正常泪道和泪道阻塞的CT检查

目的观察正常泪囊和鼻泪管以及泪道阻塞的CT表现。方法对32例正常泪道CT片及19例泪道阻塞患者CT表现进行观察分析。结果对正常泪道轴位软组织窗CT扫描图像进行分析:泪囊78.1%显影、21.9%不显影,鼻泪管均可显示;显影的泪囊和鼻泪管可分为双侧含气影、双侧黏膜影、一侧含气一侧黏膜影。4例泪道占位病变CT显示:泪囊区高密度影,鼻泪管扩张增粗,管内组织高密度。9例外伤后泪道阻塞CT显示:泪囊区软组织增厚,泪囊扩张或密度增高,泪囊区异常骨碎片影,鼻泪管骨折和阻塞。6例泪囊和鼻泪管炎症CT表现:泪囊区软组织增厚、密度增高,鼻泪管阻塞和密度增高。结论对正常泪道软组织窗轴位进行CT扫描:泪囊可显影或不显影;鼻泪管均可显影;显影的泪囊和鼻泪管表现为含气影或黏膜密度影。泪道占位、外伤和炎症均可在CT片上明确显示,利于诊断。     

Nasolacrimal duct obstruction caused by a cylindroma. Report of an atypical tumor manifestation and review of the literature

BACKGROUND: The purpose of this report is to describe the clinical characteristics, management and histological findings in a patient with obstruction of the nasolacrimal duct caused by a cylindroma. About 618 lacrimal sac tumours have been reported previously in reviews and case reports, which were reviewed after searching in medline database. CASE REPORT: A 79-year old man suffered from multiple cylindromas (Spiegler tumour) on his head for about 40 years. He presented with a 6 months' history of left-sided epiphora and a painless medial canthal mass of various size. A tumour which caused nasolacrimal duct obstruction was found during dacryocystorhinostomy. After complete excision histological examination revealed a cylindroma, which had shown expansive growth from dermis to the lacrimal sac area. The patient felt well; there was no longer any epiphora or dacryocystitis after the operation. CONCLUSION: Although very rare, lacrimal sac tumours must be considered in the differential diagnosis of nasolacrimal duct obstruction. To our knowledge this case represents the first report on an atypical manifestation on a Spiegler tumour in the lacrimal sac region.     

Adult nasolacrimal sac mucocele

Adult nasolacrimal sac mucocele is an uncommon mass arising in the medial canthal region of the orbit. Twenty-one cases with lacrimal sac mucocele were reviewed retrospectively. We gathered information about the clinical characteristics, natural history, mechanism for mucocele formation and optimal management of this disorder. The results show that the medial canthal mass was confirmed to be dacryo-cystocele-associated with distal nasolacrimal duct obstruction and proximal obstruction at the junction of the common canaliculus and sac. The interventional procedure of polyurethane stent placement is a practicable and simplified treatment for lacrimal sac mucocele.     

Occult oncocytoma of the lacrimal sac

Oncocytoma of the lacrimal sac is a rarely encountered clinical entity. We report the case of a 72-year-old female patient who was diagnosed to have bilateral nasolacrimal duct obstruction during a pre-cataract surgery screening. Subsequently, she underwent bilateral dacryocystectomy. Histopathological examination of the left lacrimal sac revealed a tumour composed of acini lined by oncocytic cells; features consistent with those of a lacrimal sac oncocytoma. Although rare, oncocytomas arising from the lacrimal sac may co-exist with a nasolacrimal duct obstruction. This report describes the histological and immunochemistry characteristics of oncocytomas and underscores the need to subject all excised lacrimal sacs to histopathological examination.     

