A Clinical Study on the Treatment of Chronic Pelvic Inflammation of Qi-stagnation with Blood Stasis Syndrome by Penyanqing Capsule (盆炎清胶囊)

Objective: To observe the clinical efficacy of Penyanqing Capsule (盆炎清胶囊, PYQC) in treating pelvic inflammation of Qi-stagnation with blood stasis syndrome. Methods: The randomized, single blinded, parallel positive drug controlled method was adopted, with 82 patients assigned into two groups by envelop method. The 42 patients in the treated group received PYQC 3 times a day, 4 capsules each time taken orally; the 40 patients in the control group were given orally Fuyankang tablets (妇炎康片, FYKT) 3 times a day, 6 tablets each time. The therapeutic course for both groups was 2 months, and 2 courses of treatment were given successively to observe the comprehensive effect, changes of symptoms and signs before and after treatment. The effects of PYQC on hemorrheological character in part of the patients and on the pathogenetic chlamydia and mycoplasma were also observed. Results: The total effective rate in the treated group was 83.3 %, which was insignificantly different from that in the control group ( 77.5 %, P ＞ 0.05 ).However, PYQC could significantly lower the hemorrheologic indexes in patients and showed definite influence on the pathogenetic chlamydia and mycoplasma. Conclusion: PYQC has good therapeutic effect in treating chronic pelvic inflammation of Qi-stagnation with blood stasis syndrome, and showed definite effect on chlamydia and mycoplasma.     

Clinical Observation on Treatment of Acute Gouty Arthritis byTongfengkang(痛风康)

Objective To objectively evaluate the clinical therapeutic effect of Tongfengkang (TFK) in treating acute gouty arthritis. Methods: Adopting randomized single blinded controlled trial, the 40 patients were equally divided into two groups. The tested group was treated with TFK, the control group was treated with indomethacin and allopurinol, the therapeutic course for both groups was 10 days. Results: The clinical cure rate in the tested group and the control group was 30% and 35% respectively, and the total effective rate 90% and 95% respectively, with no significant difference between the two groups (P>0.05).The scores of blood uric acid and symptom significantly lowered in both groups after treatment (P <0.01), but showed no significant difference between them (P>0.05). Adverse reaction to the treatment was shown in 3 patients in the control group. Conclusion: The therapeutic effect of TFK is similar to that of indomethacin plus allopurinol but with less adverse reaction, it is an effective and safe re     

Clinical Effect and Action Mechanism of Weicao Capsule(威草胶囊)In Treating Gout

Obiective:To study the therapeutic effect of Weicao Capsule(威草胶囊,WCC)on gout.Methods:Two hundred gout patients were assigned to two groups.The treated group was groups were given the respective treatments orally 3 times a day,2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment.Changes of blood β2-microglobulin(β2-M),hemoglobin(Hb),24 h urinary protein(24 h UP),pH value of urine and blood uric acid(BUA)as well as kidney function were observed.Results:After treatment,IeveI of β2-M got lowered significantly,Hb and 24 h UP,blood urea nitrogen,serum creatinine and the clearance rate of creatinine,as well as blood lipids all improved obviously in the treated group(all P＜0.01),while these parameters remained unchanged in the control group (P＞0.05).The pH value of urine was improved in both groups showing an insignificant difference between them(P＞0.05).BUA was decreased in both groups with a decrease to a larger extent in the treated group(P＜0.01).The total effective rate was 87% in the treated group,which was superior to that in the control group(62%,P＜0.05).Conclusion:WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β2-M,BUA and lipids.     

Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout

Objective： To study the therapeutic effect of Weicao Capsule （威草胶囊, WCC） on gout. Methods： Two hundred gout patients were assigned to two groups. The treated group was treated with WCC and the control group was treated with Tongfengding Capsule （痛风定胶囊）. Both groups were given the respective treatments orally 3 times a day, 2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment. Changes of blood β2- microglobulin （13 2-M）, hemoglobin （Hb）, 24 h urinary protein （24 h UP）, pH value of urine and blood uric acid （BUA） as well as kidney function were observed. Results： After treatment, level of β 2-M got lowered significantly, Hb and 24 h UP, blood urea nitrogen, serum creatinine and the clearance rate of creatinine, as well as blood lipids all improved obviously in the treated group （all P〈0.01）, while these parameters remained unchanged in the control group （P〉0.05）. The pH value of urine was improved in both groups showing an insignificant difference between them （P〉0.05）. BUA was decreased in both groups with a decrease to a larger extent in the treated group （P〈0.01）. The total effective rate was 87% in the treated group, which was superior to that in the control group （62%, P〈0.05）. Conclusion： WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β 2-M, BUA and lipids.     

