麻风患者义齿修复情况的调查分析

目的：评估中国麻风患者缺牙后义齿修复情况。方法：随机抽取613例来自湖南、江苏和陕西三省六个麻风村的麻风患者,统计其缺牙后义齿修复情况。结果：该样本组的义齿修复率仅为23.8%,不良修复率高达85.4%。结论：麻风患者缺牙后的义齿修复率低,而不良修复率高。应对其口腔健康予以重视,采取相关措施来改善义齿修复率和修复水平。     

修复麻风病手部畸形患者义齿的体会

麻风病晚期易发生各种畸形,特别是手部畸形给患者的生活带来诸多不便,尤其是在摘戴义齿方面更增加了难度.针对其特点,在设计修复麻风病手部畸形患者的义齿与一般人群患者的义齿上应有所不同,根据我们多年来在皮防院从事口腔科工作的体会,讨论如下.     

综合防护麻风足底溃疡与麻木足底的效果

按照ＩＬＥＰ足底溃疡研究方案。采用综合防护措施，对４７例足底溃疡（６４个溃疡）及４８例足底麻木者进行了三年观察，６４个溃疡中痊愈５４个，显著进步１个，进步４个，无变化２个，恶化１个，复发２个，有效率为９２．２％，痊愈率为８４．４％。溃疡的瓣发率和复发率分别为第１年４．３％和０，第２年２．１％和７．８％，第３年２．１％和３．１％。４８例足底麻木者观察第１年，发生溃疡２例（４．２％），第２年和第３年未     

硬肿病12例分析

硬肿病１２例分析徐顺明①张旭①硬肿病是一种少见但极易诊断的皮肤疾病，本文报告１２例分析如下。临床资料：１２例中男性８例，女性４例，年龄２０岁以下１例，２１岁～５０岁５例，５０岁以上者６例。病程不足１年５例，１年～４年５例。５年以上２例，其中１例１７年...     

用乳胶作抗原的斑贴试验结果报告

用乳胶作抗原的斑贴试验结果报告李梅娇１陈忠英１林鸿昌１夏强２杨之１殷少林１温海梅１钟逢堂１１９９４年～１９９６年，我们对海南省天然橡胶工人进行皮肤病普查时，发现该人群患湿疹皮炎和接触性皮炎、荨麻疹的人较多。考虑可能与橡胶有关，对此，我们采用天然乳胶和...     

1%联苯苄唑乳膏治疗足癣的疗效观察

我科于 １９９９年 ２月～２０００年 ５月使用１％联苯苄唑乳膏（商品名孚琪乳膏，由北京四环制药厂生产）与１％硝酸益康唑软膏（商品名癣敌软膏，由广州何济公制药厂生产）通过对１９８例患者进行疗效对比观察，联苯苄唑获得满意效果，现报告如下。１资料与方法１．１临床资料 １９８例均为我院门诊患者，经临床诊断为足癣，真菌直接镜检阳性，同意接受治疗。对咪唑类药物过敏，近３月内接受过全身抗真菌药物治疗，１月内接受过外用抗真菌药物治疗者不入选。１９８例中男１２３例，女７５例，年龄１６－６７岁，病程１月～５年。１．２治…     

Tigason加羟基脲治疗银屑病2例

Ｔｉｇａｓｏｎ加羟基脲治疗银屑病２例李金贵例１男，３９岁。患寻常性银屑病５年，出现关节症状１年余。曾用强的松、ＭＴＸ等治疗，疗效欠佳。１年前双髋及腰椎关节疼痛，躯干、四肢皮损加重，给予Ｔｉｇａｓｏｎ（０．８ｍｇ／ｋｇ．ｄ）治疗１月，病情好转，渐减至１...     

伊曲康唑治疗念珠菌性龟头炎26例

伊曲康唑治疗念珠菌性龟头炎２６例李春阳，刘金耀，焦健，苑全德近年来，念珠菌性龟头炎的发病率同其他性病一样，呈逐年升高的趋势。自１９９４年１月～１９９５年７月，我们应用伊曲康唑治疗２６例，取得较好疗效，分析总结如下。１资料与方法１．１；临床资料：２６例...     

自体免疫性溶血性贫血伴发寻常型天疱疮1例报告

自体免疫性溶血性贫血伴发寻常型天疱疮１例报告陈洁，赵启明，金茶芽患者女，１６岁。间歇性酱油色尿１年半，伴头晕乏力。１９９２年１月１６日拟＂自体免疫性溶血性贫血＂曾住内科治疗１月后好转出院。近因全身皮肤出现大小不等水疱、糜烂、奇痒，发热及酱油色尿。于１...     

