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1.

Background

Ultrasound and mammography alone may not always identify malignant breast lesions. Samsung Medison has added the Smart detect? (S-detect?) program to its ultrasound features, and this may improve the identification of benign and malignant breast lesions.

Objective

To evaluate the accuracy of S-detect?, a new ultrasound added feature, and to identify benign and malignant breast lesions in women with symptoms or signs of focal breast disease.

Methods

In a pilot study, the registered data of a selected 45 women is retrospectively audited and analyzed. These women, presenting with clinical symptoms of breast disease (diagnostic), were examined by mammography and ultrasound. The interpretation and Hand Held Ultrasound (HHUS) have been done with 2 radiologists determining the BIRADS® classification results for every woman (benign or malignant). In addition, S-detect? was applied during the ultrasound examination, and S-detect? findings (benign or malignant) were recorded in either concordance or discordance with radiologists’ findings. Biopsy was performed as a gold standard.

Results

Among the enrolled 45 women in the study, 33 (73.3%) had concordant results with the radiologists while the remaining 12 (26.6%) were discordant, in 10 (22.2%) of the 12 discordant cases, S-detect? findings of benign contradicted radiologists’ findings and in 2 of the cases, S-detect? findings of malignant contradicted radiologists’ findings. In the 10 discordant cases where S-detect? recommended benign, only 2 were correct, but in the 2 discordant cases where S-detect? recommended malignant, both were correct. The overall accuracy of S-detect? was 82.22%, sensitivity 61.90%, but a specificity was 100%.

Conclusion

The use of S-detect? in this study identified additional cases of malignancy, so this technology may be a useful tool in addition to mammography and US for the diagnosis of breast disease. The specificity of the S-detect? in this study is remarkably high; yet, the sensitivity is low. Despite a small number of cases, we suggest a larger scale study, to validate the clinical utility in using the B-mode plus S-detect? to enhance diagnosis in patients presenting with symptoms and signs of breast diseases.  相似文献   

2.

Purpose

To evaluate the value of dual energy contrast enhanced (DECE) soft tissue digital mammography and ultrasound elastography (UE) in the detection of breast lesions and discrimination between benign and malignant ones.

Patients and methods

32 female patients with breast lesions were prospectively evaluated at the female imaging unit of Diagnostic and Interventional Radiology Department of the National Cancer Institute, Cairo University. Routine sono-mammography was done for each patient then these patients were submitted to DECE soft tissue digital mammography as well as UE.The DECE digital mammography scans were held via GE Senographe 2000D “GE Healthcare; Chalfont St-Giles, UK” FFDM system with some specific software and hardware adaptations.The UE exams were held on ultrasound scanner with elastography unit and 7.5?Mhz linear array electronic probe (Hitachi digital, EUB- 7500; Hitachi medical, Tokyo, Japan).

Results

This study showed that sensitivity and specificity of DECE soft tissue digital mammography and UE were 86.3%, 60% and 80.9%, 40% respectively.

Conclusion

DECE soft tissue digital mammography demonstrated significant increase in the sensitivity without a loss in specificity. DECE soft tissue digital mammography is fast-reproducible imaging tool without operator dependency. DECE soft tissue digital mammography and UE are valuable tools to evaluate equivocal lesions.  相似文献   

3.

Objectives

Unenhanced MR imaging of the breast have recently been introduced. These include STIR, T2-weighted TSE and DWIBS sequences. These sequences could characterize breast lesions, although not yet able to avoid histological characterization.

Materials and methods

The study included 46 patients referred to our radiology department at Ain shams university Hospital from March 2015 till May 2016. Sonomammography was routinely done to all patients. Only 29 patients out of the 46 were included in our MRI study after exclusion of BIRADS I & II patients on sono mammography. Interpretation was performed using an adapted BI-RADS system for both sono mammography results and MRI results. Statistical analysis was performed to show the efficacy of the added DWIBS technique in comparison to DCE-MRI. The final histopathological examination served as gold standard.

