The assessment of the outliers of logistic regression model and its clinical application

ＴｈｅａｓｓｅｓｓｍｅｎｔｏｆｔｈｅｏｕｔｌｉｅｒｓｏｆｌｏｇｉｓｔｉｃｒｅｇｒｅｓｓｉｏｎｍｏｄｅｌａｎｄｉｔｓｃｌｉｎｉｃａｌａｐｐｌｉｃａｔｉｏｎＹｉＤｏｎｇ（易东）；ＸｕＲｕｆｕ（许汝福）；ＺｈａｎｇＷｅｉ（张蔚）；ＹｉｎＱｕａｎｈｕａｎ（尹...     

Effects of Hantaan virus on cytoskeletons of human endothelial cells

ＥｆｆｅｃｔｓｏｆＨａｎｔａａｎｖｉｒｕｓｏｎｃｙｔｏｓｋｅｌｅｔｏｎｓｏｆｈｕｍａｎｅｎｄｏｔｈｅｌｉａｌｃｅｌｌｓＺｈｕｐｉｎｇ（朱平）；ＬｉｕＪｕｎｂｉｎ（刘俊彬）；Ｙａｎｒｏｎｇ（阎荣）；ＫａｎｇＷｅｎｚｈｅｎ（康文臻）；ＷｕＨｏｎｇ（吴红）...     

Pancreatic blood perfusion in sodium taurocholate－induced pancreatitis in rats

Ｐａｎｃｒｅａｔｉｃｂｌｏｏｄｐｅｒｆｕｓｉｏｎｉｎｓｏｄｉｕｍｔａｕｒｏｃｈｏｌａｔｅ－ｉｎｄｕｃｅｄｐａｎｃｒｅａｔｉｔｉｓｉｎｒａｔｓＬｉｕＱｕａｎｆａｎｇ（刘全芳）；ＷａｎｇＢｅｎｍａｏ（王本茂）；ＴａｎｇＹａｎ（唐岩）；ＬｉＳｈａｏｈｕａ（...     

Histopathological and immunohistochemical studies of 120 cases of osteosarcoma

Ｈｉｓｔｏｐａｔｈｏｌｏｇｉｃａｌａｎｄｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｃａｌｓｔｕｄｉｅｓｏｆ１２０ｃａｓｅｓｏｆｏｓｔｅｏｓａｒｃｏｍａＧａｏＦｅｎｇｘｕｎ（高奉浔）；ＬｉＺｅｎｇｐｅｎｇ（李增鹏）；ＤｏｎｇＺｈｉｑｉａｎ（董志谦）；ＳｕＨｏｎｇ...     

A clinical study of penetrating craniocerebral injuries caused by firearms

Ａｃｌｉｎｉｃａｌｓｔｕｄｙｏｆｐｅｎｅｔｒａｔｉｎｇｃｒａｎｉｏｃｅｒｅｂｒａｌｉｎｊｕｒｉｅｓｃａｕｓｅｄｂｙｆｉｒｅａｒｍｓ￥ＺｈａｎｇＸｉａｎｇ（章翔）；ＬｉｕＷｅｉｐｉｎｇ（刘卫平）；ＺｈａｎｇＪｉａｎｎｉｎｇ（张剑宁）；ＷａｎｇＬｉｇｅｎ...     

Pharmacokinetics of intravenously administered sodium dichloroacetate in rabbits

ＰｈａｒｍａｃｏｋｉｎｅｔｉｃｓｏｆｉｎｔｒａｖｅｎｏｕｓｌｙａｄｍｉｎｉｓｔｅｒｅｄｓｏｄｉｕｍｄｉｃｈｌｏｒｏａｃｅｔａｔｅｉｎｒａｂｂｉｔｓＧｕＢｉｎ（顾斌）；ＳｏｎｇＬｉｎｇ（宋岭）；ＪｉａｎｇＹｏｎｇｐｅｉ（蒋永培）；ＷｅｎＡｉｄｏｎｇ（文...     

