代谢综合征的发病机制及防治研究进展

代谢综合征(metabolic syndrome,MS)又名胰岛素抵抗代谢综合征(IRMS),或X-综合征,是由于胰岛素抵抗(IR)引发的一系列临床、生化、体液代谢失常,从而引起多种物质代谢失常的综合征[1].MS的发病原因尚未完全阐明,文献报道其与胰岛素抵抗、高胰岛素血症、超重和向心性肥胖关系密切[2].其常见原因有遗传因素、环境因素、脂肪细胞因子因素、行为因素及多种因素综合作用等,这些因素也是导致死亡和致残的主要原因[3].本研究就MS的发病相关因素、诊断与防治等综述如下.     

血浆脂蛋白相关磷脂酶A2水平在代谢综合征患者的表达变化及其意义

<正>代谢综合征(metabolic syndrome,MS)是指人体内血脂3项、血糖、胰岛素、尿白蛋白甚至尿酸等多种代谢成分发生异常改变的病理状态,是一种复杂的代谢紊乱症候群[1]。该病集肥胖、高血压、血脂异常、高血糖、高尿酸、高胰岛素血症和高脂肪肝发生率等多种代谢紊乱集于一身。有研究表明,慢性低水平的炎症反应是MS的重要特征[2],促使患者产生向心性肥胖和胰岛素抵抗,加重MS患者     

舒血宁治疗代谢综合征疗效观察

<正>代谢综合征(MS)是指个体出现高血压、高血脂、肥胖、高胰岛素血症等多种病理状态集结的疾病,统称为MS。以中心性肥胖、胰岛素抵抗为纽带构成了MS和2型糖尿病(T2DM)之间密切的交互关系,MS被证实其主要价值是预测心血管疾病(CVD)和糖尿病(DM);DM是导致CVD的独立危险因素,其预测CVD的能力不逊于MS,但当它作为MS的一个重要组分存在时,发生CVD的危险将大大     

禹州市区儿童单纯性肥胖的特点与代谢综合征

目的:探讨儿童肥胖与代谢综合征(metabolic syndrome,MS)的相关性及流行特点。方法:采用调查研究和临床研究相结合的方法,调查家族史、生活方式,测定身高、体重、腹围、血压、血脂、血糖,按照美国胆固醇教育计划(NCEP-ATPⅢ)代谢综合征标准判定儿童肥胖与MS的关系,同时设立非肥胖儿童30例作对照。结果:按美国国家胆固醇教育计划(NCEP-ATPⅢ)代谢综合征指标评定,37.43%的儿童存在MS。结论:(1)肥胖有遗传倾向,但相对于多食、偏食、少动等而言,后者作用更强。(2)儿童肥胖与MS密切相关。(3)运动、节食、教育等综合方案是防止肥胖的关键。     

代谢综合征与血脂代谢异常

代谢综合征(MS)起因于肥胖(中心性或内脏型),核心是胰岛素抵抗,由此产生的多种代谢异常成分聚集于同一个体,并以心血管疾病和(或)2型糖尿病为临床特点的一组症候群[1,2];MS还可增加主动脉瓣钙化发生的风险[3]。由于地区差异,不同机构的MS定义各不相同,其中2005年国际糖尿病联盟(IDF)代谢综合征全球共识[4]是以中心性肥胖(以腰围为标准)为必要条件,再加血清三酰甘油(TG)>l.7 mmol.L-1     

早期个性化糖尿病教育对代谢综合征的影响

代谢综合征(MS)是以腹型肥胖、糖耐量异常、高血压、血脂异常为主要内涵,以多种代谢性疾病集结出现为临床特征的一组严重影响人类健康的临床症候群.     

儿童 青少年代谢综合征流行趋势及特征

代谢综合征(MS)是指一系列代谢紊乱和心脑血管危险因素的聚集,即肥胖、高血压、血脂紊乱及糖耐量异常等多种代谢异常临床体征的综合征。研究发现,MS各组分在生命早期即存在,随着肥胖严重程度而增加,并呈轨迹现象持续至成年期[1]。近年来,随着儿童肥胖人口的迅速上升     

