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增生性瘢痕疙瘩是一种常见的病理表现,是皮肤在创伤后成纤维细胞活性异常增高,大量结缔组织沉积,过度增生;常伴有痒痛,影响生活质量及美观。其发病机制目前尚不完全清楚,虽然近年来其治疗方法种类繁多,例如,物理治疗有:压力治疗、激光治疗、超声和紫外线治疗、冷冻治疗等;药物治疗有:肾上腺皮质固醇激素、抗肿瘤药、抗组胺药、秋水仙碱、中药等。这些方法对增生性瘢痕有不同疗效,手术又容易复发,但效果都不太理想。本组病例采用^90Sr-^90Y器治疗增生性瘢痕,方法简便,取得较好的治疗效果,结果报告如下。 相似文献
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瘢痕疙瘩的治疗 ,有药物、放射、手术、压力治疗等几种方法 ,均非特效。国内学者对各种方法进行临床疗效比较 ,认为小范围的瘢痕疙瘩以去炎松注射为首选[1] 。我们自 1998年~ 2 0 0 2年用曲安缩松注射治疗瘢痕疙瘩 15 6例 ,取得了良好的效果 ,现报告如下 :1 临床资料1 1 一般资料 1998 2~ 2 0 0 2 8共使用曲安缩松注射治疗瘢痕疙瘩 15 6例 ,其中男 86例 ,女 70例 ;年龄最大 72岁 ,最小 5岁 ,瘢痕面积在 1cm2 ~ 16cm2 ,曲安缩松用量 ,成人每次 <80mg ,儿童 <40mg ,每两周注射一次 ,3~ 4次为一疗程。1 2 方法 用普通 5ml一次性注射… 相似文献
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瘢痕疙瘩是整形外科的棘手问题,特别是对瘢痕体质的患者和某些张力较大的功能部位生有瘢痕疙瘩的患者,若采用手术治疗,则瘢痕常有复发。山东省威海市文登中心医院自2010年以来采用干扰素和康宁克通组合治疗瘢痕疙瘩120例共188个瘢痕疙瘩,现将临床资料和方法介绍如下。 相似文献
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瘢痕疙瘩治疗状态综述 总被引:1,自引:0,他引:1
瘢痕疙瘩是临床上常见的一种皮肤病,因其致病机制尚不清楚,故在临床治疗上未能取得较好的临床疗效。本文根据不同的文献报道来探讨瘢痕疙瘩治疗的发展状态,从而来提高其临床疗效。 相似文献
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李瑛 《中国现代药物应用》2009,3(20):65-65
目的对瘢痕疙瘩的治疗进行临床探讨。方法采用联合疗法治疗瘢痕疙瘩。结果患者通过联合疗法治疗瘢痕疙瘩较单一治疗临床疗效好,治愈率提高,复发率有所降低。结论目前联合疗法是最有效和最安全的治疗瘢痕疙瘩的方法。 相似文献
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痤疮俗称粉刺,是青年人中最为常见的一种慢性皮肤病,病因多与内分泌及细菌感染有关,面部皮损可致较大脓肿,遗留萎缩性瘢痕或瘢痕疙瘩,目前临床上尚无理想的治疗药物,且易复发。 相似文献
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目的分析比较耳垂瘢痕疙瘩三种不同治疗方法的临床效果,为耳垂瘢痕疙瘩的治疗提供一种简单、有效的方法。方法对49例(61侧)耳垂瘢痕疙瘩患者的临床资料进行回顾性分析,按不同的治疗方法分为3组。A组:手术切除+术后曲安奈德局部注射;B组:手术切除+术后透明质酸酶局部注射;C组:常规手术组。结果 A组和B组疗效较好,而且均明显高于C组。结论手术切除加术后局部注射曲安奈德或透明质酸酶治疗耳垂瘢痕疙瘩方法简单,临床效果良好。 相似文献
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Diabetes is a common endocrine disorder increasingly encountered in patients requiring treatment with psychoactive drugs. The pharmacotherapy options for diabetes have expanded in recent years and now include 14 oral hypoglycemic drugs from 5 pharmacologic classes, as well as insulin. The diversity of drugs raises the need for clinicians to be aware of potential drug interactions. Fortunately, few drug interactions of major clinical significance involving psychoactive drugs with oral hypoglycemics have been described in the medical literature. The newer drugs for treatment of type 2 diabetes are discussed, and considerations are given for avoiding or minimizing drug interactions when prescribing psychoactive drugs to patients with diabetes. 相似文献
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以雷帕霉素为代表药物的作用于mTOR靶点的莫司类药物,在抗癌方面有着不容小觑的作用。作为靶向治疗药物,雷帕霉素及其衍生物在多种常见的癌症中起到有效的治疗效果,具有高效、低剂量等优势,具有良好的发展前景。与其他抗肿瘤药物的联合用药会成为一种更有效的治疗方法,通过抑制多个靶标来抑制肿瘤的发生发展,提高药物疗效,减少不良反应。另外,联合用药也可能会延迟肿瘤耐药性的出现。对已上市的几个莫司药物临床应用基本情况和同类在研品种的最新进展情况进行了综述。 相似文献