Effect of Xuesaitong Soft Capsule(血塞通软胶囊)on Hemorrheology and in Auxiliarily Treating Patients with Acute Cerebral Infarction

Objective: To observe the therapeutic effect of Xuesaitong soft capsule(血塞通软胶囊,XST)and its effect on platelet counts, coagulation factor 1 (CF1) as well as hemorrheologic indexes in treating patients with acute cerebral infarction (ACI). Methods: Two hundred and four patients with ACI were assigned into two groups, the control group ( n = 96) and the treated group ( n = 108). They were all treated with conventional Western medicines, including mannitol, troxerutin, citicoline, piracetam and aspirin, while to the treated group, XST was given additionally through oral intake, twice a day, 2 capsules each time for 8successive weeks. The clinical efficacy was evaluated according to the nerve function deficits scoring and the changes of platelet count. CF1 and hemorrhe.ological indexes were measured before and after treatment. Results: The total effective rate was 87.0% in the treated group, and 87.5% in the control group, respectively, showing insignificant difference between them. But the markedly effective rate in the treated group (66.7%) was significantly higher than that in the control group (27.1%, P＜0.01). The count of platelet was not changed significantly in both groups after treatment, while CF1 inthem evidently lowered at the end of the 4th and 8th weeks of treatment, but showed insignificant difference between the two groups. The hematocrit, whole blood viscosity and plasma viscosity in both groups were all improved significantly after treatment, but also showed insignificant difference in comparison of the two groups. Conclusion: XST has good efficacy in auxiliary treatment of patients with ACI, though its mechanism remains to be further explored.     

Effect of Xin’ anning Nasal Drop (心安宁滴鼻剂) in treating coronary heart disease with unstable angina pectoris

Objective： To observe the clinical efficacy of Xin＇anning Nasal Drop （XAND,心安宁滴鼻剂） in treating coronary heart disease with unstable angina pectoris （CHD-UAP）. Methods： Sixty patients with CHD-UAP were assigned, according to the randomizing number table, to two groups, the control group treated with conventional Western medicine, and the treated group treated with conventional Western medicine plus XAND. The clinical efficacy and the changes of S-T segment in resting EKG and total ischemia burden （TIB） in 24-h dynamic EKG were observed. Results： The clinical efficacy, including the effect of angina alleviation, its initiation, and the effect of TOM syndrome score reduction, were significantly superior in the treated group to those in the control group （ P〈0.05 or P〈0.01 ）. The degree and extent of myocardial ischemia were significantly improved in both groups （ P〈0.01 ）, but the improvement in the treated group was better than that in the control group （ P〈0.05）. Moreover, it was worth mentioning that the immediate effect in the treated group was better than that in the control group, and the reduction of TIB, the improvement in heart rate and myocardial oxygen consumption （ immediately after the first administration or by the end of the therapeutic course）, and systolic blood pressure after treatment in the former were all superior to those in the latter, showing significant difference （ P〈0.05 or P〈0.01 ）. Conclusion： XAND has a quick effect in alleviating angina in patients with CHD-UAP, and it is worthy of further studies and spreading in clinical practice.     

肝脂消治疗非酒精性脂肪肝临床疗效观察

Objective To evalute the clinical effect of Ganzhixiao On nonalcohol fatty liver and the accomaning hyperlipemia. Methods Forty patients with fatty liver of Pixushengshi,Tanrexueyu and Zuzhimailuo syndrome were selected and randomly divided into two groups .Group 1 was treated with Ganzhixiao (n=30),and group 2 was treated with Dongbaogantaipian (n=10)as control.The changes of clinical symptoms,blood lipids and liver uhrasonagram were observed to evaluate therapeutic effect.Results The total effective rate was 93.3% .Total cholesterol,triglyceride and low-density lipoprotein were significantly teduced,and elimination rate of fatty liver with medical imaging was up to 40.0%.All the therapeutic indices were better in Ganzhixiao group than in the control group. Conclusion Ganzhixiao has notale and reliable effect on fatty liver and accompanying hyperlipemia.     