259名机关干部代谢综合征体检结果分析

<正>代谢综合征是中心型肥胖、高血压、高血糖及血脂异常等心血管病多种代谢危险因素在个体内集结的状态,其中心环节是肥胖和胰岛素抵抗。随着部队生活水平的提高,肥胖的发生日益增多,代谢综合征(MS)的发病率也在不断增加。高尿酸血症是嘌呤代谢障碍引起的代谢性疾病,与MS的发病密切相关。由于部队机关干部工作和生活方式有其自身的特点,因而发病情况与防治方案也有特殊性。近日,笔者对259名在职机关干部和机关退休干部的体检结果进行统计,     

脾肾与代谢综合征的关系探析

代谢综合征(MS)又称为胰岛素抵抗综合征(IRS),与多种代谢相关疾病有密切的联系,主要临床表现包括糖耐量减损或糖尿病、肥胖、高脂血症和高血压等。本资料通过对代谢综合征的研究发现,脾肾与MS关系密切,而脾肾虚损、痰瘀阻滞是代谢综合征的根本病机,因此在治疗上应脾肾兼顾,整体调节。     

飞行员代谢综合征发病情况调查

<正>代谢综合征(metabolic syndrome,MS)是以肥胖、糖尿病或糖调节受损、高血压、血脂异常以及胰岛素抵抗为共同病理生理基础,以多种代谢性疾病合并出现为临床特点的一组临床症候群。     

青少年代谢综合征的现状及相关影响因素分析

目的 了解江苏省南通地区青少年中代谢综合征的流行现状及其临床特点,为采取有效干预措施提供依据.方法 对373例超重肥胖青少年进行体格检查、血压测定及血液生化检测.采用2007年国际糖尿病联盟推出的青少年代谢综合征诊断标准来诊断代谢综合征.结果 共检出代谢综合征98例,检出率为26.3%.51例超重者中代谢综合征5例(9.8%),322例肥胖者中代谢综合征93例(28.9%),其中严重肥胖者45例中代谢综合征23例(51.1%).结论 南通地区超重肥胖青少年存在明显的代谢紊乱情况,代谢综合征的流行较严重,接近中等发达国家水平.在儿童青少年期预防超重肥胖的发生是降低代谢综合征发生率的关键.

Abstract：

Objective The prevalence and clinical characteristics of metabolic syndrome(MS)in adolescents were analyzed in Nantong,Jangsu province.Methods A total of 373 cases2 of overweight and obesity adolescents were recruited.All subiects underwent the physical examination,blood pressure measurement and blood biochemical markers measurement.MS in adolescents was diagnosed according to the definition which Was adopted by the International Diabetes Federation in 2007.Results There were 98 cases of MS and the detection rate was 26.3%.51cases were overweight and there were 5 cases of MS and the prevalence was 9.8%.Three hundred and twenty-two cases were obese and there were 93 cases of MS and the prevalence was 28.9%.There were 23 Cases of MS in 45cases of severe obesity.And the detection rate Wag 5 1.1%.Condusions There are metabolic disolders in overweight and obesity adolescents in Nantong.The prevalence of MS approaches to the level of moderately developed countries.The prevention of overweight and obesityin children and adolescents is the keyto reduce the incidence of MS.     

合肥市某社区40岁以上人群代谢综合征流行特征

目的 了解合肥市某社区中老年人群代谢综合征(MS)的患病情况与流行特征。方法 采用整群随机抽样的方法,对合肥市某社区内2 860位40岁及以上常住居民进行问卷调查、体格检查和实验室检查。按照国际糖尿病联盟诊断标准(IDF)对MS进行诊断。结果 调查对象共调查2 860人,男性1 093人(38.22%),女性1 767人(61.78%),平均年龄(56.38±10.8)岁,MS患病率为34.55%,标化患病率为33.73%,女性(39.7%)明显高于男性(26.2%),不同年龄段、不同文化程度、不同婚姻状况、不同居住情况调查对象间MS患病率不同。MS各组分患病率在25.8%~56.4%,在中心性肥胖的基础上,合并两项指标异常的有499人(17.4%),合并3项指标异常的有369人(12.9%),五项全部异常的有120人(4.2%),MS异常指标组合中以中心性肥胖合并低高密度脂蛋白(HDL)和血压异常的患病率最高(18.7%),除了合并三酰甘油和血糖异常的患病率男女间差异无统计学意义外,其他5个组合的患病率女性均高于男性,差异有统计学意义(P<0.05)。结论 该社区40岁及以上居民MS患病率较高,女性较男性患病率高,合并二项及以上代谢异常的比例较高。     