适确得霜治疗儿童白癜风34例疗效观察

适确得霜治疗儿童白癜风在国内尚未见报道。我们于１９９６年８月～１９９７年８月间，用此药治疗３４例白癜风，现报告如下。１临床资料１．１一般资料３４例全部来自我科门诊病人，男性１８例，女性１６例；年龄最小４个月，最大１１岁。病程最短６天，最长６年，平均１...     

手背深部真菌感染2例

报告2例手背深部真菌感染。例1女,46岁。右手背红斑、肿胀、脓疱半年余,脓液真菌培养鉴定为申克孢子丝菌。诊断:孢子丝菌病。例2女,53岁。左手背红斑、丘疹、脓疱4月,脓液真菌培养鉴定为裴氏着色真菌。诊断:着色芽生菌病。     

Infantile generalized pustular psoriasis: Successful disease control with intermittent etretinate

Infantile generalized pustular psoriasis is a rare form of psoriasis and the best treatment is controversial. We experienced a 2‐year‐old female with erythema on her neck and axilla starting at 3 months of age. She presented with recurrent annular and geographic scaly erythema with a few pustules on the neck, precordium and axilla, but no fever. The histopathology revealed subcorneal neutrophilic infiltration and microabscesses without Kogoj's spongiform pustules. The initial diagnosis was subcorneal pustular dermatosis. However, she developed widespread geographic erythema and numerous pustules over her entire body with a fever when she got a cold. A second skin biopsy revealed monolocular pustules and Kogoj's spongiform pustules in the subcorneal layer. Etretinate was administrated after a diagnosis of pustular psoriasis was made and her condition improved gradually. The choice of treatment depends on patient age, general condition and the disease severity.     

Eosinophilic Pustular Folliculitis In Infancy

Abstract: Five infants under 1 year of age were reported with a syndrome of recurrent crops of pruritic papulopustules of the scalp. In three children there were also intermittent outbreaks on the trunk and extremities. Cultures showed the pustules to be sterile. Biopsies of scalp and skin tissues showed eosinophilic folliculitis. Some patients had eosinophilia during outbreaks of pustules. These cases are similar to the eosinophilic pustular folliculitis reported in a few adult patients with the exception that there was predominant scalp involvement in the children. We propose that eosinophilic pustular folliculitis of infancy is a distinct pustular dermatosis.     

Small pustules in Kawasaki disease. A clinicopathological study of four patients

We report the clinical and histological changes of small pustules that developed in four patients with Kawasaki disease (KD). The small pustules were superimposed on the urticarial erythema and symmetrically arranged on the genital area, buttocks, axillae, and extensor surface of the extremities. These lesions showed spongiform pustules histologically and were different from miliarial pustules. Reviewing previous reports, the clinical and histological characteristics of pustules in KD are summarized herein. This study indicates that small pustules underwent the consecutive changes related to the generalized polymorphous exanthem in KD.     

Erosive pustular dermatosis of the leg: long-term control with topical tacrolimus

Erosive pustular dermatosis of the leg is an unusual form of sterile pustulosis that typically affects the lower limbs of elderly patients. We report the cases of two women who developed erythematous skin plaques with pustules that coalesced and evolved into erosions and crusted areas. Histology showed epidermal spongiosis with subcorneal pustules and a dermal infiltrate with eosinophils and neutrophils. Lesions were treated with topical clobetasol propionate 0.05% for 10 days followed by topical tacrolimus daily until complete resolution, and then twice weekly for 1 year, without relapse. The response to topical corticosteroids and tacrolimus further support the close relationship with erosive pustular dermatosis of the scalp. Topical therapy with tacrolimus may offer good long-term disease control.     

Exanthematic type of pustular psoriasis consisting of two types of pustular lesion.

A 35-year-old female developed generalized pustules within a short period of time. Clinically, two distinct types of pustules were observed, viz. erythematous patches studded with crops of small pustules, and isolated large pustules with a red halo. Histologically, the former were subcorneal spongiform pustules, whereas the latter were unilocular pustules involving the hair follicular infundibulum or a subcorneal unilocular pustule on the palmo-plantar skin. On the basis of the sudden appearance of the pustules without any pre-existing lesions of psoriasis and the histological findings of the spongiform pustules, we made a diagnosis of the exanthematic type of pustular psoriasis. The lesions responded in a dose-dependent fashion to oral cyclosporin.     

