共查询到20条相似文献,搜索用时 31 毫秒
1.
Vesterinen M Ruokonen H Furuholm J Honkanen E Meurman JH 《Clinical oral investigations》2012,16(2):559-563
This paper aims to study oral symptoms (burning mouth sensation, xerostomia, dysphagia, and dysgeusia) and background characteristics
among chronic kidney disease (CKD) patients. The hypothesis was that patients experience oral discomfort and show interest
towards dental care differently depending on the origin of their kidney disease. One hundred thirty-eight CKD patients at
predialysis stage (94 men, 44 women, mean age 54 years) at the Helsinki University Central Hospital participated in the study.
The patients were divided into a diabetic nephropathy group and a group of patients with other kidney diseases. The patients
had a clinical oral examination and filled in a structured questionnaire. The data were analyzed and compared between the
groups (SPSS for Windows version 15.0). T test was used for parameters normally distributed while binomial data were analyzed with cross-tabulations and chi-square
test. Contrary to our study hypothesis, no statistically significant differences were seen in the questionnaire study between
the diabetic vs. non-diabetic CKD patients in any other study parameter except in the use of medication (10 ± 2.3 vs. 8 ± 3.1
drugs daily, p < 0.05), and working status (23.5% vs. 50% working full time, p < 0.01). No difference was seen in the frequency of oral discomfort among the different groups. Xerostomia, however, was
frequently observed among the predialysis patients investigated (41.7% in diabetic, 48.2% in non-diabetic patients). No difference
was seen in the frequency of oral discomfort among the different groups of predialysis patients investigated. Clinicians should
be aware of nephropathy patients who frequently suffer from oral discomfort, particularly xerostomia. 相似文献
2.
Hellevi Ruokonen Karita Nylund Jussi Furuholm Jukka H. Meurman Timo Sorsa Karoliina Kotaniemi Fernanda Ortiz Anna Maria Heikkinen 《Journal of periodontology》2017,88(1):26-33
Background: Factors related to mortality of patients with chronic kidney disease (CKD) were investigated to find out whether oral disease inflammatory burden or different etiology (diabetes nephropathy vs. other etiologies) of CKD could be associated with mortality. Methods: This prospective cohort study comprised 144 adults at the predialysis stage. Clinical oral and radiologic examination was made from 2000 to 2005. Patients were followed up until August 2015 (complete follow‐up time: 157 months). Cause of death could be verified from 62 of 65 patients. Clinical health data were combined with mortality records obtained from the Finland national statistics database. Number of teeth, total dental index (TDI), and periodontal inflammatory burden index were calculated to describe degree of oral inflammation. Results: Primary causes of death were cardiovascular diseases, infection, and cancer. There was a statistically significant difference in survival between diabetic nephropathy (23.8%) and other patients with CKD (59.9%; log‐rank test P <0.001). A Cox regression model showed fewer teeth, higher age, and diabetes mellitus were statistically significant independent risk factors for death. Deceased patients had fewer teeth (P <0.001) and higher TDI (P <0.05). Conclusions: Risk of death was higher among patients with diabetic nephropathy. The deceased had fewer teeth and more oral infections. However, indices used failed to show independent association with survival. 相似文献
3.
The aim was to study oral health status, salivary function, and oral features of Chinese people with Systemic Sclerosis (SSc).
Chinese people with SSc attending a university specialist clinic were invited for a questionnaire survey and a clinical examination.
Ethics approval was sought (UW 08-305). Gender- and age-matched individuals without SSc who attended a university dental hospital
were recruited for comparison. Forty-two SSc patients with a mean age of 54.0 ± 12.2 were examined. This study found no Chinese
people with systemic sclerosis were periodontally healthy and many (76%) had periodontal pockets despite most of them (93%)
practiced daily tooth-brushing. They all had caries experience (DMFT = 10.5) and many (65%) had untreated decay. Mucosal telangiectasia
was a common oral feature (80%). They had lower resting salivary flow rates (0.18 ± 0.17 ml/min vs. 0.31 ± 0.21 ml/min; p = 0.003) and pH values (6.90 ± 0.40 vs. 7.28 ± 0.31; p < 0.001) and reduced maximal mouth opening (40.1 ± 6.5 mm vs. 43.6 ± 7.0 mm) than people without SSc. 相似文献
4.
