Thoracic Aortic Aneurysm Presenting as Pulmonary Vein Stenosis

We present the case of a 66-year-old woman presenting with pulmonary vein stenosis with a large descending thoracic aortic aneurysm. Pulmonary vein stenosis is a rare condition and can be caused by extrinsic compression, as well as by inflammatory diseases, congenital anomalies and related surgical repair, tuberculosis, and pulmonary veno-occlusive disease. With obstruction to pulmonary vein flow, the velocity increases and becomes continuous. The finding of turbulent antegrade flow in the left atrium through the use of transthoracic color flow Doppler and pulsed-Doppler warrants further investigation to evaluate known causes of pulmonary vein stenosis. We believe this is the first reported case of a patient with an aortic aneurysm causing pulmonary vein stenosis.     

Detection of Abdominal Aortic Aneurysm During Routine Echocardiography

Objective: To determine the feasibility of detecting abdominal aortic aneurysms (AAAs) in the elderly by adding abdominal screening to a standard echocardiographic study. Methods: Prospective consecutive screening was performed on 250 patients (men over 55 years and women over 65 years) referred for standard echocardiography. After completion of the standard echocardiographic exam, abdominal aortic diameter was measured using the echocardiographic transducer. Results: Adequate aortic images were obtained in 216 patients. Thirteen aneurysms (ranging from 3.3–6.6 cm in diameter, nearly equally divided between men and women) were found. Conclusions: Screening of the abdomen in elderly men and women presenting for echocardiographic examination results in a significant yield of AAAs. This simple procedure should be added to the standard echocardiographic examination in the older population.     

Obstruction of Left Atrial Filling by a Large Descending Thoracic Aortic Aneurysm Detected by Pulsed Doppler Echocardiography

We describe the echocardiographic findings of extrinsic compression of the left atrium by a large aneurysm of the descending aorta. Pulsed Doppler echocardiography demonstrated increased velocity at the junction of left atrium and pulmonary vein suggesting obstruction of left atrial filling.     

Diagnosis of Contained Aortic Rupture by Transesophageal Echocardiography

Hematogenous seeding is the most common mechanism for the development of peripheral arterial infections. Echocardiography, and especially transesophageal echocardiography, has played an increasingly important role in the diagnosis of aortic pathology. Rupture of an aortic aneurysm is difficult to diagnose antemortem, and requires a high index of suspicion and a rapid diagnosis if surgery is to be beneficial. We present a case of a ruptured aortic aneurysm secondary to seeding from B. fragilis bacteremia suspected by transesophageal echocardiography and confirmed by surgical exploration. The two-dimensional echocardiographic and color flow Doppler findings are described and differentiated from those seen in an aortic dissection.     

胸主动脉病变术中应用经食管超声心动图的初步探讨

目的：探讨胸主动脉疾病的术中应用经食管超声心动图（ＴＥＥ）的价值及适应证。方法：本文报道８例（１５～６３岁，平均年龄４４．５岁）不同类型胸主动脉疾病术中ＴＥＥ监测结果。病例包括先天性主动脉瓣上狭窄、升主动脉瘤、主动脉夹层及主动脉夹层伴假性动脉瘤、胸降主动脉假性动脉瘤、主动脉瓣脱垂等。结果：８例患者的术中检查与术前诊断全部吻合。术中ＴＥＥ发现１例主动脉夹层累及左锁骨下动脉，而术前磁共振成像未能提示。此外，术中ＴＥＥ还显示２例胸降主动脉内的粥样硬化斑块。结论：初步显示术中ＴＥＥ可即刻评价手术效果，对拟行主动脉瓣成形术的患者最有价值；为避免升主动脉粥样斑块的脱落导致术后体循环尤其是脑栓塞，对于高龄患者也积极提倡术中ＴＥＥ监测。     

