14例口腔粘膜良性淋巴组织增生症的临床与病理分析

粘膜良性淋巴组织增生症(也称增生病Mucosal Benign Lymphoid Hyperplasia,以下称MBL),有人也称搔痒性唇炎,其组织学特征是上皮下固有层形成具有生发中心的淋巴样滤泡,是一种不多见的口腔粘膜病。本文对14例病例进行了临床与病理特点的观察分析。 1 资料与方法     

CD44与CD33在77例口腔黏膜良性淋巴组织增生病中的表达及临床意义

目的：探讨CD44与CD33在口腔黏膜良性淋巴组织增生病（benign lymphoadenosis of oral mucosa,BLOM）中的表达及临床意义。方法：选择2017年1月—2020年3月青岛市中医医院病理科77例BLOM蜡块作为实验组，另取同时间段63例正常口腔黏膜组织蜡块作为对照组。采用免疫组织化学法检测2组CD44、CD33阳性表达情况，采用Spearman分析BLOM患者病变组织中CD33与CD44阳性表达的相关性。收集患者一般资料，分析BLOM患者病变组织中CD33、CD44表达与临床病理特征的关系。采用SPSS 21.0软件包对数据进行统计学分析。结果：对照组、实验组CD33阳性表达率分别为95.24%、63.64%，差异有统计学意义（P<0.05）;CD44阳性表达率分别为93.65%、67.53%，差异有统计学意义（P<0.05）。Spearman分析结果显示，BLOM患者病变组织中CD33与CD44阳性表达呈正相关（r=0.834,P=0.002）;CD33、CD44表达与临床分型、炎症程度、有无淋巴滤泡、淋巴细胞浸润有关（P<0.05...     

口腔粘膜良性淋巴组织增生症的临床病理和免疫组化分析

目的明确口腔粘膜良性淋巴组织增生症（BLOM）的临床病理特征及其本质。方法收集分析6例BLOM的临床病理资料，并进行文献复习；对该组病例的组织标本进行免疫组化研究。结果发生在唇部和其它口腔解剖部位的口腔粘膜良性淋巴组织增生症的临床表现和诊断各有其特点；B淋巴细胞是淋巴滤泡和浸润炎症细胞的主要细胞万分。结论BLOM分为唇型和非唇型两种临床类型；BLOM是一种B淋巴细胞介导的增殖性局部体液免疫反应疾病。     

微波辐射治疗下唇良性淋巴组织增生性唇炎的探讨

目的 探讨微波辐射治疗下唇良性淋巴组织增生性唇炎的可行性。方法 用WB－100型微波多功能机对5例下唇良性淋巴组织增生性唇炎进行辐射治疗，并进行近期和远期观察。结果 5例患者近期治愈5例（5／5），远期治愈4例（4／5）。结论 微波辐射是治疗唇部淋巴组织增生性唇炎的好方法。     

良性淋巴上皮病

良性淋巴上皮病表现为单、双侧单腮腺无痛性、进行性的肿大。本文通过对８例该病的临床分析认为，单侧腮腺部分受累，易误诊为混合瘤，双侧腮腺肿大，多伴有其他小涎腺肿大和干燥综合症，涎腺的磺油造影是一个简便易行，早期诊断本病的方法。     

良性淋巴上皮病、淋巴上皮癌、MALT淋巴瘤的关系

良性淋巴上皮病(benign lymphoepithelial lesion)、淋巴上皮癌(lymphoepithelial carcinoma)、黏膜相关淋巴组织型结外边缘区B细胞淋巴瘤(MALT淋巴瘤)(extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue,MALT lymphoma)是3种性质不同但又存在某些关联的病变,本文对3种病变的病因、组织病理学表现及三者之间的关系进行了介绍,并结合叶为民等论文中的一些内容进行了简要探讨。     

口腔粘膜良性淋巴组织增生病1例报告

<正> 口腔粘膜良性淋巴组织增生病是一种发生在口腔软组织的疾病。以往文献对皮肤良性淋巴组织增生病有很多报道。Bears(1979年)认为类似皮肤病变可出现于口腔、直肠等粘膜,但本病发生于口腔粘膜专题报道不多,我院在1984年发现1例,现报告如下:患者朱××,女,37岁,工人。上下唇反复肿胀,瘙痒18年,近半年来加重。上     

