脉冲染料激光治疗面部蜘蛛痣临床疗效观察

我科自2001年1月—2004年12月应用脉冲染料激光治疗152例面部蜘蛛痣患者,取得满意疗效,现报告如下。1病例和方法1.1病例蜘蛛痣患者152例,男37例,女115例,年龄1～68岁;病程3个月～11年。1.2方法1.2.1治疗方法采用PhotoGenica V闪光激发脉冲染料激光,输出波长585nm,能量密度0～10     

脉冲染料激光治疗蜘蛛痣206例疗效观察

应用脉冲染料激光治疗206例蜘蛛痣患者，结果206例患者中201例痊愈，痊愈率为97.6%，其中102例患者经过1次激光治疗即痊愈，79例患者经过2次治疗痊愈，20例患者经过3次治疗痊愈。无1例有肥厚性或萎缩性瘢痕，随访1例均无复发。     

脉冲染料激光治疗面部毛细血管扩张162例临床分析

脉冲染料激光 (585nm)是一种直接作用于皮肤血管损害的激光,治疗鲜红斑痣 [1,2],国内已见文献报告 [1,2],本文总结其治疗面部毛细血管扩张的临床疗效,现报告如下。 1一般资料： 162例面部毛细血管扩张患者,男性 5例,女性 147例;年龄 5～ 40岁;其中 89例为面颊片状皮损,最大面积为 60cm2, 33例为鼻翼周边弧形分布皮损, 40例为蜘蛛痣。 2治疗方法：仪器是美国 Candela公司生产的脉冲染料 SPTI- 1b,波长为 585nm,脉宽为 450μ s,光斑直径为 7mm,密度为 7.5～ 8.5 J/cm2。能量密度大小取决于患者年龄、皮肤颜色深浅及部位。治…     

585 nm脉冲染料激光治疗面部毛细血管扩张疗效观察

我科1999年6月-2006年5月应用闪光灯-泵脉冲染料激光治疗42例面部毛细血管扩张患者,取得满意疗效,现报告如下. 1病例与方法     

脉冲染料激光联合微波治疗蜘蛛痣186例疗效观察

2002年以来,我们采用微波治疗仪联合585染料激光治疗面部蜘蛛痣186例,获满意疗效。现报道如下。临床资料我科共治疗蜘蛛痣患者186例,其中女130例,男56例,年龄2~50岁,病灶分布颧部、鼻部及眼眶周围,单个皮疹者140例,2个以上皮疹者46例,病灶直径0.5~1.5cm,病程6个月~10年,所有患者肝功能均正常。排除病例为:(1)对585nm波长区域激光过敏的患者;(2)有皮肤癌家族病史;(3)孕妇。治疗仪器:(1)大连为尔康科贸有限公司生产的微波治疗仪,(2)美国Cynosure公司585脉冲染料激光治疗仪(Photo Gen-ica V),激光技术参数为:波长(585±5)nm,脉宽300~500μs,…     

脉冲染料激光治疗高原地区面部毛细血管扩张症372例疗效观察

目的探讨595nm脉冲染料激光治疗高原地区面部毛细血管扩张症的临床疗效。方法用595nm脉冲染料激光治疗仪治疗面部毛细血管扩张症372例,根据病变程度调整治疗参数,以激光照射瞬间皮损呈浅灰色或轻微紫癜色为适宜能量密度,光斑间可有10%～30%的重叠。结果 372例患者通过1～3次激光治疗后,扩张毛细血管完全消除,有效率为100%。治疗后皮肤无损伤,且有明显的美白淡斑、收缩毛孔及嫩肤的功效。结论用595nm脉冲染料激光治疗高原地区的面部毛细血管扩张症安全性高,且疗效确切。     

