Bullous pemphigoid in childhood

Bullous pemphigoid is a rather rare disease in childhood. A case report is given about a seven-year-old girl suffering from juvenile bullous pemphigoid and the differential diagnosis is discussed with regard to the other bullous diseases in children. Some clues were noted in the case history of our patient concerning an effective treatment using erythromycin in bullous pemphigoid. A short summary is presented about the theoretical basis with respect to this therapeutical procedure.     

Bullous pemphigoid in childhood

A young child with clinical presentation and histology like chronic bullous dermatosis of childhood and immunopathology of bullous pemphigoid is being reported to make the readers aware of its existence in Indian population and to stress the importance of immunopathology in bullous disorders of childhood.     

Bullous pemphigoid of childhood: immunofluorescent investigation

A four-month-old Japanese girl with bullous pemphigoid of childhood (BPC) was reported. The characteristics of BPC antigen were studied by immunofluorescent technique using the serum of this patient with variously treated normal human skin as substrate. This study showed that her BPC antigen was quite similar to bullous pemphigoid antigen seen in adult patients and that this BPC antigen was differed from epidermolysis bullosa acquisita (EBA) antigen.     

Bullous pemphigoid in adolescence,a rare demographic

Bullous pemphigoid is rarely seen in adolescence, and its presentation, clinical course, and treatment can differ to that found in other age groups. We present a case of bullous pemphigoid in a 16‐year‐old with features of koebnerisation and oral mucosal involvement and provide a brief review of paediatric bullous pemphigoid.     

Bullous pemphigoid with a prolonged prodrome

Bullous pemphigoid is an autoimmune blistering skin disease of the elderly that may be preceded by a pruritic, urticarial or eczematous eruption. We report a case of bullous pemphigoid preceded by prodromal eczematous eruptions that lasted an unusually long time of 11 years. Elderly patients with persistent pruritic or eczematous eruption of unknown etiology should be carefully followed, as bullous pemphigoid may be a potential diagnosis.     

儿童大疱性类天疱疮

报告1例儿童大疱性类天疱疮.患儿男,18个月.2个月前躯干和双下肢皮肤出现紧张性水疱、大疱,尼氏征阴性,外用糖皮质激素治疗效果不佳.皮损组织病理检查示表皮下水疱;卣接免疫荧光示:lgG、C3沉积于基膜,间接免疫荧光示抗表皮基膜抗体阳性.诊断为儿童大疱性类天疱疮,予以口服泼尼松治疗后痊愈.     

大疱性类天疱疮与瘢痕性类天疱疮

通过大疱性类天疱疮与瘢痕性类天疱疮之间的比较,发现大疱性类天疱疮与瘢痕性类天疱疮之间存在相关性,表现在好发人群均为老年人、存在相同致病抗体、两者可同时合并肿瘤、间接免疫荧光显示致病抗体沉积在表皮侧等方面。近年来生物制剂如抗CD20抗体利妥昔等应用于大疱性类天疱疮与瘢痕性类天疱疮的临床治疗,具有一定疗效。瘢痕性类天疱疮的黏膜受累机制与大疱性类天疱疮180及层粘连蛋白332等自身抗体有关,发病机制尚待进一步研究。     

大疱性类天疱疮合并绒癌1例

患者女性,３８岁,因发现腹部包块５个月,全身皮肤起大疱２个月入院,皮肤科检查可见躯干,四肢大量紧张性水疱,大疱,尼氏征阴性,皮肤组织理学检查可见表皮下水疱形成伴嗜酸性粒细胞浸润,直接免疫荧光可见基底膜带ＩｇＧ和Ｇ３呈线性沉积,间接免疫荧光检查血清抗类天疱疹抗体阴性。盆腔术后病理诊断为绒癌侵及卵巢。     

Bullous pemphigoid, polymyalgia rheumatica and thyroid disease

This paper describes the occurrence of bullous pemphigoid in a 71-year-old female patient who subsequently developed polymyalgia rheumatica and hyperthyroidism. The association of bullous pemphigoid with other autoimmune disorders is discussed.