [95% CI 72% to 100%] versus 95% [95% CI 72% to 100%], respectively; specificity 100% [95% CI 46% to 100%] versus 60% [95% CI 17% to 93%], respectively) in the detection of patients with anatomical coronary artery stenosis of 50% or greater. On a per-segment basis of all 26 patients, CTA had a sensitivity, specificity, positive predictive value and negative predictive value of 72%, 99%, 91% and 95%, respectively, in all coronary segments. CONCLUSIONS: Coronary CTA has a similar sensitivity and specificity to rubidium-82 PET for the identification of patients with significant anatomical coronary artery disease.     

Cardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage

OBJECTIVES: We studied the incidence of myocardial injury in aneurysmal subarachnoid hemorrhage (SAH) using the more sensitive cardiac troponin I (cTnI) assay, correlated changes in cTnI with creatine kinase, MB fraction (CK-MB), myoglobin, and catecholamine metabolite assays, and examined the predictive value of changes in cTnI for myocardial dysfunction. BACKGROUND: Myocardial injury in aneurysmal SAH as evidenced by elevated CK-MB fraction has been reported. Little published data exist on the value of cTnI measurements in aneurysmal SAH. METHODS: Thirty-nine patients were studied for seven days. Clinical cardiovascular assessment, electrocardiographic (ECG), echocardiography, cTnI, CK, CK-MB and CK-MB index, myoglobin and 24-h urinary catecholamine assays were performed in all patients. The ECG abnormalities were defined by the presence of ST-T changes, prolonged QT intervals, and arrhythmias. An abnormal echocardiogram was defined by the presence of wall-motion abnormalities and a reduced ejection fraction. The severity of SAH was graded clinically and radiologically. RESULTS: Eight patients demonstrated elevations in cTnI (upper limit of normal is 0.1 microg/liter with the immunoenzymatic assay and 0.4 microg/liter with the sandwich immunoassay), while five had abnormal CK-MB levels (upper limit of normal is 8 microg/liter). Patients with more severe grades of SAH were more likely to develop a cTnI leak (p < 0.05). Patients with cTnI elevations were more likely to demonstrate ECG abnormalities (p < 0.01) and manifest clinical myocardial dysfunction (p < 0.01) as evidenced by the presence of a gallop rhythm on auscultation and clinical or radiological evidence of pulmonary edema as compared to those with CK-MB elevations. The sensitivity and specificity of cTnI to predict myocardial dysfunction were 100% and 91%, respectively, whereas the corresponding figures for CK-MB were 60% and 94%, respectively. Elevations in myoglobin levels (upper limit of normal <70 microg/liter) and urinary catecholamine metabolites (urinary vanilmandelate/creatinine ratio upper limit of normal, 2.6) are a nonspecific finding. CONCLUSIONS: Measurements of cTnI reveal a higher incidence of myocardial injury than predicted by CK-MB in aneurysmal SAH, and elevations of cTnI are associated with a higher incidence of myocardial dysfunction. Thus, cTnI is a highly sensitive and specific indicator of myocardial dysfunction in aneurysmal SAH.     

肌钙蛋白I对不稳定型心绞痛患者预后评价

目的观察不稳定型心绞痛（UAP）患者入院后血清肌钙蛋白I（cTnI）的变化,探讨其与ECG改变、心绞痛分级、冠状动脉病变的关系及对心脏事件的短期预报价值。方法34例UAP患者分别在入院时,入院后12h、24h、48h、10d各采血一次。用免疫发光法测定cTnI浓度,并分析其与临床状况、冠状动脉病变以及心脏事件的关系。结果在30d内,UAP患者中cTnI≥0.4μg/L者46.67%发生心脏事件;cTnI＜0.4μg/L者10.53%发生心脏事件（P＜0.05）。心绞痛Ⅲ级cTnI阳性率高,cTnI有否升高与心电图改变及冠状动脉造影、冠状动脉病变支数、狭窄部位无关（P>0.05）。cTnI对预测发生心脏事件的敏感性77.8%、特异性68%、阳性预测值46.7%、阴性预测值89.5%、准确性70.6%。结论cTnI定量测定对判断UAP患者短期内发生心脏事件有重要的预报价值。