脑干听觉诱发电们检测对亚临床肝性脑病的诊断价值

对无临床肝性脑病的30例非酒精性肝硬化患进行脑干听觉诱发电位（BAEP）检测。结果显示：肝硬化组60％BAEP异常，BAEP的Ⅰ、Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅴ、Ⅲ-Ⅴ波峰间其均比正常对照组明显延迟，提示肝化在发生临床肝性脑病前，脑干功能已有明显损害，存在亚临床肝性脑病。     

亚临床肝性脑病患者多种形式诱发电位联合检测的临床意义

目的:探讨事件相关电位(P300),脑干听觉诱发电位(BAEP),体感诱发电位(SEP),视觉诱发电位(VEP)对亚临床肝性脑病(SHE)的临床诊断价值.方法:根据临床分级,对36例临床诊断为亚临床肝性脑病(SHE)的患者进行P300、BAEP、SEP、VEP检测分析.结果:36例SHE患者中P300异常者26例(72%),BAEP异常者23例(64%),SEP异常者17例(47%),VEP异常者9例(25%).结论:P300、BAEP、SEP、VEP的检测有助于亚临床肝性脑病(SHE)的早期诊断.     

脑干听觉诱发电位检查在新生儿缺氧缺血性脑病的诊断价值

目的:观察脑干听觉诱发电位(BAEP)检查在新生儿缺氧缺血性脑病(HIE)中的临床价值。方法:对22例HIE新生儿与20例正常分娩新生儿进行BAEP检查并分析比较。结果:22例HIE新生儿中BAEP异常16例,异常率73%,经治疗后复查,仍有3例仍然异常。结论:对HIE新生儿进行BAEP检测,可了解患儿的外周听神经和脑干功能活动的变化,对于指导诊断和治疗提供客观依据,也是评定患儿预后的客观指标。     

新生儿缺氧缺血性脑病的脑干听觉诱发电位检查的价值

缺氧缺血性脑病(HIE)是造成新生儿脑损害的常见病因之一，与癫痫、脑瘫、视觉障碍、听觉障碍及智力低下等神经功能障碍密切相关，要减少缺氧缺血引起的脑损害，早期诊断、早期干预和治疗显得尤为重要。脑干听觉诱发电位(BAEP)不受睡眠和镇静药物的影响，特别适用于婴幼儿的检测．是评价外周听系和脑干功能活动的有效的电生理检测手段。我们对2000年1月至2003年12月在我院新生儿科住院的46例HIE患儿进行了BAEP检测，现报告如下。     

脑干听觉诱发电位、CT在新生儿缺氧缺血性脑病中的诊断价值

目的:应用脑干听觉诱发电位(BAEP)结合CT为诊断新生儿缺氧缺血性脑病(HIE)及分度提供科学诊断依据。方法:采用ZABR—200型脑干反应测听仪及西德SomatomDR型高分辨全身扫描机对30例HIE患儿进行检测和扫描。结果:BAEP:正常4例(13.3％),异常26例(86.7％),CT:轻度异常8例,中度异常14例,重度异常8例。结论:本研究CT所示脑损伤程度与临床表现程度有密切关系,BAEP检查敏感性高,影响因素小,结果准确可靠,对诊断HIE,预测和评价预后,指导治疗均有一定的价值。     

母乳性黄疸儿脑干听觉诱发电位检测分析

本文对30例母乳性黄痘(breast milk jaundice,BMJ)的婴儿进行脑干听觉诱发电位(BAEP)检测,以观察BMI对中枢神经系统是否有影响.结果显示BAEP总异常率为60%,随黄疸加重,BAEP异常率越高,轻、中、重度黄疸之间异常存在差异(x2=6.068,P<0.05).轻、中度黄疸表现为Ⅲ、V波潜伏期、I-Ⅲ、Ⅲ-V、I-V峰间期延长为主,重度黄痘表现为Ⅲ、V波缺失为主.因此认为BMJ无论胆红素高低,均有引起脑损伤的危险,应尽早干预.     

