子宫颈原发性非霍奇金淋巴瘤1例

患者女性，42岁。下腹胀、阴道不规则流血3个月就诊。无发热、盗汗及体重下降，既往月经正常。查体：一般情况良好，全身浅表淋巴结不肿大，皮肤、黏膜无异常，扁桃体不大。胸片及CT提示心、肺、肝、脾和肾均未见异常。妇科检查：宫颈Ⅱ度糜烂，质较硬，但未见溃疡形成，可见多个小花生米、黄豆大小的息肉状肿物增生，接触性出血。子     

卵巢原发性非霍奇金淋巴瘤1例

1病例报告 患者40岁,发现盆腔巨大包块,腹部进行性膨隆1周于2008年3月7日入院.患者于2007年初出现月经量减少,周期欠规律,40～50天.2007年7月出现腰痛、腿酸、间断出现恶心、呕吐,大便次数增多,患者未行诊治.2008年2月底突发下腹痛,在当地就诊检查,发现盆腔巨大包块合并腹水.     

子宫T淋巴细胞型非霍奇金淋巴瘤1例报告

我院收治1例子宫T淋巴细胞型非霍奇金淋巴瘤(non-Hodgkin’slymphoma,NHL)。现将其诊治情况报道如下。1病历介绍患者70岁。因阴道不规则流血伴下腹胀半个月于2009年10月12日入院。该患者50岁绝经,入院1个月前开始阴道不规则流血,并伴有下腹胀至今,自服止血药(具体药物及用量不详),2009年10月2日于我院妇科彩超     

原发性子宫内膜非霍奇金恶性淋巴瘤一例

患者７９岁，因绝经２０余年，阴道不规则出血２０天就诊。患者２０天前出现阴道出血，初期量少，色暗红，为间断性。１周后出血量增多，如月经量，并伴有血块。未发现有烂肉样物排出，白带不多，无腹痛。妇科检查：老年型外阴，阴道通畅，无血性分泌物，宫颈萎缩。宫体前...     

原发性女性生殖系统非霍奇金淋巴瘤16例临床分析

目的 探讨原发性女性生殖系统非霍奇金淋巴瘤(PFGSL)的临床特征、治疗及预后.方法 回顾性分析16例PFGSL患者临床资料,分析其临床病理特征及预后因素.结果 16例患者的中位年龄50.5岁.原发部位:卵巢7例,子宫和卵巢2例,宫颈4例,子宫1例,外阴1例,宫颈和阴道1例.按照淋巴组织肿瘤WHO(2008)分型:弥漫...     

原发性卵巢非霍奇金淋巴瘤一例

一、病例摘要 患者女性,41岁,因＂腹部触及包块半个月＂于2013年6月10日收入院。患者平素月经规律,无痛经,孕3产1。无发热、恶心、呕吐、腹痛及月经改变,无消瘦、食欲减退等。查体：心肺（-）,肝脾（-）,全身淋巴结无肿大,下腹可触及儿头大小实性肿块。B超检查提示：子宫增大,形态失常,肌层回声不均匀,内探及数个低回声团块,较大两个分别约10.1cm×8.6cm,11.3cm×8.8cm,向外凸起,考虑子宫肌瘤;盆腔CT提示：子宫肌瘤,     

原发性卵巢非霍奇金淋巴瘤1例及文献复习

目的:探讨原发性卵巢非霍奇金淋巴瘤(NHL)的诊断、治疗及预后。方法:复习1例原发性卵巢非霍奇金淋巴瘤完整的临床资料。结果:该例患者为原发弥漫大B细胞型,手术方式分期为ⅣA期,目前症状达到部分缓解。结论:原发性卵巢NHL与其他原发性卵巢恶性肿瘤表现相似,临床表现缺乏特异性,术前诊断十分困难,妇产科医生如在手术台上遇到类似病例,应果断行肿瘤细胞减灭术,尽可能行盆腔淋巴结清扫术+腹主动脉旁淋巴结清扫术+大网膜切除术+阑尾切除术,对于肿瘤局限于单侧的年轻患者可行保留生育功能的手术,术后到血液科辅以化疗等综合治疗,可以延长患者的生存期。     

"双重打击"卵巢弥漫大B细胞非霍奇金淋巴瘤1例报告并文献复习

非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)累及卵巢的概率为7％～26％[1].原发卵巢非霍奇金淋巴瘤(pri-mary ovarian non-Hodgkin's lymphoma,PONHL)非常罕见,占非霍奇金淋巴瘤的0.5％,占所有卵巢肿瘤的1.5％[2].而双重打击淋巴瘤(double ...     

