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1.
Purpose This prospective study was designed to assess the effectiveness of sacral nerve stimulation for fecal incontinence in patients
with external anal sphincter defect and to evaluate its efficacy regarding presence and size of sphincter defect.
Methods Fifty-three consecutive patients who underwent sacral nerve stimulation for fecal incontinence were divided into two groups:
external anal sphincter defect group (n = 21) vs. intact sphincter group (n = 32). Follow-up was performed at 3, 6, and 12 months with anorectal physiology, Wexner’s score,
bowel diary, and quality of life questionnaires.
Results The external anal sphincter defect group (defect <90°:defect 90°–120° = 11:10) and intact sphincter group were comparable
with regard to age (mean, 63 vs. 63.6) and sex. Incidence of internal anal sphincter defect and pudendal neuropathy was similar. All 53 patients benefited
from sacral nerve stimulation. Weekly incontinent episodes decreased from 13.8 to 5 (P < 0.0001) for patients with external anal sphincter defects and from 6.7 to 2 (P = 0.001) for patients with intact sphincter at 12-month follow-up. Quality of life scores improved in both groups (P < 0.0125). There was no significant difference in improvement in functional outcomes after sacral nerve stimulation between
patients with or without external anal sphincter defects. Clinical benefit of sacral nerve stimulation was similar among patients
with external anal sphincter defects, irrespective of its size. Presence of pudendal neuropathy did not affect outcome of
neurostimulation.
Conclusions Sacral nerve stimulation for fecal incontinence is as effective in patients with external anal sphincter defects as those
with intact sphincter and the result is similar for defect size up to 120° of circumference.
†Deceased. 相似文献
2.
Jarrett ME Dudding TC Nicholls RJ Vaizey CJ Cohen CR Kamm MA 《Diseases of the colon and rectum》2008,51(5):531-537
Purpose Sphincter repair is the standard treatment for fecal incontinence secondary to obstetric external anal sphincter damage; however,
the results of this treatment deteriorate over time. Sacral nerve stimulation has become an established therapy for fecal
incontinence in patients with intact sphincter muscles. This study investigated its efficacy as a treatment for patients with
obstetric-related incontinence.
Methods Fecally incontinent patients with external sphincter defects who would normally have undergone overlapping sphincter repair
as a primary or repeat procedure were included. Eight consecutive women (median age, 46 (range, 35–67) years) completed temporary
screening; all eventually had permanent implantation.
Results Six of eight patients had improved continence at median follow-up of 26.5 (range, 6–40) months. Fecal incontinent episodes
improved from 5.5 (range, 4.5–18) to 1.5 (range, 0–5.5) episodes per week (P = 0.0078). Urgency improved in five patients, with ability to defer defecation improving from a median of <1 (range, 0–5)
minute to 1 to 5 (range, 1 to >15) minutes (P = 0.031, all 8 patients). There was no change in anal manometry or rectal sensation. There was significant improvement in
lifestyle, coping/behavior, depression/self-perception, and embarrassment as measured by the American Society of Colon and
Rectal Surgery fecal incontinence quality of life score.
Conclusions Sacral nerve stimulation is potentially a safe and effective minimally invasive treatment for fecal incontinence in patients
with de novo external anal sphincter defects or defects after unsuccessful previous external anal sphincter repair, although numbers remain
small.
Dr. Michael Kamm is a consultant to and received research support from Medtronic, however, study design, performance, analysis,
and reporting have been conducted without the influence of Medtronic. 相似文献
3.
Purpose The study was designed to determine the effect of further vaginal delivery on anal sphincter function in women after apparently
uncomplicated primiparous forceps delivery.
Methods Fifty-two secundigravid women whose first child was forceps-assisted were compared with a control group of 20 women who had
undergone spontaneous first vaginal delivery. Both groups were studied antenatally and again at 12 weeks after second delivery
using a standardized bowel function questionnaire, endoanal ultrasound, and anal manometry. The primary outcome was fecal
incontinence score after second delivery.
