共查询到20条相似文献,搜索用时 31 毫秒
1.
Ellingson BM Kurpad SN Li SJ Schmit BD 《Journal of magnetic resonance imaging : JMRI》2008,27(3):634-642
PURPOSE: To determine differences in diffusion measurements in white matter (WM) and gray matter (GM) regions of the rat cervical, thoracic, and cauda equina spinal cord using in vivo diffusion tensor imaging (DTI) with a 9.4T MR scanner. MATERIALS AND METHODS: DTI was performed on seven rats in three slices at the cervical, thoracic, and cauda equina regions of the spinal cord using a 9.4T magnet. Axial diffusion weighted images (DWIs) were collected at a b-value of 1000 seconds/mm(2) in six directions. Regions of interest were identified via T2-weighted images for the lateral, dorsal, and ventral funiculi, along with GM regions. RESULTS: Analysis of variance (ANOVA) results indicated significant differences between every WM funiculus compared to GM for longitudinal apparent diffusion coefficient (lADC), transverse apparent diffusion coefficient (tADC), fractional anisotropy (FA), measured longitudinal anisotropy (MA1), and anisotropy index (AI). A significant difference in mean diffusivity (MD) between regions of the spinal cord was not found. Diffusion measurements were significantly different at each spinal level. In general, GM regions were significantly different than WM regions; however, there were few significant differences between individual WM regions. CONCLUSION: In vivo DTI of the rat spinal cord at 9.4T appears sensitive to the architecture of neural structures in the rat spinal cord and may be a useful tool in studying trauma and pathologies in the spinal cord. 相似文献
2.
Summers P Staempfli P Jaermann T Kwiecinski S Kollias S 《AJNR. American journal of neuroradiology》2006,27(9):1952-1961
BACKGROUND AND PURPOSE: Diffusion tensor and diffusion-weighted spinal cord imaging remain relatively unexplored techniques despite demonstrations that such images can be obtained and may yield clinically relevant findings. In this study, we examined the temporal dynamics of spinal cord motion and their impact on diffusion tensor image quality. METHODS: Four healthy volunteers underwent phase contrast-based velocity mapping and segmented echo-planar diffusion tensor scans of the cervical spinal cord. Regions of interest in the cord were used to identify the temporal patterns of motion. The delay of data acquisition after the cardiac trigger was varied to correspond to either quiescence or motion of the cord. RESULTS: The cervical spinal cord consistently displayed maximal velocities in the range of 0.5 cm/s and accelerations of up to 25 cm/s(2). In both these respects, the cervical cord values were greater than those of the medulla. Despite this pronounced motion, approximately 40% of the cardiac cycle can be described as relatively calm, with absolute velocities and accelerations less than 20% of the maximum values. Confining image acquisition to this window reduced ghosting artifacts and increased the consistency with which the dominant direction of diffusion was along the rostral-caudal axis in both gray and white matter of the spine. Preliminary clinical application and fiber tracking in pathologic cases was feasible, and alterations of the diffusion properties by multiple sclerosis lesions, tumor, and syringomyelia were seen. CONCLUSIONS: Acquiring DTI data during the quiescent phase of spinal cord motion can reduce ghosting artifacts and improve fiber tracking. 相似文献
3.
Vargas MI Delavelle J Jlassi H Rilliet B Viallon M Becker CD Lövblad KO 《Neuroradiology》2008,50(1):25-29
Diffusion tensor imaging (DTI) can visualize the white matter tracts in vivo. The aim of this study was to assess the clinical
utility of DTI in patients with diseases of the spinal cord. Fourteen subjects underwent magnetic resonance imaging of the
spine at 1.5 T. Preliminary diagnosis of the patients suggested traumatic, tumorous, ischemic or inflammatory lesions of the
spinal cord. In addition to T2-weighted images, DTI was performed with the gradients in 30 orthogonal directions. Maps of
the apparent diffusion coefficient and of fractional anisotropy were reconstructed. Diffusion tensor imaging showed a clear
displacement and deformation of the white matter tracts at the level of the pathological lesions in the spinal cord. This
capability of diffusion tensor imaging to reliably display secondary alterations to the white matter tracts caused by the
primary lesion has the potential to be of great utility for treatment planning and follow-up. 相似文献
4.