口腔黏膜良性淋巴组织增生病的免疫组化研究

目的　研究口腔黏膜良性淋巴组织增生病与口腔癌的细胞增殖能力、血管密度和细胞凋亡的变化。方法　采用免疫组化SP法检测 15例黏膜良性淋巴组织增生病、9例黏膜良性淋巴组织增生病伴上皮异常增生、15例口腔癌及 10例正常黏膜组织中Ki 6 7的表达、细胞凋亡及微血管密度。结果　口腔黏膜良性淋巴组织增生病伴异常增生及鳞状细胞癌中Ki 6 7的表达明显高于不伴异常增生的口腔黏膜良性淋巴组织增生病及正常黏膜 (P <0 0 5 ) ,在所有的口腔黏膜良性淋巴组织增生病及鳞状细胞癌中微血管密度均明显高于正常组 (P <0 0 5 )。口腔黏膜良性淋巴组织增生病中细胞凋亡明显高于正常黏膜及口腔癌 (P <0 0 5 )。结论　在伴有上皮异常增生的口腔黏膜良性淋巴组织增生病中Ki 6 7表达及微血管密度均介于正常组织和口腔癌之间 ,凋亡细胞数也明显多于正常组织。研究结果提示 :口腔黏膜良性淋巴组织增生病是一种具有癌变潜能的疾患     

良性淋巴上皮病(附8例报告)

良性淋巴上皮病表现为单、双侧单腮腺无痛性、进行性的肿大。本文通过对8例该病的临床分析认为，单侧腮腺部分受累，易误诊为混合瘤，双侧腮腺肿大，多件有其他小涎腺肿大和干燥综合症。涎腺的碘油造影是一个简便易行、早期诊断本病的方法。     

发生在唾液腺的血管滤泡性淋巴组织增生

血管滤泡性淋巴组织增生由Ｃａｓｔｌｅｍａｎ于１９５４年首先报道，是一种原因不明的局限性或系统性以淋巴组织和小血管肿瘤样增生为特征的疾病。一般认为，局限性为良性、系统性为恶性结局。好发部位以纵隔淋巴结多见，也有发生在颈部、肠系膜、后腹膜淋巴结、脾、心包...     

Chronic GVHD in minor salivary glands and oral mucosa: histopathological and immunohistochemical evaluation of 25 patients

BACKGROUND: Graft-vs.-host disease (GVHD) is the major cause of morbidity and mortality in patients undergoing allogeneic Bone Marrow Transplantation (BMT). The aim of our study was to identify the most relevant histological features for diagnosis of chronic Graft-vs.-Host Disease (cGVHD) in oral mucosa and minor salivary glands of 25 patients, as well as to evaluate the immunophenotype of the inflammatory cells. METHODS: Sixteen patients that were submitted to allogeneic BMT but did not present cGVHD were selected as a control group. The sections were studied on H & E and CD68, CD45, CD4, CD8, CD20 staining. RESULTS: The most frequent histologic findings in oral mucosa at the day of diagnosis of cGVHD were: hydropic degeneration of the basal layer of the epithelium, apoptotic bodies, lymphocytic infiltration, and focal or total cleavage between the epithelial and connective tissue. In the labial salivary glands (LSG), lymphocytic infiltration, acinar loss and fibrosis were the main alterations. Cytotoxic CD8-T cells and macrophages were predominant both in the epithelium and connective tissue, as well as in minor salivary glands. CONCLUSIONS: Histological features were useful in the diagnosis of oral cGVHD. It is suggested that CD8-T cells and macrophages play important role in the pathogenesis of the disease.     

Effect of alcohol on the oral mucosa assessed by quantitative cytomorphometry

The effect of alcohol on the oral mucosa was assessed using quantitative cytomorphology applied to smears taken from clinically normal oral mucosa of patients attending an alcohol problem unit and results were compared to a control group (consisting of social and non-drinkers) attending a hospital for routine dental care. Smears were stained using the Papanicolaou method and the nuclear and cell boundaries of 50 randomly selected cells traced and mean areas (NA and CA, respectively) calculated. The average number of units of alcohol consumed were recorded for each group together with relevant blood tests. The alcohol group was further subdivided into "binge" and "regular" drinkers. No significant differences were found between mean NA and mean CA values for these two types of alcohol drinkers, despite a marked difference in weekly units consumed. However, a statistically significant reduction in mean cytoplasmic area (P < 0.001) and mean nuclear area (P < 0.01) was found for the alcohol group when compared to controls. In conclusion, excess alcohol intake may influence results for quantitative oral cytomorphology. Further research is indicated on the relative effects of alcohol (both topical and systemic).     