A Clinical Study on Haunglian Fire-Purging Mixture In Treatment of 46 Cases of Primary Hypertension

In order to observe the therapeutic effects of Huanglian Fire-Purging Mixture (黄连清降合剂) on primary hypertension, 46 cases of primary hypertension in the treatment group were treated with Huanglian Fire-Purging Mixture to clear away heat from the liver, relieve mental stress, purge fire and remove toxin;and the other 26 cases of primary hypertension in the control group were treated with Niuhuang Bolus for Lowering Blood Pressure (牛黄降压丸). The effect in the treatment group was obviously superior to that in the control group (P＜0.05). The Huanglian Fire-Purging Mixture shows noticeable effects 3-6 hours after medication. The mixture can improve the clinical symptoms, the left ventricular diastolic function and myocardial ischemia, correct dyslipoproteinemia and dysglycemia, and reduce blood viscosity. And it is safe and with no obvious adverse reactions.     

Effects of Yixin Jiangya Capsules on Insulin Resistance and Tumor Necrosis Factor-a in Cases of Primary Hypertension with Left Ventricular Hypertrophy

To observe the effects of Ftxin Jiangya Capsules （益心降压胶囊capsules for nourishing the heart and lowering blood pressure） on insulin resistance （IR） and tumor necrosis factor-a （TNF-a） in patients with primary hypertension with left ventricular hypertrophy （LVH）. Methods： Totally 93 cases were randomly divided into a control group of 31 cases taking Enalapril and a treatment group of 62 cases taking Enalapril and Irtxin Jiangya Capsules. Results： Fasting serum insulin （FSI） and TNF-a obviously increased and insulin sensitive index （ISI） significantly decreased in both groups before treatment as compared to those of a healthy group. After treatment, FSI, TNF-a and fasting blood glucose （FBG） obviously decreased and ISI remarkably increased in the treatment group, while ISI significantly increased and TNF-a obviously decreased in the control group. The curative effect in the treatment group was remarkably superior to that in the control group. FSI was positively related to TNF-a before treatment in both groups. Conclusion： FSI and TNF-a obviously increase and ISI significantly decreases in patients with primary hypertension with LVH. FSI and TNF-a influencing each other are involved in the generation and development of hypertension. Irtxin Jiangya Capsules can improve IR and decrease TNF-a.     

Sixty-one patients with diabetic peripheral neuropathy treated by Tongluo Yangyin Recipe (通络养阴方)

Objective:To observe the therapeutic effect of Tongluo Yangyin Recipe (通络养阴方,TLYYR) in patients with diabetic peripheral neuropathy (DPN).Methods:Ninety-nine patients with diabetes mellitus type 2 were assigned,according to the order of their visit,to two groups:61 in the treated group and 38 in the control group.They were given the same information about diabetes mellitus and treated with the same therapy:strict diet control and Western drugs for hypoglycemia.In addition,the treated group received one dose (200 mL) of TLYYR in water decoction every day in two portions,while the control group had vitamin B_1 100 mg and vitamin B_(12) 250μg administered daily via intramuscular injection.The course for all patients was 28 days.Results:The treated group experienced a therapeutic effect superior to that of the control group,with the difference between the total effective rates and the markedly effective rates (P<0.05,P<0.01).The blood levels of total cholesterol (TC) and triglyceride (TG) fell,the hemorrheological manner improved,the transmission velocity of the median nerve and common peroneal nerve significantly increased in the treated group after treatment (P<0.05), although the treatment showed no significant influence on blood glucose level (P>0.05).Conclusion: TLYYR could promote blood microcirculation,improve nutritional metabolism of peripheral nerve,and thus accelerating DPN repair.     

An Experimental Study of the Protective Effects of Chinese Medicine Compound Eye-Patch on Asthenopia

Objective:To observe the therapeutic efficacy and the mechanism of Chinese medicine eye-patch with invigorating blood circulation and detoxification on asthenopia.Methods:A total of 180 rabbits were subjected to three tests,namely the skin microcirculation,the microvascular regeneration in the skin and the skin temperature change,with 60 rabbits for each test.The rabbits in each test were randomly and equally divided into three groups: the normal control group was treated with physiological saline on naked back once per day,the low dose group was treated with the eye-patch on naked back for 15 min once per day,while the high dose group was treated for three times per day.Forty Hartley guinea pigs were randomly and equally divided into four groups for the muscle tone test:the normal control group was treated with physiological saline on naked back,the model group was treated without any medication,the low dose group was treated with the eye-patch on naked back for 10 min once per day, while the high dose group was treated for three times per day.All treatments were continued for 14 days until the termination of the test.The microcirculatory blood flow was observed by using a video-microscopy system.The histological sections were used to detect the microvascular regeneration by observing the expression of factorⅧ. The temperature changes on the skin surface were measured by using infrared thermometer,and the muscle tone was tested by the electromyography.Results:In compare with the normal or the model group,the improvement in the skin microcirculation and the blood vascular regeneration,and the decreasing in the muscle tone in low dose and high dose groups were statistically significant with confident level at P<0.05.Conclusions:The eye-patch with invigorating blood circulation and detoxification has great enhancement in blood vascular regeneration and skin microcirculation,and great improvement in the indexes for muscle tone.The study explains certain therapeutic efficacy and mechanism of the eye-patch and shows that it could reduce the symptoms for patients with asthenopia.     