Results Before second delivery, 20 of 52 (39 percent) of the forceps group and 3 of 20 (15 percent) control subjects (P = 0.103) reported minor alteration in fecal incontinence. Endoanal ultrasound was more frequently abnormal (38/52 (73 percent)
vs. 6/20 (30 percent); P = 0.002), and median anal canal squeeze (71 vs. 104 mmHg; P = 0.004) and resting pressures (43 vs. 58 mmHg; P = 0.004) were lower in the forceps group. There was no difference in continence score between first and second delivery for
the forceps group (P = 0.19) group or control subjects (P = 0.18). However, 10 of 38 (26 percent) women with an abnormal endoanal ultrasound after first forceps delivery developed
new or worsening symptoms after second delivery.
Conclusions One-quarter of women with occult anal sphincter injury after first forceps delivery experienced some minor alteration in fecal
continence after the second delivery.
Presented at the 23rd annual meeting of the Society for Maternal Fetal Medicine, San Francisco, California.
Supported by the Irish Health Research Board. 相似文献
4.
Forsgren C Zetterström J Lopez A Nordenstam J Anzen B Altman D 《Diseases of the colon and rectum》2007,50(8):1139-1145
Purpose This study was a prospective evaluation of the long-term effects of hysterectomy on bowel function using self-reported outcome
measures on symptoms of constipation, rectal emptying difficulties, and anal incontinence.
Methods In this prospective cohort study, 120 consecutive patients undergoing hysterectomy for benign conditions answered a questionnaire
on bowel habits and anorectal symptoms preoperatively. Forty-four patients underwent vaginal and 76 abdominal hysterectomy.
Follow-up was performed one and three years postoperatively. Data were analyzed by using multivariate regression and nonparametric
statistics.
Results The bowel and anorectal survey was answered by 115 of 120 patients (96 percent) after one year and 107 of 120 patients (89
percent) after three years. Abdominal hysterectomy was associated with increased anal incontinence symptoms at one-year (P < 0.01) and three-year follow-up (P < 0.01). Vaginal hysterectomy was not associated with increased anal incontinence symptoms at one year follow-up, although
there was a significant increase in incontinence symptoms at the three-year follow-up (P < 0.05). Risk factor analysis indicated that a reported history of obstetric sphincter injury was correlated to an increased
risk of developing posthysterectomy anal incontinence (odds ratio, 2.07; 95 percent confidence interval, 1.05–2.87; P < 0.05). There was no significant rise in constipation symptoms or rectal emptying difficulties in either cohort through
the follow-up.
Conclusions Neither abdominal nor vaginal hysterectomy was associated with constipation, aggravation of constipation, or rectal emptying
difficulties three years after surgery. Abdominal and vaginal hysterectomy was, however, associated with an increased risk
of mild anal incontinence symptoms, and patients with a reported history of obstetric sphincter injury were at particular
risk for posthysterectomy fecal incontinence.
Supported by funds from the Swedish Society of Medicine. 相似文献
5.
Rectal Hypersensitivity Worsens Stool Frequency, Urgency, and Lifestyle in Patients With Urge Fecal Incontinence 总被引:6,自引:1,他引:6
PURPOSE Rectal sensory mechanisms are important in the maintenance of fecal continence. Approximately 50 percent of patients with urge incontinence have lowered rectal sensory threshold volumes (rectal hypersensitivity) on balloon distention. Rectal hypersensitivity may underlie the heightened perception of rectal filling; however, its impact on fecal urgency and incontinence is unknown. This study was designed to investigate the impact of rectal hypersensitivity in patients with urge fecal incontinence.METHODS Prospective and retrospective audit review of all patients (n = 258) with an intact native rectum referred to a tertiary colorectal surgical center for physiologic investigation of urge fecal incontinence during a 7.5-year period. Patients with urge fecal incontinence who had undergone pelvic radiotherapy (n = 9) or rectal prolapse (n = 6) were excluded.RESULTS A total of 108 of 243 patients (44 percent) were found to have rectal hypersensitivity. The incidence of anal sphincter dysfunction was equal (90 percent) among those with or without rectal hypersensitivity. Patients with urge fecal incontinence and rectal hypersensitivity had increased stool frequency (P < 0.0001), reported greater use of pads (P = 0.003), and lifestyle restrictions (P = 0.0007) compared with those with normal rectal sensation, but had similar frequencies of incontinent episodes.CONCLUSIONS Urge fecal incontinence relates primarily to external anal sphincter dysfunction, but in patients with urge fecal incontinence, rectal hypersensitivity exacerbates fecal urgency, and this should be considered in the management and surgical decision in patients who present with fecal incontinence.Christopher L. H. Chan, F.R.C.S., is supported by a MRC Clinical Training Fellowship. 相似文献
6.