Multimodality Imaging of Thoracic Aortic Diseases in Adults

In diagnosing and following patients with acute aortic syndromes and thoracic aortic aneurysms, high-quality imaging of the thoracic aorta is indispensable. Mainstay modalities for thoracic aortic imaging are echocardiography, computed tomographic angiography, and magnetic resonance angiography. For any given clinical scenario, the imaging modality and protocol chosen will have a significant impact on sensitivity and specificity for the aortic diagnosis of concern. Imaging can also provide important ancillary information regarding myocardial performance, aortic valve morphology and function, and end-organ perfusion. Surveillance of patients following thoracic aortic surgery with serial imaging studies can identify complications that may require reintervention, and imaging has played an integral role in development of new surgical and interventional methods. Emerging techniques in thoracic aortic imaging include positron emission tomography, which addresses vessel wall inflammation, and 4-dimensional magnetic resonance angiography, which illustrates flow dynamics.     

Live/Real Time Three‐Dimensional Transthoracic Echocardiography in the Evaluation of Post Traumatic Acquired Thoracic Aortic Coarctation

We report a young patient with post traumatic acquired thoracic aortic coarctation in whom three‐dimensional transthoracic echocardiography (3DTTE) demonstrated incremental value over two‐dimensional transthoracic echocardiography (2DTTE). 3DTTE showed (1) en face views of the obstruction site that showed a markedly narrowed, roughly circular orifice measuring 0.33 cm² in area, (2) echogenic tissue encroaching on the graft lumen consistent with fibrosis/thrombus, and (3) no graft protrusion into the aortic lumen, only hypermobility of the medial portion of the graft. These important findings were not detected by 2DTTE. (Echocardiography 2010;27:470‐472)     

腔内隔绝术治疗胸主动脉夹层动脉瘤

近年来兴起的腔内隔绝术,在治疗胸主动脉夹层动脉瘤中取得了令人满意的临床疗效。初步研究表明腔内隔绝术具有微创、简便、安全有效、并发症少、术后恢复快的优点。     

Thoracic Aortic Disease: Endovascular Stents

Aortic disease is a serious, often life-threatening condition. The keys to instituting appropriate therapy in diseases of the aorta include accurate and rapid diagnosis and anatomical assessment. Endovascular aortic repair is a new alternative to conventional surgical approaches. Because arterial rupture is a risk of this procedure, appropriate facilities for resuscitation must be present during the procedure. This paper reviews the important aspects of aortic anatomy, echocardiographic imaging of the thoracic aorta, aortic pathology, endovascular surgery, and the role of echocardiography in the evaluation of the surgical outcome.     

Routine Screening for Abdominal Aortic Aneurysm during Clinical Transthoracic Echocardiography in a Korean Population

Background: An abdominal aortic aneurysm (AAA) is potentially fatal when ruptured. Whereas the transthoracic echocardiography (TTE) protocol does not routinely include examination of the infrarenal abdominal aorta, the protocol is performed quickly and easily for AAA screening. Aim: The aim of this study was to evaluate the clinical utility of the protocol for AAA screening during TTE in a Korean population referred for clinical TTE. Methods: All of the patients who were scheduled for TTE were enrolled in the study. At the end of TTE protocol, the abdominal aorta was evaluated at the level below the renal artery origin. Results: A total of 6,267 patients were screened, and the abdominal aortas were visualized in 79% (4,939 patients) of patients screened. AAA was diagnosed in 27 patients, 23 of whom were male. The mean age of AAA patients was 66.5 years old, and 81% of AAA patients were over 60 years old. The presence of AAA was associated with male gender and older age, as well as with hypertension and smoking. Of the 27 patients, 11 patients (0.2% of the study population) did not have a history of AAA screening and were newly diagnosed by TTE. Conclusions: Screening of AAA during TTE is easy and feasible. Even though the prevalence of AAA in patients is very low, detection of asymptomatic AAA may save lives. Therefore, opportunistic examination of the abdominal aorta during routine TTE, which involves little time and cost, would appear to be effective, at least in patients over 60 years of age, especially in men. (Echocardiography 2010;27:1182‐1187)     

Mediastinal Tumor Presenting as Expanding Aortic Aneurysm Diagnosed by Transesophageal Echocardiography

This article describes a patient with suspected expanding ascending aortic aneurysm in whom trans-esophageal echocardiography appropriately determined the presence of a mediastinal soft tissue mass and visualized compression of the superior vena cava.     