Clinical Effect of Fuzheng Jiedu Granule (扶正解毒颗粒) on Serum NO,NOS and Microelements in Patients with Coronary Heart Disease in Long-term Contact with Nickel

Objective: To study the clinical effect of Fuzheng Jiedu granule (扶正解毒颗粒, FJG) and its influence on serum nitric oxide (NO), nitric oxide synthase (NOS) and rnicroelements in patients with coronary heart disease who are in long-term contact with nickel. Methods: Sixty patients were randomly divided into two groups, the treated group and the control group, 30 in each group. Conventional Western medicinal treatment was applied to both groups, but to the treated group, FJG was given additionally by oral intake, and the therapeutic course for both groups was 4 weeks. Besides, a health control group was set up with 15 healthy subjects selected from the same area, who had no history of contact with nickel. Clinical symptoms of the patients and changes in their electrocardiogram (ECG) and serum levels of NO, NOS and microelements were observed before and after treatment. Results: The total effective rate on clinical symptoms in the treated group was 93.3% and that in the control group 63.3%, comparison between the two showing significant difference (P＜0. 05); the total effective rate on ECG in the two groups was 90.0% and 56.7% respectively, which also showed significant difference ( P＜0. 05). After treatment, levels of serum NO, NOS, Mg, Zn and Ca increased and those of Ni, Mn and Fe decreased significantly ( P＜0. 05 or P＜0.01) in the treated group, while in the control group, changes in these laboratory indexes were insignificant. Conclusion: FJG could lower the blood nickel level and regulate the unbalance of microelements, help restore serum NO and NOS in persons exposed to nickel and improve the clinical symptoms of patients with coronary heart disease and in long-term contact with nickel.     

Clinical study on treatment of liver fibrosis of chronic hepatitis B patients with Ginkgo leaf

Objective: To study the anti-liver fibrosis effect of Ginkgo leaf in patients with chronic hepatitis B.Methods: Eighty-six patients with chronic hepatitis B were randomly divided into two groups with similar general condition. The 42 patients in the treated group were treated with Ginkgo leaf tablet (GLT), and the 44 patients in the control group were treated with Yiganling tablet (益肝灵片). The treatment was conducted for 3 successive months in both groups. Changes in the histo-pathology of liver, serum levels of platelet activating factor (PAF), hyaluronic acid (HA), collagen type Ⅳ (C-Ⅳ), laminin (LN) and pro-collagen peptide type Ⅲ (PCⅢ)were observed before and after treatment. Results: The markedly effective rate and the total effective rate in the treated group were 45.1% and 76.2% respectively, while in the control group the corresponding rates were 18.2% and 43.2%. Comparison between the two groups showed significant difference (P<0.01). Serum levels of PAF, HA, C-Ⅳ, LN and PCⅢ were lowered significantly in the treated group after treatment. Compared with the corresponding parameters in the control group after treatment, the differences were all significant (P<0.01 or P<0.05). The pathological examination of liver showed improvement in both groups, the inflammation grade lowered in 10 patients (55.6%) of the treated group and in 5 patients (35.7%) of the control group, insignificant difference was shown between them. But in comparing the fibrosis staging lowering patients between the two groups, 12 patients (66.7%) vs 3 patients (21.4%), the difference was significant (P<0.05). Moreover, there were 4 patients in the control group with their fibrosis aggravated, while in the treated group, none was aggravated (P<0.05).Conclusion: Ginkgo leaf tablet has some liver protective and anti-liver fibrosis benefits.     

Clinical study on treatment of hyperuricaemia by retention enema of Chinese herbal medicine combined with allopurinol

Objective:To study the effect of retention enema of Chinese herbal medicine combined with allopurinol in treating hyperuricaemia(HUE).Methods:Seventy-eight patients with HUE were assigned to two groups,the 40 patients in the treated group were treated with retention enema of Chinese herbal medicine combined with oral intake of allopurinol,and the 38 patients in the control group were treated with allopurinol alone. The therapeutic course for all was 6 weeks.The clinical efficacy,changes of symptoms,blood...     