595nm脉冲染料激光和532nm半导体泵激光治疗蜘蛛痣

传统的冷冻、电灼、透热疗法对蜘蛛痣的治疗均有效,但易产生瘢痕或复发。最近,我院引进了595nm波长的可变脉宽脉冲染料激光(V鄄beam激光)和532nm半导体泵激光(thediode鄄pumpedfrequency鄄doubledQ鄄switchedNd:YAGlaser,即Diode532激光),在面部蜘蛛痣的治疗上取得疗效。现对两种不同激光仪器治疗蜘蛛痣的疗效和副作用等进行比较。一、临床资料激光门诊要求治疗的蜘蛛痣患者共44例,随机分为2组。用V鄄beam激光治疗组23例,男11例,女12例,年龄4~32岁,平均(8.8±6.5)岁;Diode532激光治疗组21例,男9例,女12例,年龄7~28岁,平均(8.4±5.4)岁。…     

595nm脉冲染料激光治疗儿童鲜红斑痣69例疗效观察

目的:观察595 nm脉冲染料激光治疗儿童鲜红斑痣的临床疗效。方法:选取来我院就诊的儿童面颈部鲜红斑痣69例,其中粉红型52例、紫红型11例,增厚型6例,采用595 nm脉冲染料激光进行治疗。比较儿童不同类型鲜红斑痣的疗效。结果:鲜红斑痣中粉红型总有效率为100%,紫红型和增厚型的总有效率分别90.91%和83.33%。粉红型与紫红型间总有效率差异无统计学意义(2=1.95,P0.05);而粉红型与增厚型(2=64.46,P0.05)、紫红型与增厚型(2=57.32,P0.05)间总有效率差异有统计学意义。结论:595 nm脉冲染料激光治疗儿童皮肤鲜红斑痣疗效确切。粉红型及紫红型鲜红斑痣疗效较增厚型鲜红斑痣好。     

595nm脉冲染料激光治疗儿童鲜红斑痣69例疗效观察

目的:观察595 nm脉冲染料激光治疗儿童鲜红斑痣的临床疗效。方法:选取来我院就诊的儿童面颈部鲜红斑痣69例,其中粉红型52例、紫红型11例,增厚型6例,采用595 nm脉冲染料激光进行治疗。比较儿童不同类型鲜红斑痣的疗效。结果:鲜红斑痣中粉红型总有效率为100%,紫红型和增厚型的总有效率分别90.91%和83.33%。粉红型与紫红型间总有效率差异无统计学意义(2=1.95,P>0.05);而粉红型与增厚型(2=64.46,P<0.05)、紫红型与增厚型(2=57.32,P<0.05)间总有效率差异有统计学意义。结论:595 nm脉冲染料激光治疗儿童皮肤鲜红斑痣疗效确切。粉红型及紫红型鲜红斑痣疗效较增厚型鲜红斑痣好。     

脉冲染料激光治疗鲜红斑痣的临床疗效分析

利用脉冲染料激光器治疗了1617例鲜红 斑痣患者,并从年龄的大小、皮损类型、面积大小、发生的部位及副作用进行了分组观察研究。其年龄小、淡红型 皮损,面积小、发生于颈部、面部偏侧者疗效显著。1617例中仅有1例下唇发生轻度增生性瘢痕。由此认为脉冲染料激光是目前治疗鲜红斑痣安全有效的方法。     

595nm脉冲染料激光治疗儿童皮肤微静脉畸形疗效分析

目的探讨595nm脉冲染料激光治疗儿童微静脉畸形的疗效。方法应用595nm脉冲染料激光治疗351例皮肤微静脉畸形患儿,观察疗效及副作用。结果 351例患者中治疗次数最少1次,最多13次,间隔4～6周,总有效率43%;皮损位于面部的患儿138例,不同部位皮损治疗次数最少1次,最多13次,有效率在22.7%～44%之间,疗效之间无统计学差异。不良反应发生4例(1.1%)。结论 595nm脉冲染料激光治疗微静脉畸形疗效确切,不良反应少见。     

Short pulse intense pulsed light versus pulsed dye laser for the treatment of facial redness

ABSTRACT

Treating diffuse facial redness with an intense pulsed light (IPL) source usually requires multiple sessions and may not achieve complete clearance. The 595 nm pulsed dye laser (PDL) enjoys a good reputation for reducing facial redness with non-purpuric settings. The objective of this study was to compare facial redness reduction using these two devices. After establishing the lowest light dose able to achieve transient purpura for the same pulse width of 1,5 ms with each technology, right and left sides of the face were randomly assigned for each type of treatment. There were two treatment sessions 4 weeks apart and the final evaluation was performed 8 weeks after thesecond treatment. Four blinded experienced dermatologists analyzed pre and post-treatment photographs, which demonstrated an average of 60% improvement on the segment treated with the IPL as opposed to 45% on the other segment. Pain level was described as mild and the procedure was well tolerated for both types of treatment. In this study we showed that short-pulsed intense pulsed light and PDL are similar in decreasing facial redness when non-purpuric low fluence settings are used. The IPL was faster and did not have consumables.     

