微乳型列腺素E1改善冠心病人微循环和血液流变学的作用

目的 观察微乳型前列腺素Ｅ１（Ｌｉｐｏ－ＰＧＥ１）改善冠心病患者球结膜微循环（ＢＣＭ）和血液流变学的作用。方法 冠心病心绞痛患者２９例静滴Ｌｉｐｏ－ＰＧＥ１（组（１）、１６例静滴ＰＧＥ１粉针剂（组（２）），对比观察两组病人治疗前后ＢＣＭ及血液流变学变化。结果 组（１）较组（２）病人治疗后ＢＣＭ和血液流变学改善明显，微血管形态、微血流状态及周围状态积分值下降，两组间差异显著（Ｐ均〈０．０１）。两组全     

不稳定型心绞痛血液流变性障碍及脉络宁的治疗作用

目的 :探讨脉络宁注射液对冠心病不稳定型心绞痛血液流变性的影响及其疗效。方法 :将 87例冠心病不稳定型心绞痛患者随机分为脉络宁组和对照组 ,观察二组患者治疗前后的血液流变性变化和临床疗效。结果 :治疗后二组血液流变学指标均有不同程度下降 ,与治疗前相比 ,脉络宁组除血沉外各项指标均有显著性差异 (P <0 .0 1) ,而对照组仅血浆比粘度有显著差异 (P <0 .0 1)。临床疗效脉络宁组明显高于对照组 (P <0 .0 5 )。结论 :冠心病不稳定型心绞痛患者存在血液流变性障碍 ,脉络宁静滴可以改善其血液流变性异常。对冠心病不稳定型心绞痛 ,以一般药物治疗基础上加用脉络宁治疗疗效要优于仅仅采用一般药物治疗的疗效     

葛根素对冠心病患者甲襞微循环及血液流变学的影响

目的评价葛根素对冠心病患者甲襞微循环及血液流变学的作用。方法４３例冠心病患者给予葛根素２００～４００ｍｇ，加入５％葡萄糖２５０ｍｌ静滴每日１次，１０～１４ｄ为１疗程。治疗前后分别检查血液流变学、甲襞微循环及心电图。结果（１）葛根素可明显改善冠心病患者胸痛、胸闷、憋气、心悸等症状及心电图缺血性ＳＴ～Ｔ表现。（２）葛根素可明显降低甲襞微循环各项积分值及总积分值，可使微血管、微血流、微血管周围状态均有明显改善，表现为毛细血管密度增加，输入枝、输出枝口径扩大，流速加快。（３）葛根素可明显降低血液粘度。结论葛根素可显著改善冠心病患者的甲襞微循环、降低血液粘度、减慢心率、降低心肌耗氧量，从而抗心绞痛。治疗冠心病疗效确切、安全。     

探讨益心康泰胶囊对冠心病心绞痛患者预后的影响

目的分析益心康泰胶囊对冠心病心绞痛患者预后的影响。方法选取2018年5月至2019年6月本院收治的149例冠心病心绞痛患者作为研究对象,根据治疗方案的不同分为观察组(74例)与对照组(75例)。对照组患者采取常规治疗方案,观察组患者则在常规治疗的基础上加用益心康泰胶囊治疗。观察两组患者的临床疗效,并比较两组患者治疗前后血液流变学以及血管内皮功能标志物的改变。结果观察组患者临床总有效率明显优于对照组,差异有统计学意义(P0.05);观察组患者血液流变学、血管内皮功能改善情况比对照组更明显,差异有统计学意义(P0.05)。结论益心康泰胶囊能够有效改善冠心病心绞痛患者的血液流变学异常以及血管内皮功能受损的情况,从而改善患者的预后。     

参附注射液对中晚期肿瘤患者微循环及血液流变性的影响

目的观察参附注射液(SF)对中晚期肿瘤患者微循环及血液流变性的影响.方法将60例中晚期肿瘤患者配对分为两组,对照组30例予放射治疗,每次2 Gy,每周5次,共6周.治疗组30例予放疗联合SF治疗,每日1次,每次50ml,每周5次,共6周.两组分别于治疗前、治疗后检测甲襞微循环及血液流变学指标.结果肿瘤患者的甲襞微循环以血管囊状扩张、毛细血管血流减慢、红细胞聚集等改变最显著,治疗组能明显降低流态积分、综合积分(P＜0.01),从而改善微血管状态;肿瘤患者存在全面的血液流变学异常,其中血浆黏度、红细胞聚集指数(RE)、纤维蛋白原(Fg)明显增高,SF可显著降低全血低切黏度、RE及Fg(P＜0.01),改善血液流变性.结论 SF可改善中晚期肿瘤患者的微循环及血液流变学异常,为肿瘤防治开辟了前景.     

