同步录像脑电心电监测对老年癫痫的诊断价值

目的：探讨同步录像-脑电-心电(Video-EEG-ECG)监测对老年癫痫的诊断价值。方法：对46例临床拟诊癫痫且常规脑电图(EEG)检查正常的老年患者进行24h Video—EEG—ECG监测。结果：确诊为癫痫者15例，心源性发作13例，短暂脑缺血发作10例，假性发作6例，癫痫伴假性发作2例。结论：Video-EEG-ECG监测对老年癫痫和非癫痫性发作的诊断与鉴别诊断有重要价值。     

动态脑电图监测对夜间发作癫痫的诊断价值

目的： 研究动态脑电图（AEEG）监测对夜间发作的癫痫的诊断价值.方法：对98例临床拟诊为癫痫及可疑癫痫患者的AEEG资料与常规脑电图（REEG）资料进行回顾性分析.结果：98例患者中AEEG检出样放电64例（65%）,显著高于REEG放电检出率（10%）（P〈0.005）,AEEG组98例患者中有临床发作者63例（64%）,其中有57例伴有同步的样放电,诊断为癫痫,癫痫检出率为58%.结论：AEEG监测对夜间发作的癫痫的诊断及与非痫性发作的鉴别诊断具有重要价值.     

脑瘫合并癫痫及发作性疾病患儿动态脑电图监测的临床意义

目的对脑性瘫痪合并癫痫及发作性疾病患儿进行24h动态脑电图（AEEG）监测,了解其对二者的诊断价值。方法50例脑瘫合并癫痫患儿,做常规脑电图及AEEG监测,30例脑瘫伴发作性疾病患儿为对照组,比较两组患儿同步脑电图监测符合率。探讨其临床意义。结果癫痫组,痫样放电45例（90%）,40例为同步放电,符合率80%。临床下电发作发放、非癫痫性事件各5例。发作性疾病组30例,痫样放电16例（53.3%）,4例（13.3%）为同步放电,避免了癫痫的漏诊。12例为发作性疾病与临床下电发作发放并存。14例背景波为落后于生理年龄的慢波,与发作无关。两组比较,癫痫组同步放电率（80%）,明显高于发作性疾病组（13.3%）,χ^2=33.66Р〈0.005。结论AEEG监测,可提高脑瘫合并癫痫及发作性疾病患儿痫样放电检出率。还可监测到发作时同步动态特征性改变,对脑瘫合并癫痫及发作性疾病的诊断、鉴别诊断,有着重要的临床价值。两组脑电图全部异常,可能与患儿多伴有脑皮层广泛病变有关。     

24h动态脑电图对晕厥与癫痫的诊断价值

目的探讨24h动态脑电图（AEEG）对晕厥与癫痫的诊断价值。方法回顾性分析2008年1月～2013年8月,在河北联合大学开滦总医院神经外科及神经内科住院的发作性意识丧失患者52例。结合病史、临床表现、查体、血尿生化检查、直立倾斜试验、头颅影像学等,分析常规脑电图（REEG）、AEEG监测结果,进行诊断与鉴别诊断。结果52例患者27例（27／52,51．9％）诊断为癫痫,19例（19／52,36．5％）诊断为晕厥,6例（6／52,11．5％）无法明确诊断。27例癫痫患者中AEEG监测发现特异性癫痫样放电。19例晕厥患者中5例（5／19,26．3％）诊断为心源性晕厥,12例（12／19,63．2％）诊断为血管迷走性晕厥。2例（2／19,10．5％）为体位性低血压性晕厥。结论AEEG对于晕厥与癫痫有较高的诊断及鉴别诊断价值。晕厥发作期脑电图显示弥漫性低波幅慢波的患者应警惕心源性晕厥的可能。     

