外耳道腺样囊性癌3例

例 1 　 男 ,46岁。因左耳间断性疼痛 1 0年 ,左耳前肿物 3年入院。左耳屏处可触及一约 5 cm× 3cm× 3 cm大小的肿物 ,质地硬 ,触痛明显。乳突 X线片及乳突 CT均示无骨质破坏。 1 989年 5月行左外耳道肿物切除及乳突根治术。术后病理诊断腺样囊性癌。术后 1年患者因左耳道前壁肿物及左颈肿大淋巴结再次手术 ,术后配合60 Co放疗。 2年后病灶再次复发 ,检查发现左耳前及腮腺区结节样肿物约 3 cm大小 ,胸片提示双肺弥散性片状影 ,痰检发现癌细胞 ,考虑肺转移。半年后死亡。例 2 　 女 ,5 5岁。因右耳疼痛 1 1年伴肿物 6年入院。右耳道前壁有…     

外耳道腺样囊性癌1例

腺样囊性癌又称“圆柱癌”，常发生于口腔大小涎腺及呼吸道黏膜腺体，原发于外耳道的腺样囊性癌临床较为少见，我院2001年收治1例，现总结报告如下。     

外耳道腺样囊性癌5例报告

外耳道腺样囊性癌５例报告朱瑾１魏有为１外耳道腺样囊性癌临床少见，本科自１９７７～１９９５年共收治５例，现报告如下。例１女，５５岁，右耳道肿块３年，轻度疼痛，反复抗炎治疗无效。检查：右耳道口前方有蚕豆大小肿块，质偏软，皮肤颜色正常，明显压痛，耳周及颈...     

外耳道腺样囊性癌24例临床分析

目的探讨外耳道腺样囊性癌的临床诊断和治疗策略。方法回顾性分析解放军总医院1996—2007年经治的24例外耳道腺样囊性癌患者的临床资料,并用Kaplan-Meier法计算生存率。结果全组24例患者中,行局限性外耳道肿物切除术3例,行部分骨性外耳道和软骨切除加乳突根治术11例,行颞骨次全切除术9例,颞骨全切除术1例。4例晚期患者腮腺因受侵而切除。23例患者术后加用辅助放疗。全组总的5年累计生存率为71-4％．10年累计生存率为38．1％;临床误诊的患者与未被误诊患者的10年生存率分别为21．9％和59-3％（P=0．012）。结论外耳道腺样囊性癌生长缓慢,但长期效果差,对肿瘤的扩大切除可能提高生存率、降低复发,手术加放疗是有效的综合治疗策略。     

外耳道腺样囊性癌临床分析[论著]

目的　探讨外耳道腺样囊性癌的临床特点、诊断和治疗方法。方法　回顾性分析2008年1月至2020年12月在扬州大学附属苏北人民医院收治的6例外耳道腺样囊性癌患者临床资料,分析其临床症状、治疗及随访结果。2例行乳突扩大切除术,3例行颞骨次全切+腮腺浅叶切除+颞肌修复术,1例行颞骨次全切+腮腺浅叶切除、深叶部分去除术+颞肌修复术。结果　6例患者术后随访2~8年,随访5年以上者5例,术后复发1例。结论　外耳道腺样囊性癌不易及时确诊,肿瘤生长缓慢,容易复发和发生肺部转移。手术治疗结合术后辅以放疗可延长患者生存期、降低复发,是治疗外耳道腺样囊性癌的有效方法。     

外耳道腺样囊性癌（附13例报告）

腺样囊性癌常发生于涎腺和呼吸道粘膜腺体，发生于外耳道者罕见。笔者总结了1985年至1996年间收治的22例外耳道腺源性肿瘤，其中腺样囊性癌13例，现就其临床和病理特性做一回顾性分析。临床资料13例外耳道腺样囊性癌，男6例，女7例，年龄31～60岁，平均45．6岁，病史1～20年，平均5．8年，其中7例为手术后复发来诊，1例曾先后4次手术。所有患者均有较长时间耳痛史，检查除1例肿瘤位于耳廓上部，耳甲艇及三角窝外，其余12例肿瘤均位于外耳道软骨部，肿物质硬，触痛明显。治疗行扩大乳突根治术或颞骨次全切除术。随诊1例术后2年全身性骨转移，…     

外耳道腺样囊性癌的远处转移及预后分析

目的 探讨外耳道腺样囊性癌远处转移的相关危险因素及其对预后的影响.方法 回顾性分析22例江苏省人民医院2007年6月至2019年3月行原发灶根治手术且病理确诊为外耳道腺样囊性癌患者的临床和随访信息,单因素及多因素回归分析远处转移的危险因素及其对预后的影响.结果 患者远处转移率为40.9％,其中肺转移发生率最高,达66....     