Results

By DCE-MRI out of the 29 examined breast lesions, 15 (51.7%) were classified as malignant and 14 (48.3%) were benign. By non contrast study with the addition of DWIBS, patients were classified into16 (55.2%) malignant and 13 (44.8%) benign. Our histopathology results showed 14 (48.3%) malignant and 15 (51.7%) benign lesions. Thus the DWIBS had a sensitivity of 87.5% and a specificity of 86.7% while DCE-MRI had a higher sensitivity: 93.3% and specificity 93.3%.

Conclusion

DWIBS is a promising MRI technique, with a specificity near to DCE-MRI, and a large potential for improving the clinical efficiency of classical MRM.  相似文献   

4.

Objective

To evaluate the accuracy of CESM technique in predicting the final pathological response and residual tumor size post NAC in LABC.

Patients and methods

This study was prospectively carried on 21 female patients diagnosed with stage II and III breast cancer. CESM was done at the end of last cycle of chemotherapy and before definitive surgery.

Results

The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), false negative and false positive of the CESM were assessed by comparing the enhancement of the residual lesions and their size post neoadjuvant chemotherapy (NAC) with the final pathological response and residual tumor size in the MD Anderson system. The specificity of the CESM in predicting the tumor response to NAC in this initial study is 91%, sensitivity was 40% and the NPV and PPV were 80% and 62.5% respectively. The sensitivity of this technique for complete response detection was 100% with a specificity 83% and lowered sensitivity in detecting chemoresistant tumors (33.3%).

Conclusion

CESM is an emerging easy technique that can predict the final pathologic tumor response after NAC especially complete response acting as a good negative technique.  相似文献   

5.

Objective

To detect the diagnostic efficiency of sono elastographic strain ratio in discriminating malignant from benign solid breast masses and compare it with the sono elastographic elasticity score method.

Patients and methods

This study included 120 histopathologically diagnosed solid breast masses from 120 females (mean age 38.2?years). Elastography score and strain ratio (SR) were performed for each mass. Receiver operating characteristic (ROC) curve was plotted for both methods.

Results

The benign lesions had significant lower SR (mean 2.12?±?1.72) than that of malignant lesions (mean 6.91?±?3.96). The AUC from ROC curve was 0.98 for elasticity score and 0.99 for SR. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the elasticity score in the diagnosis of solid breast masses were 100%, 88%, 83.3%, 100% and 92.5% respectively, and of the strain ratio were 93.3%, 97.3%, 95.5%, 96.1% and 95.8% respectively (when cutoff value 3.77 was used). There is no statistically significant difference found between both methods.

Conclusion

SR has high diagnostic performance in differentiating malignant from benign solid breast masses, however there is no statistically significant difference between SR and elasticity score.  相似文献   

6.

Objective

To assess the efficiency of dual energy contrast enhanced mammography in the assessment of the indeterminate breast lesions (BIRADS 3 and BIRADS 4).

Materials and methods

34 female having 39 indeterminate breast lesions (BIRADS 3 and BIRADS 4) by digital mammography were further examined by dual energy contrast enhanced mammography. Two images were acquired at low and high energy in MLO view after 2 min and in CC view at 4 min post iodinated contrast injection (1.5 ml/kg with flow of 4 ml/s). Images were processed to obtain subtracted images to enhance the areas of the contrast uptake.

Results

Results from pathology were detected for all cases. Contrast enhanced digital mammography showed specificity, sensitivity, PPV, NPV, FDR, FPR and accuracy of 93.75%, 91.3%, 88.2%, 95.4%, 11.7%, 8.6% and 92.3% respectively compared to full field digital mammography which were 68.75%, 69.5%, 61.1%, 76.1%, 38.8%, 30% and 69.2% respectively.

Conclusion

Contrast-enhanced digital mammography is a useful tool to be used for breast cancer detection especially in indeterminate lesions (BIRADS 3 and 4).  相似文献   

7.

Objective

The aim of this study was to assess the ability of CT to predict the pathological nature of pancreatic cystic lesions if it is benign, malignant or premalignant.

Methods

This is a retrospective study from the database of our hospital EMR (electronic medical records) for pancreatic lesions from patients who proven to be of pathological cystic nature. The diagnosis and characterization of pancreatic cysts were done by multislice 32 CT examination. We reviewed the data from the radiology, surgery and pathology departments from the period of November 2012 until January 2015. We compared between operative and pathological data and findings of MDCT using chi square test.