Epiphora as first presenting sign of primary extranodal NK/T-cell lymphoma of the lacrimal sac

A 28-year-old Caucasian female presented with a six-month history of epiphora of the right eye. Diagnostic lacrimal syringing revealed obstruction of the right nasolacrimal duct. During external dacryocystorhinostomy (DCR), the lacrimal sac had an unusual papillary appearance. Frozen sections suggested malignant lymphoid cells. Pathologic examination revealed extranodal NK/T-cell lymphoma, nasal type. Imaging revealed a mass lesion centered on the lacrimal sac. The authors describe the youngest Caucasian patient with a primary NK/T-cell lymphoma of the lacrimal sac, as well as the first case presenting with epiphora as the sole presenting symptom, reported in the literature. Extranodal NK/T-cell lymphomas rarely occur in the orbit, and are known to be rapidly growing, aggressive lesions. Despite chemotherapy, the patient succumbed to her disease twelve months after diagnosis. Lacrimal surgeons should maintain a high index of suspicion in all cases of primary nasolacrimal duct obstruction. Pre- or intra-operative clinical suspicion of malignancy in the lacrimal sac necessitates biopsy.     

A Case of Recurrent Schneiderian Papilloma of the Lacrimal Sac Invading the Nasal Cavity

A 44-year-old man presented with a history of chronic epiphora, discharge from the right eye, and a palpable mass in the medial canthal area. Irrigation of the lacrimal system revealed bloody discharge. Orbital magnetic resonance imaging (MRI) showed a well-defined heterogeneous enhanced mass filling the lacrimal sac and upper nasolacrimal duct (NLD). A wide excision and surgical biopsy were performed. Histopathology showed the tumor to be an exophytic Schneiderian papilloma with moderate to severe dysplasia. Three months later, the mass was found to be invading the nasal cavity through the NLD. Endoscopic histopathological evaluation confirmed that it was identical to the originally identified papilloma.     

Treatment of nasolacrimal duct obstruction in adults with polyurethane stent

PURPOSE: To evaluate the efficacy of polyurethane nasolacrimal duct stents in the treatment of epiphora resulting from primary acquired nasolacrimal duct obstruction in adults. MATERIALS AND METHODS: In 25 patients (21 women and four men with mean age of 44 years, range 20 to 74 years) with nasolacrimal duct obstruction, 28 hollow polyurethane stents designed by Song and associates were placed under fluoroscopic guidance. The obstruction was complete in 20 lacrimal drainage systems and partial in eight. The lacrimal sac size was normal or large on dacryocystogram in all lacrimal drainage systems. A Ritleng probe was introduced through the upper punctum and advanced past the obstruction. A guide wire with a flexible tip was then introduced through the probe, over which the stent was advanced in retrograde fashion and placed into the lacrimal sac and nasolacrimal duct. Clinical success was defined by the demonstration of a completely patent lacrimal drainage pathway through saline irrigation and no or minimal complaint of epiphora. RESULTS: Stent placement was technically successful in 26 of 28 lacrimal drainage systems (93%). The mean time of fluoroscopy screening was 3.2 minutes (range, 1.4 to 5.8 minutes). The overall success rate was 82% (23 of 28 lacrimal drainage systems). Two stents were completely occluded. In one lacrimal drainage system with minimal epiphora, the stented drainage pathway was partially occluded. The patients were followed up from 4 to 22 months (mean, 7.2 months). CONCLUSIONS: Retrograde placement of a hollow polyurethane nasolacrimal duct stent is a technique that is simple and well tolerated by patients. This method achieves a high success rate and may be suggested as a nonsurgical procedure for adults with primary nasolacrimal duct obstruction and proper lacrimal sac size. The Ritleng probe facilitates the procedure.     

外伤性泪道阻塞的CT检查

目的　探讨外伤性泪道阻塞的CT检查方法并分析其检查结果。方法　采用CT轴位扫描、冠状扫描及三维重建的方法 ,分析 12例泪道外伤的CT检查和结果。结果　CT轴位扫描良好显示泪囊和鼻泪管断面 ,冠状CT显示周围组织合并损伤 ,三维重建则直观显示泪囊窝和上颌骨额突骨折情况。CT显示外伤性泪道病变包括 :泪囊区软组织增厚、密度增高、泪囊扩张 ,泪囊区异常骨碎片影 ;泪囊窝和鼻泪管凹陷性、粉碎性和线性骨折 ;鼻泪管密度增高。结论　泪道CT轴位扫描、冠状扫描及三维重建可良好显示泪道及其周围组织的外伤情况 ,可用于诊断和进行手术设计。     