Background
Anal sphincter defects have been shown to increase pressure asymmetry within the anal canal in patients with fecal incontinence. However, this correlation is far from perfect, and other factors may play a role. The goal of this study was to assess the impact of rectal prolapse on anal pressure asymmetry in patients with anal incontinence. 相似文献7.
Healy CF O'Herlihy C O'Brien C O'Connell PR Jones JF 《Diseases of the colon and rectum》2008,51(11):1619-1626
Purpose Childbirth is the most common cause of fecal incontinence and damage to the pudendal nerve is a major component of childbirth
injury. This study was designed to develop an acute animal model of injury to the innervation of the external anal sphincter.
Methods Forty-eight female virgin wistar rats were studied. Two models of neuropathic injury were developed. Bilateral inferior rectal
nerve crush (Group A) acted as a positive control. Prolonged intrapelvic retrouterine balloon inflation (Group B) simulated
the pelvic compressive forces of labor. Quantitative analysis of external anal sphincter muscle function was performed by
using electromyography, external anal sphincter specific force production, and stereologic calculation of external anal sphincter
mass.
Results Injury in both groups caused significant atrophy of the external anal sphincter (P = 0.002, ANOVA) and electromyographic evidence of reinnervation at one week. Specific force (mN force per mg mass) was not
altered. External anal sphincter muscle mass recovered after four weeks in Group B.
Conclusions Balloon dilation within the boney pelvis results in denervation of the external anal sphincter and offers an experimental
model of the effects of childbirth on the continence mechanism in humans.
Supported by a grant from The Health Research Board, Ireland.
Presented at the meeting of The American Society of Colon and Rectal Surgeons, St. Louis, Missouri, June 2 to 6, 2007, and
was the winner of the Research Forum Prize. 相似文献
8.
Melenhorst J Koch SM van Gemert WG Baeten CG 《International journal of colorectal disease》2008,23(1):107-111
Background and aims Faecal incontinence (FI) is a socially devastating problem. The treatment algorithm depends on the aetiology of the problem.
Large anal sphincter defects can be treated by sphincter replacement procedures: the dynamic graciloplasty and the artificial
bowel sphincter (ABS).
Materials and methods Patients were included between 1997 and 2006. A full preoperative workup was mandatory for all patients. During the follow-up,
the Williams incontinence score was used to classify the symptoms, and anal manometry was performed.
Results Thirty-four patients (25 women) were included, of which, 33 patients received an ABS. The mean follow-up was 17.4 (0.8–106.3)
months. The Williams score improved significantly after placement of the ABS (p < 0.0001). The postoperative anal resting pressure with an empty cuff was not altered (p = 0.89). The postoperative ABS pressure was significantly higher then the baseline squeeze pressure (p = 0.003). Seven patients had an infection necessitating explantation. One patient was successfully reimplanted.
Conclusion The artificial bowel sphincter is an effective treatment for FI in patients with a large anal sphincter defect. Infectious
complications are the largest threat necessitating explantation of the device. 相似文献
9.
Dr. Jonathan A. Leighton M.D. Miguel A. Valdovinos M.D. John H. Pemberton M.D. Doris M. Rath R.N. Michael Camilleri M.D. 《Diseases of the colon and rectum》1993,36(2):182-185
Our aim was to characterize the clinical spectrum of anorectal dysfunction among eight patients with progressive systemic sclerosis (PSS) who presented with altered bowel movements with or without fecal incontinence. The anorectum was assessed by physical examination, proctosigmoidoscopy, and anorectal manometry. There was concomitant involvement of the other regions of the digestive tract in all patients as determined by barium studies, endoscopy, or manometry: eight esophageal, three gastric, four small bowel, and two colonic. Seven patients had fecal incontinence, and four also had second-degree complete rectal prolapse. Abnormal anorectal function, particularly abnormal anal sphincter resting pressures, were detected in all patients; anal sphincter pressures were lower in those with rectal prolapse. Rectal capacity and wall compliance were impaired in seven of seven patients. Successful surgical correction of prolapse in three patients resulted in restoration of incontinence for six months and seven years in two of the three patients. We conclude that rectal dysfunction and weakness of the anal sphincters are important factors contributing, respectively, to altered bowel movements and fecal incontinence in patients with gastrointestinal involvement by PSS. Rectal prolapse worsens anal sphincter dysfunction and should be sought routinely as it is a treatable factor aggravating fecal incontinence in patients with PSS.This work was presented in part at the Annual Meeting of the American Gastroenterological Association, May 1992, and appears in abstract form in Gastroenterology 1992;102:A473.Supported in part by the General Clinical Research Center Grant 00585 from the National Institutes of Health. 相似文献
10.
