急性脑卒中合并脑心综合征临床分析

目的探讨脑心综合征在急性脑卒中的发生率及临床特点。方法对我科发病1d内即入院的211例急性脑卒中患者的临床资料做回顾性分析,入院1,3,14d做心电图检查,必要时随时多次复查心电图,化验心肌酶谱,心电监护观察病情变化以助临床诊治。结果脑心综合征在急性脑卒中的发生率为54．5％,其中间脑附近为损伤责任灶的卒中患者脑心综合征发病率高。结论脑心综合征在急性脑卒中的发病率高,对脑卒中患者要重视心电图的变化,做到早发现,早诊断,早治疗,早谈话告知,对患者的预后有重要意义。     

急性脑卒中合并脑心综合征的临床分析

目的:探讨急性脑卒中合并脑心综合征的临床特点、发病机制和防治措施。方法:对175例急性脑卒中患者根据发病类型分组,分别行心电图和心肌酶学检查,对结果进行分析。结果:心电图异常108例,占总数的61.71%,其中有68例(62.96%)同时发生心肌酶学的改变。出血脑卒中患者对心脏的影响比缺血性卒中患者要大,合并心脏改变者死亡率高。结论:对急性脑卒中进行原发病治疗的同时应重视脑心综合征的发生,及早发现,及早干预,以取得良好的预后。     

老年急性脑血管病合并脑心综合征133例临床分析

目的:探讨脑心综合征的发病机制、临床特点和预后。方法:对133例脑心综合征(cerebro-cardiac syndrom,CCS)患者作心肌酶谱检测,并对其病变部位及预后进行分析。结果:CCS发生率为48.12%,其中脑叶组为23.94%,基底节、丘脑组为72.22%,脑干卒中组为80.76%。表明脑干及基底节、丘脑组发生CCS的比率较脑叶组高(P<0.05)。发现脑出血组心肌酶比脑梗死组心肌酶有明显升高。结论:CCS常发生在脑干及基底节、丘脑卒中患者中,且脑出血组心肌损害较严重,应积极治疗,改善预后。     

急性脑血管意外并脑心综合征46例临床回顾分析

目的:探讨脑心综合征(BHS)的发病机制、临床特点及防治方法。方法:对46例经诊断为急性脑血管意外合并脑心综合征患者的心电图、心肌酶谱、治疗及其预后进行回顾性分析。结果:本组患者均有不同程度心电图改变,心肌酶谱升高30例(62.5%),其中以脑出血发病率最高(63.33%),死亡5例(17.5%)。结论:脑心综合征以出血性脑卒中更为多见。应加强对脑血管意外患者心功能的监护,及时发现和治疗心脏并发症,是提高急性脑血管意外患者抢救成功率的关键。     

通心络治疗急性脑卒中致脑心综合征95例分析

目的探讨通心络胶囊治疗急性脑卒中致脑心综合征的临床疗效。方法脑心综合征患者192例随机分为治疗组95例,对照组97例。对照组给予常规西药治疗,治疗组在常规治疗的基础上,加服通心络胶囊3粒,每日3次,观察其临床疗效。结果本组脑心综合征发病率为46.6%(192/412)。治疗组总有效率93.7%(89/95),对照组为75.3%(73/97),2组比较差异有非常显著意义(P<0.01)。2组治疗后心电图情况比较差异有显著意义,心律失常、ST-T改变、心肌酶改变均有显著改善(P<0.05或P<0.01)。结论通心络胶囊治疗急性脑卒中致脑心综合征疗效肯定。     

急性脑卒中后心电图及心肌酶谱和肌钙蛋白-T的变化

目的 :观察急性脑卒中患者心电图、心肌酶谱和肌钙蛋白 - T的变化情况。方法 :2 16例急性脑卒中患者入院后做心电图 ,对其中有异常者再行心肌酶谱和肌钙蛋白 - T的检测 ,并动态观察。结果 :2 16例急性脑卒中患者 174例有心电图异常(80 .6 % ) ,出血性卒中的心电图异常率为 92 .31% ,高于缺血性卒中组 (71.0 9% ) ;174例心电图异常的患者中 ,有心肌酶谱改变的 10 3例 ,出血性卒中组心肌酶谱水平较缺血性卒中组高 (P <0 .0 5 ) ;174例心电图异常患者中肌钙蛋白 - T阳性者为 88例 ,其中出血性卒中组有 4 2例 ,缺血性卒中组有 4 6例 ,两组比较差异无统计学意义 ;治疗后 ,部分患者的心电图、心肌酶谱、肌钙蛋白 - T均有不同程度的恢复。结论 :急性脑卒中患者应加强心脏功能的监护 ,监测心电图、心肌酶谱及肌钙蛋白 - T,使可逆性的心肌损害得到恢复。     