激光指示光引导鼻内镜下手术治疗外伤性鼻泪管阻塞伴泪囊移位

目的 观察通过激光指示光引导定位泪囊，行鼻内镜下泪囊鼻腔吻合手术治疗泪囊移位的方法。方法 对12例（12眼）经CT、MRI或泪囊造影后证实泪骨、鼻骨、或上颌骨鼻突骨折造成鼻泪管阻塞和泪囊移位，在局麻下激光指示光针于上或下泪小管进入泪囊，鼻内镜光源反复打开和关闭以观察指示光最靠近骨窗的最佳位置，切开相应鼻黏膜，做骨窗，然后顺势扩大鼻黏膜和骨窗口，准确找到泪囊后放入泪囊鼻腔引流支架。结果 12眼外伤性鼻泪管阻塞伴泪囊移位采用上述方法均顺利完成泪囊鼻腔吻合手术，术中大大减少了手术探查寻找泪囊带来的鼻黏膜和骨组织过多的损伤，术中患者痛苦少，术后恢复快，鼻腔换药次数减少。结论 激光指示光引导行鼻内镜下泪囊鼻腔吻合手术其定位准确，操作简单，组织损伤少，手术时间短。     

Nasolacrimal duct obstruction and dacryocystocele associated with a concha bullosa mucocele

PURPOSE: To describe the rare occurrence of a concha bullosa mucocele producing secondary nasolacrimal duct obstruction and dacryocystocele. DESIGN: Case report. PARTICIPANT: Forty-two-year-old man with 6-month history of left medial canthal mass. INTERVENTION: Clinical evaluation with lacrimal testing, computed tomography and surgical exploration, including biopsy, dacryocystorhinostomy, and excision/marsupialization of the middle turbinate concha bullosa mucocele were performed. RESULTS: The medial canthal mass was confirmed to be a dacryocystocele associated with nasolacrimal duct obstruction and bone destruction caused by concha bullosa mucocele. CONCLUSIONS: Concha bullosa mucoceles are uncommon and even more rarely can produce secondary nasolacrimal duct obstruction and dacryocystocele formation. The clinical and radiologic features may mimic a lacrimal sac malignancy.     

Anatomic position of the common canaliculus in patients with a large lacrimal sac

PURPOSE: To study the canalicular anatomy in patients with an enlarged sac secondary to nasolacrimal duct obstruction. METHODS: This study included 76 lacrimal drainage systems (LDS) of 41 adult patients with a palpable sac, which were visualized using posteroanterior digital subtraction macrodacryocystography. In 42 LDS, there was a palpable enlarged sac secondary to nasolacrimal duct obstruction. In 20 LDS, the sac enlargement was associated with a valve-type canalicular obstruction preventing retrograde reflux of the sac content, and in 22 LDS, there was no associated canalicular obstruction. Thirty-four LDS were either normal or had a nasolacrimal duct obstruction without a palpable sac. RESULTS: Dacryocystography showed a common canaliculus in all LDS. In 35 (83%) of 42 LDS with a palpable sac (17 LDS with and 18 LDS without canalicular obstruction), the anatomic orientation of the common canaliculus in the superior-inferior direction showed a consistent change. The common canaliculus was bending inferiorly with a sharp angle as it was coursing to the sac. In all LDS with a nonpalpable sac, the common canaliculus had an approximately direct, horizontal, or slightly upward course to the sac. CONCLUSIONS: Lacrimal sac enlargement secondary to nasolacrimal duct obstruction changes the anatomic orientation of the common canaliculus. The canaliculus shows an acute, inferior angulation from the superior-to-inferior direction while coursing to the sac in most instances. This anatomic variation should be considered during lacrimal interventions.     

Clinicopathologic study of lacrimal sac and nasal mucosa in 44 patients with complete acquired nasolacrimal duct obstruction.

We studied 44 patients who had dacryocystorhinostomy for primary acquired complete nasolacrimal duct obstruction. The lacrimal sac and nasal mucosa adjacent to the osteotomy were examined histologically. The lacrimal sac had chronic inflammatory changes in 33 of 37 patients with varying degrees of fibrosis in 34 of 37. Focal ulceration of the lacrimal sac epithelium was present in 15 cases. Goblet cells, present in 11 specimens, were not identified in 26 specimens. Moderate or severe chronic inflammation was found in 14 of 44 nasal mucosal specimens and marked fibrosis in 22. The pathology of the lacrimal sac and nasal mucosa is similar to that of the nasolacrimal duct in complete nasolacrimal duct obstruction. The nasal inflammation may have resulted from dacryocystitis or alternatively contributed to the dacryocystitis.     