老年气虚血瘀证患者微循环和血液流变学特征及通心络胶囊的治疗作用观察

目的 :观察老年气虚血瘀证患者甲襞微循环和血液流变性特征及通心络胶囊的治疗作用。方法 :选择年龄 60岁以上的心、脑血管疾病患者 (中医辨证属气虚血瘀型 ) 60例 ,检测微循环和血液流变学指标 ,再随机分为治疗组 (通心络胶囊组 ) 3 3例和对照组 (尼莫地平组 ) 2 7例作比较 ,观察通心络胶囊对改善微循环和血液流变性及临床症状的治疗作用。结果 :气虚血瘀症患者治疗前甲襞微循环中度及重度异常者 5 2例 ( 86.67% ,5 2 /60 ) ,其中治疗组 2 9例 ( 87.9% ,2 9/3 3 ) ,对照组2 3例 ( 85 .7% ,2 3 /2 7) ,以形态积分 ( 2 .5 8) >流态积分 ( 2 .2 2 ) >袢周积分 ( 0 .83 )为主要特征 ;血液流变学指标两组异常率同为 10 0 % ,其中以全血粘度、血浆粘度、红细胞聚集指数明显升高 ,红细胞变形能力降低为主要特征。治疗 3 0天后 ,微循环及血液流变学指标较治疗前均有显著改善 (P均 <0 .0 5～ 0 .0 1)。并且治疗组与对照组比较均有显著差异 (P <0 .0 5 )。临床治疗总有效率 ,治疗组为 90 .9% ,对照组为 70 .3 9 % ,两组比较有显著性差异 (P <0 .0 5 )。结论 :老年气虚血瘀证患者甲襞微循环异常和血液流变学指标异常率极高 ,通心络胶囊对改善微循环和血液流变学指标有显著疗效     

人参再造丸对帕金森病患者甲襞微循环及血液流变性的影响

目的 :探讨人参再造丸对帕金森病患者甲襞微循环及血液流变学的影响。方法 :对 32例帕金森病患者应用人参再造丸治疗前后进行甲襞微循环及血液流变学的检测。结果 :人参再造丸治疗后甲襞微循环流速、流态、总积分明显改善 ,全血粘度、血浆粘度、纤维蛋白原明显下降 (P <0 .0 1)。结论 :人参再造丸具有“补气活血、祛风化痰”作用 ,能改善帕金森病患者微循环 ,降低血粘度     

步长脑心通改善老年冠心病患者血液流变学及甲襞微循环的观察

本文采用自身对照法用步长脑心通对35例冠心病患者血液流变学及甲襞微循环进行观察。结果显示步长脑心通能降低血液流变学的各项指标（P＜0．05）。甲襞微循环的流态、管周状态、总积分值均显著改善（P＜0．01）。提示步长脑心通对冠心病有预防及治疗双重作用。     

通心络对脑梗塞患者血液流变性及甲襞微循环的影响

目的 :探讨通心络对脑梗塞患者甲襞微循环及血液流变性的影响。方法 :6 0例脑梗塞患者随机分为对照组及通心络治疗组 ,并于治疗前后进行甲襞微循环及血液流变学的检测。结果 :通心络治疗组与对照组相比 ,甲襞微循环及全血粘度、血浆粘度、纤维蛋白原明显下降 (P <0 .0 5 )。结论 :通心络具有“益气活血、通络止痛”等作用 ,能改善脑梗塞患者的微循环 ,降低血粘度     

益气活血法对冠心病心绞痛及血液流变学的影响

目的:观察益气活血法对冠心病心绞痛及血液流变学的影响。方法:益气活血法治疗冠心病心绞痛35例;对照组 35例采用活血法,疗程均为4周,观察两组疗效及血液流变学各项指标的变化。结果:治疗组总有效率97．1％,对照组总有效率77．1％,二者相比有显著性差异(p<0．05)。治疗组血液流变学各项指标治疗前后均有明显改变(p<0．05或p< 0．01),对照组除血浆粘度和红细胞压积外治疗前后均有明显改变。(p<0．05或p<0．01)。结论:益气活血法在治疗冠心病心绞痛及改善血液流变学方面优于活血法。     