Håkan Flink Åke Tegelberg Judith E. Arnetz Dowen Birkhed 《Acta odontologica Scandinavica》2020,78(3):229-235
AbstractObjective: The aim was to study prevalence of xerostomia, hyposalivation and quality of life among caries active younger adults.Materials and methods: A questionnaire regarding oral and general health, xerostomia and quality of life was mailed to 134 caries active (CA) and 40 caries inactive (CI) patients, 25–50 years of age (mean age 39.9?±?6.2 years) treated at a Swedish Public Dental Service clinic, regarding oral and general health, xerostomia and quality of life. Caries data and unstimulated whole salivary flow rates were obtained from dental records.Results: The overall response rate was 69%. Dental records confirmed that CA patients had more decayed teeth over time than CI patients (p?<?.001). The CA group reported worse oral health (p?<?.001) and general health (p?<?.01), more xerostomia (p?<?.001) and lower salivary flow rate (p?<?.01) compared to CI patients. Xerostomia was inversely related to unstimulated whole salivary flow rates as well as to oral and general health (p?<?.01). There were no differences between groups in quality of life.Conclusion: Younger caries active adult patients reported significantly more xerostomia and hyposalivation compared to caries inactive patients. Xerostomia and hyposalivation were inversely related to perceptions of oral and general health, but not to quality of life. 相似文献
5.
Dental erosion is a common oral finding in chronic renal failure and may develop due to extrinsic and/or intrinsic causes.
The aim of this study was to compare the salivary calcium and phosphorus levels, salivary flow rate, salivary buffer capacity,
salivary pH, serum calcium and phosphorus levels and parathyroid hormone levels in chronic renal failure patients with and
without dental erosion. Twenty-four men and 19 women who had had chronic renal failure for at least 2 years were studied.
Twenty-two subjects displayed erosion-like patterns on their teeth and the other 21 patients showed no signs of erosion. Two
closely age- and sex-matched control groups (control groups 1 and 2) were enrolled in this study because of the age disparity
between the erosion and non-erosion groups. The data were analyzed by Mann–Whitney U test, Student t test, Pearson’s and Spearman’s correlation tests. None of the comparisons were statistically different between the erosion
and non-erosion groups. There were statistically significant differences in salivary calcium (P < 0.01) and phosphorus (P < 0.01) levels, serum phosphorus level (P < 0.01) and serum PTH level (P < 0.01) for the erosion group and control group 1 and also for the non-erosion group and control group 2. There was also
a significant difference in salivary flow rate (P < 0.05) for the erosion group and control group 1. There was a positive significant correlation between saliva buffer capacity
and salivary phosphorus level (r = 0.454, P < 0.05) in the erosion group. 相似文献
6.
D. A. Queiroz J. R. Cortelli M. Holzhausen E. Rodrigues D. R. Aquino W. A. Saad 《Clinical oral investigations》2009,13(3):263-267
It is believed that an increased arginase activity may lead to less nitric oxide production, which consequently increases
the susceptibility to bacterial infection. Considering the hypothesis that smoking may alter the arginase activity and that
smoking is considered a risk factor to dental implant survival, the present study aimed at evaluating the effect of smoking
on the salivary arginase activity of patients with dental implants. Salivary samples of 41 subjects were collected: ten non-smoking
and with no dental implants (group A), ten non-smoking subjects with dental implants (group B), ten smoking subjects with
implants (group C), and 11 smoking subjects with no dental implants (group D). The levels of salivary arginase activity were
determined by the measurement of l-ornithine and expressed as mIU/mg of protein. A significant increase in the salivary arginase activity was verified in groups
C (64.26 ± 16.95) and D (49.55 ± 10.01) compared to groups A (10.04 ± 1.95, p = 0.00001 and p = 0.0110, groups C and D, respectively) and B (11.77 ± 1.45, p = 0.00001 and p = 0.0147, groups C and D, respectively). No significant difference was found between groups C and D (p = 0.32). Within the limits of the present study, it can be concluded that salivary arginase activity is increased in smoking
subjects with dental implants in contrast to non-smoking subjects with dental implants, therefore suggesting a possible mechanism
by which cigarette smoking may lead to implant failure. The analysis of salivary arginase activity may represent an important
tool to prevent implant failure in the near future. 相似文献
7.