Hepatic steatosis and vascular disease

Nonalcoholic fatty liver disease (NAFLD) refers to a wide picture of liver damage, ranging from steatosis to steatohepatitis, fibrosis and cirrhosis. The epidemiological studies demonstrated an association of NAFLD with obesity, type 2 diabetes and hyperlipidemia. Under this light the metabolic syndrome (MS), including NAFLD, obesity, central fat distribution, diabetes, dyslipidemia, hypertension and atherosclerotic cardiovascular disease (CVD) can be considered the link to explain the presence of vascular diseases in patients with NAFLD. In NHANES III, the authors demonstrated that the presence of MS was associated with increased risk of myocardial infarction, stroke or both. In a prospective study on 1209 Finnish middle-aged men without CVD or diabetes at baseline, Lakka showed that MS per se is associated with an increased risk of CVD and all-cause mortality. Finally the Atherosclerosis Risk in Communities (ARIC) confirmed that subjects with MS were 2 times more likely to have prevalent coronary heart disease. From a pathophysiological point of view, growing evidences implicate the oxidative stress as the unifying mechanism for many CVD risk factors. Under this light there is emerging evidence suggesting that there is a significant increase in vascular oxidative stress in patients with MS, with the presence of endothelial dysfunction in the early stage of the syndrome. Indeed, the inflammation process evidentiated in these patients is initiated at the endothelial level, stressing the key role of this active and dynamic tissue in the pathophysiological pathways. Under this light the endothelium can be considered as the last effector of a multi-syndrome and the main target of all the future studies focused on the underlying mechamisms of this complex network. Because of the potential serious public health impact, the comprehension of these patophysiological pathways will be crucial to design new preventive measures and therapeutic strategies.     

Preventive effect of Terminalia bellirica on obesity and metabolic disorders in spontaneously obese type 2 diabetic model mice

Visceral obesity induces insulin resistance and is recognized as an important risk factor for metabolic syndrome (MS). Therefore, inhibition of lipid absorption from the intestine is regarded as an effective way of preventing MS. Terminalia bellirica is extensively used in Ayurvedic medicine in India and neighboring countries, and the fruit of this plant has been reported to have hypoglycemic and hypolipidemic effects. In this study, we investigated the preventive effect of a hot water extract of T. bellirica fruit (TB) on obesity and various metabolic disorders, and explored its molecular mechanisms and active ingredients. TB treatment had a preventive effect on obesity, insulin resistance, and hyperlipidemia in spontaneously obese type 2 diabetic TSOD mice. To clarify the molecular mechanisms of TB in preventing obesity, we investigated the inhibitory effect on lipid absorption. TB suppressed absorption of triacylglycerol in an olive oil loading test (in vivo) and showed a strong inhibitory effect on pancreatic lipase activity (in vitro). Furthermore, a search for the active ingredients in TB revealed that gallic acid is the component primarily responsible for the inhibition of pancreatic lipase activity. Thus, our findings indicate that TB could be useful in preventing MS. The mechanisms probably involve suppression of the absorption of meal-derived lipids mediated by gallic acid.     

高尿酸血症与代谢综合征关联性的流行病学研究进展

随着我国经济水平的提高及居民生活方式的改变,代谢综合征(MS)的患病率不断上升.有研究显示我国老年人群MS患病率高达25.5%,现已成为我国重要的公共卫生问题.MS是集肥胖、高血压、血脂紊乱及糖代谢异常于一体的临床症候群,也是心血管疾病重要的危险因素.由于MS发病机制尚缺乏明确认识,对其危险因素进行干预是目前控制MS的重要手段.近年来,大量研究发现高尿酸血症(HUA)不仅是痛风的主要诱因,且与肥胖、高血压、高脂血症、糖尿病等MS主要组分密切相关,是MS和心血管疾病的独立危险因素.鉴于此,笔者从人群流行病学研究着手,就HUA与MS的关联性作一综述,探索采用血尿酸筛选MS高危人群的可行性,为MS及心血管疾病的防控提供科学依据.     