脑卒中继发心电图、心肌酶谱异常的临床研究

目的:探讨脑心综合征的临床特点和发病机制。方法:对126例既往无心脏损害的急性脑卒中患者入院后做心电图和心肌酶谱检测,同时检测102例健康体检者与之对照分析。结果:126例急性脑卒中患者心肌酶谱水平明显高于对照组,心肌酶谱异常率46.8%,心电图异常率高达69.8%,心电图的异常主要表现为心律紊乱、S-T段及T波改变、Q-T间期延长、U波出现和心梗样图型,其中脑干及丘脑基底节区病灶发生心电图及心肌酶谱异常明显高于脑叶病灶(P<0.01),出血性脑卒中发生心电图及心肌酶谱异常明显高于缺血性脑卒中(P<0.01)。结论:脑心综合征临床以心电图异常和心律失常常见,其次是心肌损伤,发生与脑卒中部位与类型等因素有关,发病机制可能与脑卒中导致植物神经功能失调、神经体液功能紊乱有关。     

脑心综合征40例临床分析

目的: 探讨脑心综合征(cerebral cardiac syndrome,CCS)的发病机制及其对卒中患者病死率和住院时间的影响。方法: 选择我院2003年10月~2004年12月入院的40例脑心综合征患者与同期入院的心电图正常的86例脑卒中患者作对照分析。结果: 脑心综合征以出血性卒中最多见,病死率明显高于对照组(P<0.01),住院时间延长(P<0.001)。结论: 脑心综合征的发生与脑卒中病情严重程度相关,可作为判断预后的重要指标。     

急性脑卒中并发脑心综合征74的例临床分析

目的观察急性脑卒中患者并发脑心综合征的发生率,探讨脑心综合征对急性脑卒中患者预后的影响。方法对2017年10月至2018年11月我院收治的急性脑卒中患者120例进行回顾性统计分析,收集患者心电图、心肌酶谱改变情况,记录患者的转归及基本信息。统计急性脑卒中患者脑心综合征的发生率及对急性脑卒中患者预后的影响。分析总结急性脑卒中并发脑心综合征的临床特点、发病原因以及相应的防治对策。结果 120例急性脑卒中患者,有74例并发脑心综合征,发生率为61.67%。其中出血性脑卒中与缺血性脑卒中患者例数分别为32例、88例,并发脑心综合征例数分别为23例、51例,发生率分别为71.87%和57.95%。出血性脑卒中患者脑心综合征发生率高于缺血性脑卒中患者(P0.05)。组内比较,合并脑心综合征患者病死率高(P0.05)。结论急性脑卒中患者脑心综合征的发生率较高,且出血性脑卒中患者的发生率更高。并发脑心综合征患者的预后差。临床治疗中在加强治疗原发病的同时,亦需要加强心脏监护,并采取积极的防治措施,从而确保患者生命安全。     

脑心综合征的中西医机制研究探析

目的研究探析脑心综合征的中西医机制。方法回顾性分析我院四年半来收治的81例急性脑血管病脑心综合征患者的临床资料。结果中医学:在中风病中以中脏和中腑并发脑心综合征的比率较大。西医学:本研究中急性脑卒中再发脑心综合征的比率为40.5%。心脏损害表现主要是心电图异常,包括心律失常、ST-T段改变,另有心肌酶谱的异常,肌钙蛋白与肌红蛋白异常。其发生率与卒中类型密切相关,出血性脑卒中(59.3%)明显比缺血性脑卒中(40.7%)高,P<0.01,具有统计学意义。结论中医学:脑与心在结构和功能上都存在着密切联系。西医学:脑心综合征的发生可能与脑实质中某些特定功能部位损害导致的自主神经功能紊乱、神经体液调节失调、电解质紊乱有关。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.