国产微孔聚四氟乙烯心脏补片的实验观察与临床应用

采用上海塑料研究所和我院协作研制的微孔聚四氟乙烯心脏补片经动物实验和６００余人次先心病纠治术中的应用，效果满意，使用安全，该补片裁剪方便，无正反面，修补前无需预凝，材料生物相容性好，修补时补片与受体组织平整服贴，强度高，耐老化，为目前较为理想的合成心脏修补材料。     

Use of Autologous Costal Cartilage Combined with Expanded Polytetrafluoroethylene in Asian Rhinoplasty

BackgroundThe corresponding author's experience and recent methods employed in autologous costal cartilage grafts combined with expanded polytetrafluoroethylene (ePTFE) in Asian rhinoplasty were presented in this study.ObjectivesThe purpose of this study was to assess the outcomes of rhinoplasty performed on patients using autogenous costal cartilage grafts combined with an ePTFE implant.MethodsSeventy-five rhinoplasty cases with autologous costal cartilage grafts and an ePTFE implant were retrospectively reviewed. Graft types, complications associated with the graft itself or graft harvesting, surgical outcomes, and patient satisfaction were assessed.ResultsThe mean follow-up time post-operation was 13.5 months. A total of 42/75 patients underwent revision surgeries. Graft-related complications were found in 8% of cases, including two warped graft and four infection cases. Three individuals with infections had mild graft resorption. One patient with an infection removed the implant. Graft exposure, mobility, and substantial resorption were not recorded. A total of two cases underwent revision procedures for infection and perforation, respectively. Chest incision lengths for graft harvesting averaged 2.1 cm. No pneumothorax or significant donor-site pain was found. Donor-site scars were negligible, although two cases had hypertrophic chest scars. In general, functional and esthetic outcomes were mostly satisfactory among the assessed patients.ConclusionsRhinoplasty using autologous rib cartilage provides adequate support and sufficient cartilage amounts for correcting nasal contouring. Meanwhile, ePTFE alone for nasal dorsum augmentation safely achieves satisfactory outcomes. Rib cartilage rhinoplasty performed by an experienced surgeon yields excellent, long-lasting results with minimal risk; however, the potential for infection should be considered following revision surgery.     

Postoperative Angiographic Assessment of Modified Blalock-Taussig Shunts Using Expanded Polytetrafluoroethylene (Gore-Tex)

Thirty-six of 87 modified Blalock-Taussig shunts done with expanded polytetrafluoroethylene (Gore-Tex) were restudied angiocardiographically. In 7 patients the study was carried out within 1 month of the shunt operation because the patients failed to make satisfactory clinical progress. Two shunts were occluded and 1 was itenosed; all 3 were in neonates. The remaining 29 patients were reinvestigated electively between 5 and 29 months postoperatively and had a 97% shunt patency rate. Because of the rather high incidence of irregular or stenosed shunts among neonates with 4 mm conduits, we now prefer to use a larger conduit even in this age group.     

Gore-Tex在耳郭部分缺损修复中的应用

目的:探索用于部分耳郭缺损再造的理想材料。方法:对13例外伤后导致的部分耳郭缺损的病人,采用Gore-Tex整形材料作为再造耳的支架,在耳后设计局部皮瓣覆盖进行修复,供瓣区直接缝合或另取皮片植皮。结果:本组共13例13耳,4例术后发生假体外露,经再次手术修整,随访1～2年,所有再造耳郭外形满意,与对侧正常耳外形基本一致。结论:Gore-Tex材料具有良好的组织相容性和可塑性,是部分耳郭再造的理想材料之一。     

The Use of Polytetrafluoroethylene (Gore-Tex) Grafts in Reconstruction of the Urinary Bladder

The safety and histopathologic effects of polytetrafluoroethylene (Gore-Tex) grafts in reconstruction of the urinary bladder were examined. Following partial excision of the bladder Gore-Tex was placed, and the rats were sacrificed at days 7, 14 and 30. Gore-Tex did not cause urine infection, and there was no peritonitis or sepsis in any of the rats. Inflammation around the Gore-Tex diminished after four weeks. Some mononuclear cells and exudate were observed on the inner surface of the Gore-Tex. There was no inflammation or fibrosis in the mucosa and muscular layers of the remaining bladder. In this study the Gore-Tex graft was found to be an infection resistant, urine impermeable material, with no adverse effects on the urinary bladder. Gore-Tex is suggested as a safe material for the reconstruction of the urinary bladder.     