Van Hecke W Leemans A Sijbers J Vandervliet E Van Goethem J Parizel PM 《Journal of magnetic resonance imaging : JMRI》2008,27(5):978-991
PURPOSE: To compare region of interest (ROI)-based and diffusion tensor tractography (DTT)-based methods for evaluating diffusion properties of the spinal cord as a function of age. MATERIALS AND METHODS: Commonly, an ROI segmentation is used to delineate the spinal cord. In this work, new segmentation methods are developed based on DTT. In a first, DTT-based, segmentation approach, the diffusion properties are calculated on the tracts. In a second method, the diffusion properties are analyzed in the spinal cord voxels that contain a certain number of tracts. We studied the changes in diffusion properties of the human spinal cord in subjects of different ages. Diffusion tensor imaging (DTI) measurements of the cervical spinal cord were acquired on 42 healthy volunteers (age range = 19-87 years). The fractional anisotropy (FA), the mean diffusivity (MD), and eigenvalues (lambda(1), lambda(2), and lambda(3)) were compared for the ROI- and DTT-based segmentation methods. RESULTS: Our automatic techniques are shown to be highly reproducible and sensitive for detecting DTI changes. FA decreased (r = -0.38; P < 0.05), whereas MD and eigenvalues increased (r = +/- 0.45; P < 0.05) with age. These trends were not statistically significant for the ROI-based segmentation (P > 0.05). CONCLUSION: DTT is a robust and reproducible technique to segment the voxels of interest in the spinal cord. 相似文献
5.
Diffusion-weighted MR imaging of the normal human spinal cord in vivo 总被引:13,自引:0,他引:13
Holder CA Muthupillai R Mukundan S Eastwood JD Hudgins PA 《AJNR. American journal of neuroradiology》2000,21(10):1799-1806
BACKGROUND AND PURPOSE: Diffusion-weighted imaging is a robust technique for evaluation of a variety of neurologic diseases affecting the brain, and might also have applications in the spinal cord. The purpose of this study was to determine the feasibility of obtaining in vivo diffusion-weighted images of the human spinal cord, to calculate normal apparent diffusion coefficient (ADC) values, and to assess cord anisotropy. METHODS: Fifteen healthy volunteers were imaged using a multi-shot, navigator-corrected, spin-echo, echo-planar pulse sequence. Axial images of the cervical spinal cord were obtained with diffusion gradients applied along three orthogonal axes (6 b values each), and ADC values were calculated for white and gray matter. RESULTS: With the diffusion gradients perpendicular to the orientation of the white matter tracts, spinal cord white matter was hyperintense to central gray matter at all b values. This was also the case at low b values with the diffusion gradients parallel to the white matter tracts; however, at higher b values, the relative signal intensity of gray and white matter reversed. With the diffusion gradients perpendicular to spinal cord, mean ADC values ranged from 0.40 to 0.57 x 10(-3) mm2/s for white and gray matter. With the diffusion gradients parallel to the white matter tracts, calculated ADC values were significantly higher. There was a statistically significant difference between the ADCs of white versus gray matter with all three gradient directions. Strong diffusional anisotropy was observed in spinal cord white matter. CONCLUSION: Small field-of-view diffusion-weighted images of the human spinal cord can be acquired in vivo with reasonable scan times. Diffusion within spinal cord white matter is highly anisotropic. 相似文献
6.
7.
Diffusion tensor imaging of in vivo and excised rat spinal cord at 7 T with an icosahedral encoding scheme. 总被引:4,自引:0,他引:4
Regional values of fractional anisotropy (FA) and mean diffusivity (D(av)) of in vivo and excised rat spinal cords were measured using an iscosahedral encoding scheme that is based on 21 uniformly distributed and alternating gradient directions with an echo planar imaging (EPI) readout. Based on the water phantom studies, this scheme was shown to provide unbiased estimation of FA. The stability of the scanner during the acquisition of diffusion tensor imaging (DTI) data was evaluated. Repeated measurements of the FA values demonstrated excellent reproducibility, as assessed by the Bland-Altman analysis. These studies demonstrated a reduced anisotropy in excised samples relative to in vivo cords. Diffusion in the spinal cord gray matter was shown to be anisotropic. The FA value in the dorsal white matter (WM) was found to be higher relative to the ventral WM. Results from these studies should provide the necessary baseline data for serial in vivo DTI of injured spinal cord. 相似文献
8.