老年人代谢综合征患病情况分析

目的 综合分析老年人代谢综合征（MS）的患病情况。方法 对600例老年人的身高、体重、腰围、体重指数、心率、血压、血糖、总胆固醇、甘油三酯、载脂蛋白、高密度脂蛋白、低密度脂蛋白进行检测分析。结果 老年男性代谢综合征发病率为14．86％，女性为19．38％，其中60～75岁年龄组发病率较高，达21．46％。结论 老年人代谢综合征发病率有增高趋势，其中肥胖加高血压加高血脂型多见，肥胖加高血压加血糖异常型也有所增加。     

基于气相色谱-质谱联用技术的肥胖儿童血清代谢组学研究

目的：筛选与儿童肥胖相关的血液中差异代谢物,探讨肥胖儿童代谢紊乱的发生机制。方法：采用气相色谱-质谱联用（GC/MS）和模式识别技术分析肥胖儿童血清中代谢物的变化,GC/MS检测25例肥胖儿童（肥胖组）和25例健康儿童（正常组）血清中代谢物,采用偏最小二乘判别分析（partial least squares discrimination analysis,PLS-DA）识别两组样本的血清代谢谱及代谢物。结果：肥胖组和正常组的代谢谱分离良好,肥胖儿童和正常儿童之间的血清代谢成分存在33个差异代谢物,绘制33个差异代谢物ROC曲线,计算曲线下面积,肌酐、马来酸、莽草酸等16个代谢物面积大于0.5,可能是诊断肥胖儿童潜在的生物标志物。结论：肥胖儿童患者血清代谢物的变化机制和甘氨酸,丝氨酸和苏氨酸的代谢、丙氨酸、天冬氨酸和谷氨酸代谢、乙醛酸和二羧酸酯代谢密切相关。     

儿童肥胖和代谢综合症患儿血清高敏C反应蛋白水平变化及意义

目的探讨单纯性肥胖和代谢综合症患儿血清高敏C反应蛋白（hs—CRP）水平变化及其意义。方法40例儿童单纯性肥胖患者、40例儿童代谢综合症（MS）患者和40例正常儿童对照者,检测血压、体重、腰围、空腹血糖、胰岛素、高敏C反应蛋白,甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇。对上述资料进行统计分析。结果（1）单纯肥胖组和代谢综合症组高敏C反应蛋白水平明显高于正常对照组（P〈0．05）,MS组明显高于单纯肥胖组（P〈0．05）;（2）直线相关分析表明,hs—CRP水平与BMI、腰围、血压、MS组分数呈正相关（P〈0．05）,与高密度脂蛋白胆固醇呈负相关（P〈0．05）;（3）Logistic法分析结果表明,hs—CRP水平的显著影响因素依次为MBI（OR=I．170,P〈0．05）、腰围（OR=1．141,P〈0．05）。结论hs—CRP在MS和单纯肥胖患儿中表现出不同程度的升高,并与MS各判断指标密切相关,血清hsCRP水平可作为判断病情及进展的有效指标。     

Pharmacology in health foods:merits and demerits of food with health claims for the prevention of metabolic syndrome

The merits and demerits of food with health claims for the prevention of metabolic syndrome (MS) are reviewed. One major underlying cause of MS is obesity. Diet and lifestyle changes remain the cornerstones of therapy for obesity, but resulting weight loss is often small and long-term success is extremely uncommon and disappointing. Many anti-obesity drugs have been associated with unintended therapeutic outcomes. Currently, only one drug (mazindol) is approved in Japan for short-term treatment of individuals with a BMI over 35 kg/m(2). Treatment with orlistat with dietary modification, caffeine, or protein supplementation; consuming a low-fat diet; adherence to physical activity routines; prolonged contact with participants; problem-solving therapy; and the alternative treatment of acupressure are efficacious in reducing weight regain after weight loss treatment. Because obesity is highly stigmatized, any effective treatment should be made available to improve quality of life and self-image. Therefore, it is necessary to provide information to consumers through the media concerning 1) basic knowledge about health foods and laws concerning them, 2) scientifically based information on safety/effectiveness of health foods and food elements, and 3) reports on health disturbances associated with health foods around the world.     

代谢综合征与三阴性乳腺癌关系的研究进展

【摘要】代谢综合征（MS）、乳腺癌是女性常见疾病,三阴性乳腺癌（TNBCs）是近年来备受关注的乳腺癌的一个类型。MS的重要组分向心性肥胖、高血糖、高甘油三酯和低高密度脂蛋白（HDL-C）增加了TNBCs的患病风险。MS的常见生物标记物胰岛素、脂联素和瘦素等在乳腺癌特别是TNBCs的发生发展中起到重要作用。胰岛素样生长因子-IImRNA结合蛋白3(IMP3,是一种癌胚蛋白)可能是TNBCs浸润性癌新的生物标记物。本文对MS与TNBCs关系的研究进展进行综述。