The pustule in palmoplantar psoriasis: transformed vesicle or mature microabscess? A three-dimensional study.

Psoriasis on the palms and soles is characterized by pustules, vesicles and hyperkeratotic plaques. Several studies have postulated that the pustules and vesicles are round or egg-shaped. This three-dimensional study reveals that neither pustules nor vesicles have a regular spherical morphology. The vesicles are located in the upper and middle layers of the epidermis and may exhibit dumb-bell- or banana-shaped lumina. The pustules consist of different compartments combining characteristics of a dyshidrotic vesicle with those of a microabscess of Munro.     

Acute generalised exanthematous pustulosis

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is caused by drugs in >90% of cases. It is rare, with an incidence of 1-5 patients per million per year. The clinical manifestations are characterised by fever and the rapid appearance of disseminated sterile pustules 3-5 days after the commencement of treatment. It is accompanied by marked neutrophilia. Mucous membranes are not typically involved. The drugs conferring the highest risk of AGEP according to the EuroSCAR study are aminopenicillins, pristinamycin, hydroxychloroquine, antibacterial sulphonamides, terbinafine and diltiazem. The pathogenesis of AGEP involves the initial influx of CD8 cytotoxic T-cells resulting in the apoptosis of keratinocytes and formation of vesicles. Then CXCL-8-producing and granulocyte macrophage-colony stimulating factor-producing CD4 cells enter the epidermis, resulting in neutrophil mediated inflammation and the formation of pustules. As a result, the histology reveals intraepidermal, usually subcorneal, pustules and an accompanying neutrophilic and lymphocytic infiltrate. Epicutaneous patch testing may also support the diagnosis by causing a localised pustular reaction 48-96 h after the offending drug is applied. The condition usually resolves by 15 days after the causative drug is withdrawn but oral corticosteroid therapy may be necessary in some individuals. The mortality rate is up to 5% and mostly occurs in elderly people who have significant comorbidities.     

重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白联合治疗泛发性连续性肢端皮炎一例

患者,男性,16岁,右手指甲周皮肤起红斑、脓疱9年,右手第4和5指指节间关节畸形1年入院。皮肤科检查：右手掌背及第1、4和5指弥漫性红斑,表面散在或密集米粒大小脓疱,部分形成脓湖或脓痂,指甲脱失,手指末端变细;第4、5指指节间关节屈曲畸形,功能受限。四肢皮肤见散在分布少数浸润性红斑,表面有少量小脓疱。患者家族中无银屑病史及类似疾病史。实验室检查：血常规：WBC 7.77×109/L、中性粒细胞百分比57.6%、淋巴细胞百分比30.28%、RBC 4.75×1012/L、HGB 136g/L、PLT 278×109/L。肝功能检查：ALT 13 U/L、AST 17 U/L、ASP 160 U/L、γ-GT 17 U/L、TBIL 19.2 umol/L。抗核抗体(-)、抗dsDNA抗体（-）。梅毒螺旋体特异抗体和艾滋病抗体检测阴性。Hbs-Ag（-）,HCV-cAg（-）。脓疱细菌培养无细菌生长。结核菌素纯蛋白衍化物(PPD)试验（+）;胸部X片检查未见明显异常。心电图检查大致正常。诊断：泛发型连续性肢端皮炎。入院后予阿维A胶囊、火把花根片、复方甘草酸苷注射液等联合糠酸莫米松乳膏、莫匹罗星软膏及钙泊三醇倍他米松软膏治疗,经2周治疗皮损部分消退,偶有少量新脓疱形成,受累手指疼痛减轻,但病情仍继续进展,右手第2指和左手第5指亦受累。为遏制病情进一步发展,审慎地权衡利弊后,遂决定开始rhTNFR:Fc治疗。治疗12周后,四肢皮损消退,新脓疱形成停止,但手指畸形和功能无改善,治疗获得部分成功。     

Pediatric Pyoderma Gangrenosum with Splenic and Pulmonary Involvement

An 8‐year‐old boy presented with ulcers on the lip and limbs, scattered pustules, fever, and general malaise. Further investigation revealed splenic and pulmonary lesions. A diagnosis of pyoderma gangrenosum with splenic and pulmonary involvement was made. The authors have not found a previous report of pediatric pyoderma with splenic involvement in the literature.