A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris by auricular therapy combined with optimized Yinxieling Formula (银屑灵优化方)

Objective:To explore the therapeutic effect of auricular therapy combined with optimized Yinxieling Formula(银屑灵优化方) on psoriasis vulgaris.Methods:A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris was conducted.The patients were randomized to a treatment group(43 cases treated by auricular therapy combined with optimized Yinxieling Formula) and a control group (41 cases treated by optimized Yinxieling Formula alone) according to a random number generated by SPSS 17.0 software.The treatment duration for both groups was 8 weeks.The therapeutic effect was comprehensively measured by the primary outcome measure[Psoriasis Area and Severity Index(PASI) reduction rate]and the secondary outcome measure[PASI,Visual Analogue Scale(VAS),Dermatology Life Quality Index(DLQI), Self-rating Depression Scale(SDS),and Self-rating Anxiety Scale(SAS)].The outcomes of both groups were obtained and compared before and after the intervention.Results:The PASI reduction rate in the treatment group was 74.4%(32/43),which was higher than that in the control group(36.6%,15/41,P<0.01).The PASI scores decreased in both groups after treatment and was lower in the treatment group compared with the control group (P<0.01).With stratified analysis,there were significant differences between the PASI scores in the following subgroups:age 18-30,baseline PASI>10 and stable stage(P<0.05).DLQI decreased in both groups on some categories after treatment,but there were no significant differences between the two groups in SDS,SAS and VAS(P>0.05).No obvious adverse reactions were found in either group.Conclusion:The therapeutic effect of auricular therapy combined with Optimized Yinxieling Formula was superior to Optimized Yinxieling Formula alone with no obvious adverse reaction.     

Clinical Study on the Wrist-Ankle Acupuncture Treatment for 30 Cases of Diabetic Peripheral Neuritis

To study the mechanisms of wrist-ankle acupuncture for prevention and treatment of diabeticperipheral neuritis.Methods:Ninety cases of diabetic peripheral neuritis were randomly divided into 3groups,and treated respectively with wrist-ankle acupuncture,body-acupuncture,and the western routinemedical treatment,with 30 cases in each of the groups;and therapeutic effects and laboratory resultscompared.Results:It is proved that the therapeutic effects of the wrist-ankle acupuncture group and bodyacupuncture group were significantly superior to those of the control group,with no significant differencesbetween the former two groups.Conclusion:Wrist-ankle acupuncture has the actions of improving themetabolisms of blood sugar and blood-lipid,lowering down blood viscosity,and restoring the functions ofperipheral nerve cells,thus giving definite therapeutic effects for diabetic peripheral neuritis.     

Cardio-protective Effects of Corocalm （疏冠胶囊） on Acute Myocardial Ischemia/Reperfusion Injury in Rats

Objective: To investigate the cardio-protective effects of Corocalm (疏冠胶囊)on acute myocardial ischemia in rats, and to explore its possible therapeutic mechanisms. Methods: The acute ischemic model was prepared by ligating the left anterior descending (LAD) coronary artery in rats. The animals were divided into 6 groups, 8 in each group. The sham operated group underwent heart exposure without ligation and were treated with normal saline 3 ml/kg, while the other 5 groups, the model groups, consisted of acceptable acute ischemic model rats and were also treated with normal saline, with the Guanxin Capsule (冠心胶囊,GXC) group treated with refined GXC, 600 mg/kg, the low and high dose Corocalm groups treated with 85 mg/kg and 340 mg/kg of Corocalm respectively, and the Diltiazem group, treated with Diltiazem 5 mg/kg, with all the tested drugs prepared with normal saline into equal volume (3 ml/kg) and administrated once via duodenum 10 min before ligation. Myocardial infarction area was determined by the quantitative histoiogical assay with nitroblue tetrazolium (N-BT) stain. And the levels of creatine phosphokinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA) content, and the activity of superoxide dismutase (SOD) in serum were measured by biochemical assay and spectrophotometry respectively. Besides, the blood viscosity in another 50 rats was determined, who received for 7 successive days oral administration with different concentration of Corocalm or aspirin. Results: It showed that low and high dose Corocalm could significantly reduce the infarction area, inhibit the increase of serum CK, LDH activity and MDA content, and enhance the SOD activity after ischemia/reperfusion. The whole blood viscosity at different shear rates in rats treated with high dose Corocalm was significantly lower than those treated with normal saline (P<0.05).Conclusion: Corocalm has favourable protective effects on heart in ischemic condition, the effect of which might be through its actions in inhibiting CK and LDH activity, scavenging oxygen free radicals, and lowering blood viscosity.     