Effect of neoadjuvant chemoradiation on postoperative fecal continence and anal sphincter function in rectal cancer patients 总被引:2,自引:2,他引:0
Pietsch AP Fietkau R Klautke G Foitzik T Klar E 《International journal of colorectal disease》2007,22(11):1311-1317
Background and aims Neoadjuvant chemoradiation (nCRT) followed by curative surgery has gained acceptance as the therapy of choice in locally advanced
rectal cancer. This prospective study evaluates the effect of nCRT on postoperative anorectal function and continence.
Patients and methods Group A consisted of 12 patients (59.8 ± 11.9 years, male:female = 8:4) who received nCRT (5-FU, CPT-11. 45 + 5.4 Gy boost)
before surgery and Group B of 27 patients (61.9 ± 10.6 years, male:female = 16:11) who were treated by surgery alone. All
patients received a questionnaire to evaluate stool continence and anorectal function before as well as after surgery. Anorectal
function was further analyzed by perfusion manometry pre- and postoperatively.
Results Preoperatively, none of the patients had signs or symptoms of fecal incontinence, and preoperative measurements showed values
within normal limits. Postoperatively, fecal continence was impaired in both groups, but no significant difference was found
between patients with or without nCRT. Anorectal manometry revealed an impairment of anorectal function after low anterior
resection regardless of the treatment regime.
Conclusion nCRT does not impair anorectal function and fecal continence. The deterioration of continence and anal sphincter function
after sphincter preserving surgery is solely caused by the surgical procedure. 相似文献
11.
Terra MP Deutekom M Dobben AC Baeten CG Janssen LW Boeckxstaens GE Engel AF Felt-Bersma RJ Slors JF Gerhards MF Bijnen AB Everhardt E Schouten WR Berghmans B Bossuyt PM Stoker J 《International journal of colorectal disease》2008,23(5):503-511
Purpose Pelvic-floor rehabilitation does not provide the same degree of relief in all fecal incontinent patients. We aimed at studying
prospectively the ability of tests to predict the outcome of pelvic-floor rehabilitation in patients with fecal incontinence.
Materials and methods Two hundred fifty consecutive patients (228 women) underwent medical history and a standardized series of tests, including
physical examination, anal manometry, pudendal nerve latency testing, anal sensitivity testing, rectal capacity measurement,
defecography, endoanal sonography, and endoanal magnetic resonance imaging. Subsequently, patients were referred for pelvic-floor
rehabilitation. Outcome of pelvic-floor rehabilitation was quantified by the Vaizey incontinence score. Linear regression
analyses were used to identify candidate predictors and to construct a multivariable prediction model for the posttreatment
Vaizey score.
Results After pelvic-floor rehabilitation, the mean baseline Vaizey score (18, SD ± 3) was reduced with 3.2 points (p < 0.001). In addition to the baseline Vaizey score, three elements from medical history were significantly associated with
the posttreatment Vaizey score (presence of passive incontinence, thin stool consistency, primary repair of a rupture after
vaginal delivery at childbed) (R
2, 0.18). The predictive value was significantly but marginally improved by adding the following test results: perineal and/or
perianal scar tissue (physical examination), and maximal squeeze pressure (anal manometry; R
2, 0.20; p = 0.05).
Conclusion Additional tests have a limited role in predicting success of pelvic-floor rehabilitation in patients with fecal incontinence. 相似文献
12.
