内关,心俞与心脏相关的神经基础

应用辣根过氧化物酶（ＨＲＰ）法和荧光素双标记法，研究了家兔心脏与心俞穴、内关穴的外周神经联系，结果提示心脏和心俞穴、内关穴除通过中枢途径联系外，心俞穴和心脏可通过外周突分支投射的感觉神经元直接联系；支配心脏和内关穴的交感节后神经元之间，可能还存在直接或间接联系，此结果为穴位一内脏相关的机理提供了形态学证据。     

内关,公孙配伍相关性的神经解剖学研究

目的　对内关、公孙配伍机理及两穴配伍应用能调节胃等内脏功能,从神经解剖学角度进行探讨。方法　运用ＣＢ－ＨＲＰ神经示踪法。结果　两穴配伍应用可使相应的感觉神经元和运动神经元阳性标记细胞,在数量上增多和节段性分布扩大;阳性运动神经元树突皆向第Ⅶ、Ⅵ、Ⅴ层特异性延伸;能使在孤束核、腹腔神经节和背根神经节的阳性标记细胞明显减少。结论　提示内关、公孙配伍应用,其针刺信息在脊髓内经中间内、外侧核的神经元纤维感传至相应脊髓节段,再分别通过与交感神经、副交感神经形成突触联系,形成两穴配伍在脊髓层次的协同增效关系。同时通过两穴在脊髓内相应神经元向孤束核的投射纤维产生突触联系,实现对胃等内脏传入信息在脊髓和孤束核水平的调节整合作用     

前苏联针灸治疗神经,精神科疾病的临床研究

本文收集前苏联临床针灸治疗神经、精神科疾病的近况,简述如下,供参考。一、脑部疾病等观察因低血压引起的神经循环张力障碍患者64例。临床采用针刺与药物疗法相结合。针刺主穴:合谷、曲池、三阴交、浮郄肩髎、中府、照海;配穴:内关、劳宫、中冲、列缺、太渊、中渚、外关、厉兑、本神、阳白、大赫、角孙、少冲、风池、公孙、孔最。耳针取有益于神经系统的大脑周围皮层、肾、肾上腺、心、卵巢和睾丸穴。针刺一次取穴4～8个,每穴刺激5～7min,一个疗程10～15次,每日一次,而后根据疾病改善情况隔天一次。治疗中所有患者同时进行药物疗法(刺五加、白刺、漏卢根茎、维生素制剂等)。作者认为针刺综合疗法治疗此类病症有明显疗效。等采用针刺疗法治疗大脑器质性疾病患者156例。主要病症为脑蛛网膜炎、扩散性(大)脑炎、脑中风后遗症等。针刺以电刺激为     

Journal of Acupuncture and Tuina Science by the editorial department of Shanghai Journal of Acupuncture and Moxibustion, bimonthly,64 pages,USD 10,00 Abstracts,April,2003

Analysis of the Characteristics of Diarrhea by Acupunc-ture Treatm ent in Ancient Times,by L IU L i- gong et al:The data concerning the treatment of diarrhea byacupuncture in 6 2 ancient books are computerized andthus show that the ancient acupuncturists …     

Journal of Acupuncture and Tuina Science by the editorial department of Shanghai Journal of Acupuncture and Moxibustion,bimonthly,64 pages,USD 10,00 Abstracts,February, 2003

Characteristics of Acupuncture Treatment of Dementia inAncient Times,by L IU L i- gong et al:This paper m akesa statistical analysis on the acupuncture treatm ent of de-m entia recorded in 93ancient books. The statistics showthat the comm on acupoints are…     

足三里穴与胫前动脉,腓深神经及胫神经的定位关系

目的：为了足三里穴位注射时，避免对胫前动脉，胫神经，腓深神经的损伤，方法：解剖７０例成人下肢。结果：足三里穴直刺进针时，针体由皮肤穿及骨间膜的深度为２．２２±０．３１ｃｍ，针体由皮肤穿达胫骨后肌后缘的深度为４．４２±０．５３ｃｍ。胫骨后肌的后后需针体深方是含有胫神经，胫后血管的血管神经束。     

An ethnobotanical study of the traditional medicine of the Mestizo people of Suni Miraño,Loreto, Peru

Research on the ethnobotany of Mestizos in Suni Miraño in 1994 documented 60 plant species used for medicinal purposes. Some cultural data on traditional healing and etiology were also collected. Of these 60 species, 31 were submitted to antibacterial and antifungal assays in the presence and absence of UV light and a number of species were shown to be active.     

In vitro assessment of antioxidant,neuroprotective, anti-urease and anti-tyrosinase capacities of Tamarix africana leaves extracts

OBJECTIVE: To characterize the chemical profile of methanolic crude extract and its fractions(Ethyl acetate, n-butanol and aqueous) using liquid chromatographymass spectrometry(LC-MS) analysis, to evaluate their biological and pharmacological properties: antioxidant(1, 1-diphenyl-2-pycrylhydrazyl(DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic)(ABTS·+), galvinoxyle free radical scavenging, reducing power, phenanthroline and β carotene-linoleic acid bleaching assays), enzymes inhibitory ...     