Heikkinen AM Pitkäniemi J Kari K Pajukanta R Elonheimo O Koskenvuo M Meurman JH 《Clinical oral investigations》2012,16(2):571-580
The aim of our study was to investigate how teenage smoking affects the prevalence of periodontal bacteria and periodontal
health with the hypothesis that smoking increases the prevalence of the bacteria. Oral health of 264 adolescents (15- to 16-year-olds)
was clinically examined, and their smoking history was recorded. The participants also filled in a structured questionnaire
recording their general health and health habits. Pooled subgingival plaque samples were taken for polymerase chain reaction
analysis of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Prevotella nigrescens, and Treponema denticola. The prevalence of P. intermedia (21% vs. 4%, p = 0.01) and T. forsythia and T. denticola (23% vs. 8%, p < 0.05, for both) was higher among female smokers than among non-smokers. T. forsythia and T. denticola were more often associated with bleeding on probing (29% vs. 12%; 25% vs. 10%, respectively) and deep pockets (25% vs. 15%;
23% vs. 10%, respectively) with smokers than non-smokers. Among the girls, a significant association was found between pack-years
and the prevalence of P. nigrescens (p < 0.007). In both genders, A. actinomycetemcomitans and P. gingivalis were rare in this study. To conclude, periodontal bacteria were associated with higher periodontal index scores among all
teenage smokers. Smoking girls harbored more frequently certain periodontal bacteria than non-smokers, but this was not seen
in boys. Hence, our study hypothesis was only partly confirmed. 相似文献
8.
Chronic kidney disease (CKD) is a debilitating systemic condition. Our working hypothesis is that CKD predialysis patients with periodontitis would respond poorly to periodontal treatment owing to immunologic compromise. Twenty-one predialysis patients (group 1) and 19 individuals without clinical evidence of kidney disease (group 2) with chronic periodontitis were subjected to non-surgical periodontal treatment with no antibiotics. Clinical periodontal and systemic parameters were evaluated at baseline and 3 months after treatment. Both groups showed significant and similar post-treatment improvements in all periodontal parameters examined. Most interestingly, periodontal treatment had a statistically significant positive effect on the glomerular filtration rate of each individual (group 1, p = 0.04; group 2, p = 0.002). Our results indicate that chronic periodontitis in predialysis kidney disease patients improved similarly in patients with chronic periodontitis and no history of CKD after receiving non-surgical periodontal therapy. This study demonstrates that CKD predialysis patients show a good response to non-surgical periodontal treatment. 相似文献
9.
Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease
下载免费PDF全文
![点击此处可从《Journal of periodontology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Karita M. Nylund Hellevi Ruokonen Timo Sorsa Anna Maria Heikkinen Jukka H. Meurman Fernanda Ortiz Taina Tervahartiala Jussi Furuholm Nagihan Bostanci 《Journal of periodontology》2018,89(1):117-129
1 Background
Triggering receptor expressed on myeloid cells (TREM‐1) is a cell‐surface receptor involved in amplification of inflammatory response to bacterial infections, along with its ligand peptidoglycan recognition protein 1 (PGLYRP1). TREM‐1 is shed by matrix metalloproteinases (MMPs) to its soluble (s) form. The aim of the study is to investigate association of sTREM‐1 and PGLYRP1 with oral inflammatory burden among patients with chronic kidney disease (CKD) at predialysis and posttransplantation stages.2 Methods
One hundred forty‐four patients with CKD were examined at predialysis, and oral infection foci were treated prior to kidney transplantation. Fifty‐three patients were available for follow‐up after transplantation. Oral inflammatory burden was assessed by the Periodontal Inflammatory Burden Index (PIBI) and Total Dental Index. sTREM‐1, PGLYRP1, and interleukin (IL)‐1β were measured in saliva by enzyme‐linked immunosorbent assay, and MMP‐8 was measured by immunofluorometric assay.3 Results
In the predialysis stage, sTREM‐1 and PGLYRP1 were positively associated with IL‐1β, MMP‐8, and PIBI. More specifically, patients with deeper probing depth (PD) (at least two sites with ≥6 mm) had higher concentrations of salivary sTREM‐1 and PGLYRP1 compared with those with shallower PD. Higher concentrations of PGLYRP1 and IL‐1β were associated with a higher number of teeth (> 25). On follow‐up, higher PGLYRP1 and sTREM‐1 were associated with one or more sites with ≥4 mm PD.4 Conclusions
sTREM‐1 and PGLYRP1 are elevated in patients with CKD with poor oral health and positively correlate with number of active periodontal pockets after oral infection therapy. Moreover, they positively correlate with MMP‐8 and IL‐1β. Hence, the salivary sTREM‐1/PGLYRP1 axis could be useful as a diagnostic marker for oral infection within patients with CKD. 相似文献10.
