Subcutaneous Sarcoidosis with Plantar Involvement

Sarcoidosis is a multisystem granulomatous disorder of an unknown etiology. Subcutaneous sarcoidosis is a rare manifestation of sarcoidosis, and plantar involvement is extremely rare and there is only one such case report in the medical literature. Herein we present an interesting case of a patient who was diagnosed as having subcutaneous sarcoidosis at a plantar localization because plantar involvement is extremely rare and also because of the successful outcome after performing intralesional corticosteroid therapy.     

Epidermolytic hyperkeratosis and congenital platelike osteoma cutis in a child

Epidermolytic hyperkeratosis is a rare congenital ichthyosis. Platelike osteoma cutis also is a rare diagnosis and is associated with abnormal ossification of cutaneous or subcutaneous tissue. A 17-month-old Hispanic girl presented with a plate of subcutaneous bone since birth as well as considerable scaling and hyperkeratosis centered around the joints. Histologic examination confirmed the diagnosis of both epidermolytic hyperkeratosis and osteoma cutis. Although there have been some cases of epidermolytic hyperkeratosis with other dermatologic conditions, we report a rare case of epidermolytic hyperkeratosis and platelike osteoma cutis.     

Bilateral naevus of OTA

Bilateral naevus of Ota is a rare condition. It is still more rare in males. Here is a report of such a case with review of literature.     

Trichilemmal carcinoma--a rare tumor: case report

Trichilemmal carcinoma is a rare cutaneous cancer that usually occurs on photoexposed areas in elderly individuals. Most of the time, there is a unique lesion that presents a papulonodular aspect with possible keratosis or ulceration on the top of it. We report on a case of this rare tumor, discussing various aspects of this entity and possible therapy. Simple excision with adequate safety margin is a safe, low-cost and effective mode of treatment for this type of carcinoma. Although a rare form of neoplasia, trichilemmal carcinoma has good prognosis when treated correctly.     

Malignant melanoma associated with lichen sclerosus in the vulva of a 10-year-old

Malignant melanoma of the vulva in childhood is a rare neoplasm. Lichen sclerosus of the vulva in childhood is also a rare disease. The association of these two rare lesions in the vulva of young girls is extremely rare. We present a 10-year-old white girl with malignant melanoma associated with lichen sclerosus of the vulva. She had dark pigmentation of both the labia minora and posterior fourchette. The inner labia majora and fourchette showed whitish, glistening areas of skin. Histologic examination found mostly an in situ lentiginous/mucosal melanoma with focal invasion to a depth of 0.44 mm in the left upper labium majus. All specimens showed evidence of lichen sclerosus. Partial vulvectomy was performed, and no metastases were detected at the time of treatment. The patient has been disease free for the 12 months after treatment. It is critical for physicians to realize that melanoma can occur in children, and although rare, can occur in the vulva. We feel that lichen sclerosus in this instance may represent a pattern of host immune response to melanoma.     

Generalized acanthosis nigricans related to type B insulin resistance syndrome: a case report

Acanthosis nigricans (AN) is a cutaneous marker for many underlying states such as endocrine abnormality, obesity, certain drugs, and malignancy. Generalized AN is a rare condition and is commonly seen in adults with an underlying malignancy. The type B insulin resistance syndrome, a rare autoimmune disorder, is caused by the autoantibodies to the insulin receptor. Patients typically present with hyperglycemia but also may present with hypoglycemia. We report a rare case of a 36-year-old man with generalized AN and type B insulin resistance syndrome with hypoglycemia.     

Zinsser-Cole-Engmann syndrome

Zinser-Cole-Engmann syndrome is a rare syndrome characterized by atrophy and pigmentation of skin, nail dystrophy and oral leukoplakia. Here we report a case of this rare entity.     

Bilateral extensive periorbital milia en plaque treated with electrodesiccation

BACKGROUND: Milia en plaque (MEP) is a rare form of milia. Only 25 cases of this rare condition have been reported to date (MEDLINE search). Only one previous case of MEP has been treated with electrodesiccation. OBJECTIVE: To report a new case of this rare condition and present the outcome with electrodesiccation. CONCLUSION: The case is being reported here to highlight the features of this rare but now well-recognized dermatologic condition, which has been reported increasingly in the recent past, to discuss the various treatments tried, and to share our experience of treating patients with the simple, inexpensive, easily available, and nonsophisticated office procedure of electrodesiccation.     

Asymptomatic solitary mass on the sacral region

Nuchal‐type fibroma (NTF) is a rare, benign, tumour‐like fibrous proliferation of unknown pathogenesis. Despite the name, approximately one‐third of cases occur at extranuchal sites. We report a rare case of NTF of the sacral region, an extremely uncommon extranuchal site. As NTF is often misdiagnosed because of its rarity and histopathological similarity with other fibrous tumours, we present this case to increase understanding of this rare disease entity.     