595nm脉冲染料激光治疗婴幼儿皮肤真性血管瘤疗效观察

目的探讨595 nm脉冲染料激光治疗婴幼儿皮肤真性血管瘤的疗效。方法应用595 nm脉冲染料激光治疗40例婴幼儿皮肤真性血管瘤并观察疗效。结果 40例患者中,治疗3次以内6例,治疗3次及以上34例。治愈18例(45%),显效15例(37.5%),有效3例(7.5%),无效3例(7.5%),总有效率82.5%。结论 595 nm脉冲染料激光治疗婴幼儿皮肤真性血管瘤疗效确切、安全,可在临床推广。     

Flashlamp pulsed dye laser and argon-pumped dye laser in the treatment of port-wine stains: a clinical and histological comparison

BACKGROUND: Port-wine stains (PWS) are congenital vascular malformations occurring in 0.3% of children. The pulsed dye laser is a well established treatment for PWS. OBJECTIVES: To compare, clinically and histologically, the effects of the flashlamp pulsed dye laser with the argon-pumped dye laser in the treatment of PWS. METHODS: Thirty patients were treated on two to four test areas with both laser types using different energy fluences. A flashlamp pulsed dye laser with 0.45 ms pulse duration and a spot size of 5 mm was compared with an argon-pumped dye laser, with a spot size of 1 mm delivered with a robotic scanning laser handpiece (Hexascan) and 70-190 ms pulse duration. Both were tuned to 585 nm. Twelve weeks later the degree of lightening was evaluated and biopsies were taken. To count the vessels the skin sections were stained with CD34 using an immunohistochemical technique. The vessels were divided into three groups by diameter (d): d < 10 microm, 10 < or = d < 20 microm, d > or = 20 microm. RESULTS: The clinical results showed a significantly better lightening using the flashlamp pulsed dye laser than with the argon-pumped dye laser. The histological results showed a significant decrease in the number of vessels of diameter larger than 20 microm in treated compared with untreated lesions. We found no histological difference in the number of vessels between the two laser treatments. However, there was a tendency towards more small vessels (diameter < 10 microm) after one treatment with the flashlamp pulsed dye laser compared with untreated PWS. CONCLUSIONS: The flashlamp pulsed dye laser is clinically superior to the argon-pumped dye laser in the treatment of PWS.     