Obesity, dental caries and periodontal diseases are among major public health concerns which may affect children’s growth
and development. This study seeks any clustering between obesity, oral health and life-style factors among school children
in Istanbul, Turkey. A cross-sectional study of children, 10- to 12-year-olds, from a public and a private school was undertaken
with questionnaires for children and their mothers and child oral health data, in Istanbul (n = 611). DMFS (number of decayed, missing and filled surfaces of permanent teeth), CPI (Community Periodontal Index), body
mass index (BMI) and life-style factors (tooth-brushing frequency, milk consumption at breakfast and bedtimes on school nights)
of children were examined. Data analysis included factor analysis, Student’s t test and Chi-square tests by cross-tabulation. Public school children were more dentally diseased but less obese than were
those in private school (P < 0.001). They more frequently had calculus (62%) and reported non-recommended tooth-brushing (68%) than did those in private
school (37%, 56%; P < 0.05). Principal component analysis revealed that DMFS, CPI and BMI shared the same cluster among all children. A need exists
for addressing obesity, oral health and nutrition jointly in health promotion strategies to improve children’s well-being
and empower good life-style factors. 相似文献
11.
Pellegrini GG Gonzales Chaves MM Fajardo MA Ponce GM Toyos GI Lifshitz F Friedman SM Zeni SN 《Clinical oral investigations》2012,16(2):651-657
No studies had investigated circadian and circannual rhythms of bone biomarkers in whole saliva. We evaluated the salivary
daily and seasonal rhythm of carboxy-terminal telopeptide of type I collagen (CTX) and bone alkaline phosphatase (b-ALP).
Forty clinical and oral healthy ambulatory pre- and postmenopausal women from two southern Argentine cities: Comodoro Rivadavia
(latitude 45o S) and Ushuaia (latitude 54o S) were included in the study. CTX levels were evaluated in serum, urine, and saliva,
and b-ALP levels were measured in serum and saliva. In both groups of women, salivary CTX showed a maximum percentage of change
early in the morning (80%) and a minimum in the late afternoon (45%), similarly to the pattern observed in urinary samples.
No daily rhythm was observed in serum or salivary b-ALP. 25-Hydroxyvitamin D levels decreased in winter vs. summer (p < 0.01) without differences between the two studied groups. Conversely, parathormone reached higher levels in winter (p < 0.05) which induced a slight non-significant increment in salivary CTX and b-ALP levels. The results showed that, as in
serum and urinary samples, salivary CTX exhibits daily and a slight seasonal rhythmicity. Whole non-stimulated saliva is a
useful tool to detect several oral and systemic diseases because it has important advantages compared to serum and urinary
samples. Then, it may also be a promising sample to test changes in bone metabolism contributing to diagnose and to monitor
the therapy of several metabolic bone diseases. 相似文献
12.
van Gemert-Schriks MC van Amerongen WE ten Cate JM Aartman IH 《Clinical oral investigations》2008,12(4):361-368
The aim of the present study is to verify which strategy is the most effective in the treatment of dental decay of the deciduous
dentition in a moderate to high caries child population under remote field conditions. This study was carried out in the rain
forest of Suriname. Three hundred and eighty schoolchildren, mean age 6.1 years (SD 0.5, range 5.1–7.1 years), were randomly
assigned to four different groups: full dental treatment, only extractions, only restorations (ART) and no treatment. Parameters
for oral health were defined as caries prevalence (dmft), caries increment, sequela to dental caries and dental pain. Restorative
dental care of the primary dentition, by means of ART, resulted in a caries increment from a dmft of 5.48 (SD 3.2) at baseline
to 6.35 (SD 2.6) after 2 years (p < 0.001). Extensive dental treatment, performing only extractions, or no treatment did not render significant changes in
the caries prevalence of children (p > 0.05). Full dental treatment should be the strategy of choice whenever oral health care programmes are developed. However,
when priorities are required due to situational, practical or economical reasons, extraction of severely decayed teeth is
an effective treatment strategy. 相似文献
13.