A simple theoretical framework to compute the eigenvalues of a cylindrically symmetric prolate diffusion tensor (D) from one of the rotationally-invariant diffusion anisotropy indices and average diffusivity is presented and validated. Cylindrical or axial symmetry assumes a prolate ellipsoid shape (lambdaparallel=lambda1>lambdaperpendicular=(lambda2+lambda3)/2; lambda2=lambda3). A prolate ellipsoid with such symmetry is largely satisfied in a number of white matter (WM) structures, such as the spinal cord, corpus callosum, internal capsule, and corticospinal tract. The theoretical model presented is validated using in vivo DTI measurements of rat spinal cord and human brain, where eigenvalues were calculated from both the set of diffusion coefficients and a tensor analysis. This method was used to retrospectively analyze literature data that reported tensor-derived average diffusivity, anisotropy, and eigenvalues, and similar eigenvalue measurements were obtained. The method provides a means to retrospectively reanalyze literature data that do not report eigenvalues. Other potential applications of this method are also discussed. 相似文献
9.
Korzan JR Gorassini M Emery D Taher ZA Beaulieu C 《Journal of magnetic resonance imaging : JMRI》2002,16(1):21-27
PURPOSE: To demonstrate the feasibility of obtaining high-quality magnetic resonance (MR) images of the human cervical spinal cord in vivo at a magnetic field strength of 3 T and to optimize the signal contrast between gray matter, white matter, and cerebrospinal fluid (CSF) on 2D gradient recalled echo (GRE) images of the cervical spinal cord. MATERIALS AND METHODS: Using a custom-built, anatomically molded radio frequency (RF) surface coil, the repetition time and flip angle of a 2D GRE sequence were systematically varied in five volunteers to assess tissue contrast in the cervical spinal cord. RESULTS: The 2D GRE parameters for an optimal balance between gray-white matter and CSF-white matter contrast at 3 T were determined to be a time-to-repetition (TR) of 2000 msec and a flip angle of 45 degrees, with the constant short time-to-echo (TE) of 12 msec used in this study. Excellent tissue contrast and visualization of the internal anatomy of the spinal cord was demonstrated reproducibly in eight subjects using these optimal parameters. CONCLUSION: This study demonstrates that imaging the cervical spinal cord and delineating internal spinal cord structures such as gray and white matter is feasible at 3 T. 相似文献
10.
MR diffusion tensor imaging and fiber tracking in spinal cord arteriovenous malformations: a preliminary study 总被引:4,自引:0,他引:4
Ozanne A Krings T Facon D Fillard P Dumas JL Alvarez H Ducreux D Lasjaunias P 《AJNR. American journal of neuroradiology》2007,28(7):1271-1279
BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) of the spinal cord in patients harboring spinal arteriovenous malformations (AVMs) was carried out to evaluate the feasibility of this new technique to determine the displacement of the spinal cord tracts and to correlate morphologic and functional DTI data (fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) with the clinical symptoms. MATERIALS AND METHODS: Nine patients with spinal cord AVMs were investigated at 1.5T using a sagittal spin-echo single-shot echo-planar generalized autocalibrating partially parallel acquisition diffusion-weighted imaging sequence. ADC and FA maps were computed in different regions of interest (both above and below the nidus), and tractography was used to visualize the course of the tracts. The data were correlated with the clinical symptoms and compared with 12 healthy control subjects. RESULTS: At the level of the nidus, tracts were normal, shifted, separated, or interrupted but not intermingled with the nidus. Interruption of the tracts was coherent with the clinical symptoms. In patients with severe neurologic deficits, FA values caudal to the nidus showed a reduced anisotropy consistent with loss of white matter tracts. CONCLUSIONS: We demonstrate that AVMs may interrupt, displace, or separate the fiber tracts and that clinical symptoms may be reflected by the quantitative FA results and the morphologic loss of fibers distant to the lesion. DTI with fiber tracking offers a novel approach to image spinal cord AVMs and may open a window to understand the complex pathophysiology of these lesions. 相似文献
11.
磁共振弥散张量成像对正常大脑白质纤维束构象的初步研究 总被引:3,自引:0,他引:3
目的利用磁共振弥散张量成像(DTI)研究正常成人脑内各部位各向异性程度及正常白质纤维束构象特征.方法对25名正常志愿者进行常规MR及DTI序列检查,重建FA图及三维彩色编码张量图.分别在半卵圆中心、基底节区和大脑脚层面测量主要白质束的FA值.结果DTI显示灰质与白质区各向异性存在显著差异,不同部位的白质纤维束各向异性程度亦不相同,且左右两侧基本对称,重建FA图和三维彩色编码张量图可显示白质内大部分主要的白质纤维束.结论DTI可清晰显示脑内白质纤维束的走行及分布,为了解脑功能与白质通路间关系提供了有力研究手段. 相似文献
12.