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Human cytomegalovirus remains an important pathogen for transplant recipients. To date, a limited number of drugs have been licensed for the treatment of HCMV infection and disease, all sharing the same target molecule, the viral DNA-polymerase. Although combating HCMV with DNA-polymerase inhibitors is effective and has been established for many years, there are several drawbacks associated with the use of these drugs including toxicity and emergence of drug resistance. In order to overcome these problems different treatment options and durations have been assessed and new and improved antiviral drugs with novel molecular targets have been discovered. However, not all of these novel drugs had the properties for success in clinical development, and alternative treatment options with known drugs have been evaluated in parallel. Today the need for an antiviral drug that is potent, safe and well tolerated remains. 相似文献
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Leo E. Hollister 《Drug development research》1986,9(1):9-21
More than 30 years have passed since the introduction of effective antipsychotic drugs. These drugs have revolutionized both the treatment of patients with schizophrenia and the thinking about the nature of this disorder. During this time, technical improvements have widened the scope of usefulness of these agents. However, no newer drug has been more effective overall than was the first, chlorpromazine. In addition, many patients respond poorly or not at all to drug therapy; others find the side effects of present drugs unbearable. Tardive dyskinesia and tardive psychosis are developments following long-term treatment that may have serious import. Many questions about drug therapy remain unanswered. Which drug? How much? Intermittent or continual maintenance therapy? What new approaches to treatment can be considered? Atypical neuroleptics that may specifically bind to receptors in the mesolimbic system constitute the major thrust of current drug development. Interest in benzodiazepines as adjunctive agents have revived. The role of propranolol remains uncertain; it seems more to be an adjunctive treatment. Lithium and carbamazepine may be suitable adjuncts for patients who are otherwise refractory to treatment. Use of neuropeptides was greeted with initial enthusiasm, which is rapidly waning as more experience develops. New approaches to drug treatment for schizophrenia are desperately needed. 相似文献
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高原低氧环境通过改变机体胃肠排空速率、器官血流量、药物血浆蛋白结合率、药物代谢酶和转运体表达等影响药物的药代谢动力学过程。癫痫是一种需长期用药的脑部疾病,而大多数抗癫痫药物的治疗指数低、有效血药浓度范围窄。临床上常用治疗药物监测(therapeutic drug monitoring, TDM)来寻找抗癫痫药物的最佳个体化用药方法。该文对临床上常用抗癫痫药及其治疗窗进行归纳总结,并分析高原低氧环境对抗癫痫药物药代动力学的影响,为高原抗癫痫药物临床用药提供参考。 相似文献
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药物基因组学是在药物遗传学基础上发展起来的,是以功能基因组学与分子药理学为基础的一门科学。药物基因组学通过对特定药物具敏感性或抵抗性的患病人群的单核苷酸多态性差异检测,指导制定适合每个个体的治疗方案,使病人既能获得最佳治疗效果,又能避免药物不良反应,达到用药个体化的目的。抗栓药物是临床应用非常普遍的一类药物,用于预防冠脉支架内血栓、心肌梗死和脑卒中,但是不同的人对抗栓药物的反应性存在差异,少数人甚至有"抵抗"现象,导致药物不能达到治疗效果。用基因检测指导个体化抗栓治疗能为用药的合理性和安全性提供参考依据,减少不良事件的发生。 相似文献
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在抗击新型冠状病毒肺炎(COVID-19)疫情的关键时期,国家连续颁布了7版诊疗方案,每一新版诊疗方案对治疗药物都有补充、完善。α-干扰素、磷酸氯喹、阿比多尔、洛匹那韦/利托那韦、利巴韦林等抗病毒药物得到了临床专家的广泛认可与推荐。本文从药物不良反应、药物禁忌、药物相互作用、注意事项等多个方面对《新型冠状病毒肺炎诊疗方案(试行第七版)》涉及的抗病毒药物进行归纳与总结,对抗病毒药物的合理使用与药学监护提出建议,旨在为临床治疗药物选择提供参考,提高药物治疗效果。 相似文献