Effect of kangxianling on hepatic fibrosis in murine schistosomiasis

ＥｆｆｅｃｔｏｆｋａｎｇｘｉａｎｌｉｎｇｏｎｈｅｐａｔｉｃｆｉｂｒｏｓｉｓｉｎｍｕｒｉｎｅｓｃｈｉｓｔｏｓｏｍｉａｓｉｓＹａｎｇＹｕｎｇａｏ（杨运高）；ＧｕｏＺｈｅｎｇｑｉｕ（郭振球）；ＹｕａｎＺｈａｏｋａｉ（袁肇凯）；ＧｕｏＳｈｏｕｈｅｎｇ（郭绶衡...     

Screening of controls in cass-control study of infectious diseases

Ｓｃｒｅｅｎｉｎｇｏｆｃｏｎｔｒｏｌｓｉｎｃａｓｓ－ｃｏｎｔｒｏｌｓｔｕｄｙｏｆｉｎｆｅｃｔｉｏｕｓｄｉｓｅａｓｅｓＬｉＬｉａｎｇｓｈｏｕ（李良寿）；ＸｕＤｅｚｈｏｎｇ（徐德忠）；ＹａｎＹｏｎｇｐｉｎｇ（阎永平）（ＤｅｐａｒｔｍｅｎｔｏｆＥｐｉｄｅｍ...     

Dynamic study of TNF effects on skeletal muscle proteolysis in early stage of severe scalding in rats

ＤｙｎａｍｉｃｓｔｕｄｙｏｆＴＮＦｅｆｆｅｃｔｓｏｎｓｋｅｌｅｔａｌｍｕｓｃｌｅｐｒｏｔｅｏｌｙｓｉｓｉｎｅａｒｌｙｓｔａｇｅｏｆｓｅｖｅｒｅｓｃａｌｄｉｎｇｉｎｒａｔｓ￥ＬｉＬｉｎ（李林）；ＤｏｎｇＹａｎｌｉｎ（董燕麟）；ＹａｎｇＣｈｕｎ（杨春）；...     

Study of the structure and architecture of aortic smooth muscle cells under pressure overloading in rats

ＳｔｕｄｙｏｆｔｈｅｓｔｒｕｃｔｕｒｅａｎｄａｒｃｈｉｔｅｃｔｕｒｅｏｆａｏｒｔｉｃｓｍｏｏｔｈｍｕｓｃｌｅｃｅｌｌｓｕｎｄｅｒｐｒｅｓｓｕｒｅｏｖｅｒｌｏａｄｉｎｇｉｎｒａｔｓＺｈａｎｇＦａｎｇｍｉｎｇ（张放鸣）；ＨｅＧｕａｎｇｃｈｉ（何光篪）；Ｌ...     

冲击波超压所致速发死亡大鼠的心脏病理变化

191只大鼠受单纯超压后64只于30min内死亡,心脏病变特点为:①心壁血液循环障碍;②气栓形成,气泡并溢入心肌间质;③心肌变性坏死、断裂及闰盘解离。分析心肌病变主要由于超压直接效应、气栓影响及心肺相互影响所致。防护心肺损伤是避免或减少速发死亡的关键。     

模拟炮口冲击波的生物效应

本研究的目的在于阐明多次低强度冲击波对内脏器官的效应。实验动物为雌雄两性绵羊36只,用10kgTNT药柱单次和多次爆炸致伤。伤后6～13h作形态学检查。结果表明单次爆炸后,肺损伤的阈值为37.27kPa,胃肠道为41.0kPa,而上呼吸道直到77.0kPa时仍为阴性。多次爆炸致伤后,肺、胃肠道和上呼吸道的损伤阈值分别为20.2、20.2和40.89kPa。结果提示经受多次低强度冲击波作用时,肺仍是内脏损伤最敏感的器官,与单次致伤比,可显示相加效应,损伤阈值降低。     