正常成人脑结构的弥散张量成像参数测定及分析 总被引:12,自引:3,他引:9
目的 运用弥散张量成像 (DTI)方法来探讨脑内不同组织及解剖部位的弥散各向异性特点。资料与方法 采用单次激发自旋回波EPI成像序列 ,将弥散敏感梯度依次施加在六个不同 (P、M、S、MP、PS、MS)的方向进行DTI,获得正常成人脑的弥散张量图及各向异性指数图 ,在脑内不同解剖部位进行各向异性指数、张量的轨迹及平均弥散率测定并进行统计学分析。结果 脑内不同组织及解剖部位的弥散各向异性程度不同 ,脑白质的弥散各向异性远大于丘脑与脑灰质 (P <0 .0 1) ;在脑白质的不同解剖部位 ,其各向异性特点也不相同 (P <0 .0 5 ) ,脑白质连合纤维 (胼胝体 )的各向异性程度最高 ,其次为脑白质的投射纤维 (内囊 ) ,再次为联合纤维 (半卵圆中心 )。张量的轨迹及平均弥散率在脑内的不同部位具有一致性。结论 DTI可准确测定脑内不同组织弥散的各向异性特点 ,并且可清晰显示脑内神经纤维束的方向及走行 ,可为临床脑白质病的研究提供新的功能测定方法 相似文献
13.
Helton KJ Phillips NS Khan RB Boop FA Sanford RA Zou P Li CS Langston JW Ogg RJ 《AJNR. American journal of neuroradiology》2006,27(4):786-793
BACKGROUND AND PURPOSE: Conventional MR imaging permits subcategorization of brain stem tumors by location and focality; however, assessment of white matter tract involvement by tumor is limited. Diffusion tensor imaging (DTI) is a promising method for visualizing white matter tract tumor involvement supratentorially. We investigated the ability of DTI to visualize and quantify white matter tract involvement in pontine tumors. METHODS AND MATERIALS: DTI data (echo-planar, 1.5T) were retrospectively analyzed in 7 patients with pontine tumors (6 diffuse, 1 focal), 4 patient controls, and 5 normal volunteers. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were calculated from the diffusion tensor in 6 regions of interest: bilateral corticospinal tracts, transverse pontine fibers, and medial lemnisci. Relationships between FA and ADC values and results of the neurologic examinations were evaluated. RESULTS: The corticospinal tracts and transverse pontine fibers were affected more often than the medial lemnisci. The DTI parameters (FA and ADC) were significantly altered in all tracts of patients with pontine tumors (P < .05), compared with those values in the control groups. A marginally significant (P = .057) association was seen between the severity of cranial nerve deficit and decreased FA. CONCLUSION: DTI provided superior visualization and quantification of tumor involvement in motor, sensory, and transverse pontine tracts, compared with information provided by conventional MR imaging. Thus, DTI may be a sensitive measure of tract invasion. Further prospective studies are warranted to assess the ability of DTI to delineate tumor focality and improve risk stratification in children with pontine tumors. 相似文献
14.
Itamar Ronen Keun-Ho Kim Michael Garwood Kamil Ugurbil Dae-Shik Kim 《Magnetic resonance in medicine》2003,49(5):785-790
Diffusion tensor imaging (DTI) uses water diffusion anisotropy in axonal fibers to provide a tool for analyzing and tracking those fibers in brain white matter. In the present work, multidirectional diffusion MRI data were collected from a cat brain and decomposed into slow and fast diffusion tensors and directly compared with conventional DTI data from the same imaging slice. The fractional anisotropy of the slow diffusing component (D(slow)) was significantly higher than the anisotropy measured by conventional DTI while reflecting a similar directionality and appeared to account for most of the anisotropy observed in gray matter, where the fiber density is notoriously low. Preliminary results of fiber tracking based on the slow diffusion component are shown. Fibers generated based on the slow diffusion component appear to follow the vertical fibers in gray matter. D(slow)TI may provide a way for increasing the sensitivity to anisotropic structures in cortical gray matter. 相似文献
15.