新生儿缺氧缺血性脑病脑干听觉诱发电位观察

目的：观察新生儿缺氧缺血性脑病（HIE）急性期脑干听觉诱发电位（BAEP）变化的临床意义。方法：对16例HIE患儿进行BAEP及头颈CT检查，并与20例正常对照组进行比较。结果：HIE患儿BAEP异常率69％，CT异常率88％，二者差异无显著（P＞0．05），BAEP异常以中枢型为主。结论：BAEP为HIE急性期观察脑功能的敏感指标。     

脑干听觉诱发电位在慢性酒精中毒性脑病听神经损害的诊断价值

目的:探讨脑干听觉诱发电位(BAEP)对慢性酒精中毒性脑病(CAE)患者听神经和听通路损害的诊断价值。方法:对47例CAE患者及20例正常受试者详细询问病史、查体,记录酒精摄入量和进行BAEP测定,并作组间比较。结果:与正常对照受试者比较,39例CAE患者BAEP的Ⅰ波潜伏期延长(异常率为83%),所有患者Ⅲ波、Ⅴ波潜伏期及Ⅰ—Ⅲ波、Ⅲ—Ⅴ波的波间潜伏期均延长,其间差异具有显著意义(P<0.05)。结论:CAE患者存在脑干听觉通路损害和亚临床的听神经损害,BAEP可作为其有效的评价方法。     

脑干听觉诱发电位对听神经瘤的早期诊断价值

目的：观察脑干听觉诱发电位（BAEP）对听神经瘤的诊断价值。方法：对20例疑诊为听神经瘤的患者，进行BAEP、CT或MRI影像学检查。结果：20例患者BAEP检查均异常，阳性率为100%，其中17例经CT检查为听神经瘤，3例经MRI检查，后均经手术证实为听神经瘤。结论：BAEP检查是早期观察听神经瘤对听觉通路损害较敏感的方法，并对其现损部位能进行初步定位。     

亚临床肝性脑病患者BAEP的研究

目的:探讨脑干听觉诱发电位(BAEP)对评价亚临床肝性脑病患者早期脑力能状况价值.方法:对94例经临床确诊的肝硬化失代偿期的患者进行BAEP检测,并与100例正常对照者进行对比分析.结果:疾病组Ⅰ、Ⅲ、Ⅴ波的潜伏期(PL)及Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ波波峰间期(IPL)均延长.期中以Ⅲ、Ⅴ波的潜伏期(PL)及Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ波波峰间期(IPL)延长较明显,与正常对照组比较有显著差异(P＜0.01).结论:BAEP对亚临床肝性脑病患者患者工能的评价提供了一项客观指标,有助于临床早期诊断和治疗.     

肝硬化患者视觉和体感诱发电位的研究

对 30例临床无明显肝性脑病的非酒精性肝硬化患者和 30例正常对照进行了视觉诱发电位 (VEP)和短潜时体感诱发电位 (SSEP)检查。结果显示 ,肝硬化组VEP和SSEP各波潜伏期及SSEP的N13～N2 0、N13～P2 5峰间期均比对照组明显延长 ,肝硬化组VEP的P10 0、N12 5波幅明显低于对照组。肝硬化组VEP、SSEP的异常率分别是 36 .7%、6 0 %,有 1种或 2种诱发电位异常的患者占 76 .7%。以上结果表明肝硬化患者在临床发生肝性脑病之前 ,已经有脑诱发电位异常和脑功能损害。脑诱发电位能敏感、客观地早期诊断肝硬化患者的亚临床性肝性脑病 ,其中SSEP最敏感。     

Brainstem Auditory Evoked Potentials (BAEPS) and Selective Attention Revisited

Evidence of peripheral filtering of auditory information at the cochlear and brainstem levels was sought using brainstem auditory evoked potentials (BAEPs) recorded during auditory and visual tasks. It can be argued that the discrimination tasks used in the past to investigate peripheral filtering of sensory information in humans involve two levels of discrimination, the consequences of which result in two independent types of inhibition: crossmodal inhibition as a result of between-modality discrimination, and intramodal inhibition as a result of within-modality discrimination. Therefore, the observed effects on the BAEPs may reflect the extent to which these two types of inhibition are engaged. In this investigation a paradigm that included two non-discrimination (passive) tasks and two discrimination (active) tasks was employed. BAEPs recorded during listening (a passive auditory task) provided a baseline measure, against which comparisons of BAEPs recorded during auditory and visual discrimination could be made for independent evidence of crossmodal and intramodal inhibition. The data in this study did not support the presence of two types of inhibition proposed above, or show evidence of peripheral filtering of auditory information at the cochlear and brainstem levels. However, the sensitivity of BAEPs to efferent system activation at the cochlea and hence their value as a tool in investigations of peripheral filtering in humans was questioned.     