Ichthyosis,petechiae, and arthrogryposis in a neonate

Gaucher disease is a rare lysosomal storage disorder caused by a deficiency in glucocerebrosidase. This enzyme deficiency leads to the accumulation of toxic metabolites in various organs. Multiple subtypes of this disease have been described; however, the perinatal-lethal form is extremely rare and challenging to diagnose. We present a case of a newborn girl with ichthyosis, petechiae, and arthrogryposis, later found to be homozygous for a pathogenic variant of the glucocerebrosidase gene. This case highlights the potential role of dermatologists in the recognition of this rare disease.     

Indeterminate hansen's disease in a patient with hereditary sensory and autonomic neuropathy

Hereditary sensory and autonomic neuropathy (HSAN) is a group of rare hereditary diseases. A young female with Type I HSAN with indeterminate Hansen's disease (HD) is reported which is a rare association.     

Giant superficial basal cell carcinoma of the scrotum

The majority of basal cell carcinomas (BCCs) occur on sun-exposed areas. BCCs arising on the genitalia and ones over 5 cm in size are exceedingly rare. Most of the histopathologic subtypes of giant BCC are micronodular, morpheaform and nodular, but superficial subtype is rare. We reported a very rare case of a giant, scrotal superficial BCC. Scrotal carcinomas, the discovery of which is delayed, may become large. Because giant BCC is potentially life threatening, early diagnosis and adequate treatment are essential to prevent both recurrence and metastasis.     

Tumor in the plantar region: dermatofibrosarcoma protuberans in an infrequent topography

Dermatofibrosarcoma protuberans is a rare mesenchymal tumor; it is locally aggressive and presents high rates of local recurrence. It may present as a nodular or plaque vegetating lesion. It mainly affects the trunk and proximal limbs, being rare in the distal extremities. Biopsy and immunohistochemistry help confirm the diagnosis. The authors report a case of dermatofibrosarcoma protuberans with plantar region involvement, a rare presentation. To the best of the authors’ knowledge, only 11 cases of involvement of the feet were described in the international literature.     

Epidermolysis bullosa simplex with mottled pigmentation

Epidermolysis bullosa is a rare disorder with several variants. Included in this disorder is epidermolysis bullosa with mottled pigmentation (EBS-MP). We report a case of a young child with this rare disorder and explain the genetic cause.     

Folie a deux and delusional disorder by proxy: an atypical presentation

Delusion of parasitosis is a rare condition characterised by an individual harbouring the delusion of being infested with insects or parasites. We report a rare and interesting case of delusion of parasitosis presenting as folie a deux, that is, the delusion is shared by both the parents of an 18‐month‐old child, with proxy projection of parental delusion on the child. The case highlights the rare concomitant occurrence of two psychocutaneous disorders and emphasizes the importance of early recognition and appropriate intervention to safeguard the well‐being of the child.     

Familial Reactive Perforating Collagenosis: A Report of Two Cases

Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which genetically altered collagen is extruded through the epidermis. Of the acquired and inherited form, inherited form is extremely rare. Here, we present two cases of inherited form of RPC in a family.     

Maffucci'S syndrome associated with hyperparathyroidism

Maffucci's syndrome is a rare, congenital, nonhereditary, mesodermal dysplastic disease characterized by venous malformations and benign cartilaginous tumors. The occurrence of endocrine tumors in Maffucci's syndrome is very rare. We report a case of Maffucci's syndrome associated with hyperparathyroidism and multinodular goiter.     

Perianal Paget disease associated with non-invasive colorectal adenoma

Perianal skin Paget disease (PPD) is an unusual subtype of extramammary Paget disease, which is usually caused by a primary intraepithelial adnexal tumor and secondary spread from colorectal adenocarcinoma. The reports of secondary PPD associated with non-invasive colorectal adenoma are rare. We report a rare case of non-invasive colorectal-adenoma-associated PPD. In this case, the intraepithelial Paget cells of perianal skin manifested with colorectal phenotype by immunohistochemistry, and adjacent adenomas had high-grade intraepithelial neoplasia but not invasion. Although this is a rare manifestation of PPD, understanding this phenomenon is important to prevent overdiagnosis and invasive overtreatment. Clinical management is variable and, therefore, close follow-up examination is necessary.     

Olmsted syndrome: report of a new case with unusual features

Olmsted syndrome is a rare disorder characterized by the combination of periorificial keratotic plaques and bilateral palmoplantar keratoderma. New associated features continue to be reported. Olmsted syndrome in a female patient is particularly rare, and we report such a case having a haemangioma in addition to other features of the syndrome.     

Doubled nail of the thumb. A rare form of polydactyly.

Bifid thumb is a rare manifestation of polydactyly. The trait is autosomal dominant, but the expressivity is highly variable. It must be distinguished from apical dystrophy, a rare form of brachydactyly. Severe surgical procedures have been suggested for both functional and cosmetic reasons. Two families affected are described.