Recovery of the internal anal sphincter following rectopexy: A possible explanation for continence improvement 总被引:20,自引:1,他引:20
Twenty-one patients suffering from rectal prolapse (n=15) or internal rectal procidentia (n=6) were investigated clinically and by anorectal manometry prior to and six months following rectopexy. Rectal prolapse was associated with incontinence in 67% (10/15) of the patients preoperatively. The moderately or severely incontinent patients had lower than normal maximum anal resting pressures (MAP) and those with severe incontinence also had lower than normal maximum squeeze pressure (MSP). Postoperatively only 20% (3/15) of the patients remained incontinent and none of them suffered severe incontinence. MAP values increased significantly indicating that improvement of the function of the internal anal sphincter may be one of the factors contributing to better continence. Rectal sensibility was impaired in patients with rectal prolapse as compared to 15 controls. There was no postoperative change. Patients with internal rectal procidentia had normal MAP and MSP and no postoperative change could be demonstrated. 相似文献
13.
Purpose This study was designed to evaluate the effects of caffeine on anorectal function by anorectal manometry.
Methods Ten healthy subjects were studied. They drank 200 ml of water and later 200 ml of a solution that contained caffeine 3.5 mg/kg
body weight. The anorectal manometric study was divided into three periods: basal, water, and caffeine; each period lasted
45 minutes.
Results After the ingestion of water, the basal anal sphincter pressure showed no change during the 45-minute recording, whereas after
caffeine consumption the basal anal sphincter pressure increased at 10 minutes (P = 0.047) and 15 minutes (P = 0.037). The average basal anal sphincter pressure throughout the 45 minutes was significantly higher after caffeine ingestion
than after water (P = 0.013). After caffeine intake, the maximum squeeze pressure increased significantly (P = 0.017) compared with the basal period. Both water and caffeine consumption caused a decrease in the rectal sensory threshold
for the desire to defecate.
Conclusions Caffeine 3.5 mg/kg body weight in 200 ml of water resulted in stronger anal sphincter contractions both at basal period and
during voluntary squeeze. The sensory threshold was also decreased, leading to an earlier desire to defecate. Caffeine consumption
may result in an earlier desire to defecate, leading to defecation if the anal sphincter can relax voluntarily. 相似文献
14.
Purpose This randomized study was designed to compare the effect of sacral neuromodulation with optimal medical therapy in patients
with severe fecal incontinence.
Methods Patients (aged 39–86 years) with severe fecal incontinence were randomized to have sacral nerve stimulation (SNS group; n = 60)
or best supportive therapy (control; n = 60), which consisted of pelvic floor exercises, bulking agent, and dietary manipulation.
Full assessment included endoanal ultrasound, anorectal physiology, two-week bowel diary, and fecal incontinence quality of
life index. The follow-up duration was 12 months.
Results The sacral nerve stimulation group was similar to the control group with regard to gender (F:M = 11:1 vs. 14:1) and age (mean, 63.9 vs. 63 years). The incidence of a defect of ≤ 120° of the external anal sphincter and pudendal neuropathy was similar between
the groups. Trial screening improved incontinent episodes by more than 50 percent in 54 patients (90 percent). Full-stage
sacral nerve stimulation was performed in 53 of these 54 “successful” patients. There were no septic complications. With sacral
nerve stimulation, mean incontinent episodes per week decreased from 9.5 to 3.1 (P < 0.0001) and mean incontinent days per week from 3.3 to 1 (P < 0.0001). Perfect continence was accomplished in 25 patients (47.2 percent). In the sacral nerve stimulation group, there
was a significant (P < 0.0001) improvement in fecal incontinence quality of life index in all four domains. By contrast, there was no significant
improvement in fecal continence and the fecal incontinence quality of life scores in the control group.
Conclusions Sacral neuromodulation significantly improved the outcome in patients with severe fecal incontinence compared with the control
group undergoing optimal medical therapy.
*Deceased.
Read at the meeting of The American Society of Colon and Rectal Surgeons, St. Louis, Missouri, June 2 to 6, 2007. 相似文献
15.
Brusciano L Limongelli P Pescatori M Napolitano V Gagliardi G Maffettone V Rossetti G del Genio G Russo G Pizza F del Genio A 《International journal of colorectal disease》2007,22(8):969-977
Background Anal ultrasound is helpful in assessing organic anorectal lesions, but its role in functional disease is still questionable.