椎－基底动脉供血不足患者脑干听觉诱发电位的观察

检查５８例椎－基底动脉供血不足患者脑干听觉诱发电位（ｂｒａｉｎｓｔｅｍａｕｄｉｔｏｒｙｅｖｏｋｅｄｐｏｔｅｎｔｉａｌＢＡＥＰ），异常率为６３．８％。ＢＡＥＰ异常可反映内耳前庭缺血、中枢缺血或两者皆有。ＢＡＥＰ检测对脑干缺血性疾病的诊断有一定的价值。     

Auditory Evoked Potentials to Unpredictable Shifts in Pitch

Auditory evoked potentials (EPs) were recorded from subjects presented with a regular series of tone pips at one of three rates (1/sec, 2/sec, or 4/sec). Occasionally one of the pips was 5%, 25%, or 100% (an octave) different in pitch from the repetitive background pips. These “mismatch” tones occurred at random with a mean interval of 12 sec (range 1–24 sec) for all of the repetition rates. This determined an average sequential probability = 0.083, 0.042, 0.021 that a tone would be a mismatch. On different runs, subjects either responded with a button press each time they heard a mismatch or they read a book. The amplitude of a large negative component (N2 at 154 msec) evoked after mismatch tones was unrelated to degree of mismatch but was larger to all the mismatch tones than to the background pip. Instructions to attend did not affect N2. A subsequent positive peak at 277 msec (P3), recorded during reading, did increase in amplitude with increasing mismatch, as did a P3 at 330 msec recorded during responding. Sequential probability had no main effect on N2 or P3. This lack of an effect on P3 suggests that the well-known influence of stimulus uncertainty on P3 may be determined by the temporal rather than sequential uncertainty of events, or that our range of probabilities was too narrow to obtain the effect.     

Auditory Evoked Potentials and Divided Attention

In a multi-channel divided attention task, 8 subjects listened to a sequence of tones delivered at one of two stimulation rates and at one of three spatial locations (channels): left ear, right ear, and an apparent position midway between left and right ears. Subjects were instructed to monitor one, two, or all three channels and detect slightly louder target tones in the monitored channel(s). Seven listening conditions were used, three in which subjects monitored one channel and ignored the others, another three in which two channels were simultaneously monitored and the third ignored, and a further condition in which all three channels were monitored. With a high stimulation rate, the N1 component of the vertex evoked potential (latency 70–130 msec) in both attended and unattended channels significantly decreased in amplitude with an increase in the number of monitored channels. At the same time, N1 was significantly larger when a channel was attended than when it was ignored. There were no significant effects under slow stimulation rate conditions. Like N1, target detectability (d') declined with increasing monitoring load only with a fast stimulation rate, but the correspondence between these two measures was not upheld in every condition. The results indicate that with a high “information load” in a multi-channel task, selective attention increases the vertex response in all attended channels, while divided attention decreases the response in both attended and unattended channels, thus suggesting that the N1 component of the auditory evoked potential reflects the apparent division of attentional capacity among competing auditory inputs.     

葛根素对豚鼠卡那霉素耳中毒听觉诱发电位的影响

观察葛根素在豚鼠卡那霉素耳中毒中的作用。将豚鼠 30只随机分两组 :对照组 15只 ,肌注卡那霉素 40 0mg/kg/d ,共 12天 ;葛根素组 15只 ,除肌注卡那霉素 40 0mg/kg/d外 ,腹腔注射葛根素 10mg/kg/d ,共 12天。以听觉诱发电位为指标进行组间比较 ,听觉诱发电位阈值对照组明显高于葛根素组 (P <0 0 5 ) ;对照组诱发电位各波幅值则明显低于葛根素组 (P <0 0 1)。葛根素能减轻卡那霉素耳毒性 ,对卡那霉素耳中毒具有一定的保护作用 ,为耳毒性抗生素致聋的防治提供了一条新的研究途径     

Human Brainstem Auditory Evoked Potentials Fail to Provide Evidence of Efferent Modulation of Auditory Input During Attentional Tasks

