高同型半胱氨酸血症与疾病发生相关性的研究现状

同型半胱氨酸(Hcy)是蛋氨酸的中间代谢产物,蛋氨酸来源于食物蛋白中基本的含硫氨基酸,叶酸、维生素B6及维生素B12是Hcy代谢过程中重要的辅助成分.Hcy代谢异常使血浆Hcy升高,可导致高同型半胱氨酸血症(hHcy)的发生.其与多种疾病的发生有密切的联系,现综述如下.     

高同型半胱氨酸血症与脑梗塞的相关性分析

目的:对高同型半胱氨酸血症与脑梗塞的相关关系进行探讨,以期为防治脑梗塞提供新的思路。方法:将急性脑梗塞患者分为首发性脑梗塞组(FCI组)和复发性脑梗塞组(RCI组),与健康者(对照组)对照研究空腹血浆同型半胱氨酸(t Hcy)水平。结果:空腹血浆t Hcy水平RCI组高于FCI组,FCI组高于对照组,差异有统计学意义(P<0.05)。RCI组HHcy发生率高于FCI组,但差异无统计学意义(P>0.05);二者的HHcy发生率均高于对照组,差异有统计学意义(P<0.05)。结论:HHcy与脑梗塞关系密切,可能为其独立的一个危险因素。     

高同型半胱氨酸血症与眩晕

眩晕是临床的常见症状,可因为由于同型半胱氨酸在体内蓄积造成的高同型半胱氨酸血症引发。通过对高同型半胱氨酸血症的干预治疗,可以缓解头晕症状,为临床治疗眩晕提供新的思路。     

高同型半胱氨酸血症与高血压、冠心病相关性研究

目的 探讨高同型半胱氨酸血症与高血压、冠心病的相关性.方法 选取2011 年1 月-2013 年1 月诊治的高血压患者152 例为A 组,选取同期冠心病患者147 例为B 组,选取同期高血压合并冠心病患者143 例为C 组,选取同期健康体检人员151 名为对照组（D 组）.均行同型半胱氨酸检测、血压检查、心功能指标检查、B 型脑钠肽检测,分析高同型半胱氨酸血症与高血压、冠心病的相关性.结果 A 组舒张压、收缩压、同型半胱氨酸均明显高于对照组,A 组左室射血分数明显低于对照组.C 组舒张压、收缩压明显高于对照组和B 组,C 组同型半胱氨酸、B 型脑钠肽均明显高于对照组、A 组、B 组,C 组左室舒张末期内径明显高于对照组和A 组,C 组左室射血分数明显低于对照组、A 组、B 组,差异均有统计学意义（P 〈0.05）.结论 高同型半胱氨酸血症与高血压、冠心病均存在明显的正相关性,同型半胱氨酸可作为高血压、冠心病的有效检测指标.     

高同型半胱氨酸血症与视网膜微血管疾病的相关性研究

近年来,血浆同型半胱氨酸(homocysteine hcy)水平升高与视网膜微血管疾病的研究受到广泛关注,并成为视网膜微血管疾病的一个危险因素.其作用机制亦渐受重视.     

高同型半胱氨酸血症和缺血性中风相关性的研究进展

<正>同型半胱氨酸(Homocysteine,Hcy)是一种体内不能合成的含硫四碳氨基酸,其既是蛋氨酸循环的正常代谢产物,也是能量代谢和甲硫氨酸代谢障碍的重要产物。高同型半胱氨酸血症是指血浆或血清中的同型半胱氨酸升高的一种疾病。近年来,随着研究的深入,高同型半胱氨酸(High homocysteine,Hhcy)作为心脑血管病的独立危险因素^[1],越来越受到众多学者的重视,而大量的研究结果表明Hhcy血症与缺血性中风密切相关。本文就近年来对高同型半胱氨酸血症与缺血性中风的相关性研究所取得的最新进展作一综述,以便更好地服务与指导临床。     

高同型半胱氨酸血症中西医研究进展

高同型半胱氨酸血症是脑卒中、冠心病等缺血性血管疾病的独立危险因素。现代医学认为同型半胱氨酸（Hcy）是蛋氨酸的代谢产物,血浆Hcy浓度受到遗传缺陷、营养障碍、性别与年龄、药物等因素的影响,其致病机制主要表现在对血管内皮细胞的毒性作用,促使血管平滑肌细胞增殖,影响血小板功能,影响纤溶系统等方面。本症主要涉及中医“中风”、“胸痹”、“痴呆”、“消渴”等病范畴,与痰、瘀密切相关,中药对本症有较好的治疗作用。     

高同型半胱氨酸血症与高血压病相关性研究进展

同型半胱氨酸是蛋氨酸代谢的重要中间产物,其代谢异常所致的高同型半胱氨酸作为心脑血管病独立危险因素,越来越受到重视,而其与高血压病相互协同,使患病风险性明显增大,从而提出了H型高血压的概念。现介绍了两者的相互关系及中西医治疗方面的研究进展。     

