The effect of stimulants and depressants on the activity of solitary neurons in the spinal cord associated with stimulation of the cerebellum

Summary The method of intracellular conduction of potentials from motor and internuntial neurons of the spinal cord (7th thoracic and 1st lumbar segments) was used in cats to study the influence of various neurotropic substances on the facilitating and inhibitory effects secondary to the rhythmic stimulation of the anterior lobe of the cerebellum. Hypnotics (nembutal, hexenal, urethan) depressed the facilitating effects of the cerebellum, both in the motor and internuntial neurons, while analeptics (corasol, caffeine) considerably intensified them. Promedol decreased the activity of the motor neurons associated with cerebellar stimulation. All the compounds studied were capable of influencing the cerebellar effects in considerably smaller doses than those which changed the cellular response to afferent stimuli.(Presented by Active Member of the Academy of Medical Sciences, USSR, Zakusov) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 57, No. 2, pp. 73–77, February, 1964     

The effect of stimulants on the electrical activity of solitary neurons of the spinal cord

Summary The effect exerted by strychine, securinine and corazole (pentamethylenetetrazole) on the electric activity of single motor and neurons of the spinal cord, was studied by intracellular recording of the potentials. The data obtained demonstrated that the stimulants studied had a different effect on inhibitory processes in the spinal cord. Due to this, with the action of some substances (corazole) there was not only a rise, but also a depression of the activity of the individual neurons. The excitatory action of the stimulants was mainly directed upon the neurons of the spinal cord.(Presented by Active Member AMN SSSR V. V. Zakusov) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 54, No. 10, pp. 70–76, October, 1962     

The effect of higher nervous activity disturbance on hemoglobin metabolism

Summary The effect of higher nervous activity disturbances on hemogiobin metabolism in the dog was studied. The disturbances were caused by the combination of food and defense unconditioned reflexes and by a combination of inhibitory and excitatory processes, after a conditioned defense electric skin reflex and its differentiation had been previously formed. It was discovered that after the development of the neurotic state caused by such disturbances, hemoglobin decomposition in animals was intensifled. Due to the compensatory augmented erythrocyte formation, the hemoglobin level of the blood did not materially change at the beginning, but with the progressive aggravation of the neurotic state, compensation failed and the hemoglobin level considerably decreased.Presented by Academician G. N. Speransky     

The selective effect of some chemical stimulants on the reflexes from chemoreceptors

Summary Short-term experiments were performed on cats under urethan anesthesia. The effect of streptomycin administered parenterally on the reflexes from the pericardial chemoreceptors and mechanoreceptors was studied. Intravenous injection of streptomycin in the dose of 250,000–400,000 units and in intramuscular injection of 70,000–127,000 units completely depresses or considerably inhibits the reflexes from the pericardial chemoreceptors caused by nicotine. However, in the majority of experiments no depression of reflexes appearing in stimulation of pericardial mechanoreceptors was noted in similar experimental conditions. At times only an insignificant decrease of these reflexes was revealed.Presented by Active Member Acad. Med. Sci. USSR, V. N. Chernigovskii     

The effect of manipulation of reticuloendothelial system activity on glomerular deposition of aggregated protein and immune complexes in two different strains of mice.

Glomerular uptake of intravenously administered aggregated albumen or immune complexes in mice appears to be inversely related to the activity of the reticuloendothelial system (RES). Stimulation of RES activity diminishes the amount of material appearing in the glomerulus whereas RES blockade enhances glomerular uptake. The possible relevance of these observations to experimental models of immune complex disease is discussed.