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Purpose

To evaluate meibomian gland morphology and function in children without ocular discomfort.

Method

A total of 266 eyes of 266 children without signs or symptoms of ocular surface dysfunction were enrolled. Morphology of meibomian glands (MG) and non-invasive break-up time (BUT) was assessed by noncontact meibography. Based on lipid layer thickness (LLT) of the tear film measurements, 66 children were chosen to be assessed by meibomian glands yielding liquid secretion (MGYLS).

Results

Based on the presence of physiologic conjunctival follicles (PCF), participants were divided into normal or PCF groups. The distortion and deficiency of MG function was significantly higher in PCF group (P?=?0.002, 0.007, respectively). Five different gland duct shapes (vertical, tortuous, overriding, hooked, U-shaped) were observed. MG deficiency was positively correlated with age (R?=?0.362, P?<?0.001). Distortion and the number of MG showed no correlation with age (P?>?0.05). However, distortion and deficiency of MG were negatively correlated with LLT (P?<?0.001, P?<?0.01).

Conclusion

Children with PCF had significantly more MG distortion and deficiency which was associated with LLT. These results prompt future studies to determine if changes in MG morphology are congenital or acquired.  相似文献   

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Objective

Lower eyelid retraction is a common and challenging complication of the anophthalmic socket. The underlying pathophysiology includes contraction of the posterior lamellae of the eyelid, shortening of the inferior fornix, and lateral canthal tendon laxity. This study aimed to evaluate the surgical efficacy of hard palate mucosa as a posterior spacer graft in the lower eyelid retraction repair in the anophthalmic socket.

Methods

The surgical technique involved hard palate grafting combined with recession of inferior retractors and lateral tarsal strip suspension to lengthen the posterior lamellar and strengthen the support of the lower eyelid. The records of anophthalmic patients with lower eyelid retraction who underwent this technique from January 2009 through August 2014 were reviewed. Postoperative outcomes were determined by lower eyelid elevation, presence of lagophthalmos, complications, prosthesis fitting, and patient satisfaction.

Results

A total of 12 patients (12 eyelids) were included. The mean age at surgery was 36 years (range, 29–52 years) and the mean follow-up period was 53 months (range, 20–71 months). The lower eyelids of the operated eyes significantly elevated by 2.9 ± 0.8 mm, and mild residual lagophthalmos was observed in 3 patients. All patients were satisfied with the surgical outcomes. Minor complications occurred in 3 cases, including mild recurrent retraction, granuloma, and mucous discharge. There were no complications detected at the donor site.

Conclusion

Hard palate grafting combined with recession of lower eyelid retractors achieves long-term stable outcomes in lower eyelid retraction repair in the anophthalmic socket.  相似文献   

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