A Clinical Study on the Effect of Yinxing Damo (银杏达莫) Combined with Betahistine Hydrochloride Injection on Vertebral Basilar Artery Ischemic Vertigo

Objective: To evaluate the therapeutic efficacy of Yinxing Damo (银杏达莫, YXDM) combined with Betahistine Hydrochloride Injection (BHI) on vertebra basilar artery ischemic vertigo (VBIV).Methods: Ninety patients with VBIV were randomly divided into two groups; 45 patients (the treated group)were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients (control clinical syndromes and the index of the transcranial Doppler (TCD) and hemorheology were observed. Results: The total effective rate was 100% in the treated group, which was better than that in the control group90.5%, (P＜0.05). The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, (P＜0.01). Conclusion: YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.     

Clinical Observation on Senile Patients with Impaired Glucose Tolerance Treated by Point Application

In order to observe and evaluate the therapeutic effects of point application on senile impaired glucose tolerance （IGT）, 64 senile IGT patients were randomly divided into two groups with 32 cases in each group. The control group was treated with interference therapy of controlling diet, while the observation group was given point application at Yishu （胰俞 1.5 cun lateral to the Du Channel, at the level of the lower border of the spinous process of the eighth thoracic vertebra）, Pishu （BL 20）, Sanyinjiao （SP 6）, Zusanli （ST 36） and other points in addition to interference therapy of controlling diet. After 2 courses of treatment, the postprandial blood sugar was detected. As a result, the postprandial blood sugar obviously reduced in both groups （P〈0.05, P〈0.01） with a lower level in the observation group than in the control group （P〈0.05）, indicating that point application in combination with interference therapy of controlling diet has a reliable therapeutic effect on senile IGT patients.     

Clinical Observation and Mechanism Study on Treatment of Senile Dementia with Naohuandan(脑还丹)

Objective: To observe the therapeutic effect and mechanism of Naohuandan (脑还丹, NHD)in treating senile dementia (SD). Methods: Clinical study: Fifty-eight patients with SD, whose diagnosis conforms to the Diagnostic Standard of DSM-Ⅳ issued by American Association of Psychiatry, were enrolled and randomly assigned into two groups. The 30 patients in the treated group were treated with NHD, 4 capsules each time, 3 times daily. The 28 patients in the control group were treated with Piracetam, 1.6 g each time, 3 times daily. The therapeutic course for both groups was 3 months. The therapeutic efficacy was estimated and compared by comprehensive scores of memory and cognition, scores of Mini-mental State Examination (MMSE) and Activities of Daily Living (ADL). Experimental study: Rats were divided into the control group,the model group and the high-dosage and Iow-dosage NHD treated groups. The protective effect of NHD on the per-oxidative damage of hippocampal neurons in β-amyloid protein induced SD model was observed and the related criteria were determined. Results: Clinical study showed that both NHD and Piracetam could improve the clinical symptoms of patients, the two medicines showing insignificant difference in total effective rate. But NHD was better in elevating MMSE score and lowering ADL score in patients than Piracetam ( P＜0.05 and P＜0.01). Experimental study showed that (1) 24 and 72 hrs after modeling, the activity of SOD and GSH were lower and the level of MDA higher in the model group than those in the control group ( P＜0.05or P＜0.01). Compared with the model group at the corresponding time points, in the high-dosage NHD group, SOD and GSH were higher, MDA was lower ( P＜0.05 or P＜0.01); but in the Iow-dosage NHD group, SOD at the 72th hr was higher (P＜0.05) and MDA at 24th and 72th hrs was lower ( P＜0.01). And most of the criteria in the high-dosage NHD group was improved better than that in the Iow-dosage NHD group. ( 2) The survival rates of neurons in various groups were not different significantly (P＞0.05) 24 hrs after modeling, but that in the high-dosage NHD group was significantly higher than that in the model group ( P＜0.01 ) and in the Iow-dosage NHD group 72 hrs after modeling( P＜0.05). Conclusion: NHD is an effective Chinese herbal preparation for treatment of SD, and its mechanism is related with its inhibition on peroxidative injury and protection on neurons.