女性青春期后痤疮的发病因素分析

目的:分析女性青春期后痤疮发病的危险因素.方法:选取133例女性青春期后痤疮患者进行问卷调查,对部分患者检测血清性激素水平.结果:单因素分析年龄、家族史、油性皮肤、化妆品使用、精神紧张或工作压力、体重指数偏大、雄激素水平高是发病的危险因素(P＜0.05);多因素分析年龄、家族史、化妆品、皮肤类型、精神紧张为危险因素(P＜0.05).结论:女性青春期后痤疮发病涉及多方面,确切病因仍有待进一步研究.     

98例青春期后痤疮临床分析

为了探讨青春期后痤疮可能的病因因素,对98例25岁以上痤疮患者的临床特征进行了分析。女86例,男12例。多数患者为持续性痤疮,仅31例（31.63%)患迟发性痤疮（25岁后发病）,痤疮多为轻度或中度,外界因素似乎没有明显的致病作用。精神紧张可能量 种有意义的病因因素,87.5%女性患者月经前痤疮突发或加重。24例（24.49%)患者有青春期后痤疮阳性家族史,19例（22.09%)女性患者伴有多毛症或脱发等雄激素过多症的特征。     

69例女性青春期后痤疮临床分析

痤疮通常为青春期疾病，但近年来青春期后痤疮的发病率明显增高，且临床疗效不稳定。为了探讨其可能的发病因素，现将我科诊治的69例青春期后痤疮的临床特点总结如下。     

乌鲁木齐市女性青春期后痤疮病因初探

为探讨乌鲁木齐市女性青春期后痤疮可能的发病因素,我们自2002年9月~2003年9月,对门诊就诊的85例年龄在25岁以上女性痤疮患者进行了有关病因方面的总结分析,现报道如下。资料方法与结果在我科门诊就诊的85例年龄25岁以上女性痤疮患者,由专人详细询问病史、发病相关因素,进行体检和记录。患者年龄25~47岁,平均34.2岁。其中25~35岁52例(61%),36~45岁28例(33%),46岁及以上5例(6%)。油性皮肤51例,干性皮肤12例,中性皮肤22例;室内工作者62例,室外工作者23例;已婚49例,未婚36例;月经规律者47例,不规律者30例,停经者8例;经前加重者41例;便秘者58例;…     

女性青春期后痤疮外在诱发因素的初步调查

近年来,女性迟发性痤疮(年龄＞25岁)患病人数有增多趋势。我们调查了此类患者182例,对其诱发因素进行统计分析,现报告如下。     

青春期后女性痤疮患者血清性激素水平的研究

目的：检测青春期后女性痤疮患者体内性激素的水平。方法：采用放射免疫法对25岁以上的34例女性痤疮患者血清睾酮（T）、雌二醇（E2）、泌尿素（PRL）、黄体生成素（LH）和卵泡刺激素（FSH）进行了测定,并以32例正常女性作为对照。结果：患者组T显著高于对照组（P＜0．001）;E2和LH显著低于对照组（P＜0．001）;PRL和FSH无明显变化（P＞0．05）。结论：性激素异常可能是女性痤疮迟发和持久不退的主要原因。     

中医情志疗法治疗女性青春期后痤疮患者的临床研究

目的 观察中医情志疗法对女性青春期后痤疮患者的临床疗效及对患者心理健康的影响。方法 全部病例均来自于潍坊市中医院皮肤科门诊,共60例,随机分为治疗组和对照组各30例。对照组口服自拟方疏肝消痤汤,治疗组在口服疏肝消痤汤的同时配合中医情志疗法。治疗1个疗程即4周后比较2组的临床疗效。同时采用焦虑自评量表（SAS）、抑郁自评量表（SDS）来评估焦虑、抑郁程度。结果 (1)临床疗效比较,治疗组显效率65%、总有效率97%,对照组显效率25%、总有效率71%,治疗组临床疗效明显优于对照组。(2)治疗组SDS、SAS积分较治疗前下降明显（P<0.05）,对照组SDS、SAS积分较治疗前有所下降（P<0.05）;治疗后组间比较,治疗组SDS、SAS积分明显低于对照组,差异有统计学意义（P<0.05）。结论 女性青春期后痤疮患者发病与精神心理因素明显相关,在中医辨证论治的基础上加以中医情志疗法,有助于改善患者焦虑及抑郁的心理状态,可以明显提高临床疗效,有利于患者的心理健康。     