Prevalence of Intracranial Aneurysms in Patients with Infrarenal Abdominal Aortic Aneurysms: A Multicenter Experience

Prior studies suggest high prevalence of intracranial aneurysms (IA) in patients with infrarenal abdominal aortic aneurysms (AAA). We reviewed our multicenter experience in clinical detection/treatment of IAs in AAA patients and estimated the risk of IA in patients with AAA relative to patients without AAA. We reviewed cases of vascular surgery infrarenal AAA repairs at three Mayo Clinic sites from January 1998 to December 2018. Concurrent controls were randomly matched in a 1:1 ratio by age, sex, smoking history, and head imaging characteristics. Conditional logistic regression was used to calculate odds ratios. We reviewed 2,300 infrarenal AAA repairs. Mean size of AAA at repair was 56.9 ± 11.4 mm; mean age at repair, 75.8 ± 8.0 years. 87.5% of the cases ( n = 2014) were men. Head imaging was available in 421 patients. Thirty-seven patients were found to have 45 IAs for a prevalence of 8.8%. Mean size of IA was 4.6 ± 3.5 mm; mean age at IA detection, 72.0 ± 10.8 years. Thirty (81%) out of 37 patients were men. Six patients underwent treatment for IA: four for ruptured IAs and two for unruptured IAs. All were diagnosed before AAA repair. Treatment included five clippings and one coil-assisted stenting. Time from IA diagnosis to AAA repair was 16.4 ± 11.0 years. Two of these patients presented with ruptured AAA, one with successful repair and a second one that resulted in death. Odds of IA were higher for patients with AAA versus those without AAA (8.8% [37/421] vs. 3.1% [13/421]; OR 3.18; 95% confidence interval, 1.62–6.27, p < 0.001). Co-prevalence of IA among patients with AAA was 8.8% and is more than three times the rate seen in patients without AAA. All IAs were diagnosed prior to AAA repair. Surveillance for AAA after IA treatment could have prevented two AAA ruptures and one death.     

小腹主动脉瘤的内科治疗

腹主动脉瘤破裂是一常见的致死性疾病。现代指南主张动脉瘤体直径≥5.0 cm者进行修复手术。但扫描发现绝大多数腹主动脉瘤是无症状的小腹主动脉瘤(<5.0 cm)。我们回顾有关小腹主动脉瘤的进展观察,影响小腹主动脉瘤进展的因素,特别是对小腹主动脉瘤内科治疗的研究。     

Transesophageal Echocardiography in Thoracic Aortic Atherosclerosis

Transesophageal echocardiography opened a new window to the thoracic aorta and for the first time permitted in vivo imaging of aortic atherosclerotic disease. The technique is useful in assessing the extent of the disorder, its complications, and possible treatment modalities. It will also be useful in the assessment of the progression as well as the possible regression of the disorder with appropriate (dietary or chemical) therapy.     

Inflammatory Thoracic Aortic Aneurysm in a Patient with Advanced Lung Adenocarcinoma Treated with Pembrolizumab

A 57-year-old man with lung adenocarcinoma was treated with chemotherapy and immune checkpoint blockade. After two cycles of carboplatin, pemetrexed, and pembrolizumab, he developed a persistent fever. Chest computed tomography (CT) suggested inflammation of the aortic wall. We treated the patient with corticosteroids. After four cycles of carboplatin, pemetrexed, and pembrolizumab, chest CT showed an aneurysm in the ascending aorta. We diagnosed him with inflammatory thoracic aortic aneurysm induced by pembrolizumab and performed surgical replacement of the ascending aorta. Although this might be a very rare case, we should be aware of aortitis as a potential adverse effect of pembrolizumab.