大鼠超压冲击伤和烧冲复合伤肺出血的量化研究

本文用图象分析方法测量了冲击伤、烧伤和烧冲复合伤大鼠伤后不同时间肺出血情况。结果,冲击伤速发死亡大鼠平均肺出血体积和出血积分显著高于存活动物(P<0.01);单冲和烧冲组大鼠于伤后2、12 h肺出血明显,24 h出血体积有所增加,至72 h出血已明显吸收。单烧组无出血。实验结果表明,超压冲击伤肺出血是速发死亡的主要原因,活存动物在24 h内可能有续发性肺出血,烧冲复合伤时肺出血吸收速度较单冲减慢。文中初步讨论了以肺出血体积和积分划分伤情分度的标准。     

Effects of Blast Wave-induced Biomechanical Changes on Lung Injury in Rats

Objective To observe the dynamic impacts of shock waves on the severity of lung injury in rats with different injury distances.Methods Simulate open-field shock waves; detect the biomechanical effects of explosion sources at distances of 40, 44, and 48 cm from rats; and examine the changes in the gross anatomy of the lungs,lung wet/dry weight ratio, hemoglobin concentration, blood gas analysis, and pathology.Results Biomechanical parameters such as the overpressure peak and impulse were gradually attenuated with an increase in the injury distance. The lung tissue hemorrhage, edema, oxygenation index, and pathology changed more significantly for the 40 cm group than for the 44 and 48 cm groups.The overpressure peak and impulse were significantly higher for the 40 cm group than for the 44 and 48 cm groups(P 0.05 or P 0.01). The animal mortality was significantly higher for the 40 cm group than for the other two groups(41.2% vs. 17.8% and 10.0%, P 0.05). The healing time of injured lung tissues for the 40 cm group was longer than those for the 44 and 48 cm groups.Conclusions The effects of simulated open-field shock waves on the severity of lung injuries in rats were correlated with the injury distances, the peak overpressure, and the overpressure impulse.     

Development of serial bio-shock tubes and their application.

ＤｅｖｅｌｏｐｍｅｎｔｏｆｓｅｒｉａｌｂｉｏｓｈｏｃｋｔｕｂｅｓａｎｄｔｈｅｉｒａｐｐｌｉｃａｔｉｏｎＷａｎｇＺｈｅｎｇｇｕｏ王正国，ＳｕｎＬｉｙｉｎｇ孙立英，ＹａｎｇＺｈｉｈｕａｎ杨志焕，ＬｅｎｇＨｕａｇｕａｎｇ冷华光ＪｉａｎｇＪｉａｎｘｉｎ蒋建...     

Development of serial bio-shock tubes and their application

OBJECTIVE: To design and produce serial shock tubes and further examine their application to experimental studies on blast injury. METHODS: Bio-medical engineering technique was used for the design and development of the serial shock tubes. One thousand four hundred and fifty nine animals (757 rats, 105 guinea pigs, 335 rabbits, 240 dogs and 22 sheep) were then used to test the wounding effects of the shock tubes. RESULTS: Three types of bio-shock tubes, that is, large-, medium- and small-scale shock tubes were made in our laboratory. The large-scale shock tube is 39 meters long; the inner diameter of the test section is 1 meter; and the maximum overpressure in the driving section is 10.3 MPa. A negative pressure could be formed by means of the reflected rarefactive wave produced by the end plate. The medium-scale shock tube is 34.5 meters long; the maximum overpressure in the driving section is 22 MPa; the test section is designed to be a knockdown, showing 5 basic types with inner diameter of 77 to 600 millimeters, which could be used for researches on overpressure, explosive decompression, underwater explosion, and so on. The small-scale shock tube is 0.5 meter long with the maximum endured overpressure of 68.6 MPa. Results from animal experiments showed that this set of shock tubes could induce various degrees of systemic or local blast injury in large or small animals. CONCLUSIONS: This set of bio-shock tubes can approximately simulate typical explosive wave produced by nuclear or charge explosion, and inflict various degrees of blast injury characterized by stability and reproducibility. Therefore, they can meet the needs of blast research on large and small animals.     