Results

We reviewed the data from the radiology, surgery and pathology departments from the period of November 2012 until January 2015. The study was done on 66 patients. Our results showed that CT features for benign cystic lesions are lobulated shape and a thin wall (≤1?mm) while the round or oval shape or a complex cystic shape with tubular cyst and a thick wall (>1?mm) are more frequently seen in pancreatic premalignant and malignant macrocytic lesions.

Conclusion

CT with thin section images allows adequate morphological characterization of macrocytic pancreatic masses that could predict its pathological nature if benign or malignant.  相似文献   

8.

Purpose

To evaluate the role of ultrasound elastography, Doppler and micropure imaging in the assessment of thyroid nodules, using the pathological analysis as the reference standard.

Patients and methods

A prospective study was carried on all patients referred to radio-diagnosis department at Tanta Cancer Centre between November 2015 and November 2016 for evaluation of undiagnosed thyroid nodules. All patients were examined by B-mode ultrasound, color Doppler, micropure imaging and ultrasound elastography. All thyroid nodules were subjected to fine-needle aspiration biopsy.

Results

90 patients (78 women, 12 men) with 159 incompletely diagnosed thyroid nodules. 24 nodules were malignant and 135 nodules were benign, micro calcification was detected by micropure imaging in 40 nodules (29.6%) in the benign thyroid nodules and in 20 nodules (83.3%) in the malignant thyroid nodules (sensitivity 83.3%, specificity 70.4%, and accuracy 84.9%). Color flow Doppler (type III) with marked intranodular and absent or slight perinodular blood flow, was detected in 19 malignant nodules, with sensitivity 79.2%, specificity 95.6%, and the overall accuracy rate was 88.7%. The predictivity of ultrasound elastographic score measurement has high sensitivity 87.5%, and specificity 91.1%, Strain elastography cutoff value for malignant nodules was 2.7 (Sensitivity 83.3% and specificity 91.1%).

Conclusion

Elastography and micropure imaging technique are useful imaging modalities to detect the nature of thyroid nodules. In combination with Doppler and B-mode sonography, they could give a better assessment for undiagnosed thyroid nodules.  相似文献   

9.

Objectives

To assess the role of DW-MRI and ADC values in distinguishing benign from malignant endometrial disorders.

Patients and methods

Pelvic ultrasound, conventional MRI, DW-MRI and histopathologic examinations were done for 42 female patients with abnormal vaginal bleeding. Mean ADC values of endometrial lesions were calculated and compared.

Results

Endometrial malignancies showed significant low ADC values (0.82 + 1.09 × 10?3 mm2/s) compared to benign lesions (1.44 + 0.15 × 10?3 mm2/s) (p: 0.000). Using 1.19 × 10?3 mm2/s as cut-off value for distinguishing malignant from benign lesions achieved 88.9% sensitivity and 100% specificity.

Conclusion

DW-MRI is useful in distinguishing malignant from benign endometrial lesions and tumor staging as well.  相似文献   

10.

Objective

To detect if strain ultrasound elastography and strain ratio have additional value to the conventional grey scale ultrasound in predicting thyroid malignancy.

Patients and methods

This study included 92 thyroid nodules from 62 patients (the mean age was 40.64?±?13.93). Morphologic aspects of the thyroid nodule in conventional grey scale ultrasonography and elastographic examinations with elastography score and strain ratio (SR) were performed for all nodules. The final diagnosis was confirmed by fine needle aspiration biopsies in 72 nodules and by excisional biopsies in 20 nodules.

Results

We found that combination of both conventional ultrasound and strain elastography score have the best diagnostic performance with sensitivity, specificity, PPV, NPV and accuracy accounting for 80%, 97%, 57%, 99% and 96% respectively. The means SR for benign nodules (1.37?±?0.56) was significantly lower than that for malignant nodules (3.0?±?0.71) [p-value .003].The optimal SR cutoff is 2.5 with estimated 80% sensitivity, 98% specificity, PPV 67%, NPV 99% and accuracy 97%.

Conclusion

The clinical application of elastography score and SR should be carried out hand in hand with conventional sonographic assessment of thyroid nodules to achieve the best diagnostic performance.  相似文献   

11.

Objectives

To evaluate the diagnostic accuracy of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in characterization of inconclusive ovarian tumors, with histologic findings as the reference standard.