复方甘草酸苷治疗女性青春期后痤疮疗效观察

目的：评价复方甘草酸苷治疗女性青春期后痤疮的有效性、安全性，并探讨其作用机理。方法：49例女性青春期后痤疮患者随机分为两组。治疗组27例，口服复方甘草酸苷片；对照组22例，口服安体舒通片。两组患者在口服药物的同时均外用5％硫磺霜。疗程均为8周。于用药前、用药后2、4、8周末分别观察记录面部各种皮损的实际数目、全身及局部不良反应。并分别在用药前、用药后8周检测血清睾酮（T）、雌二醇（E2）及胰岛素样生长因子1（IGF-1）水平。结果：治疗4周后两组平均皮损数目分别由50.2±11．54、48．5±12．26减少为17，8±9．54、38．9±10，64（P〈0．05），复方甘草酸苷起效比安体舒通快；治疗8周后两组有效率分别为85．2％、68．2％（P〉0．05），二者总体疗效相当；复方甘草酸苷治疗女性青春期后痤疮复发率低、无明显不良反应。实验室结果显示，治疗组患者的血清T和IGF-1水平分别由78．4±32．93ng／dL、338．6±91．58ng／mL下降为36．5±13．91ng／dL（P〈0．01）、196．6±60．95ng／mL（P〈0．05），但复方甘草酸苷对E2水平的影响不大。结论：复方甘草酸苷是治疗女性青春期后痤疮安全、有效的方法，并有调节患者血清T及IGF-1水平的作用。     

89例青春期后痤疮临床分析

青春期后痤疮是指２５岁以后的痤疮,Ｇｏｕｌｄｅｎ将其分为持续性和迟发性两种［１］,前者指２５岁以前发病,临床表现持续到２５岁以后,后者为２５岁以后发病。我们观察了８９例病人,分析总结如下。１临床资料和结果１．１一般资料　门诊病人８９例,男２４例,女６例,男女比１：２．７。年龄２５～４８岁,平均３３．５岁,２５～３５岁５５例（６１．８％）,３６～４５岁３０例（３３．７％）,４６岁以上４例（４．５％）。初发年龄男平均１６．７岁,女平均１８岁。持续性痤疮７５例,其中男２１例,女５４例;迟发性痤疮１４例…     

青春期后痤疮流行病学研究回顾

本文就近年青春期后痤疮流行病学调查的相关文献进行回顾性综述,总结青春期后痤疮的发病情况、临床特征、相关影响因素,探讨可能的发病机理.     

The correlation between ABO blood types and acne vulgaris severity

Background

Acne vulgaris is a chronic inflammatory disease with multifactorial etiology. Studies on the pathogenesis of acne are still important. Recently, various studies have been conducted on the significance of genetics in the pathogenesis of acne. Blood group is transferred genetically and could affect the development, progress, and severity of certain diseases.

Aim

In the current study, the correlation between the severity of acne vulgaris and ABO blood groups was investigated.

Materials and Methods

A total of 380 patients (263 mild and 117 severe acne vulgaris patients) and 1000 healthy individuals were included in the study. Severity of acne vulgaris patients and healthy controls was determined based on the blood group and Rh factor data obtained retrospectively from the patient files in the hospital automation system.

Results

In the study, the rate of females was significantly higher in the acne vulgaris group (X²:154.908; p:0.000). The mean age of the patient was significantly lower when compared to the controls (t:37.127; p:0.0001). The mean age of the patients with severe acne was significantly lower when compared to those with mild acne. When compared to the control group, the incidence of severe acne was higher in those A blood type when compared to the patients with mild acne, while the incidence of mild acne was higher in other blood groups when compared to the control (X²:17.756; p:0.007). No significant difference was determined between the Rh blood groups of the patients with mild, severe acne and the control group (X²:0.812; p:0.666).

Conclusion

The results revealed a significant correlation between acne severity and ABO blood groups. Future studies that would be conducted with larger samples in different centers could confirm the current study findings.     

寻常痤疮严重程度和痤疮瘢痕相关因素分析

目的：了解门诊痤疮患者严重程度的相关因素及导致出现痤疮瘢痕的危险因素。方法：对2331例门诊痤疮患者进行问卷调查。结果：14～19岁、居住在农村、初中文化程度、油性皮肤、伴发脂溢性皮炎、每天睡眠时间少于8h的患者痤疮病情更严重。男性、有瘢痕家族史、痤疮程度严重的患者出现痤疮瘢痕的概率比较大。结论：对于具备重度痤疮高危因素的患者，应及早干预，给予积极的治疗。由于重度痤疮出现瘢痕的概率更高，因此早期、及时的治疗对于避免出现瘢痕也有一定帮助。     

Impulsivity in patients with acne excoriee

Background

Impulsivity is the tendency to make decisions and act quickly without adequate planning and anticipating risks. Impulsivity is among the core symptoms of many psychiatric disorders. In addition, impulsivity can affect the course of various diseases shaped by behaviors.

Aims

This study aimed to evaluate the relationship between the presence of acne excoriee and different impulsivity dimensions.

Study Design

A case–control study.

Methods

Thirty patients with acne excoriee (AE+) and 30 acne vulgaris patients without excoriated lesions (AE-) enrolled in this study. Impulsivity was evaluated by The Barratt Impulsivity Scale (BIS). In addition, The Beck Anxiety Inventory, The Beck Depression Inventory, and The Skin Picking Scale were applied to assess the clinical characteristics of the participants.

