共查询到3条相似文献,搜索用时 0 毫秒
1.
Frank C. Schroeder Andrew E. Taggi Matthew Gronquist Rabia U. Malik Jacqualine B. Grant Thomas Eisner Jerrold Meinwald 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(38):14283-14287
Extensive chemical analyses of spider venoms from many species have revealed complex mixtures of biologically active compounds, of which several have provided important leads for drug development. We have recently shown that NMR spectroscopy can be used advantageously for a direct structural characterization of the small-molecule content of such complex mixtures. Here, we report the application of this strategy to a larger-scale analysis of a collection of spider venoms representing >70 species, which, in combination with mass spectrometric analyses, allowed the identification of a wide range of known, and several previously undescribed, small molecules. These include polyamines, common neurotransmitters, and amino acid derivatives as well as two additional members of a recently discovered family of natural products, the sulfated nucleosides. In the case of the well studied brown recluse spider, Loxosceles reclusa, sulfated guanosine derivatives were found to comprise the major small-molecule components of the venom. 相似文献
2.
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hahn CK Ross KN Warrington IM Mazitschek R Kanegai CM Wright RD Kung AL Golub TR Stegmaier K 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(28):9751-9756