The purpose of this study was to assess the degree of pain during periodontal probing and mechanical non-surgical therapy
according to age, gender, and intersubject variation such as tooth type, tooth surfaces or regions of mouth, probing depth,
and bleeding on probing. The study was carried out on 64 patients with chronic periodontitis. Pain/discomfort of patients
during both periodontal probing and scaling and root planing (SRP) was measured using a visual analog scale (VAS). During
periodontal probing and SRP, VAS scores decreased with increasing age for two procedures (Spearman ρ, −0.301 and −0.348, respectively; P < 0.01). VAS scores were considerably lower for oral sites than for facial sites. VAS scores in probing were significantly
higher in sites ≥4 mm deep than sites <4 mm deep. Sites bleeding on probing had a significantly higher VAS scores than sites
no bleeding on probing (p < 0.05). The results showed that although there is no difference between genders, the intensity of pain during periodontal
probing and SRP was different dramatically between patients as well as vary between different locations in the same mouth.
If pain responses for probing in different several regions in the same mouth during initial examination were noted into patient
chart used for initial examination, the therapist will recognize patients with elevated pain responses. If need be, they will
then apply some pain control medication or anesthetic for patients during probing and SRP. 相似文献
14.
Dental anxiety causes patients to refuse or delay treatment, which may exacerbate oral diseases. The aim of the current randomized controlled trial was to determine whether progressive muscle relaxation therapy could relieve dental anxiety. The trial included 68 periodontal patients with dental anxiety scores of ≥13 who were randomly assigned to either an intervention group or a control group (n = 34 per group). The intervention group was administered progressive muscle relaxation therapy for 20 min and oral health education for 15 min before periodontal treatment once per week for 4 wk. The control group was provided with oral health education only, for the same duration. Changes in dental anxiety, depression symptoms, blood pressure, heart rate, and salivary cortisol were evaluated 4 wk and 3 months after the intervention. The intervention group exhibited statistically significantly greater reductions in dental anxiety scores than did the control group at the 4‐wk (?3.82 vs. ?0.89) and 3‐month (?4.22 vs. ?0.28) assessments. They also exhibited significantly greater reductions in depression symptoms, systolic and diastolic blood pressure, pulse rate, and salivary cortisol levels at both time‐points. Progressive muscle relaxation therapy relieves tension and anxiety in dental patients. 相似文献
15.
Aron Naimi-Akbar Barbro Kjellström Lars Rydén Nilminie Rathnayake Björn Klinge Anders Gustafsson 《Acta odontologica Scandinavica》2019,77(4):282-289
Objective: The aim of the present study was to investigate attitudes to and perceptions of dental treatment and costs, self-assessed personal oral health status and dental self-care in an adult Swedish population, with special reference to potential associations between these factors and periodontal status.Material and methods: The study population comprised 1577 subjects who had undergone radiographic dental examination. The subjects were grouped by severity of periodontitis, based on extent of bone loss, as none, mild/moderate or severe. Subjects answered a questionnaire about socioeconomic factors, oral care habits and attitudes to dental treatment. Other questions covered medical history, smoking and other life style factors. Associations were tested using the Chi-squared test and a logistic regression model.Results: Compared to subjects with no periodontitis, those with mild/moderate or severe periodontitis were less likely to afford (p?<?.001), more often refrained from treatment due to costs (p?<?.001) and in the past year had experienced dental problems for which they had not sought treatment (p?<?.001). They also reported more anxiety in relation to dental appointments (p?=?.001). Regarding caries prevention, the severe periodontitis group used least fluoride products (p?=?.002).Conclusions: Swedish adults regard their oral health as important, those with periodontitis have a more negative perception of their oral health and are less prone to seek help. These discouraging findings suggest the need for targeted measures, which focus on improving the care of this group of patients. 相似文献
16.