Efferent modulation of auditory input at the level of the brainstem during attention-demanding tasks has been described in animal studies. Attempts to demonstrate these effects in humans have produced conflicting results, however. These studies are reviewed with particular reference to those animal experiments that have demonstrated peripheral effects. The human experiments have used a number of attentional conditions which have not been related either to each other or to the successful animal work. Two of the most important conditions in these studies--the use of an intermodal attention task and the manipulation of attentional states--have been examined rarely or not at all in the human research. Two experiments were conducted to investigate the possibility of attention-related effects on the human brainstem auditory evoked potential. These experiments were designed to examine experimental conditions common to both successful and unsuccessful attempts to demonstrate attention-driven efferent modulation at the periphery in humans. Also examined was the gradation of attention effects on efferent modulation demonstrated in animals but never studied in humans. No significant changes in either the latency or the amplitude of the brainstem auditory evoked potential were found in any of the attention-demanding conditions. Results are discussed in terms of psychophysiological theories of attention. Also, the interpretation of the most recent animal work is questioned.     

孤独症患儿脑干听觉诱发电位研究

目的 :探讨孤独症患儿脑干听觉诱发电位 (BAEP)的表现。方法 :将研究对象分 3组 :(I)孤独症组 (AD ;2 2例 ) ;(II)单纯智力低下组 (MR ,2 0例 ) ;(III)正常对照组 (NG ,30例 )。智商测验采用 0 - 4岁小儿神经心理发育量表及韦氏智力量表 ;研究对象给予脑干听觉诱发电位测试。结果 :(1 )ADBAEP之III、V波潜伏期及I-III,I-V波峰间期 (IPL)较NG延长 (P <0 0 0 1 )。(2 )ADBAEP之III波潜伏期及I-III波IPL较MR组延长 (P <0 0 0 5)。 (3) :MRV波潜伏期及III-V、I-V波IPL较NG延长 (P <0 0 0 1 )。结论 :(1 )孤独症患儿的脑干听觉诱发电位异常 ,尤其是脑干传导时间 (BTT)的延长 ,提示脑干机能障碍导致信息向大脑传递通路的损害可能是造成孤独症患儿在认知、社会及语言能力等方面异常发育的原因之一。 (2 )孤独症患儿BAEP异常原因可能与孤独症本病特性有关而非伴随智力低下所致。     

体温过低对大鼠脑干听觉诱发电位和中潜伏期反应的影响

目的：探讨体温过低对大鼠脑干听觉诱发电位（BAEP）和中潜伏期反应（MLR）的影响。方法：计算机平均叠加技术颅表记录大鼠BAEP和MLR，体表物理降温法逐步降低大鼠体温，传感探头式数字体温计监测大鼠直肠温度，体温每降低1 ℃测试1次BAEP和MLR，观察波峰潜伏期（PL）和波幅的变化及各波消失的临界体温。结果：随体温逐渐降低（36 ℃-22 ℃），BAEP和MLR各波PL逐步延长；BAEP Ⅰ、Ⅱ、Ⅳ 3主波和MLR N1、P3 2主波的波幅在体温过低至26 ℃以下时方先后出现显著降低；BAEP和MLR各波在体温19 ℃-21 ℃全部消失，且两者同步消失。结论：体温过低对大鼠BAEP和MLR均有显著影响。     

中国乒乓球听障奥运选手脑诱发电位特点的研究

探讨中国乒乓球听障奥运队员视觉诱发电位P100和事件相关电位P300的特点,为该项目运动员的选材和机能学评定提供参考。采用上海海神医疗电子仪器厂生产的NDI-200（海神号）神经电检诊仪,对参加2013年7月在保加利亚举行的第22届夏季听障奥林匹克运动会的8名中国乒乓球听障奥运选手和74名常人大学生的视觉诱发电位和视觉事件相关电位进行了记录、分析比较。奥运选手组和对照组之间视觉诱发电位P100波幅和潜伏期均无显著性差异（P＞0．05）。奥运选手组与对照组相比,视觉事件相关电位P300表现为：Cz点的波幅呈极显著性增加（P＜0．01）、Fz点的波幅呈显著性增加（P＜0．05）、Pz点的波幅有一定的增加（P＝0．061）;Pz点的潜伏期呈极显著性缩短（P＜0．01）;Pz、Cz、Fz点的反应时均呈极显著性缩短（P＜0．01）。听障乒乓球运动员和常人对照组之间视觉诱发电位P100波幅和潜伏期均无显著性差异;视觉事件相关电位P300表现为波幅增加、潜伏期缩短、反应时缩短的特点。