Patients & methods

DCE-MRI was done in 30 patients with 32 complex ovarian masses, prior to surgical excision. We analyzed the following kinetic parameters: enhancement amplitude (EA) in the form of MRE%, time to peak in the form of T max and maximal slope (MS) and correlated them with histopathology.

Results

DCE-MRI showed higher overall accuracy (96%) and specificity (100%) than conventional MRI. Malignant masses showed higher MRE% than benign (p?=?.004) or borderline masses (p?=?.036). A shorter T max was found in malignant compared to benign (p?=?.0002) and borderline (p?=?.049) masses. MS was best at discrimination between benign, borderline and malignant tumors. Finally, Type III curve showed 100% specificity for invasive malignant tumors.

Conclusion

DCE-MRI sequence is a helpful adjunct to conventional MRI for discrimination of inconclusive ovarian masses into benign, borderline and invasive malignant tumors.  相似文献   

12.

Objective

The aim of this study was to highlight the role of MRI in detecting and diagnosing trigeminal nerve neoplastic lesions.

Patients and methods

56 patients included in our study presented with trigeminal symptoms with or without other neurological symptoms, subjected to conventional MRI sequences and 3D sequences as (CISS) and T1 magnetization-prepared rapid acquisition gradient echo (MP-RAGE). The inclusion criteria included patients with intracranial neoplastic lesions involving the trigeminal nerve and/or its branches.

Results

28 patients met our inclusions criteria and subjected to statistical analysis; 19 patients were females and 9 were males ranging between 15 and 70?years with a mean age of 47.5?years. 14 lesions were benign and 14 were malignant, and were distributed according to final diagnosis as meningiomas (10 cases), lymphoma (6 cases), deposits (4 cases), nasopharyngeal carcinoma (4 cases) schwannoma (3 cases), and neurofibroma (one case). The most frequent involved segments of the trigeminal nerve was simultaneous involvement of both Meckel’s cave and cavernous sinus in nine cases (32%).

Conclusions

MRI is very helpful in demonstrating the whole intra-cranial course of the trigeminal nerve and in diagnosing various neoplastic lesions involving the nerve, and thus providing full roadmap before management.  相似文献   

13.

Aim

To assess the role of DW-MRI and ADC value in evaluation of hepatic focal lesions in cirrhotic patients compared to triphasic CT and dynamic MRI.

Patients and methods

164 cirrhotic patients with hepatic focal lesions were subjected to full clinical examination and laboratory evaluations. DW-MRI with ADC value measurement was done for all patients in addition to triphasic CT and dynamic MRI. The radiological diagnosis was correlated to pathological results in all patients.

Results

164 included cirrhotic patients (312 lesions), their mean age (57.7 ± 3.2). 206 lesions were diagnosed pathologically as malignant; hepatocellular carcinoma was the most common (83%), metastasis (32%) and cholangiocarcinoma (1.5%). 106 lesions were diagnosed pathologically as benign; hemangioma was the most common (61.3%), cirrhotic regeneration nodules (32.1%) and cysts (6.6%). The mean ADC values for malignant lesions were lower than those for benign lesions with significant P-value (0.007) and cutoff value 1.2 × 10?3 mm2/sec. DWI-MRI was more accurate in the assessment of HFLs (96.1% sensitivity, 98.1% specificity and 96.8% accuracy) than triphasic CT and dynamic MRI.

Conclusion

DW-MRI with ADC value can be used in the assessment of HFLs in cirrhotic patients with comparable results to dynamic MRI and more accurate than the use of triphasic CT.  相似文献   

14.

Objective

To assess DWI and ADC value in characterization of orbital masses (differentiation of benign, inflammatory and malignant orbital masses).

Patients & methods

Cross-sectional study included 38 patients, and diagnosed histopathologically, clinically and radiologically 26 with benign and inflammatory masses and 12 with malignant masses. Their ages ranged from 15 to 63 years. They were examined using 1.5 T MR machine.