用搜风解毒汤为主,治愈神经性皮炎1例

患者杨××,女,27岁,教师。于1962年6月13日就诊。门诊号:10648。自诉于三个月前臀部患“癣”,并向两侧大腿内侧伸延。抓破后患部流出少许水液,干燥后有皮层脱落,范围逐步增大。继见颈部“皮癣”一处,沿大椎部向下偏右方扩散,形如出水荷叶、边缘清晰。自一个月前开始,除局部搔痒外,每日黄昏临卧时,出现全身奇痒,烦躁不得入眠;便祕溲赤,纳食不香。经某院外科诊断为神经性皮炎。多次外用止痒消炎药水,注射氯化钙十余次,内服苯海拉明计六十余粒,未效。每夜需服鲁米那二粒,才能模糊入睡。我们根据病起因于湿、热、风的观点,用搜风解毒肠     

Assessment of phytotoxic,genotoxic and enzyme inhibition potential of Sterculia diversifolia

OBJECTIVE:To evaluate Sterculia diversifolia stem bark and leaves for phytotoxic, genotoxic and enzymes inhibition potential. METHODS:Phytotoxic activity of both stem bark and leaves were screened using Lemna minor. The genotoxic activity of Sterculia diversifolia stem bark and leaves extracts were tested using comet assay protocol while enzyme inhibition activity of crude extract and various fractions of both stem bark and leaves were evaluated using acetyl cholinesterase, lipoxygenase, β-glucu...     

The metabolism of constituents of Huangqin- Tang decoction,a traditional Chinese medicinal preparation,in conventional, germ-free and gnotobiote mice

ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｔｅｓｔｉｎａｌｂａｃｔｅｒｉａｐｌａｙａｎｅｓｓｅｎｔｉａｌｒｏｌｅｉｎｔｈｅｍｅｔａｂｏｌｉｓｍｏｆｍａｎｙｇｌｙｃｏｓｉｄｅｓｉｎｖａｒｉｏｕｓｍｅｄｉｃｉｎａｌｈｅｒｂｓｔｏｔｈｅｉｒａｇｌｙｃｏｎｅｓ[1] .Ｓｏｍｅｇｌｙｃｏｓｉｄｅｓｏｆｈｅｒｂｓａｒｅｃｏｎｓｉｄｅｒｅｄｔｏｂｅｍａｉｎｃｏｍｐｏ ｎｅｎｔｓｉｎｍａｎｉｆｅｓｔａｔｉｏｎｏｆｔｈｅｉｒｍｅｄｉｃｉｎｅｅｆｆｅｃｔｓ[2 ] .Ｉｎｐｒｅｖｉｏｕｓｐａｐｅｒ ,ｕｓｉｎｇａｎＨＰＬＣｍｅｔｈｏｄｅｓ ｔａｂｌｉｓｈｅｄｉｎｏｕｒｌａｂｏｒａｔｏｒｙ ,1 5ｃｈｅｍｉｃａｌｃｏｍｐｏｎｅｎｔｓｉｎｃｌｕｄｉｎｇｔｈｅｏｒｉｇｉｎａｌｃｏｍｐｏｕｎｄｓｉｎｔｈｅｔｒａ ｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎａｌｐｒｅｐａｒａｔｉｏｎＨｕａｎｇｑｉｎ ＴａｎｇａｎｄｔｈｅｉｒｍｅｔａｂｏｌｉｔｅｓｂｙＨＩＢｗｅｒｅｓｉ ｍｕｌｔａｎｅｏｕｓｌｙｉｄｅｎｔｉｆｉｅｄａｎｄｄｅｔｅｒｍｉｎｅｄ .ＴｈｅｒｅｓｕｌｔｓｓｈｏｗｅｄｔｈａｔｔｈｅｇｌｙｃｏｓｉｄｅｓｏｆＨｕａｎｇｑｉｎ ＴａｎｇＢＧ ,ＷＧ...     

