Effect of adaptation to moderate physical loads on the increased resistance of the isolated heart to ischemia and reperfusion

Adaptation to physical loads elicits pronounced anti-ischemic and antireperfusion effects on the isolated heart. By the 20th min of total ischemia contracture in the hearts of adapted animals is much less than that in the control group. During reperfusion of hearts from adapted animals the degree of restoration of the contractile force was 6-fold higher, contracture was lesser, and the total period of tachycardia and fibrillation were 3-fold shorter than in the control. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 1, pp. 25–27, January, 1995 Presented by S. S. Debov, Member of the Russian Academy of Medical Sciences     

Seasonal differences in the development of heightened resistance of the isolated heart during adaptation to physical exercise

Substantial seasonal differences are found in the development of the cardioprotective effect of adaptation to physical exercise: in winter such adaptation results in an increase of the resistance of the isolated heart to the contracture and arrhythmogenic effects of ischemia and reperfusion, while in summer the anticontracture effect is absent and the antiarrythmic effect is significantly lowered. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 9, pp. 299–301, September, 1995 Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences     

Study of cardioprotective effect of α-tocopherol and panthenol using an experimental model of ischemized-reperfused isolated heart

Using an experimental ischemia-reperfusion model it is found that combined treatment with α-tocopherol and panthenol markedly increases the content of endogenous antioxidant tocopherol during total ischemia and reperfusion, i.e., it improves the antioxidant state of the postischemized myocardium, thus preventing possible damage caused by stepped-up production of active oxygen forms during reoxygenation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 6, pp. 574–576, June, 1994 Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences     

Impact of 13(S)-HPODE,a lipoxygenase product of linoleic acid,on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma

In thisin vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE) increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter, stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC₅₀=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca²⁺ transport and of membrane-bound enzymes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 9, pp. 255–257, September, 1995 Presented by D. F. Chebotarev, Member of the Russian Academy of Medical Sciences     

Adaptation to hypoxia,unlike adaptation to stress,fails to protect the isolated heart from reperfusion after total ischemia (An NMR study)

Effects of adaptation to hypoxia on the contractility of isolated rat hearts and on their levels of ATP and inorganic phosphate after total ischemia were evaluated. This adaptation failed to render the cardiac energy-supplying system more resistant to postischemic reperfusion and thus did not accelerate the restoration of cardiac contractility after ischemia. The results of adaptation to hypoxia were then compared with those of adaptation to stress, which had been shown to bring about a marked increase in cardiac resistance to postischemic reperfusion. It is concluded that the profound differences noted between the cardioprotective effects of these two forms of adaptation are due to a much greater accumulation of stabilizing proteins from the HSP70 family during adaptation to stress. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 11, pp. 481–484, November, 1995 Presented by N. R. Paleev, Member of the Russian Academy of Medical Sciences     

The effect of delta-sleep-inducing peptide on the Ca-transporting system of the sarcoplasmic reticulum and activity of the myocardial antioxidant enzymes

It is demonstrated that immobilization stress against the background of lowered catalase activity impairs the function of the sarcoplasmic reticulum Ca pump, particularly at high Ca²⁺ levels. the membranes of intracellular Ca²⁺ depots are destroyed much more rapidly than in the control, which results in Ca²⁺ release. Administration of delta sleep-inducing peptide to control animals results in a 30% increase in catalase activity for an unchanged level of superoxide dismusase and markedly improves the function of the Ca-transporting system at elevated levels of free Ca²⁺. A long-term stress after administration of the peptide not only causes no damage to the Ca-transporting system but actually increases its efficiency (compared with the control) at a high catalase level. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 3, pp. 248–251, March, 1996 Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences     

Effect of nifedipine and ruthenium red on the contractile function and oxidative metabolism of the myocardium

Translated fromByulleten' Experimental'noi Biologii i Meditsiny, Vol. 115, N ^o 4, pp. 375–378, April, 1993     

Evaluation of the antipyretic effect of psychotropic agents and their influence on the fever-lowering effect of acupuncture

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ⁰ 3, pp. 262–264, March, 1993     

Effect of amiridine and tacrine on potassium currents in the nerve fiber

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 10, pp. 397–400, October, 1993     

Synchronization and desynchronization of the “Hypertensive” heart

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 7, pp. 17–19, July, 1993     

Morphological characteristics of the brain in 20–21-day-old rat embryos and in 1–5-day-old rats

Translated fromByulleten' Experimental'noi Biologii i Meditsiny, Vol. 116, N ^o 12, pp. 641–642, December, 1993     

Contribution of the ventral structures of the medulla oblongata to the hemodynamics and transcapillary fluid exchange in the lungs

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 12, pp. 563–566, December, 1993     

In vitro effect of bilirubin on antioxidant activity and lipid peroxidation in the plasma and erythrocytes of cord blood

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 7, pp. 50–52, July, 1993     

Effect of defensins on the blood level of corticosterone and the immune response during stress

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 6, pp. 646–649, June, 1993     

Cardiodynamics and pumping function of the heart under conditions of hyperthermia

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 8, pp. 115–116, August, 1993     

Relationships between catecholamine levels in the salivary glands,oral mucosa,and saliva of rats with experimental staphylococcal sialadenitis

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 7, pp. 38–40, July, 1993.     

The effect of interleukin-2 on rosette formation and its dependence on the level of serotonin

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 8, pp. 183–186, August, 1993     

Changes of the efficacy of vasoconstrictive stimuli in acute and chronic hypotension in the microcirculatory bed of rat skeletal muscle

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 8, pp. 139–142, August, 1993     

Effect of endothelin-1 on the adrenoreactivity of blood vessels and on the participation of G-proteins and protein kinase C in endothelin-1-induced vasoconstriction

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 10, pp. 374–376, October, 1993     

Effects of ultrasound,the polyene antibiotic amphotericin B,and their combination on biomembranes of yeastlikeCandida fungi

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 10, pp. 391–393, October, 1993