Results

There was a significant difference in ADC value of malignant and benign orbital masses. Malignant masses have a lower ADC values and restricted diffusion, compared with benign masses. Using 0.93 × 10?3 mm2/s as a cutoff value, in differentiating malignant from benign lesions, resulted in a total of 80% sensitivity, 83.3% specificity and 82% accuracy. Lesions with ADC values less than 0.87 × 10?3 mm2/s, had 90% likely to be of malignant nature. Lesions with ADC greater than 1.1 × 10?3 mm2/s, had 90% likely to be of benign nature. In between these two values, lesions are indeterminate.

Conclusion

Diffusion weighted imaging with ADC value, can help in differentiating malignant from benign orbital masses. Malignant orbital masses have a significant lower ADC value than benign masses. We can use ADC cutoff value between malignant and benign masses.  相似文献   

15.

Aim

To evaluate the role of using a single shot spin echoplanar DW sequence (SSSEP-DWI) compared to conventional MRI and contrast enhanced T1WI in differentiation between vertebral osteoporotic fractures and malignant compression fractures. The sensitivity and specificity of (SSSEP-DWI) will also be calculated.

Patients and methods

Sixty-eight acute vertebral compression fractures in 41 patients were imaged using conventional MRI, fat suppressed contrast enhanced T1WI and DW sequence on a 1.5 T MR machine. Quantitative assessment of the abnormal signal intensity was done by measuring apparent diffusion coefficients (ADCs). Also, the areas of abnormal signal intensity were compared to adjacent normal marrow.

Results

We had 38 benign fractures, and 30 malignant fractures. Post contrast enhancement showed sensitivity of 92% and specificity of 70% for malignant compression fractures. The hyperintense signal on DWI has 89% PPV for malignancy, while the sensitivity and specificity were 86% and 91% respectively. The mean ADC for malignant fractures was significantly lower than those of osteoporotic fractures (p = 0.0002).

Conclusions

SSSEP-DWI is a reliable adjunct parameter that supports conventional MRI in differentiating benign and malignant vertebral fractures.  相似文献   

16.

Purpose

We aimed to assess potential role of strain sonoelastography in diagnosing focal testicular lesions.

Patient & methods

21 patients with 23 focal testicular lesions were subjected to sonoelastography. Compression was performed manually by the transducer upon the testis and monitored on the compression graph on the machine. Diagnosis was reached either by surgical resection, or follow-up.

Result

23 focal testicular lesions were included. 10 lesions were in the right and 9 in the left, and 2 lesions are bilateral. Cases included 7 focal orchitis (30.5%), two hematomas (8.7%), 7 scar tissue (30.5%), 4 seminomas (17.4%), one choriocrcinoma (4.3%), one epidermoid cyst (4.3%), and one hydatid cyst (4.3%). On strain Sonoelastography; all four seminomas and 7 scars were of low strain, also the epidermoid cyst and the two hematomas were hard, while the 7 cases of focal orchitis showed high strain. The cases of choriocarcinoma and the hydatid cyst showed mixed strain patterns. Statistical analyses showed a sensitivity of 100% in identifying neoplastic lesions, with a specificity of 40%, a negative predictive value of 100%, and a positive predictive value of 37.5%.

Conclusion

Strain Sonoelastography is useful adjunct method to differentiate benign from malignant focal testicular lesions.  相似文献   

17.

Background

Diffusion-weighted imaging is a fundamental tool integrated in MR protocols useful in differentiating benign from malignant mediastinal masses, assessing mediastinal lymphadenopathy and investigating central bronchogenic carcinoma. This method is an excellent alternative to CT or PET/CT in the investigation of mediastinal masses. Current applications of diffusion MRI in malignancies include monitoring the treatment response and detecting recurrent cancer.

Aim of the work

This study aims to assess the value of using MRI diffusion in differentiating benign and malignant mediastinal masses, differentiating central masses from post obstructive collapse and differentiating lymphoma versus sarcoidosis.

Patients and methods

This study included 30 patients; 16 males and 14 females in the period from June 2013 to July 2014. The mean age was 49.3 ± 16.85 (range: 22–82 years).Cases were referred for MRI assessment and were approved by the ethical committee in our department.The complaints varied between dyspnea, chest pain, cough, hemoptysis, fatigue and loss of weight. A superconducting 1.5 T MRI machine with a four-channel body phased-array coil was used for the examination. Biopsy and histopathological assessment was done after that.