自体软骨联合膨体聚四氟乙烯应用于鼻综合整形中的效果

目的 探讨自体肋软骨联合膨体聚四氟乙烯应用于鼻综合整形中的临床疗效。方法 选取2019年 11月-2022年11月我院收治的100例鼻综合整形患者为研究对象,根据不同手术方式分为对照组与研究组, 各50例。对照组采用膨体聚四氟乙烯填充,研究组采用自体肋软骨联合膨体聚四氟乙烯填充,比较两组临 床疗效、愈合情况、鼻部相关参数、不良反应发生率及满意度。结果 研究组治疗总有效率为96.00%,高 于对照组的80.00%（P＜0.05）;研究组愈合时间短于对照组,完全愈合率高于对照组（P＜0.05）;研 究组鼻尖突出度、鼻背长度、小柱-小叶比、鼻额角、鼻根部的鼻梁高度均优于对照组（P＜0.05）;研 究组不良反应发生率为4.00%,低于对照组的20.00%（P＜0.05）;研究组满意度为96.00%,高于对照组 的78.00%（P＜0.05）。结论 自体肋软骨联合膨体聚四氟乙烯可有效提高鼻综合整形效果及愈合效果,改 善鼻部相关参数,且并发症少,患者满意度高。     

戈尔（Gore）平片在腹股沟疝无张力修补术中应用的临床体会

目的总结Gore平片在腹股沟疝无张力修补术中的临床应用。方法回顾性分析我院2004年5月至2008年5月413例使用Gore平片行腹股沟疝无张力疝修补手术的临床资料。结果本组随访3个月到2年，治愈410例，复发3例，复发率0．73％（3／413）。术后伤口感染2例，感染率0．48％（2／413）。术后疼痛2例，发生率0．48％（2／413）。术后异物感3例，发生率0．73％（3／413）。结论本方法具有适应证广，操作简便，复发率低，异物感轻，并发症少等优点，是安全有效的无张力疝修补法。     

Large Perigraft Seroma After Aortoiliac Bypass with an Expanded Polytetrafluoroethylene Graft: Report of a Case

A 63-year-old man who had undergone aortoiliac bypass with an expanded polytetrafluoroethylene (PTFE) graft was referred to our hospital for investigation and treatment of a possible pseudoaneurysm of the abdominal aorta. A tender, pulsatile, and bulging mass, about the size of an adult fist, was palpated around the navel. Enhanced computed tomography (CT) showed a large low-density area around the abdominal aorta and PTFE graft, and aortography showed a patent graft with no anastomotic leakage. Operative inspection revealed that the pulsatile mass was a large perigraft seroma, and we replaced the PTFE graft with a new woven Dacron graft. The patient has been well with no sign of recurrence for 1 year, although close long-term follow-up is mandatory.     

An Immunohistochemical Analysis of Implanted Woven Dacron and Expanded Polytetrafluoroethylene Grafts in Humans

Abstract: An immunohistochemical analysis was performed to clarify the healing process in implanted vascular grafts in human. Eight woven Dacron grafts and 6 expanded polytetrafluoroethylene grafts were obtained following redo surgery, limb amputation, and autopsy. The implantation periods ranged from 5 days to 148 months. The antibodies used for the analysis were specific to a-actin (smooth muscle cells), macrophages, von Willebrand factor (endothelial cells), fibrin, elastin, collagen types 1–5, CD3 (T cells), and CD20 (B cells). At 5 and 24 days after implantation, thrombi containing red blood cells and fibrin covered the anastomotic lines and some of the luminal surfaces of the grafts. Macrophages were scattered throughout the thrombi. At 11–148 months after implantation, either a single layer of endothelial cells or a thin layer of fibrin covered the anastomotic segments of the grafts, and smooth muscle cells and collagen fibers were seen forming anastomotic intimal hyperplasia (AIH). The AIH in the grafts at 94 and 148 months after implantation was almost the same thickness and length as that in the grafts at 11–36 months after implantation. Apart from the anastomotic segments, a connective tissue matrix containing collagen fibers covered the luminal surfaces, and some thrombi were noted. Most of the collagen present was type 3, in addition to some type 1, 4, and 5 collagen. No type 2 collagen was noted. Some elastin was also detected in the AIH but not in the midportion of the grafts. Some macrophages and T cells were noted in the perigraft tissues.     

Complications of Expanded Polytetrafluoroethylene (e-PTFE) Facial Implant

Implantation of the expanded polytetrafluoroethylene (e-PTFE) implant to achieve correction of nasolabial folds or thinning lip has been fraught with complications in spite of patient acceptance since its introduction in 1997. The four most frequent postoperative complications are extrusion, movement, infection, and swelling. In examination of 86 insertions of the 3.2 mm tubular implants, these sequelae are generally manageable for the physician and patient. If the patient understands possible courses of healing, both physician and patient satisfaction may be achieved.     

鼻缺损修复术中衬里组织的修复

目的 探讨鼻缺损修复术中衬里组织的修复方法.方法 自2003年1月至2012年10月,根据鼻缺损的情况,对195例各类鼻缺损患者采用局部组织翻转皮瓣、外被皮瓣远端折叠、双瓣法、预制皮瓣等方法来修复衬里,并观察术后效果.结果 所有方法衬里皮瓣均成活良好.随访6个月至5年,局部组织翻转皮瓣法最大的并发症是皮瓣挛缩导致的鼻孔狭窄、通气不良,其他方法未见明显并发症.结论 在鼻缺损的衬里修复中,需要正确评估鼻部缺损范围、程度,以及周围可利用的残留组织量,选择合适的衬里修复方法,以获得良好的手术效果.     