Congenital lacrimal sac fistula: intraoperative visualization by polyvinyl siloxane cast

We report the intraoperative use of polyvinyl siloxane impression material to demonstrate the anatomy of the lacrimal sac, canaliculi, and lacrimal duct in a case of congenital lacrimal sac fistula. A 1-week-old boy was examined for tearing since birth. Examination revealed a left congenital lacrimal sac fistula. After a failed surgery to close the fistula with silicone intubation at 6 months of age, the patient underwent endonasal dacryocystorhinostomy performed at 14 months of age, aided by intraoperative injection of polyvinyl siloxane (trade name Reprosil) to mark and protect the nasolacrimal sac and facilitate endonasal visualization. A polyvinyl siloxane cast demonstrated the anatomy of the accessory canaliculus causing nasolacrimal duct obstruction. Postoperatively, the epiphora resolved and the fistula remained closed. The polyvinyl siloxane cast provides a 3-dimensional "ex vivo " model of the lacrimal sac, upper duct, and canalicular anatomy, and can be used in dacryocystorhinostomy surgery to identify and protect the lacrimal sac.     

Nasolacrimal duct obstruction associated with radioactive iodine therapy for thyroid carcinoma

A 50-year-old woman presented with a 5-year history of unilateral epiphora that began shortly after 131I therapy for thyroid carcinoma. A recent recombinant human thyroid-stimulating hormone (Thyrogen) scan had shown a focus of uptake adjacent to the right eye that was initially thought to be a possible metastasis. Probing and irrigation revealed complete blockage of the right nasolacrimal duct. The patient underwent a right dacryocystorhinostomy (DCR) and biopsy of the lacrimal sac. Histopathologic examination of the lacrimal sac and nasal mucosa revealed foreign-body reaction and fibrosis with no malignant cells. A repeat Thyrogen scan after DCR showed no residual focus of activity in the nose or near the lacrimal sac and confirmed reestablishment of lacrimal drainage on the right side. This case demonstrates that 131I therapy for thyroid carcinoma can be associated with nasolacrimal duct obstruction. The appearance of a focus of uptake near the lacrimal sac on Thyrogen scanning in a patient with a history of thyroid carcinoma may not be due to a new focus of metastasis and may indeed be due to pooling of 131I in the lacrimal sac due to nasolacrimal duct blockage.     

Combined external-endonasal approach for complete excision of the lacrimal drainage apparatus

PURPOSE: The purpose of this study was to describe a new surgical technique for the complete excision of the lacrimal drainage apparatus (LDA) that combines external and endoscopic approaches. METHODS: This study involved a noncomparative, retrospective chart review of the clinical and pathological findings of four patients presenting with LDA papillomas who underwent a combined open and endonasal excision of the lacrimal system. RESULTS: Of the four patients, three were male. The mean age at referral was 41 years, and all cases were unilateral. Histopathology revealed two transitional cell papillomas, one squamous cell papilloma, and one combined transitional/squamous papilloma. Epiphora and an external lesion were the main complaints at presentation. Nasolacrimal duct obstruction was present in all four patients. Papilloma virus infection was suggested in two cases and was confirmed in the only patient who had recurrence. CT identified a solid enhancing mass in two cases. The surgical approach in all cases was performed with the patient under general anesthetic supplemented with infiltration of local anesthesia with vasoconstriction. The lacrimal sac was exposed as per an external dacryocystorhinostomy with biopsy collection from the lacrimal sac lumen to confirm the diagnosis prior LDA excision. The superior aspect of the LDA was isolated by using lacrimal probes in each canaliculus to stabilized parallel incisions and careful dissection toward the common canaliculus until they met the medial aspect of the lacrimal sac. The sac was then separated from the periosteum from the medial orbital wall, using sharp dissection. Finally, an endoscopic dissection of the lower end of the nasolacrimal duct released the most inferior aspect of the LDA, allowing the surgeon to pull and excise the complete system from the external wound. CONCLUSIONS: Extensive LDA papillomas required complete excision of the drainage system to prevent recurrence and/or malignant transformation. The use of a combined approach through an open excision of the superior part of the LDA in conjunction with the direct manipulation of the nasolacrimal duct guided by the nasal endoscope facilitates the complete excision of the system for extensive benign lesions.     