Results

MRI examination with diffusion imaging was able to differentiate between benign and malignant mediastinal and hilar lesion confirmed by the biopsy and histopathology.

Conclusion

MRI with diffusion weighted images can detect and stage lung cancer, differentiate benign from malignant mediastinal masses and differentiate lymphoma from sarcoidosis in mediastinal/hilar lymphadenopathy.  相似文献   

18.

Background

Ninety percent of hepatic cancers are hepatocellular carcinomas (HCC) which have an unfavorable prognosis. HCC is a hypervascular tumor supplied mainly by the hepatic artery. It has a higher blood supply than the surrounding hepatic tissue due to neovascularization. Computed tomography with perfusion imaging (CTP) is a non invasive tool which quantifies the blood flow parameters of HCC and compares it to the surrounding tissue.

Purpose

To prove that CTP is a valuable diagnostic tool in diagnosis of HCC and posttherapeutic assessment.

Patients and methods

One hundred and twenty-six HCC patients with 150 focal lesions are enrolled this study. Perfusion parameters are quantified and results are compared to those of triphasic CT.

Results

CTP detected 141 lesions with 94% sensitivity and 40% specificity with elevated arterial perfusion (AP) and perfusion index (PI) with low portal flow (PF). It missed 5 lesions because of their hypovascularity and 4 lesions following radiofrequency ablation (RFA) and trans arterial chemo embolization (TACE).

Conclusion

CTP is a safe and specific imaging tool for diagnosis and assessment of therapeutic interventional procedures in HCC.  相似文献   

19.

Objective

Assessing the role of MSCT compared to TTE in pediatric patients with congenital heart diseases especially the thoracic congenital vascular anomalies.

Methods

54 pediatric patients underwent a 128 detectors computed tomography cardiac angiography with retrospective ECG-gating. Images were reviewed based on segmental approach using the operative data (35/54 patients) or cardiac catheterization (19/54 patients) findings as reference standard. Sensitivity, specificity, positive and negative predictive values and accuracy of TTE and MDCT were evaluated.

Results

MDCT was superior to TTE in evaluating vascular lesions (aortic, conotruncal, coronary artery, major aorto-pulmonary collaterals, patent ductus arteriosus, venous anomalies and postoperative complications) as well as pulmonary lesions; while TTE was superior in intracardiac anomalies with equal performance in (pulmonary artery anomalies, concordance and valvular atresia). MDCT achieved (100%, 96.3% and 87%) accuracies compared to TTE (94.4%, 85.2% & 96.3%) for delineating isolated vascular anomalies, complex vascular anomalies and intracardiac anomalies respectively.

Conclusion

The main added value of cardiac MDCT to TTE is the precise illustration of the extracardiac anatomic structures, without adding significant information on intracardiac abnormalities. Using MDCT with TTE has improved the diagnostic accuracy thus obviating the need for diagnostic cardiac catheterization especially in critically ill patients.  相似文献   

20.

Purpose

Evaluation of the role of real-time elastography in differentiating between benign and malignant cervical lymph nodes (LNs), comparison with B-mode and Doppler Ultrasonography.

Patients and methods

This prospective study included 30 patients, with cervical lymphadenopathy, their age ranged from (18–79 years). The total number of the examined lymph nodes (LNs) was 75 LNs. These (LNs) subjected to B-mode US followed by Doppler evaluation, then elastographic evaluation including strain ratio which was calculated for each lesion, and compared with the histological results after fine needle aspiration cytology.

Results

We evaluate the size, shape, echogenicity, and hilum on the B-mode images. The presence of the hilum showed the highest accuracy & sensitivity. Doppler Ultrasonography evaluation of nodal vascular pattern was of high sensitivity & specificity. The calculated sensitivity of elastographic pattern and scoring was 86%, specificity was 100%, PPV and NPV were 100% and 78.1% respectively, and the total accuracy was 90%. The mean elastographic strain ratio for malignant LNs (3.4 ± 1.2) was significantly greater than that for benign LNs (mean, 1.2 ± 0.3).

Conclusion

Elastography is a promising improvement for differentiation between benign and malignant cervical lymphadenopathy. Sensitivity and specificity of elastography increased especially if combined with gray scale US and Doppler US.  相似文献   

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