Results

AE+ patients had higher non-planning subscale scores of BIS than AE- patients in this study. In addition, the acne-picking severity score determined by The Skin Picking Scale was positively correlated with non-planning subscale scores of BIS. There was no significant difference between the groups regarding the Beck Depression Inventory and Beck Anxiety Inventory.

Conclusions

These results indicate that AE patients have a lack of forethought. In other words, it has been shown that impulsive personality traits, which indicate a lack of planning for the future, may be associated with the acne-picking behavior of the patients.     

痤疮及相关因素对患者生活质量的影响

新的医学模式提倡临床医生在治疗寻常痤疮患者时,不仅要考虑痤疮分型及临床严重程度,还要考虑患者生活质量受到的影响.近年来,应用不同量表为工具的调查研究均表明,痤疮对患者生活质量有较大的影响,但其对不同年龄、性别患者的影响评价不一.提示专科医生有必要对患者生活质量所受到的影响进行个体化评估,进而选择最佳的治疗方案.     

重庆市某高校610名大学生痤疮流行病学调查及危险因素分析

目的为进一步了解重庆地区高校大学生痤疮流行病学特点及其发病危险因素。方法采用随机抽样调查方法,对重庆某高校610名大学生开展问卷调查,收集痤疮的认知及发病因素资料,用SPSS20.0软件进行统计分析。结果 610名大学生的痤疮患病率为25.2%。多因素Logistic回归分析显示,不常食用蔬菜水果、饮食不均衡、有抽烟和饮酒习惯、睡眠不足、不注意皮肤清洁卫生、油性皮肤以及过敏性皮肤是重庆地区大学生痤疮发病的危险因素。结论重庆高校在校大学生的痤疮患病率较高,一定程度上影响了其心理及社交生活。该群体发生痤疮的危险因素较多,且对痤疮的认知不足,可能是患病率较高的原因。     

痤疮与胰岛素抵抗相关性的研究进展

痤疮是好发于青春期的毛囊皮脂腺慢性炎症性疾病,激素是痤疮发生的最重要内源性因素。近年来发现,除雄激素外,胰岛素抵抗及其诱导的胰岛素和胰岛素样生长因子1水平异常也与痤疮密切相关,胰岛素与胰岛素样生长因子1通过间接刺激雄激素分泌、直接诱导角质形成细胞增殖和皮脂腺细胞脂质分泌以及炎症过程参与痤疮发生。此外,痤疮作为某些系统性疾病或综合征如多囊卵巢综合征、高雄激素血症?胰岛素抵抗?黑棘皮病综合征的重要特征以及饮食、吸烟、肿瘤与痤疮的相关性也为胰岛素抵抗在痤疮发生中的潜在作用提供了依据。     

524例青春期后女性痤疮患者的性激素和血脂分析

目的: 检测青春期后女性痤疮患者血脂和性激素水平变化情况,探讨痤疮与性激素和血脂的关系.方法: 收集青春期后女性寻常痤疮患者和健康对照者,检测BMI、甘油三酯、高密度脂蛋白、垂体泌乳素、促卵泡生成素、促黄体生成素、睾酮和硫酸脱氢表雄酮水平和盆腔超声.结果: 共纳入524例青春期后女性痤疮患者(轻、中、重度痤疮分别为23...     

The familial risk of adult acne: a comparison between first-degree relatives of affected and unaffected individuals

Acne is principally a disorder of adolescence but persists into middle age in a small minority of individuals. There is some evidence, primarily from twin studies, to suggest that acne may be an inherited disease. We have carried out an investigation of the familial risk of persistent adult acne by studying the occurrence of this condition in first-degree relatives of patients with adult persistent acne compared with the relatives of unaffected matched controls. Two hundred and four patients over the age of 25, referred to our department with facial acne which had persisted from adolescence, were included in the study. For each patient, a detailed pedigree which included all first-degree relatives was drawn up. For all relatives over the age of 25, demographic details and the presence or absence of facial acne was recorded. One hundred and forty-four unaffected controls were recruited. These were matched with the patient group in terms of age, social class and ethnic origin. The same questions were asked of controls as of the cases, and they provided the same information on their first-degree relatives. In total, 204 acne cases and 144 non-acne control volunteers were studied, contributing 1203 and 856 first-degree relatives, respectively. Two hundred and three first-degree relatives of cases were affected with facial acne, compared with 42 first-degree relatives of volunteers. The risk of adult acne occurring in a relative of a patient with adult acne was significantly greater than for the relative of an unaffected individual (odds ratio 3.93, 95% confidence interval 2.79-5.51; P < 0.001). Our study suggests that familial factors are important in determining individual susceptibility to adult persistent facial acne. Genetic factors may determine the failure of acne-prone follicles to evolve into acne-resistant follicles in early adult life.