Masaaki Hori Tomoko Maekawa Kouhei Kamiya Akifumi Hagiwara Masami Goto Mariko Yoshida Takemura Shohei Fujita Christina Andica Koji Kamagata Julien Cohen-Adad Shigeki Aoki 《Magnetic resonance in medical sciences》2022,21(1):58
Diffusion tensor imaging (DTI) has been established its usefulness in evaluating normal-appearing white matter (NAWM) and other lesions that are difficult to evaluate with routine clinical MRI in the evaluation of the brain and spinal cord lesions in multiple sclerosis (MS), a demyelinating disease. With the recent advances in the software and hardware of MRI systems, increasingly complex and sophisticated MRI and analysis methods, such as q-space imaging, diffusional kurtosis imaging, neurite orientation dispersion and density imaging, white matter tract integrity, and multiple diffusion encoding, referred to as advanced diffusion MRI, have been proposed. These are capable of capturing in vivo microstructural changes in the brain and spinal cord in normal and pathological states in greater detail than DTI.This paper reviews the current status of recent advanced diffusion MRI for assessing MS in vivo as part of an issue celebrating two decades of magnetic resonance in medical sciences (MRMS), an official journal of the Japanese Society of Magnetic Resonance in Medicine. 相似文献
16.
Hesseltine SM Law M Babb J Rad M Lopez S Ge Y Johnson G Grossman RI 《AJNR. American journal of neuroradiology》2006,27(6):1189-1193
BACKGROUND AND PURPOSE: Evaluation of the spinal cord is important in the diagnosis and follow-up of patients with multiple sclerosis. Our purpose was to investigate diffusion tensor imaging (DTI) changes in different regions of normal-appearing spinal cord (NASC) in relapsing-remitting multiple sclerosis (RRMS). METHODS: Axial DTI of the cervical spinal cord was performed in 24 patients with RRMS and 24 age- and sex-matched control subjects. Fractional anisotropy (FA) and mean diffusivity (MD) were calculated in separate regions of interest (ROIs) in the anterior, lateral, and posterior spinal cord, bilaterally, and the central spinal cord, at the C2-C3 level. Patients and control subjects were compared with respect to FA and MD with the use of an exact Mann-Whitney test. Logistic regression and receiver operating characteristic (ROC) curve analysis assessed the utility of each measure for the diagnosis of RRMS. RESULTS: DTI metrics in areas of NASC in MS were significantly different in patients compared with control subjects; FA was lower in the lateral (mean +/- SD of 0.56 +/- 0.10 versus 0.69 +/- 0.09 in control subjects, P < .0001), posterior (0.52 +/- 0.11 versus 0.63 +/- 0.10, P < .0001), and central (0.53 +/- 0.10 versus 0.58 +/- 0.10, P = .049) NASC ROIs. Assessing DTI metrics in the diagnosis of MS, a sensitivity of 87.0% (95% confidence interval [CI], 66.4 to 97.1) and a specificity of 91.7% (95% CI, 73.0 to 98.7) were demonstrated. CONCLUSION: The NASC in RRMS demonstrates DTI changes. This may prove useful in detecting occult spinal cord pathology, predicting clinical course, and monitoring disease progression and therapeutic effect in MS. 相似文献
17.
Hughes M Sundgren PC Fan X Foerster B Nan B Welsh RC Williamson JA Attwood J Maly PV Chenevert TL McCune W Gebarski S 《Acta radiologica (Stockholm, Sweden : 1987)》2007,48(2):213-222
PURPOSE: To investigate whether apparent diffusion coefficient (ADC), fractional anisotropy (FA), and eigenvalues in neuropsychiatric systemic lupus erythematosus (NPSLE) patients differ from those of healthy controls. MATERIAL AND METHODS: Eight NPSLE patients (aged 23-55 years, mean 42.9 years) and 20 healthy age-matched controls (aged 22-59 years, mean 44.4 years) underwent conventional brain magnetic resonance (MR) and diffusion tensor imaging (DTI). The ADC, FA, principal eigenvalue (lambda parallel), and the corresponding average perpendicular eigenvalue (lambda perpendicular) (=(lambda2+lambda3)/2) were measured in selected regions of normal appearing gray and white matter brain parenchyma. For statistical evaluation of differences between the two groups, a Student's t-test was used. The P value for statistical significance was set to P=0.0025 after Bonferroni correction for multiple measurements. RESULTS: Significantly increased ADC values were demonstrated in normal-appearing areas in the insular cortex (P<0.001), thalamus (P<0.001), and the parietal and frontal white matter (P<0.001 and P<0.001, respectively) in NPSLE patients. Significantly decreased FA values were demonstrated in normal-appearing thalamus (P<0.001), corpus callosum (P=0.002), and in the parietal and frontal white matter (P<0.001 and P<0.001, respectively) in NPSLE patients compared to healthy controls. The lambda perpendicular was significantly higher in several of these regions in NPSLE patients compared to healthy controls. CONCLUSION: Our study demonstrates alterations in normal-appearing gray and white matter brain parenchyma of patients with NPSLE by means of abnormal ADC, FA, and eigenvalues. These alterations may be based on loss of tissue integrity in part due to demyelination. It is possible that DTI in the future could assist in the diagnosis of NPSLE and possibly help to further elucidate the pathogenesis of NPSLE. 相似文献
18.