Endoscopic-assisted retrieval of retained lacrimal stent material in congenital nasolacrimal duct obstruction without dacryocystorhinostomy

We report a 3-year-old child with history of congenital nasolacrimal duct obstruction who failed lacrimal probing and underwent bicanalicular intubation. Removal of stent from the superior punctum was unsuccessful and it was trapped in the lacrimal sac. We performed endonasal endoscopic-assisted retrieval of retained stent material without necessitating dacryocystorhinostomy (DCR). There was no recurrence of infection and nasolacrimal duct obstruction symptoms during 6 months of follow-up.     

Chronic dacryocystitis with spontaneous resolution of sac mucocele: fact or fiction

The purpose of this study is to highlight the rare possibility of spontaneous resolution of a lacrimal sac mucocele by means of a retrospective case note analysis. The authors identified 3 patients with nasolacrimal duct obstruction and clinical and radiological evidence of mucocele. In all 3 cases, resolution of symptoms was reported prior to dacryocystorhinostomy. In each case, the mucocele was no longer palpable, and the patency of the nasolacrimal duct was confirmed by sac washout. A lacrimal sac mucocele may rarely rupture in the nose and resolve spontaneously. Although this is a rare outcome, lacrimal surgeons should be aware of this prospect to avoid unnecessary surgery and investigations. The authors recommend that lacrimal surgeons present spontaneous resolution as one of the possible outcomes in their patient information literature.     

Vasculitis of the lacrimal sac wall in Wegener granulomatosis

A 35-year-old woman with a 4-year history of generalized Wegener granulomatosis (WG) had clinically controlled disease. She was evaluated for a 6-month history of right lacrimal sac mass. On examination, a right chronic dacryocystitis and mucocele were observed. A right external dacryocystorhinostomy was performed. The surgical biopsy specimen from the lacrimal sac showed leukocytoclastic vasculitis with more aggressive damage to the small vessels in the deeper mucosa and focal microhemorrhages. The patient was free of symptoms 1 year after surgery. We believe this is the first report of generalized WG presenting features of an active vasculitis of the lacrimal sac wall on surgical biopsy specimen. We conclude that the lacrimal drainage system can be affected directly by focal WG vasculitis, suggesting that nasolacrimal duct obstruction is not always due to contiguous paranasal disease.     

CT-泪道造影术（CT-DCG）在泪道阻塞性疾病中的临床应用

目的　探讨CT-泪道造影术（computed tomography-dacryocystography。CT-DCG）在泪道阻塞性疾病中的临床应用价值，进一步明确CT-DCG术前检查的必要性。方法　收集2016年8月至2018年4月因泪道阻塞性疾病就诊于南昌大学附属眼科医院以泪溢为主诉的患者216例（235眼）。所有患者术前均进行泪道CT-DCG检查，每人均行泪道轴位及冠状薄层CT扫描，层厚1 mm，层间距1 mm。轴位上至眶上缘，下至硬腭下鼻道顶；冠状位行多平面重建；从轴位和冠状位观察泪道及周围情况，明确泪道阻塞情况及CT造影征象。结果　本研究216例235眼泪道造影均成功，发现患者均存在泪道阻塞性疾病，其中10例复发性泪囊炎，178例慢性泪囊炎，23例泪囊囊肿，5例外伤性泪囊炎。泪道狭窄6眼；高位阻塞（泪总管以上）5眼；中位阻塞（泪囊阻塞）28眼；低位阻塞（鼻泪管中上段）189眼；极低位阻塞（鼻泪管膜性段阻塞）7眼。结论　CT-DCG可提供泪道阻塞的具体位置和泪囊大小及与周围组织的关系，其检查结果是个性化手术方式选择的重要影像学依据。