生殖系统原发性非霍奇金淋巴瘤的临床病理特征和免疫表型检测

目的观察生殖系统原发性非霍奇金淋巴瘤的临床病理表现及免疫表型,并分析其与预后的关系。方法回顾性分析43例女性生殖系统原发性非霍奇金淋巴瘤的临床病理资料,按WHO（2001年）关于淋巴造血组织肿瘤的分类标准进行病理类型的分类,采用免疫组化染色、原位杂交及PCR技术分别检测其免疫表型、EB病毒感染及免疫球蛋白重链基因重排。采用Cox回归模型对生殖系统原发性非霍奇金淋巴瘤的预后进行多因素分析。结果（1）原发灶部位：卵巢24例,子宫内膜3例,宫颈10例,阴道2例,外阴4例;（2）临床分期：Ⅰ期12例,Ⅱ期9例,Ⅲ期22例;（3）病理类型：经病理活检、免疫组化、原位杂交及PCR技术检测结果显示,弥漫性大B细胞淋巴瘤37例（86％）,伯基特淋巴瘤和非特指外周T细胞淋巴瘤各3例;（4）预后分析：乳酸脱氢酶水平增高、临床Ⅲ期、弥漫性大B细胞淋巴瘤及单纯手术治疗患者的生存率明显低于乳酸脱氢酶水平正常、临床Ⅰ和Ⅱ期、伯基特淋巴瘤和非特指外周T细胞淋巴瘤、手术＋化疗和手术＋放化疗者（P〈0．05）。Cox回归模型多因素分析显示,乳酸脱氢酶水平、临床分期、病理类型及治疗方案均为影响原发性非霍奇金淋巴瘤患者预后的独立因素（P〈0．05）。结论病理活检、免疫组化、原位杂交及PCR技术检测对生殖系统原发性非霍奇金淋巴瘤的诊断和鉴别诊断具有重要作用。乳酸脱氢酶水平、临床分期、病理类型及治疗方案均为女性生殖系统原发性非霍奇金淋巴瘤的独立预后因素。     

新式非脱垂子宫经阴道切除术

非脱垂子宫经阴道切除术 (ｔｒａｎｓｖａｇｉｎａｌｈｙｓｔｅｒｅｃｔｏｍｙ,ＴＶＨ)具有损伤小、恢复快、住院时间短、术后无切口疼痛、无腹壁瘢痕等诸多优点。目前 ,国内大多数医院仍未普遍开展ＴＶＨ。主要原因是该术式术野小、暴露困难 ,副损伤并发症发生率较高。本研究特制了阴式子宫切除专用器械 ,并对手术的关键步骤进行了较大改进 (即新式ＴＶＨ) ,使该手术变得简单易行 ,扩大了手术的适应证 ,手术质量明显提高。现报道如下。一、新式ＴＶＨ的方法1 环切宫颈、分离膀胱宫颈间隙和子宫直肠间隙 :方法与苏应宽[1] 介绍的方法相似。…     

Primary leiomyosarcoma of the vagina

A case of primary leiomyosarcoma of the vagina is described and discussed. The tumor recurred and the patient died 8.5 years after the diagnosis and primary treatment. This is the longest survival time reported in the literature for a primary vaginal leiomyosarcoma.     

Non-Hodgkin's lymphoma presenting as a pelvic mass with elevated CA-125

BACKGROUND: We report a case of pelvic lymphoma with an elevated serum CA-125 level, initially misdiagnosed as ovarian carcinoma. A review of the literature is presented and a possible mechanism for CA-125 elevation in diseases other than ovarian cancer is discussed. CASE: A 50-year-old woman presented with symptoms of progressive dyspnea, early satiety, fatigue, and weight loss. Workup revealed a pelvic mass and an elevated CA-125 level. Paclitaxel and carboplatin were administered to facilitate therapy and provide symptomatic relief for a presumed bulky ovarian carcinoma. A biopsy was obtained after the initiation of chemotherapy, yielding the diagnosis of diffuse large B cell non-Hodgkin's lymphoma, stage II-B. A regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone followed by radiotherapy resulted in long-term disease remission. A search of the literature revealed several clinical series describing the elevation of CA-125 in a variety of diseases, both benign and malignant. CONCLUSIONS: In the setting of a newly diagnosed pelvic mass, care should be taken when interpreting an elevated CA-125 level. While ovarian cancer is high on the list of differential diagnoses, lymphoma cannot be excluded until a tissue diagnosis is obtained.     

Successful treatment of primary non-Hodgkin's lymphoma of the vagina with chemotherapy

Introduction The vagina as a primary site of malignant lymphoma in woman is extremely rare.Case report We report here a 30-year-old patient with a primary vaginal non-Hodgkin's lymphoma stage IEA, follicular large cell of B lineage, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free survival of 28 months.Conclusion Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women chemotherapy should be considered to preserve fertility, as well as quality of life.     

Primary non-Hodgkin lymphoma of the vagina: case report

The authors consider a rare case of non-Hodgkin primitive lymphoma of the vagina, 1st E stage for Ann Arbor classification. The treatment was primarily chemotherapy, because of the wide extension of the neoplasia and the older patient age, and it was followed by a complete clinical response, still lasting after two years. The results of treatments in the literature are at least examined and discussed.     

An acquired sensation of wide/smooth vagina: a new classification

Objective

To establish a new clinical classification for a wide/smooth vagina.

Study design

A prospective multiple time series clinical study without intervention. Vaginal rugation, and vaginal/perineal site-specific defects associated with wide/smooth vagina were used as basic clinical parameters to establish a new classification. One hundred symptomatic women associated with acquired sensations of wide/smooth vagina were enrolled. Main outcome measures were to establish the absence or presence of vaginal columnar rugae and/or site-specific vaginal/perineal/vaginal orifice defects.

Results

The absence of columnar rugation and the absence of vaginal/perineal site-specific defects were identified in 16 subjects; the absence of columnar rugae and the presence of vaginal/perineal site-specific defects were present in 76 women. The presence of columnar rugae and the presence of vaginal/perineal site-specific defects were demonstrated in 5 subjects; and the presence of columnar rugae and absence of vaginal/perineal site-specific defects were recognized in 3 subjects.

Conclusions

A wide vagina classification was developed as a “Category A, Category B, Category C or Category D”.     

Congenital absence of vagina and uterus

Agenesia of the Müllerian system is a congenital syndrome seldom seen in siblings. This report concerns two sisters with the syndrome. In one of them, the vagina was successfully reconstructed, and the other is awaiting the same operation.