Diffusion tensor imaging in the assessment of normal-appearing brain tissue damage in relapsing neuromyelitis optica 总被引:3,自引:0,他引:3
Yu CS Lin FC Li KC Jiang TZ Zhu CZ Qin W Sun H Chan P 《AJNR. American journal of neuroradiology》2006,27(5):1009-1015
BACKGROUND AND PURPOSE: Normal-appearing brain tissue (NABT) damage was established in multiple sclerosis by histology, MR spectroscopy, magnetization transfer imaging and diffusion tensor imaging (DTI). However, whether this phenomenon can be detected in relapsing neuromyelitis optica (RNMO) remains unclear. The aim of this study was to use DTI to investigate the presence of NABT damage in RNMO patients and its possible mechanism. METHODS: Conventional MR imaging and DTI scans were performed in 16 patients with RNMO without visible lesions on brain MR imaging and in 16 sex- and age-matched healthy control subjects. Histogram analysis of mean diffusivity (MD) and fractional anisotropy (FA) was performed in the entire brain tissue (BT), white matter (WM), and gray matter (GM). Region of interest (ROI) analysis of MD and FA was also performed in WM regions connected with the spinal white matter tracts or optic nerve (including medulla oblongata, cerebral peduncle, internal capsule, and optic radiation), in corpus callosum without direct connection with them, and in some GM regions. RESULTS: From histogram analysis, we found the RNMO group had a higher average MD of the BT, WM, and GM, a lower average MD peak height and a higher average MD peak location of the GM, and a higher average FA peak height of the WM than did the control group. From ROI analysis, compared with control subjects, RNMO patients had a higher average MD and a lower average FA in ROIs of WM connected with the spinal white matter tracts or optic nerve and a normal average MD and FA in corpus callosum without direct connection with them. In addition, a high average MD was found in parietal GM in these patients. CONCLUSIONS: Our findings confirm the presence of abnormal diffusion in brain tissue in patients with RNMO and suggest that secondary degeneration caused by lesions in the spinal cord and optic nerve might be an important mechanism for this abnormality. 相似文献
19.
目的:探讨磁共振扩散张量成像(DTI)技术在颈髓病变诊断中的临床应用。方法:应用1.5T磁共振机器对39例颈髓病变患者和15例健康志愿者行MRI常规和DTI检查,测定病变区和对照部位的FA值、ADC值并进行对照分析,并重建白质纤维束图。结果:健康志愿者颈髓的FA值为0.66±0.06,ADC值为(0.96±0.14)×10^-3mm^2/s。颈椎病病例FA值为0.47±0.05、ADC值为(1.16±0.28)×10^-3mm^2/s;与对照组统计学分析FA值明显降低(P〈0.01),ADC值明显增高(P〈0.01)。颈髓急性损伤病例FA值为0.38±0.08、ADC值为(0.89±0.25)×10^-3mm^2/s;与对照组统计学分析FA值明显降低(P〈0.01),ADC值与对照组无明显差异(P=0.130〉0.05)。颈髓炎症:FA值为0.40±0.06、ADC值为(1.25±0.40)×10^-3mm^2/s;与对照组统计学分析FA值明显降低(P〈0.01),ADC值明显增高(P〈0.01)。所有病例通过DTI技术成功显示了白质纤维束在病变区变形、移位及中断等改变。结论:DTI可以探测到颈髓病变中常规MR未能发现的病灶;白质纤维束成像可以显示白质束的受损情况。 相似文献
20.
Jürgen Finsterbusch PhD 《Journal of magnetic resonance imaging : JMRI》2009,29(4):987-993