L. Miia J. Helenius Jukka H. Meurman Ilkka Helenius Kirsti Kari Jarkko Hietanen Riitta Suuronen 《Acta odontologica Scandinavica》2013,71(5):284-293
We studied the presence of secondary Sjögren's syndrome (SS) and the composition of saliva, prevalence of oral pathogens, periodontitis, mouth mucosa, and teeth in patients with various rheumatic diseases and in healthy controls. The hypothesis was that different rheumatic diseases might cause differences in oral health characteristics because of the liability of secondary SS in the patients. The study involved 77 patients and 77 age-matched and sex-matched controls. Twenty patients were suffering from spondylarthropathy (SPA), 18 from ankylosing spondylitis (AS), 24 from rheumatoid arthritis (RA), and 15 from mixed connective tissue disease (MCTD). Clinical and radiographic oral health status was recorded and salivary flow rates were measured. Selected salivary proteins and immunoglobulins were analysed by routine methods. Minor salivary gland biopsy samples were taken from the patients for assessment of inflammatory focus scores. Differences between patients and controls and in between the different rheumatic diseases were analysed statistically. Secondary SS was diagnosed in 39% (30/77) of the patients. A severe periodontal condition (community periodontal index of treatment needs score 3 or 4) occurred in 58% (45/77) of the rheumatic patients compared with only 26% (20/77) of the controls (p<0.0001). The severity of focal sialadenitis (focus score) correlated significant with salivary IgA, IgG, and IgM concentrations. Salivary albumin, total protein, IgG, and IgM concentrations were higher in all patient groups than in the controls. The number of patients with low salivary flow rates was higher in all patient groups compared to controls. Oral yeast counts were significantly higher in the patients than in the controls (p<0.001). In a subgroup analysis, patients with SS had higher values for salivary IgA and IgM than patients without SS. Dental caries and oral lactobacilli were more frequent in patients with SS, but SS was not associated with periodontitis. No major differences were noted in other salivary biochemical parameters between these two groups. Patients with rheumatic diseases, irrespective of specific diagnosis, thus had various alterations in salivary flow and composition and oral health. The findings may reflect the autoimmune inflammation of the salivary glands frequently observed in these patients. 相似文献
17.
The purpose of this study was to compare the effect of tooth related and patient related factors on the success of non-surgical
and surgical periodontal therapy. In 41 patients (22 female) with untreated and/or recurrent periodontitis, no therapy, scaling
and root planing (SRP), or access flap (AF) were assigned according to probing pocket depth (PPD). PPD and vertical relative
attachment level (RAL-V) were obtained initially, 3 and 6 months after therapy. Baseline data were compared according to therapy,
jaw, tooth type, and site. Factors influencing clinical parameters were identified using multilevel analyses. Baseline PPDs
were deeper interproximally, in the maxilla and at premolars compared to buccal/oral sites, mandibular, and anterior teeth.
At 6 months, PPD reduction and RAL-V gain were significantly greater at sites receiving SRP and AF as compared to untreated
sites (p < 0.001). PPD reduction and RAL-V gain were significantly less (p < 0.005) in smokers as compared to nosmokers and at interproximal sites (p < 0.0001) as compared to buccal/oral sites. RAL-V gain was less in aggressive periodontitis, and PPD reduction was less in
the maxilla (p < 0.001). In sites with greater bone loss and infrabony defects, a poorer response was observed regarding RAL-V gain or PPD
reduction, respectively. The conclusions of the study are the following: (1) Nonsurgical and surgical periodontal therapies
are effective in single-rooted teeth; (2) severe interproximal bone loss and infrabony defects deteriorate clinical results;
and (3) there seem to be more defect-associated (tooth, site) factors influencing treatment outcome than patient-associated
factors. 相似文献
18.