中度以上冲击伤狗的早期临床观察

用直径348mm激波管致狗冲击伤,超压峰值在1.05～1.33kg/cm~2,超压作用时间为40～54毫秒,激波速度为473～509m/s,34只狗中极重度11只占32.4％,重度5只占14.7％,中度17只占50％,轻度1只占2.9％。超压峰值及超压作用时间是动物伤情的决定因素,动物的体位与伤情也有关系。脏器对冲击波的敏感性从高到低依次排列为:听器、肝肺、脾、心、膀胱及肾。认为听器检查、白细胞总数及其分类在冲击伤诊断上是有价值的。脏器敏感性与其位置、体积大小、游离度和组织结构性质有关。冲击伤动物早期死亡的主要原因为大量失血,其次为颅脑损伤。激波管致狗冲击伤的病理损伤与核爆炸直接冲击伤基本相似,但由于超压作用时间短,所以,超压峰值相近时,损伤程度较核爆炸为轻。     

短时激波作用下家兔胸腹内压力的变化

在短时激波作用下,机体胸腹腔之间存在着压力差,但缺乏实验证据。本实验通过引爆200g TNT炸药块致伤家兔,观察距爆心1.6m、1.8m和2.0m处爆炸激波作用下的家兔胸腹内压同步变化情况。动物致伤后立即解剖,观察动物伤情。实验结果显示,胸内正、负压峰值明显大于腹内正、负压峰值,而且压力的变化存在着时相上的差异,从胸腹内压峰值和时相变化上证实胸腹间存在着压力差,家兔胸腹腔之间的压力呈双向传导。实验结果提示家兔胸腹腔内器官组织冲击伤的发生可能与体腔扩张引起的负压增高有关,本文就肺冲击伤发生机理从压力差角度加以讨论。     

冲击波瞬时生物效应的高速摄影研究

本研究用三只狗观察了生物体在受冲击波瞬间体腔的变化。通过三种不同速度的高速摄影(563幅/秒,6526幅/秒和1526幅/秒)证实。当狗接受0.777kg/cm~2超压时,体腔平均被压缩11.7％。作者结合以往实验及其文献进行了讨论,初步认为被压缩的11.7％可能与血液动力学急剧变化所造成的严重肺损伤有关。     

内皮素和一氧化氮在烧冲复合伤肺损伤中的作用

目的　探讨内皮素 (Endothelin ,ET)和一氧化氮 (NO)在烧冲复合伤肺损伤中的作用及可能机制。方法　制作大鼠烧冲复合伤模型 ,用 99Tcm 人聚巨蛋白 ( 99Tcm macro aggregatedalbumin ,99Tcm MAA)标记方法观察肺部血液循环状况和肺血管通透性 ,并检测血液流变学和动脉血气变化 ;分别用ET受体 (ETR)拮抗剂PD 14 2 893和NO合酶 (NOS)抑制剂硝基左旋精氨甲酯 (Nitro L argininemethylester ,L NAME)干预 ,观察其对上述与肺损伤密切相关的指标变化。结果　烧冲复合伤大鼠全血粘度、动脉血气分析、支气管肺泡灌洗液 (Bronchoalveolarlavagefluid ,BALF)放射性活性和肺部血液循环状况均出现了显著变化 (P <0 .0 5 ) ,给予PD 14 2 893和L NAME分别可减轻和加重这些指标的变化 (P <0 .0 5 )。结论　烧冲复合伤大鼠可出现明显肺损伤 ,ET和NO通过多种途径影响烧冲复合伤肺损伤的发生和发展。