The purpose of the present study is to assess anal–vaginal–dynamic perineal ultrasonographic findings in patients with obstructed
defecation (OD) and healthy controls.
Materials and methods Ninety-two consecutive patients (77 women; mean age 51 years; range 21–71) with symptoms of OD were retrospectively evaluated.
All patients underwent digital exploration, endoanal and endovaginal ultrasound (US) with rotating probe. Forty-one patients
underwent dynamic perineal US with linear probe. Anal manometry and defaecography were performed in 73 and 43 patients, respectively.
Ultrasonographic findings of 92 patients with symptoms of OD were compared to 22 healthy controls. Anismus was defined on
US when the difference in millimetres between the distance of the inner edge of the puborectalis muscle posteriorly and the
probe at rest and on straining was less then 5 mm. Sensitivity and specificity were calculated by assuming defaecography as
the gold standard for intussusception and rectocele and proctoscopy for rectal internal mucosal prolapse. Since no gold standard
for the diagnosis of anismus was available in the literature, the agreement between anal US and all other diagnostic procedures
was evaluated.
Results The incidence of anismus resulted significantly higher (P < 0.05) in OD patients than healthy controls on anal (48 vs 22%), vaginal (44 vs 21%), and dynamic perineal US (53 vs 22%).
A significantly higher incidence of rectal internal mucosal prolapse was observed in OD patients when compared to healthy
controls on both anal (61.9 vs 13.6%, P < 0.0001) and dynamic perineal US (51.2 vs.9% P = 0.001). For the diagnosis of rectal internal mucosal prolapse, anal US had a 100% sensitivity and specificity. For diagnosis
of rectal intussusception, anal US had an 83.3% sensitivity and 100% specificity and perineal US had a 66.6% sensitivity and
100% specificity. In the diagnosis of anismus, anal ultrasonography resulted in agreement with perineal and vaginal US, manometry,
defaecography, and digital exam (P < 0.05). Other lesions detected by US in patients with OD include solitary rectal ulcer, rectocele and enterocele. Damage
of internal and/or external sphincter was diagnosed at anal US in 19/92 (20%) patients, all continent and with normal manometric
values.
Conclusion Anal, vaginal and dynamic perineal ultrasonography can diagnose or confirm many of the abnormalities seen in patients with
OD. The value of the information obtained by this non-invasive test and its role in the diagnostic algorithm of OD is yet
to be defined. 相似文献
16.
Remes-Troche JM Ozturk R Philips C Stessman M Rao SS 《International journal of colorectal disease》2008,23(2):189-194
Aim/Background Cholestyramine may improve fecal incontinence, but its use has not been assessed. We report our experience with the use of
cholestyramine in the treatment of fecal incontinence.
Materials and methods Twenty-one patients (19 female, mean age 65 years) with fecal incontinence (≥1 episode/week) received cholestyramine along
with biofeedback therapy (group A). Stool frequency, stool consistency (Bristol scale), number of incontinent episodes, satisfaction
with bowel function (VAS), and anorectal physiology were assessed at 3 months and at 1 year after treatment. Data were compared
with a matched group of 21 incontinent subjects (19 female, mean age 64 years) who received biofeedback alone (group B).
Results At 3 months and at 1 year, group A patients showed decreased stool frequency (p < 0.01), stool consistency (p = 0.001), and number of incontinent episodes (p < 0.04). In contrast, stool frequency (p = 0.8) and stool consistency (0.23) were not different from baseline in group B subjects. In both groups, there was improvement
in the satisfaction with bowel function (p < 0.05), anal sphincter pressures (p < 0.05) and ability to retain saline infusion (p < 0.05). Mean dose of cholestyramine used was 3.6 g; 13 subjects (62%) required dose titration, and 7 (33%) subjects reported
minor side effects.
Conclusion Cholestyramine is safe and useful adjunct for the treatment of diarrhea and fecal incontinence. Most patients require small
doses, and dose titration is important. The improvement in stool characteristics favors a drug effect, over and above the
benefits of biofeedback therapy.
Portions of this work were presented at the 2006 American College of Gastroenterology Meeting, Las Vegas, Nevada and published
as an abstract in Am J Gastroenterol 2006; 101 (Suppl):S210–S211. 相似文献
17.