高同型半胱氨酸血症与缺血性脑卒中关系探讨

急性脑血管病（脑卒中）是严重危害人类健康的疾病,是造成人类死亡的三大疾病之一,是导致机体瘫痪的主要原因,其中缺血性脑卒中占70％～80％。据统计,我国脑卒中每年新发病例约150～200万,在一些发达城市脑卒中死亡率达到第1位,是成人最常见的致死或致残原因之一。随着人口老龄化及人们生活水平的提高、生活节奏的不断加快,脑血管病的发病年龄逐渐提前,发病率逐年上升,     

糖尿病大鼠高同型半胱氨酸血症模型研究

目的探讨糖尿病大鼠高同型半胱氨酸(hcy)血症模型的建立。方法SD大鼠禁食不禁水14~18 h后以60 mg/kg的剂量腹腔注射1%链脲佐菌素,72 h后断尾取血测随机血糖,血糖大于16.7 mmol/L者为糖尿病模型造模成功,将糖尿病大鼠筛选按血糖随机分为模型组和空白组,模型组以1%高蛋氨酸饲料喂养,正常组和空白组以普通饲料喂养,共计1个月。结果hcy水平各组间比较均有显著性差异(P<0.05)。结论给予链脲佐菌素诱导的糖尿病大鼠1%高蛋氨酸饲料喂养1个月可以诱发高蛋氨酸血症。     

高同型半胱氨酸血症与重症脑卒中的关系及维生素干预治疗

目的：研究重症脑卒中（急性重症脑梗塞与脑出血）和高同型半胱氨酸（Homocystoine，Hey）血症的关系及维生素干预治疗的必要性。方法对50例重症脑卒中患者与50例轻疰脑卒中患者进行血清同型半胱氨酸测定，对重症组与轻症组两组病人进行比较。结果发现重症组Hcy水平与轻症组Hcy水平有明显差异（P〈0．05）。但重症组与轻症组在年龄、TC、GLU方面在统计学上无明显差异。结论重症脑卒中患者的血清同型半胱氨酸水平明显高于轻症脑卒中组。但重症脑卒中组与轻症组患者的甘油三脂在统计学上有差异，即重症组低于轻症组，而血脂增高艾是心脑血管病的危险因素，更说明高同型半胱氨酸血症的危害性，因此对患者高Hcy血症的干预治疗对其生存期及预后有重要作用。     

Effects of ephedra on autonomic nervous modulation in healthy young adults

Aim of the study

Given the popularity of the use of ephedra in traditional Chinese medicine around the world, a greater understanding of its actions is required. This study aims to assess the effects of ephedra on autonomic nervous modulation using power spectral analysis of heart rate variability (HRV).

Methods

This was a randomized, double-blind, placebo-controlled, crossover study. Twenty healthy subjects were given 1 g of ephedra dry extract or placebo once per day for 14 days in a crossover fashion with a 7-day washout period between treatments. Sequential HRV measures at baseline and at 30, 60, 120, and 180 min after taking ephedra or the placebo on days 1 and 14 were obtained and compared. In addition, the baseline HRV measurements on days 1, 3, 7, 10, and 14 were also obtained and compared.

Results

The normalized low-frequency component (LF%) and the low/high-frequency component ratio (LF/HF) of the HRV were significantly increased, whereas the high-frequency component (HF) and normalized HF (HF%) were significantly decreased at 120 and 180 min after taking ephedra on days 1 and 14. In addition, the baseline LF% and LF/HF were significantly increased, whereas the baseline HF% was significantly decreased on days 10 and 14, as compared to day 1.

Conclusions

By power spectral analysis of the HRV of healthy young adults, it is suggested that ingestion of ephedra dry extract acutely and chronically affects autonomic nervous activity by tilting the sympathovagal balance toward increased sympathetic activity, whereas parasympathetic activity was impaired.     

Qi-training enhances respiratory burst function and adhesive capacity of neutrophils in young adults: a preliminary study

The main objective of this study is to examine the effect of Qi-training on the immune system, especially neutrophil bactericidal function. Nine healthy male subjects were studied for the effects of one bout of ChunDoSunBup (CDSB) Qi-training on superoxide (O2- production and adhesion capacity of neutrophils at times immediately after (Post I) and 2 hours after the Qi-training (Post II). The Qi-training enhanced O2- production, reaction velocity and neutrophil adhesion capacity and there were significant differences at Post I compared to before Qi-training (Pre). In addition, the number of white blood cells (WBC), monocytes and lymphocytes were changed significantly through Qi-training.Therefore, it seems that CDSB Qi-training may increase the resistance of trained individuals against common infection and inflammation.     