Human papillomavirus infections in the oral mucosa

BackgroundPublic awareness of human papillomavirus (HPV) as the causal agent of cervical cancer and of the availability of HPV vaccines has increased. As a result, more patients are asking their dentists about oral HPV infection and its prevention by means of vaccination. Parents of pediatric dental patients also may be concerned when their children have HPV-associated oral lesions, because HPV infection still often is considered a purely sexually transmitted disease. In this review, the authors provide the latest information for dental professionals about HPV infection in the oral mucosa and in general.Types of Studies ReviewedThe authors searched PubMed for all studies regarding HPV infection in the oral mucosa, and they reviewed relevant publications focusing exclusively on HPV infections of the oral cavity. In selecting studies for review, the authors made a clear distinction between studies regarding HPV infections in the mouth and those regarding HPV infection in the oropharynx or in other head and neck sites.ResultsHPV can infect oral mucosa. A subgroup of oral cancer clearly is associated with HPV. Oral HPV infection is transmitted sexually but also can be transmitted from mouth to mouth and vertically from an infected mother during delivery.Conclusions and Clinical ImplicationsPersistent HPV infection in the oral mucosa might increase the risk of developing oral cancer. Regular and meticulous clinical examination is the dentist's most important tool in detecting HPV-associated changes in the oral mucosae. HPV-associated oral cancer may affect a population younger than that typically affected by HPV-independent oral cancer. Alcohol and tobacco use increase the risk of developing oral cancer, so good practice includes encouraging patients to avoid these habits. The availabel HPV vaccines cover the HPV genotypes found most commonly in the oral mucosa, but their protective effect against oral cancer remains to be elucidated.     

组织工程化口腔黏膜支架材料的研究进展

随着组织工程技术的发展,近年来国内外许多学者致力于口腔黏膜组织工程的研究,取得了一定的成就,支架材料是黏膜组织工程的一个重要因素,本文对组织工程化口腔黏膜的支架材料研究作一简要综述。     

雌激素受体在口腔粘膜癌前病变中的表达及意义

目的阐明雌激素受体（ER）在口腔粘膜癌变过程中的表达状况及其对临床诊断、治疗的意义。方法采用链霉素抗生物素蛋白一过氧化物物酶（SP）免疫组化法，检测了口腔鳞状细胞癌（SCC）、口腔白斑（1．K）、口腔扁平苔藓（I．P）、正常口腔粘膜（NM）中的ER表达状况。结果NM中42．86％ER阳性，成灶状分布于棘细胞层内，胞浆染色均匀。IP、IK、SCC中ER阳性率分别为71．43％、60．0％、68．42％，成片位于棘层胞浆中，胞浆染色不均匀。ER表达与患者性别、病理类型无关。结论提示SCC、LK、LP中ER存在是确实的，口腔粘膜肿瘤可能是激素依赖肿瘤。但ER不宜作为监测癌变潜能的指标。     

正常人口腔粘膜脱落细胞微核计数的研究

目的：了解正常人口腔粘膜中染色体损伤发生的情况,探讨不同部位细胞微核数的差异。方法：对90例正常口腔粘膜颊部,舌背,舌腹3个部位进行了脱落细胞微核计数的分析,并判定微核计数的影响因素。结果：正常口腔膜颊部细胞微核数大于舌背,舌腹细胞微核数（非吸烟组P＜0．05,吸烟组PK＜0．01）,非吸烟组细胞微核数远远低于吸烟组（P＜0．001）,多元回归分析显示吸烟量和吸烟年数同微核数有着密切的关系,结论：颊粘膜受到的各种理化刺激因素的作用较舌腹粘膜更直接,烟草刺激在肿瘤发生中具有重要的作用。     

口腔黏膜瘙痒症的病因与治疗

口腔黏膜瘙痒症是发生于口内1处或多处黏膜的一种可引发搔抓欲望的不愉快感觉,引发舌部舔舐、咬嚼、用手搔抓,导致瘙痒—搔抓恶性循环,在一定程度上影响着患者的正常生活。口腔黏膜瘙痒症的发病原因复杂多样,可由口腔内的多种因素引发,也与多种口腔外的因素相关。随着民众口腔保健意识的加强,每年因口腔黏膜瘙痒而就诊的患者逐年增加。为了增进口腔医生对这一特殊症状的了解,提高相关疾病的诊疗效率,本文就口腔黏膜瘙痒症的病因与治疗作一综述。