传统疝修补与疝环充填式无张力疝修补术治疗腹股沟嵌顿疝比较

目的 探讨疝环充填式无张力疝修补术治疗腹股沟嵌顿疝的临床价值。方 法比较2000年6月～2005年4月我院102例腹股沟嵌顿疝行疝环充填式无张力疝修补术与1992年12月～2000年6月我院124例腹股沟嵌顿疝传统疝修补术的临床资料。结果疝环充填式无张力疝修补术组手术时间（1.18±9．387）min显著短于传统组（79．73±11．840）min（t=-12．845，P=0．000），切口疼痛22例显著少于传统组53例（χ^2=11．315，P=0．001），下床活动时间（17．12±4．340）h显著短于传统组（75．02±7．331）h（t=-73．653，P=0．000），切口感染6例显著少于传统组26例（χ^2=11．613，P=O．003），术后肺部感染、尿潴留、阴囊血肿、下肢深静脉血栓等并发症共5例显著少于传统组30例（χ^2=21．167，P=0．000），住院（7．0±1．395）d显著短于传统组（7．98±1．876）d，（t=4．048，P=0．000），术后复发0例显著少于传统组6例（χ^2=119．320，P=O．000），差异有统计学意义。结论 疝环充填式无张力疝修补术具有手术时间短、创伤小、无张力、疼痛轻、住院时问短、复发率低、康复时间短等优点，也是治疗腹股沟嵌顿疝的理想术式。     

嵌顿性腹股沟疝的无张力修补术治疗

目的:讨论无张力修补术在嵌顿性腹股沟斜疝中的应用和范围。方法:观察嵌顿性腹股沟斜疝行无张力疝修补术的临床资料。结果:25例切口无感染,术后随访无复发。结论:无张力疝修补术可以安全应用于嵌顿性腹股沟斜疝修复。     

无张力疝修补术治疗腹股沟嵌顿疝的临床分析

目的 评价无张力疝修补手术治疗腹股沟嵌顿疝的效果.方法 回顾性分析28例腹股沟嵌顿疝行无张力修补术的临床资料.结果 28例腹股沟嵌顿疝均行Lichtenstein手术,平均手术时间48分钟,术后并发症有一例皮下血肿,阴囊积液二例,切口感染一例,无排异发生,无死亡病例,随访0.4～2年无短期内复发病例,有一例有切口疼痛.结论 采用无张力疝修补术治疗嵌顿性疝是安全的,与常规疝修补术相比不会增加并发症、及复发率,可避免再次手术.     

疝无张力修补术治疗嵌顿性腹股沟斜疝、股疝的体会

目的探讨疝无张力修补术在治疗嵌顿性腹股沟斜疝、股疝中的价值。方法回顾总结行疝无张力修补术治疗嵌顿性腹股沟斜疝、股疝39例患者的临床资料。其中腹股沟斜疝嵌顿31例,股疝嵌顿8例;腹股沟斜疝中7例行腹膜前间隙疝无张力修补术,24例行疝环充填式疝无张力修补术;股疝均行腹膜前间隙疝无张力修补术。结果39例均获随访3~60个月,无手术死亡病例,无伤口感染,术后无复发。结论疝无张力修补术可以安全有效地用于嵌顿性腹股沟斜疝、股疝的患者。     

应用三维超普疝修补装置行无张力疝修补术治疗嵌顿性腹股沟斜疝的疗效分析

目的 探讨应用三维超普疝修补装置（UHS）行无张力疝修补术治疗嵌顿性腹股沟斜疝的临床疗效.方法 回顾分析应用三维UHS行无张力疝修补术治疗14例嵌顿性腹股沟斜疝患者的临床资料.结果 全组病例均治愈出院,随访8个月～3年未见复发.结论 在严格掌握适应证的前提下可以应用无张力疝一期修补术治疗嵌顿性腹股沟斜疝.     

平片式无张力疝修补在腹股沟嵌顿疝中的治疗体会

目的:探讨平片式无张力疝修补在治疗嵌顿性腹股沟斜疝中的价值。方法:回顾性分析行平片式无张力疝修补术治疗嵌顿性腹股沟斜疝32例患者临床资料。结果:手术经过顺利,无手术死亡病例,无伤口感染,随访12～24个月,术后出现阴囊血肿2例,无术后复发。结论:平片式无张力疝修补治疗嵌顿性斜疝具有安全、可靠、价廉等优点且复发率低。对于疝内容物无坏死,无严重感染者可避免二次手术。     

嵌顿性腹股沟斜疝一期无张力疝修补27例患者的疗效

目的 探讨一期无张力疝修补术治疗嵌顿性腹股沟斜疝的临床效果.方法 回顾性分析合肥市第三人民医院2010年1月至2016年12月收治的27例成人无肠坏死或肠穿孔的嵌顿性腹股沟斜疝一期无张力疝修补术27例患者临床资料.结果 27例患者均治愈出院,平均手术时间(81.9±23.3)min,平均术中出血量(16.5±22.8)mL,平均住院时间(7.7±2.3)d;25例患者切口甲级愈合,1例切口有渗液及1例切口局部淤血患者均对症处理后痊愈,术后随访6个月以上,均无复发.结论 如无肠坏死或肠穿孔,一期无张力疝修补术治疗嵌顿性腹股沟斜疝效果良好.     

成人嵌顿性腹股沟疝一期无张力修补6例分析

目的：探讨无张力疝修补术在治疗嵌顿性腹股沟疝中的应用效果及价值。方法：总结分析我院于2008年3月—2013年3月入院确诊为腹股沟嵌顿疝6例患者一期行疝无张力修补术治疗。其中腹股沟斜疝嵌顿5例,股疝嵌顿1例;腹股沟斜疝中3例行腹膜前间隙疝无张力修补术,3例行疝环充填式疝无张力修补术。结果：1例失访、5例均获随访（3~24）个月,无手术后复发病例,无伤口感染及补片排异反应。结论：疝无张力修补术可以安全有效地用于嵌顿性腹股沟斜疝的患者,但应注意病例的选择。     

成人嵌顿性腹股沟斜疝一期疝环充填式无张力疝修补术 21 例疗效分析

目的探讨一期疝环充填式无张力疝修补术使用于成人嵌顿性腹股沟斜疝患者的安全性及可行性。方法21例成人嵌顿性腹股沟斜疝患者采用一期疝环充填式无张力疝修补手术治疗。结果21例患者均恢复顺利,切口无感染,无红肿渗液,无阴囊血肿,无吻合口瘘出现,无明显异物感,随访无慢性疼痛、睾丸萎缩、迟发性深部补片感染及疝复发病例。结论对于成人嵌顿性腹股沟斜疝患者,手术医师具有熟练地操作技术,良好的疝环充填式无张力疝修补手术经验,通过严格的无菌操作,细致的解剖分离,严格止血,一期疝环充填式无张力疝修补术仍是一种安全有效的首选方法。     

无张力疝修补术在腹股沟嵌顿性斜疝患者的临床应用价值

目的 无张力疝修补术在腹股沟嵌顿性斜疝患者的临床效果.方法 选择2006年1月-2010年1月进行治疗的腹股沟嵌顿性斜疝男性患者64例为研究对象,将其随机分为对照组(传统手术方法 组)32例和观察组(无张力疝修补术组)32例,比较2组患者的手术时间、下床活动时间、复发率、住院时间、患者满意率及手术前、手术后3d的症状自...     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.