雷公藤甲素抗肿瘤血管新生的研究进展（英文）

雷公藤甲素(triptolide,TPL)是从中草药雷公藤中提取的一种有效活性物质,已被用来治疗多种疾病,包括系统性红斑狼疮,类风湿性关节炎,肾病综合征等,TPL甚至有很强的抑制肿瘤的活性。近些年的研究显示,TPL具有抗血管新生的能力,TPL不仅可以抑制肿瘤的增殖,诱导细胞的凋亡,还可以抑制肿瘤的转移,可以增加其它化疗药物的抗肿瘤活性。本综述将讨论TPL在抗肿瘤血管新生方面的研究进展,以及初步探讨其潜在的作用机制。     

Changes in activity of neutral proteases in tissues of ground squirrels in the dynamics of hibernation

Total activities of neutral proteases in the cerebral, hepatic, and myocardial tissues of ground squirrel vary during hibernation: in autumn (before hibernation) activities of the enzymes in the brain and myocardium start increasing, while in the liver they do not change. A common feature for all tissues is minimum activity of active neutral proteases in the middle of hibernation month 1 bout, while the maximum activity is recorded before awakening. Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 9, pp. 278–280, September, 2008     

Kinetics of decline of maternal measles virus-neutralizing antibodies in sera of infants in France in 2006

The optimal age for measles vaccination is an important health issue, since maternal antibodies may neutralize the vaccine antigen before a specific immune response develops, while delaying vaccination may increase the risk of complicated diseases in infants. However, measles vaccination impacts the duration of protection afforded by transplacental transfer of maternal antibodies: vaccination-induced maternal antibodies disappear faster than disease-induced antibodies. In order to maintain protection against measles in infants, it is important to monitor the dynamics of this phenomenon in vaccinated populations. To assess the current situation in France, a multicenter, prospective seroepidemiological study was conducted in seven French hospitals between October 2005 and January 2007. Maternal measles antibody concentrations from 348 infants 0 to 15 months old were measured using the plaque reduction neutralization assay. Geometric mean concentrations and the percentage of infants with maternal measles antibody concentrations above the protection threshold (≥120 mIU/ml) were assessed according to age. Results show that after more than 20 years of routine measles vaccination in France, maternal measles-neutralizing antibodies decrease dramatically in French infants by 6 months of age, from 1,740 mIU/ml for infants 0 to 1 month old to 223 mIU/ml for infants 5 to 6 months old, and that 90% of infants are not protected against measles after 6 months of age. Infant protection against measles could be optimized both by increasing herd immunity through an increased vaccine coverage and by lowering the age of routine vaccination from 12 to 9 months.     

Effect of vitamin C in reducing the toxicity of endosulfan in liver in rabbits

In this study, the effect of endosulfan, an organochlorine pesticide, and the ameliorating effect of vitamin C on the livers of New Zealand white rabbits were studied. Livers of the rabbits were examined grossly and histopathologically, and caspase-3 activity was detected by immunohistochemical methods. A total of twenty-four rabbits were divided into four groups (n=6). Rabbits in Group I (END) were daily given a sublethal dose of endosulfan (1 mg/kg bw) in corn oil by oral gavage for 6 weeks. Group II (END+C) received the same dose of endosulfan and additionally Vit C (20 mg/kg bw) every other day during this period. Group III (OIL+C) received corn oil daily by oral gavage and vitamin C every other day for 6 weeks. Group IV (OIL), the control group, received only corn oil daily, by oral gavage throughout the experiment. The concentration of α-endosulfan in the END group was higher in livers (0.102±0.012 ppb) than the β-endosulfan (0.072±0.001 ppb). Decreased accumulation of α and β endosulfan was observed in the END+C group (0.025±0.003 and 0.016±0.002 ppb, respectively) (p<0.0001). The most prominent gross findings at the necropsy were seen in the END group, in which swollen and pale livers were commonly observed. Hemorrhages, degenerations, necrosis, and in some rabbits bile duct hyperplasia were the marked histopathological findings of the END group. Caspase-3 positive reaction was more severe in this group than in the others. An ameliorating effect of Vit C on gross, histopathological and immunohistochemical findings was observed in the END+C group. The results revealed that endosulfan is highly toxic for rabbit livers. However, toxicity was decreased by Vit C treatment, which reduced the accumulation of endosulfan in livers four-fold.