外耳道耵聍腺囊性腺样癌

外耳道盯聍腺囊性腺样癌是头颈部肿瘤中较为突起见的恶性肿瘤，本文就1976-1993年间收治的13例外耳道盯聍腺囊性腺样癌临床表现及治疗结果进行回顾，13例中男4例，女9例，年龄24-79岁，平均46.7岁，除1例拒绝治疗外，12例均接受了手术治疗，5例随访10年以上，6例随访2-4年，1例胡访1年，1例失访，随访10年的5例病人中3例死于癌转移，1例死于肺感染，1例存活；6例随访2-4年者均存活，无癌复发。结合文献息就外耳道盯聍腺囊性腺样癌的发病率、临床表现、病理特征、诊断、治疗及预后进行讨论。     

外耳道腺样囊性癌6例

目的：探讨外耳道腺样囊性癌的临床及病理特点,以提高诊断和治疗水平。方法：回顾性分析6例外耳道腺样囊性癌患者的临床表现、治疗及随访结果,其中5例行颞骨次全切除术（含外耳道全切除）,1例行外耳道后下壁广泛切除及鼓室成形术。结果：全部患者术后随访8～21个月无复发。结论：外耳道腺样囊性癌生长缓慢,可长期带瘤生存,但远期预后不佳,首次治疗应该采用扩大根治性手术以提高治愈率。     

An immunohistochemical study of adenoid cystic carcinoma of the external auditory canal

Summary Specimens from five cases of adenoid cystic carcinoma of the external auditory canal were studied by immunohistochemical staining, and findings were compared with those from adjacent non-neoplastic tissues containing ceruminous glands. In the ceruminous gland, cytokeratin showed diffuse positive staining, while myoepithelial cells were stained for smooth muscle actin, desmin, S-100 protein and vimentin. The epithelial markers used were cytokeratin, carcinoembryonic antigen and secretory component and stained at various densities the inner cells of the tubular component and ductlining cells in the cibriform component of tumor tissues. In contrast, the muscular markers, smooth muscle actin and desmin, and the mesenchymal marker, vimentin, were positive in the outer cells of the tubular component and in the cyst-lining cells of the cribriform component. S-100 protein immunoreactivity showed pradoxical results; positive findings occurred in the myoepithelial cells of the ceruminous glands and in the inner cells of the tubular component and duct-lining cells of the cribriform component of the tumor. Present findings demonstrate that adenoid cystic carcinoma of the external auditory canal had dual epithelial and myoepithelial differentiation and can mimic the ceruminous glands of the auditory canal.     

外耳道腺样囊性癌侵犯中耳、颞叶且伴颈部淋巴结转移一例报告

正1病历资料1.1一般资料患者,女,53岁。患者2016年初出现左耳流脓,伴听力下降,抗炎及局部用药等治疗后病情仍反复。拟"慢性化脓性中耳炎"于2016年5月25日入住当地医院治疗,中耳乳突CT示"左侧乳突气房、乳突窦、鼓室内可见软组织样密度影填充,骨质未见明显破坏",专科查体:左外耳道见脓性分泌物,伴肉芽生长,鼓膜窥视不清。2016年5     

Lateral temporal bone resection for malignancy of external auditory meatus: our approach

Objective  Surgical management of tumors of the external ear remains controversial with regard to the extent of resection and the efficacy of piecemeal resection compared to standard en bloc resection. The objective was to study the results of lateral temporal bone resection with soft tissue resection used at our centre in managing a series of such cases. Setting  Tertiary referral centre Patients  A retrospective study was carried out on seven cases of temporal bone malignancies treated at our center, with lateral temporal bone resection by the otologic microsurgical technique and superficial parotidectomy, with adjuvant radiotherapy where indicated. The mode of presentation, clinical and pathological staging, extent of surgical resection, reconstructive methods used and adjuvant therapy given were evaluated. The disease free survival on follow-up was noted. Results  Disease free survival achieved was comparable with other published series, with acceptable morbidity patterns. Conclusion  Lateral temporal bone resection using otologic microsurgical technique with soft tissue resection is an effective way of achieving control of temporal bone malignancies. This paper was read by the fifth author at the 59th Annual Conference of the Association of Otolaryngologists of India held at Bhubaneshwar from 4–7 January 2007.     