长程视频脑电图监测对非癫痫性发作诊断价值探讨

目的探讨长程视频脑电图监测在非癫痫性发作诊断中的应用价值。方法对48例酷似非癫痫性发作患者行24 h长程视频脑电图监测,将发作表现及同期的脑电图进行分析。结果 48例患者在监测中均出现临床发作,长程视频脑电图监测所有发作期脑电图均未见痫样放电。其中1例患者表现单个θ波发放,27例患者为肌电伪差或动作伪迹。13例患者在发作间期脑电图见单个尖波或慢波发放,35例患者为正常范围。结论长程视频脑电图监测可将非癫痫性发作的临床表现和同步脑电图结合起来,为非癫痫性发作的诊断提供重要的临床资料。     

儿童植物神经性发作与痫样放电的关系

目的：探讨儿童植物神经发作性疾病与癫痫样异常放电的关系。方法：对167例临床诊断为植物神经性发作儿童的24h动态脑电图进行回顾性分析。结果：共监测到69例患儿临床发作，痫样放电（棘波、尖波、棘慢、尖慢波综合）11例，间期6例，痫样放电率为10．2％，腹痛性发作痫样放电率较高（X^2=9．35，P〈0．01）。结论：24h动态脑电图监测对儿童植物神经性发作诊断和鉴别诊断有着非常重要意义。     

视频脑电图监测对小儿癫痫的诊断价值探讨

目的探讨视频脑电图(VEEG)对小儿癫痫的诊断价值。方法对102例临床拟诊为癫痫患儿进行4～8h视频脑电图监测,其中包括清醒、睡眠期记录;分析临床发作和异常放电的关系,异常放电出现的时相。结果监测到临床发作并且同步异常放电者23例,仅发作间期癫痫样放电者53例,两者共76例(76/102,74.51%)结合病史确定为癫痫,其中局灶性52例(52/76,68.42%),睡眠中出现55例(55/76,72.37%)。10例(10/102,9.80%)临床发作但无同步异常放电,判定为非癫性发作。结论视频脑电图可提高儿童癫痫诊断的正确率,有助于癫痫的定位,部分剥夺睡眠有助于癫痫样放电的检出率。     

动态脑电图对癫痫诊断和鉴别诊断的意义

癫痫是以反复癫痫发作为特征的慢性神经系统疾病或综合症,可由遗传因素、多种神经系统疾病及全身性疾病引起.癫痫发作是脑内神经元阵发性异常超同步化脑电活动的临床表现.这种异常电活动可通过头皮脑电图或颅内脑电图记录到,称为癫痫样放电.常规脑电图检查痫样放电检出率较低.2005年9月至2008年10月,我们对120例癫痫患者和65例非癫痫发作性疾病患者作了常规脑电图(REEG)和动态脑电图(AEEG)的对比研究,以探讨AEEG在癫痫诊断和鉴别诊断中的价值,现报告如下.     

儿童植物神经性发作与(癎)样放电的关系

目的:探讨儿童植物神经发作性疾病与癫样异常放电的关系。方法:对167例临床诊断为植物神经性发作儿童的24h动态脑电图进行回顾性分析。结果:共监测到69例患儿临床发作,样放电(棘波、尖波、棘慢、尖慢波综合)11例,间期6例,样放电率为10.2%,腹痛性发作样放电率较高(X2=9.35,P<0.01)。结论:24h动态脑电图监测对儿童植物神经性发作诊断和鉴别诊断有着非常重要意义。     

动态脑电图监测对癫痫诊断和鉴别诊断的意义

癫痫为短暂性发作性疾病，常规脑电图(REEG)因描记时间短，常捕获不到痫样放电，由于24h动态脑电图(AEEG)因监测时间长，从而大大提高痫样放电检出率。现将我院2001年7月至2003年4月间检查的127例临床确诊为癫痫及90例非癫痫性发作性疾病患者的AEEG检查资料，分析报告如下。     