Association Between Periodontal Disease and Kidney Function Decline in African Americans: The Jackson Heart Study
下载免费PDF全文
![点击此处可从《Journal of periodontology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Vanessa Grubbs Eric Vittinghoff James D. Beck Abhijit V. Kshirsagar Wei Wang Michael E. Griswold Neil R. Powe Adolfo Correa Bessie Young 《Journal of periodontology》2015,86(10):1126-1132
Background: Chronic kidney disease (CKD) remains a prevalent public health problem that disproportionately affects African Americans, despite intense efforts targeting traditional risk factors. Periodontal disease, a chronic bacterial infection of the oral cavity, is both common and modifiable and has been implicated as a novel potential CKD risk factor. The authors seek to examine to what extent periodontal disease is associated with kidney function decline. Methods: This retrospective cohort study examines 699 African American participants with preserved kidney function (defined by estimated glomerular filtration rate (eGFR) >60 mL/minute/1.73m2 at baseline) who underwent complete dental examinations as part of the Dental‐Atherosclerosis Risk in Communities study (1996 to 1998) and subsequently enrolled in the Jackson Heart Study (2000 to 2004). Using multivariable Poisson regression, the authors examined the association of periodontal disease (severe versus non‐severe) with incident CKD, defined as incident eGFR <60 mL/minute/1.73m2 and rapid (5% annualized) eGFR decline at follow‐up among those with preserved eGFR at baseline. Results: Mean (± SD) age at baseline was 65.4 (± 5.2) years, and 16.3% (n = 114) had severe periodontal disease. There were 21 cases (3.0%) of incident CKD after a mean follow‐up of 4.8 (± 0.6) years. Compared with participants with non‐severe periodontal disease, those with severe periodontal disease had a four‐fold greater rate of incident CKD (adjusted incidence rate ratio 4.18 [95% confidence interval 1.68 to 10.39], P = 0.002). Conclusions: Severe periodontal disease is prevalent among a population at high risk for CKD and is associated with clinically significant kidney function decline. Further research is needed to determine if periodontal disease treatment alters the trajectory of renal deterioration. 相似文献
19.
Sakallioğlu EE Aliyev E Lütfioğlu M Yavuz U Açikgöz G 《Clinical oral investigations》2007,11(2):115-120
It has been demonstrated that diabetes mellitus (DM) may have an inductive effect on the vascular endothelial growth factor
(VEGF) levels of periodontium during periodontal disease. The aim of this study is to confirm this phenomenon, investigating
whether it is also valid for diabetic periodontitis patients under good metabolic control. Sixteen type II DM patients, all
with a glycosylated hemoglobin (HbA1c) value less than 7 (test), and 15 systemically healthy (control) chronic periodontitis
patients were included in the study. The VEGF concentrations in the gingival supernatants and gingival crevicular fluid (GCF)
samples of the study groups were measured by enzyme-linked immunosorbent assay. The data were analyzed by Student’s t test in statistical means. The VEGF levels were significantly higher in the gingival supernatants of the test group (55.89 ± 8.11 pg/ml)
than that of the control group (24.81 ± 2.04 pg/ml; p < 0.01). However, there was no statistically significant difference in the VEGF levels of GCF between the study groups (38.96 ± 4.89 pg/ml
in the test and 32.20 ± 4.02 pg/ml in the control group; p > 0.05). Our study confirms that DM affects the VEGF levels of periodontal soft tissues in periodontal disease, and our results
also suggest that this effect may not be influenced by the metabolic control of DM. 相似文献
20.
Neda Babaee Arash Mansourian Fatemeh Momen-Heravi Aliakbar Moghadamnia Jalil Momen-Beitollahi 《Clinical oral investigations》2010,14(1):65-70
Recurrent aphthous stomatitis (RAS) is a common, painful, and ulcerative disorder of the oral cavity with unknown etiology.
Treatment is a highly controversial topic. The aim of this study was to evaluate the clinical efficacy of a novel paste containing
Myrtus communis (Myrtle) in the treatment of recurrent aphthous stomatitis. Myrtle is a particular herb used in some cultures as treatment
for mouth ulcers. The study was a randomized, double-blind, controlled before–after clinical trial. Forty-five patients with
RAS randomly participated in this study. The subjects were treated with placebo paste and myrtle oral paste in two consecutive
episodes. The paste was applied by subjects themselves four times a day for 6 days. Five parameters (size change, pain scale,
erythema and exudation level, oral health impact profile, and patient overall assessment of their treatment) were recorded
both before (baseline) and during each episodes of treatment (on the morning of days 2, 4, and 6). There were no statistically
significant differences between baseline parameters (p > 0.05). The data indicated a statistically significant reduction of ulcer size (p < 0.001), pain severity (p < 0.05), and erythema and exudation level (p < 0.001). Oral Health Impact Profile improved significantly in the treatment group (p < 0.001). Patient overall assessment of their treatment improved after applying paste containing myrtle (p < 0.05). No side effects were reported. This study has shown myrtle to be effective in decreasing the size of ulcers, pain
severity and the level of erythema and exudation, and improving the quality of life in patients who suffer from RAS. 相似文献