Adenoid cystic carcinoma of the external auditory canal

Objective/Hypothesis: To describe the clinical history and outcome of patients with adenoid cystic carcinoma (ACC) of the external auditory canal (EAC). Study Design: Retrospective case series. Methods: A search of our institution's tumor registry identified 22 patients with ACC of the EAC. Both clinical histories and pathology slides, when available, were reviewed. Results: The mean age at diagnosis was 42 years (median, 38.5 years), and the most common presenting complaints were otalgia and ear canal mass. Nine patients (41%) developed recurrences at a mean of 8 years (median, 8 years) after initial diagnosis, six died of ACC, and three were living with distant metastases at their last follow-up. The mean duration of symptoms at the time of diagnosis was 7.7 years (range, 2–30 years) for patients who developed a recurrence after treatment vs. 1.2 year (range, 0–2 years) for patients who remained disease-free (P = .137). Every patient who had recurrent disease reported a duration of symptoms of ≥2 years (P = .013), and every patient with a duration of symptoms >2 years recurred (P = .002). There was a trend for more local recurrences after limited resection (P = .061). Conclusions: ACC of the EAC often recurs many years after definitive treatment. Although our sample size was too small to make definitive conclusions, we recommend aggressive local therapy with lateral temporal bone resection and adjuvant postoperative radiotherapy. In addition to successful local therapy, early diagnosis may be the only other effective means of preventing distant metastases.     

Basaloid squamous cell carcinoma of the external auditory canal: case report

Basaloid squamous cell carcinoma (BSCC) is a rare malignancy, with features of both basal cell carcinoma and squamous cell carcinoma. The tumor has a predilection for the upper aerodigestive tract, and has been suggested to behave more aggressively than squamous cell carcinoma (SCC). To the author’s knowledge, BSCC confined to the external auditory canal (EAC) has not been previously described. BSCC of EAC manifests similar characteristics as the conventional EAC cancer, presenting a mass with chronic otorrhea and itching sense. Excision of the tumor was accomplished by modified lateral temporal bone resection. This report describes the first case of BSCC in this location, and includes reviews of the pathologic and clinical aspects of this disease.     

Diagnosis and treatment of carcinoma in external auditory canal

ObjectivesTo evaluate outcomes in treating carcinoma of external auditory canal (EAC) and to analysis factors which effect the prognosis of this disease.MethodsA retrospectively review of 16 patients treated for carcinoma of EAC at our department between April 2000 and April 2014 was conducted. All patients underwent surgical treatment and the diagnosis confirmed by pathological examination.ResultsThere were adenoid cystic carcinoma (ACC) in 8 patients, squamous cell carcinoma (SCC) in 5 patients, adenocarcinoma (AC) in 2 patients, and verrucous carcinoma (VC) in 1 patient. The tumors were classified as Stage I in 4 cases, Stage II in 2 cases, Stage III in 3 cases, and Stage IV in 7 cases. Five patients underwent extensive tumor resection (ETR), 2 patients underwent lateral temporal bone resection (LTBR), 5 patients underwent modified LTBR, 2 patients underwent subtotal temporal bone resection (STBR), and 2 patients underwent only open biopsy. Besides, adjunctive procedures, including neck dissection, parotidectomy and pinna resection were performed when indicated. Ten patients received postoperative radiotherapy. By the end of follow up, two patients had died of their disease, 2 lost to follow up, 2 survived with the disease, and the rest survived disease-free. The median follow-up period was 24 months.ConclusionComplete tumor resection appears to be an effective treatment for carcinoma of the EAC. Patients with SCC seem to have worse prognosis than those with ACC. Radiation therapy seems less effective for the disease than surgical treatment.