Evaluation of Lip Augmentation with Gore-Tex Facial Implant

Although numerous materials, including autogenous, homogeneous, and alloplastic materials, have been used for lip augmentation with varying degrees of success, no ideal one has been found to achieve a soft and long-lasting result. Gore-Tex implant has been successfully used in cardiovascular surgery. So far, it has not been used much in lip augmentation. In this study, a Gore-Tex SAM facial implant (1.8 mm in diameter) was used for lip augmentation in 23 lips of 17 female patients. In 10 consecutive lips with three segments of the implant each, a computer-assisted imaging system was used to scrutinize the results. The results have shown that the three segments of the implant enhanced the lip projection with about 0.98 mm in mean (p < 0.01) and the exposed vermillion width with about 1.94 mm (p < 0.01) in the over 6 months follow-ups. No major complications, only some minor ones, were seen. For lip augmentation, we find that only minor changes can be achieved with three segments of the Gore-Tex facial implant. We feel that it is safe and believe it gives a permanent result which is not the case with collagen injection and usually not the case with lipofilling despite reinjections. Furthermore, we consider the implant quite expensive at present.     

膨体聚四氟乙烯补片在胸壁重建中的应用

目的分析膨体聚四氟乙烯(Gore-Tex)补片在胸壁重建中的注意事项,总结临床应用经验。方法回顾性分析第二军医大学长海医院2001年1月至2010年l2月期间33例使用Gore-Tex补片进行修复巨大胸壁缺损的临床资料,男19例,女14例;平均年龄45.7(20～73)岁。根据肿瘤位置、大小选择不同的手术切口;术中尽量保留正常的胸壁软组织,骨性胸壁缺损采用Gore-Tex补片进行重建,软组织直接对拢缝合,全层胸壁缺损采用转移肌皮瓣覆盖创面。结果全组33例均手术顺利,围术期无死亡患者;恶性肿瘤25例,良性肿瘤8例,均被完整切除,切除瘤体直径8～20 cm。随访5～60个月,失访3例(9.09%),无排斥反应及反常呼吸,无异物感,感染率3%(1/33)。结论 Gore-Tex补片具有极佳的生物相容性,是安全有效的胸壁重建材料;选择合适的肌皮瓣覆盖补片,能够减少并发症发生。     

Complications Associated With Isotretinoin Use After Rhinoplasty

Background This study aimed to evaluate the association between the postoperative use of isotretinoin and the formation of nasal tip deformities after rhinoplasty.Methods A retrospective study investigated a case series of patients who presented with nasal tip deformities subsequent to the use of isotretinoin after rhinoplasty. Patients who had taken isotretinoin after rhinoplasty were identified from a single surgeon’s case log. Clinic charts and operative reports were reviewed. Predisposing factors and time intervals to complications were identified.Results Three patients were found to have undergone isotretinoin therapy after rhinoplasty. Nasal tip deformities included bossa formation, asymmetry, and prominence of a composite graft. All three patients required subsequent procedures to repair soft tissue nasal tip deformities. In all three cases, isotretinoin was started within 2 years of the primary rhinoplasty. The nasal tip deformities were first observed within 6 months after isotretinoin was started.Conclusions Three cases are described in which postoperative use of isotretinoin was associated with nasal tip deformities after rhinoplasty. Further studies are needed to investigate this possible causative relationship and to describe the risks involved.     

膨体聚四氟乙烯联合鼻中隔软骨及耳软骨在分段搭建美学亚单位鼻综合整形术中的应用

目的:探讨依据鼻部局部美学亚单位间不同的解剖特点,采用膨体聚四氟乙烯(Expanded polytetrafluoroethylene,e-PTFE)联合鼻中隔软骨及耳软骨在鼻综合整形术中对鼻部进行分段调整的效果。方法:2017年8月至2019年3月,应用该方法进行了32例手术,取鼻正中飞鸟形切口加双侧鼻翼缘切口,利用膨体聚四氟乙烯、鼻中隔软骨、耳软骨,对鼻背、鼻小柱、鼻尖等各个美学分区进行逐一调整,观察其效果。结果:本组29例获得随访,随访时间3~17个月,恢复都较满意,取得了较好效果,无慢性感染、假体歪斜、鼻尖皮肤变薄等并发症发生。结论:根据鼻部的美学分区,通过对鼻部美学亚单位分别修饰处理,可以达到鼻部外观和手感完美统一的效果。     

膨体聚四氟乙烯在鼻整形术中的应用

目的 探讨应用膨体聚四氟乙烯在鼻整形中应用价值.方法 局部麻醉下应用膨体聚四氟乙烯假体或复合自体耳甲腔软骨进行隆鼻手术.结果 本组20例患者术后随访鼻外形均良好,无免疫排斥反应、假体外露、假体摆动等情况发生.结论 膨体聚四氟乙烯在鼻整形中效果良好;假体复合自体耳甲腔软骨能有效延长鼻长度,抬高鼻尖.