Comparative evaluation of polysaccharides isolated from Astragalus,oyster mushroom,and yacon as in-hibitors of α-glucosidase

The incidence of diabetes has increased considerably, and become the third serious chronic disease following cancer and cardiovascular diseases. Though acarbose, metformin, and 1-deoxynojirimycin have good efficacy for clinical application as hypoglycemic drugs, their expensive costs and some degree of side effects have limited their clinical application. Recently, increasing attention has concentrated on the polysaccharides from natural plant and animal sources for diabetes. In order to illustrate the pharmaceutical activity of polysaccharides as natural hypoglycemic agents, polysaccharides isolated from Astragalus, oyster mushroom, and Yacon were evaluated for their inhibitory effects on α-glucosidase. Polysaccharides were extracted and purified from Astragalus, Oyster mushroom, and Yacon with hot water at 90 °C for 3 h, respectively. The total sugar content of the polysaccharide was determined by the phenol-sulfuric acid method. The α-glucosidase inhibitory activity was measured by the glucose oxidase method. The results exhibited that the inhibitory effects on α-glucosidase were in decreasing order, Astragalus 〉 oyster mushroom 〉 Yacon. The α-glucosidase inhibition percentage of Astragalus polysaccharide and oyster mushroom polysaccharide were over 40% at the polysaccharide concentration of 0.4 mg·mL^-1. The IC50 of Astragalus polysaccharide and oyster mushroom polysaccharide were 0.28 and 0.424 mg·mL^-1, respectively. The information obtained from this work is beneficial for the use polysaccharides as a dietary supplement for health foods and therapeutics for diabetes.     

Synergistic effect of α-mangostin on antibacterial activity of tetracycline,erythromycin, and clindamycin against acne involved bacteria

Objective: To evaluate the synergistic effect of α-mangostin with tetracycline, erythromycin, and clindamycin against bacteria involved in acne production.Methods: A broth microdilution method was used to determine the minimum inhibitory concentration(MIC) of α-mangostin and a range of antibiotics. Synergistic effects on antibacterial activity were determined based on their own MIC, and then using a checkerboard method and a time-kill assay at 37 °C for24 h.Results: α-Mangostin exhibited antibacterial activity against Propionibacterium acnes, Staphylococcus aureus, S. epidermidis and S. pyogenes with MIC values of 0.78, 3.13, 0.78, and 6.25 μg/m L, respectively. The results of the checkerboard assay showed that α-mangostin produced synergistic effects with tetracycline, erythromycin, and clindamycin against all tested bacteria, with a fractional inhibitory concentration index(FICI) between 0.09 and 0.32. Moreover, time-kill curve data indicated that α-mangostin increased the antibacterial activity of tetracycline, erythromycin, and clindamycin.Conclusion: These findings suggested that α-mangostin may be used to enhance the antibacterial activity of some antibiotics against bacteria involved in acne production.     

耳针加锌离子透入治疗湿疹,神经性皮炎135例

我们应用祖国医学中的耳针疗法合并锌透入法治疗局限性湿疹、神经性皮炎135例,经临床观察效果较好,现报道如下。一般资料1.局限性湿疹治疗组65例中男49例,女16例。年龄5～56岁.病期3月～6年.急性15例,亚急性10例,慢性40例。对照组60例中男42例,女18例。年龄4～59岁。病期4月～5年。急性10例,亚急性23例,慢性27例。2.神经性皮炎治疗组70例中男48例,女22例。年     

Inhibition of pancreatic lipase, α-glucosidase, α-amylase,and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves

Ethnopharmacological relevance

Nelumbo nucifera Gaertn. leaves have been used as medicinal herbs in the past 1300 years, specifically utilized to cure hyperlipidemia, hyperglycemia, and obesity. It has been recorded in the most famous medicinal book in China for more than 400 years. The present study aims to identify the potential therapeutic activities of the flavonoids isolated from Nelumbo nucifera leaves.

Materials and methods

Nelumbo nucifera leaf flavonoids (NLF) were tested for the inhibition of lipase, α-glucosidase, and α-amylase activities in vitro. A single dose of NLF was administered by oral gavage in mice for acute toxicity. Wistar rats with high-fat diet-induced hyperlipidemia and two other animal models were used to evaluate the hypolipidemic effects of NLF.

Results

Our in vitro biochemistry tests revealed that the NLF showed high inhibitory activity against porcine pancreatic lipase, α-amylase, and α-glucosidase with IC₅₀ values of 0.38±0.022, 2.20±0.18, and 1.86±0.018 mg/mL, respectively. Furthermore, the NLF significantly lowered the lipid components, such as the total cholesterol, triglycerides, low-density lipoprotein cholesterol, and malondialdehyde, in various established in vivo systems and raised the high-density lipoprotein cholesterol. Moreover, the NLF alleviated high-fat diet-induced lipid accumulation in the liver.

Conclusions

The results demonstrate that NLFs can effectively ameliorate hyperlipidemia and inhibit the key enzymes related to type 2 diabetes mellitus. Our findings may provide new pharmacological basis for the treatment of hyperlipidemia, hyperglycemia, and obesity using NLFs.     

神经性皮炎

<正> ①处方:新鲜鸡蛋30枚,好高梁醋10斤(以没过鸡蛋为度)。用法:用小口大腹瓦罐1个盛鸡蛋,浸醋后密封罐口,埋在阴坡墙下1米深处(防腐)。经5～14天蛋皮变软时取出,贮冰箱中备用。用时将浸泡好的鸡蛋取出,酒精消