雷公藤甲素抗肿瘤血管新生的研究进展（英文）

雷公藤甲素(triptolide,TPL)是从中草药雷公藤中提取的一种有效活性物质,已被用来治疗多种疾病,包括系统性红斑狼疮,类风湿性关节炎,肾病综合征等,TPL甚至有很强的抑制肿瘤的活性。近些年的研究显示,TPL具有抗血管新生的能力,TPL不仅可以抑制肿瘤的增殖,诱导细胞的凋亡,还可以抑制肿瘤的转移,可以增加其它化疗药物的抗肿瘤活性。本综述将讨论TPL在抗肿瘤血管新生方面的研究进展,以及初步探讨其潜在的作用机制。     

Changes in activity of neutral proteases in tissues of ground squirrels in the dynamics of hibernation

Total activities of neutral proteases in the cerebral, hepatic, and myocardial tissues of ground squirrel vary during hibernation: in autumn (before hibernation) activities of the enzymes in the brain and myocardium start increasing, while in the liver they do not change. A common feature for all tissues is minimum activity of active neutral proteases in the middle of hibernation month 1 bout, while the maximum activity is recorded before awakening. Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 9, pp. 278–280, September, 2008     

Kinetics of decline of maternal measles virus-neutralizing antibodies in sera of infants in France in 2006

The optimal age for measles vaccination is an important health issue, since maternal antibodies may neutralize the vaccine antigen before a specific immune response develops, while delaying vaccination may increase the risk of complicated diseases in infants. However, measles vaccination impacts the duration of protection afforded by transplacental transfer of maternal antibodies: vaccination-induced maternal antibodies disappear faster than disease-induced antibodies. In order to maintain protection against measles in infants, it is important to monitor the dynamics of this phenomenon in vaccinated populations. To assess the current situation in France, a multicenter, prospective seroepidemiological study was conducted in seven French hospitals between October 2005 and January 2007. Maternal measles antibody concentrations from 348 infants 0 to 15 months old were measured using the plaque reduction neutralization assay. Geometric mean concentrations and the percentage of infants with maternal measles antibody concentrations above the protection threshold (≥120 mIU/ml) were assessed according to age. Results show that after more than 20 years of routine measles vaccination in France, maternal measles-neutralizing antibodies decrease dramatically in French infants by 6 months of age, from 1,740 mIU/ml for infants 0 to 1 month old to 223 mIU/ml for infants 5 to 6 months old, and that 90% of infants are not protected against measles after 6 months of age. Infant protection against measles could be optimized both by increasing herd immunity through an increased vaccine coverage and by lowering the age of routine vaccination from 12 to 9 months.     

Effect of vitamin C in reducing the toxicity of endosulfan in liver in rabbits

In this study, the effect of endosulfan, an organochlorine pesticide, and the ameliorating effect of vitamin C on the livers of New Zealand white rabbits were studied. Livers of the rabbits were examined grossly and histopathologically, and caspase-3 activity was detected by immunohistochemical methods. A total of twenty-four rabbits were divided into four groups (n=6). Rabbits in Group I (END) were daily given a sublethal dose of endosulfan (1 mg/kg bw) in corn oil by oral gavage for 6 weeks. Group II (END+C) received the same dose of endosulfan and additionally Vit C (20 mg/kg bw) every other day during this period. Group III (OIL+C) received corn oil daily by oral gavage and vitamin C every other day for 6 weeks. Group IV (OIL), the control group, received only corn oil daily, by oral gavage throughout the experiment. The concentration of α-endosulfan in the END group was higher in livers (0.102±0.012 ppb) than the β-endosulfan (0.072±0.001 ppb). Decreased accumulation of α and β endosulfan was observed in the END+C group (0.025±0.003 and 0.016±0.002 ppb, respectively) (p<0.0001). The most prominent gross findings at the necropsy were seen in the END group, in which swollen and pale livers were commonly observed. Hemorrhages, degenerations, necrosis, and in some rabbits bile duct hyperplasia were the marked histopathological findings of the END group. Caspase-3 positive reaction was more severe in this group than in the others. An ameliorating effect of Vit C on gross, histopathological and immunohistochemical findings was observed in the END+C group. The results revealed that endosulfan is highly toxic for rabbit livers. However, toxicity was decreased by Vit C treatment, which reduced the accumulation of endosulfan in livers four-fold.