Clinical study on acupuncture and ischemic stroke

目的：观察针刺治疗缺血性中风的临床疗效及其对血浆内皮素1的影响。方法：将63例患者按随机数字表分为2组,治疗组31例,对照组32例。治疗组用针刺加内科一般治疗,对照组用内科一般治疗。7天为1个疗程,疗程间休息2天,治疗4星期后评定两组患者临床疗效,并比较治疗前后血浆内皮素1的变化。结果：治疗组总有效率96．8％,对照组为75％,两组比较差异有统计学意义（P〈0．05）;治疗后两组血浆内皮素1差异有统计学意义（P〈0．05）;本组治疗前、后血浆内皮素1比较,治疗组差异有统计学意义（P〈0．01）,对照组无差异。结论：针刺治疗缺血性中风患者有较好临床疗效,并能降低缺血性中风患者血浆内皮素l水平。     

二陈丸治疗高同型半胱氨酸血症脑梗死疗效观察

目的观察二陈丸治疗高同型半胱氨酸血症脑梗死患者的临床疗效。方法将62例高同型半胱氨酸血症脑梗死患者随机分为2组,对照组31例给予叶酸片、维生素B6及维生素B12口服治疗,治疗组31例在此基础上加用二陈丸口服,2组疗程均为1个月。观察2组治疗前后血生化指标(Hb、AST、Cr、血糖)、血浆内皮素-1(ET-1)、同型半胱氨酸(Hcy)、血管内皮功能变化情况以及临床疗效。结果 2组治疗前后血生化指标比较差异无统计学意义(P均0.05)。治疗后,治疗组ET-1、Hcy较对照组明显改善,差异均有统计学意义(P均0.01)。治疗组总有效率明显高于对照组(P0.05)。结论二陈丸治疗高同型半胱氨酸血症脑梗死效果确切,能有效降低ET-1和Hcy水平,减轻血管内皮功能损害,改善患者的预后,值得临床推广应用。     

针刺在刚果金治疗脑中风的临床研究(英文)

目的:观察应用通络豁痰针刺法在刚果金治疗脑中风的临床疗效。方法:将刚果(金)金沙萨中刚友谊医院就诊的脑中风患者随机分为针刺组和药物组,每组30例。针刺组在每日静脉点滴脉络宁注射液的基础上加用针刺疗法,取穴四神聪、中脘、丰隆、内关等,每日治疗1次,10 d为1个疗程;药物组采用每日静脉点滴脉络宁注射液20 mL或低分子右旋糖酐500 mL,10 d为1个疗程。两组均治疗3个疗程后进行临床疗效评定。结果:治疗后两组患者的神经功能评分均较治疗前下降(均P<0.05);与药物组相比,针刺组神经功能评分下降更明显(P<0.05)。针刺组总有效率为93.3 %(28/30),优于药物组的80.0 %(24/30),差异有统计学意义(P<0.05)。结论:通络豁痰针刺法治疗脑中风临床疗效显著。     

中医介入治疗中风恢复期及后遗症期临床研究

脑卒中是一种致残率极高的常见病,发病年龄多为40岁以上的中老年人,加强脑卒中病的综合治疗,有助于患者的功能恢复和提高患者的生存和生活质量。针对中风病恢复期及后遗症期的病理特点,充分发挥中医药的治疗优势,通过以中药内服为主,针灸、按摩、功能锻炼为辅的综合治疗,使中风患者康复水平得到了提高。     

中风病的临床防治探讨

目的：探讨中风病的临床防治。方法：了解中风病的两种类型,缺血性脑卒中和出血性脑卒中。结果：一位病患,辨证为肝阳上亢风火上扰之中风,给予平肝泻火通络的药物加之生大黄、车前子研磨冲服治疗10d,诸症均好转。     

针灸治疗中风的疗效研究

目的：观察针灸疗法治疗中风偏瘫的临床疗效.方法：对40例中风患者采用针灸疗法30天.结果：治疗组有效率达95%.结论：针灸治疗从整体着手,在改善中风偏瘫患者临床神经功能缺损方面较单纯康复疗效更加显著.     

~1H nuclear magnetic resonance-based metabolomic study on efficacy of Qingrehuatan decoction against abundant phlegm-heat syndrome in young adults with essential hypertension

OBJECTIVE: To observe the influence of Qingrehuatan decoction(QRHT) on serum metabolic profile in young essential hypertension(YEH) patients with abundant phlegm-heat syndrome and provide a basis for treatment with the decoction.METHODS: Twelve male YEH patients were randomly selected and serum samples were collected for examination before and after 4 weeks of thetreatment with QRHT. Twelve healthy males were randomly selected and their serum samples were collected as a control. All serum samples were detected using metabolomic technology with1 H nuclear magnetic resonance. Differences in metabolites were studied by principal component analysis and partial least squares-discriminate analysis,which produced scores and loadings plots.RESULTS: After 4 weeks of treatment, serum substances could be distinguished between the YEH patients with abundant phlegm-heat syndrome and the control patients. The specific serum endogenous metabolites tended to improve after the treatment. QRHT can appropriately increase the levels of glucose, lactic acid, citric acid, high-density lipoprotein, phosphatidylcholine, glycerophosphate choline, hydroxybutyrate, alanine, and glutamate.QRHT could also decrease the levels of low-density lipoprotein/very low-density lipoprotein, lipids,N-acetyl glycoprotein, and O-acetyl glycoprotein.CONCLUSION: QRHT can effectively ameliorate metabolic disorders in YEH Patients with abundant phlegm- heat syndrome.1H NMR-based metabolomic technology can provide an objective basis for the treatment of YEH patients with abundant phlegm-heat syndrome using QRHT.