Soerensen MM Bek KM Buntzen S Højberg KE Laurberg S 《Diseases of the colon and rectum》2008,51(3):312-317
Purpose Traditionally sphincter repair has not been performed during the puerperium. This prospective study was designed to determine
the long-term outcome of delayed primary or early secondary sphincteroplasty in the puerperium.
Methods Between 1991 and 2005, 22 females underwent delayed primary or early secondary repair after third-degree or fourth-degree
anal sphincter rupture. Delayed primary reconstruction was performed more than 72 hours after delivery. Early secondary reconstruction
was performed within 14 days postpartum. The reconstruction of the anal sphincter was performed without a covering stoma,
in all cases. A control group of 19 age-matched and parity-matched females, without known anal sphincter injury after vaginal
delivery, were included. Current degree of continence and associated quality of life were determined by a fecal incontinence
severity questionnaire and a quality of life questionnaire.
Results None of the females had complications postoperatively. Mean follow-up was 50 (range, 2–155) months in the case group and 60
(range, 12–132) months in the control group. At time of follow-up, the Wexner score was 4.1 (range, 0–13) in females with
delayed primary or early secondary reconstruction and 1.1 (range, 0–8) in the control group (P < 0.01). The inconvenience of incontinence after reconstruction was significantly higher (P < 0.01) compared with the control group, but the quality of life was not significantly affected (P = 0.75).
Conclusions It is safe to perform a delayed primary or early secondary reconstruction without a covering stoma in females who have sustained
a third-degree or fourth-degree obstetric tear. The long-term functional outcome is acceptable.
Poster presentation at the meeting of European Society of Coloproctology (ESCP), Lisbon, Portugal, September 13 to 16, 2006. 相似文献
18.
Purpose A remarkable incidence of failures after stapled axopexy (SA) for hemorrhoids has been recently reported by several papers,
with an incomplete resection of the prolapsed tissue, due to the limited volume of the stapler casing as possible cause. The
stapled transanal rectal resection (STARR) was demonstrated to successfully cure the association of rectal prolapse and rectocele
by using two staplers. The aim of this randomized study was to evaluate the incidence of residual disease after SA and STARR
in patients affected by prolapsed hemorrhoids associated with rectal prolapse.
Methods Sixty-eight patients were selected on the basis of validated constipation and continence scorings, clinical examination, colonoscopy,
anorectal manometry, and defecography and randomized: 34 underwent a SA and 34 a STARR operation. The operated patients were
followed-up with clinical examination, visual analog scale for postoperative pain, a satisfaction index, and defecography.
Results At a mean follow-up of 8.1 +/− 2.0 and 7.9 +/− 1.8 months for the SA and STARR groups, respectively, the incidence of residual
disease was significantly higher in the first group (29.4 vs 5.9 in the STARR group, p = 0.007), while a significantly lower incidence of residual skin-tags was found after STARR (23.5% vs 58.8 after SA, p = 0.03). All patients with residual disease showed prolapsed tissue over half the length of the anal dilator at the time
of the operation. Operative time and incidence of transient fecal urgency were significantly higher in the STARR group (with
p = 0.001 and 0.08, respectively), while SA was followed by a significantly higher incidence of poor results at the overall
patient satisfaction index (p = 0.04). No significant differences were found in hospital stay, operative complications, postoperative pain, time to return
to normal activity, continence, and constipation scores. All the defecographic parameters significantly improved after STARR,
while SA was followed only by a trend to a reduction of rectal prolapse.
Conclusions STARR provides a more complete resection of the prolapsed tissue than SA in patients with association of prolapsed hemorrhoids
and rectal prolapse with equal morbidity and significantly lower incidence of residual disease and skin-tags. The anal dilator
can be used for selecting the surgical technique. 相似文献
19.
Sacral nerve stimulation for treatment of fecal incontinence 总被引:6,自引:6,他引:0
Dr. Ezio Ganio M.D. Alberto Realis Luc M.D. Giuseppe Clerico M.D. Mario Trompetto M.D. 《Diseases of the colon and rectum》2001,44(5):619-629
PURPOSE: Many patients with fecal incontinence demonstrate a functional deficit of the internal anal sphincter or the external sphincter muscles without any apparent structural defects. Few patients are amenable to repair or substitution of the sphincter. However, sacral nerve stimulation appears to offer a valid treatment option for fecal incontinence. The objectives of this study were: to evaluate the efficacy of temporary stimulation of the sacral nerve roots (percutaneous nerve evaluation) in patients with functional fecal incontinence; to determine the mechanisms of possible improvement; and to evaluate if temporary stimulation could be reproduced and maintained by implanting a permanent neurostimulation system. METHODS: Twenty-three patients with fecal incontinence, 18 females and 5 males, median age of 54.9 years (range 28–71), underwent a percutaneous nerve evaluation test. Eleven patients (47.8 percent) also had urinary disorders: urge incontinence (4), stress incontinence (3), and retention (4). Associated disorders included perineal and rectal pain (1), spastic paraparesis (1), and syringomyelia (1). All patients underwent a preliminary evaluation using stationary anal manovolumetry, pudendal nerve terminal motor latency measurements, and anal ultrasound. A percutaneous electrode for the stimulation of the sacral nerve roots was positioned at the level of the third sacral foramen (S3) in 20 patients and S2 in 2 patients (1 patient missing). Stimulation parameters used were: pulse width 210µsec, frequency 25 Hz, and average amplitude of 2.8 V (range 1–6). The electrode was left in place for a minimum of 7 days. Five patients were successively implanted with a permanent sacral electrode with a stimulation frequency of 16 to 18 Hz and amplitude of 1.1–4.9 V. RESULTS: Seventeen of the 19 patients (89.4 percent) who completed the minimum percutaneous nerve evaluation period of 7 days (median 10.7 (range 7–30)), had a reduction of liquid or solid stool incontinence by more than 50 percent, and fourteen (73.6 percent) were completely continent for stool. The most important changes revealed by manovolumetry were an increase in resting pressure (P<0.001) and voluntary contraction (P=0.041), reduction of initial pressure for first sensation (P=0.049) and urge to defecate (P=0.002), and a reduction of the rectal volume for urge sensation (P=0.006). The percutaneous nerve evaluation results were reproduced at a median follow-up of 19.2 months (range 5 to 37) in the 5 patients who received a permanent implant. CONCLUSIONS: Temporary stimulation of the sacral roots (percutaneous nerve evaluation) can be of help in those patients with fecal incontinence, and the results are reproduced with permanent implantation. The positive effect on continence seems to be derived from not only the direct efferent stimulation on the pelvic floor and the striated sphincter muscle, but also from modulating afferent stimulation of the autonomous neural system, inhibition of the rectal detrusor, activation of the internal anal sphincter, and modulation of sacral reflexes that regulate rectal sensitivity and motility. 相似文献
20.
Bordeianou L Lee KY Rockwood T Baxter NN Lowry A Mellgren A Parker S 《Diseases of the colon and rectum》2008,51(7):1010-1014
Introduction We describe the relationship between anorectal manometry, fecal incontinence severity, and findings at endoanal ultrasound.
Methods A total of 351 women completed the Fecal Incontinence Severity Index, underwent anorectal manometry, and endoanal ultrasound.
Severity index and manometry pressures in 203 women with intact sphincters on ultrasound were compared with pressures in 148
women with sphincter defects. Relationships between resting and squeeze pressures, severity index, and size of sphincter defects
were evaluated.
Results Mean severity index in patients with and without sphincter defect was 35.7 vs. 36.7 (not significant). Worsening index correlated with worsening mean and maximum resting pressure (P < 0.0001). Differences were observed in mean and maximum resting pressure between the patients with and without sphincter
defects (26.6 vs. 37.2, P < 0.0001; 39.4 vs. 51.7, P < 0.001). Resting pressures correlated with the sizes of defect (P < 0.0001).
Conclusions Patients with and without sphincter defects had similar severity scores, but patients with defects had a significant decrease
in resting pressures. Patients with larger sphincter defects had lower severity scores and resting pressures. Until a manometry
cutoff can be set to discriminate between absence and presence of defects, both manometry and ultrasound should be offered
to patients with history of anal trauma.
Read at the meeting of The American Society of Colon and Rectal Surgeons, St. Louis, Missouri, June 2 to 6, 2007.
Reprints are not available. 相似文献