595 nm染料激光联合外用0.5%马来酸噻吗洛尔溶液治疗浅表型婴儿血管瘤的疗效评价

目的 评价595 nm染料激光联合0.5%马来酸噻吗洛尔溶液局部治疗浅表型婴儿血管瘤的疗效和安全性。方法 回顾性分析2015年7月至2016年7月在温州医科大学附属第二医院育婴儿童医院皮肤科门诊接受595 nm染料激光联合0.5%马来酸噻吗洛尔溶液治疗且资料完整的156例浅表型婴儿血管瘤患儿的临床资料。男44例,女112例,年龄（3.8 ± 0.7）个月（范围24 d至1岁）。激光治疗间隔为5周,噻吗洛尔溶液每天外敷2次,每次30 min,瘤体基本消退时停止激光及噻吗洛尔治疗。分别于第5、10、15、30周每次治疗前,用视觉模拟评分（VAS）评价疗效,记录不良反应,随访至治疗结束后6个月。分析血管瘤面积和厚度与治疗时间、次数和VAS之间的关系。结果 156例患儿经5 ~ 30周治疗后,血管瘤均有不同程度缓解,治愈率为93.59%（146/156）。治疗第5、10、15、30周时,VAS分别为3.12 ± 0.23、4.45 ± 0.52、5.45 ± 0.71、7.59 ± 1.64。重复测量数据的方差分析显示,血管瘤初始厚度 < 1 mm组、1 ~ 3 mm组和 > 3 mm组VAS随时间延长而逐渐增加（F = 189.35,P < 0.05）,各个时间点不同厚度血管瘤组间VAS存在组间差异（F = 215.56,P < 0.05）,其中血管瘤厚度 < 1 mm组VAS更高。< 1 mm组总治疗时间（2.71 ± 0.58个月）分别短于1 ~ 3 mm组（8.22 ± 0.67个月,P < 0.05）和 > 3 mm组（11.03 ± 0.72个月,P < 0.05）。血管瘤初始面积 < 3 cm2组、3 ~ 9 cm2组和 > 9 cm2组VAS亦有不同,且随治疗时间变化,Kruskal?Wallis H检验显示,3组间治疗次数差异有统计学意义（H = 10.45,P < 0.01）, < 3 cm2组治疗次数最少。不良反应轻微,且未发现心血管、呼吸系统方面的不良反应。结论 595 nm染料激光联合0.5%马来酸噻吗洛尔溶液局部治疗浅表型婴儿血管瘤疗效确切,安全性好。     

强脉冲光及595nm染料激光治疗面部痤疮后红斑自身对比研究

目的 评价及对比强脉冲光和595 nm染料激光治疗痤疮后红斑的临床疗效及安全性.方法 采用随机自身左右面部对照临床试验研究方法,选取20例患有痤疮后红斑的患者,每例患者的两侧面颊随机分配接受强脉冲光或595 nm染料激光治疗3次,每次间隔4周.分别在每次治疗前以及最后1次治疗1个月后使用VISIA拍照,测量红斑值;通过四分红斑严重程度表评价治疗前后双侧面部红斑严重程度.每次治疗后均填写疼痛评分表、不良反应记录表,最后1次随访通过问卷形式对患者进行满意度调查.结果 强脉冲光侧平均红斑值治疗前472.25±86.02,治疗后357.15±82.71;595 nm染料激光侧治疗前476.40±74.25,治疗后360.05±64.83,经重复测量资料方差分析,可以认为随治疗时间延长,患者红斑值有所降低(F=197.666,P＜0.001);强脉冲光侧治疗效果优于595 nm染料激光侧(F=1 173.909,P＜0.001).强脉冲光侧治疗前后四分红斑值差异有统计学意义(Z=28.735,P＜ 0.001),595 nm染料激光侧差异亦有统计学意义(Z=31.450,P＜0.001).激光术后VAS视觉评分发现,595 nm染料激光治疗侧疼痛度低于强脉冲光,两者差异有统计学意义(t=2.468,P＜0.05).评价满意和非常满意的患者595 nm染料激光17例,强脉冲光15例,两组差异无统计学意义(Z=2.696,P＞0.05).强脉冲光不良反应包括红斑、灼烧感、紧绷感、水疱、色素沉着,595 nm染料激光不良反应包括红斑、紫癜反应,均在数小时至数天消失.结论 应用强脉冲光及595 nm染料激光治疗痤疮后红斑均安全有效,适合临床推广应用,强脉冲光相较于595 nm染料激光疗效更优,但疼痛度更高.     

The application of 595-nm pulsed dye laser for vascular anomalies in a Chinese population: a 10-year experience

Background: The 595-nm pulsed dye laser (PDL) has been used to treat vascular anomalies for about 30 years; however, there are insufficient data in Chinese patients concerning therapeutic efficacy, optimized parameters, and procedure techniques.

Objective: To study the efficacy and relevant factors in PDL therapy for vascular anomalies in Chinese patients.

Method: We enrolled 431 patients with 8 different vascular anomalies and no previous treatment in this retrospective study. A detailed classification of vascular anomalies and various parameters and techniques of PDL were studied. The clinical outcomes were analysed using the Investigator Global Assessment.

Results: Improvements were significantly correlated with infantile haemangioma (IH) subtypes (p < 0.05). A significant correlation between efficacy and lesion colour, anatomical sites, and hypertrophic-type port-wine stain (PWS) was found (p < 0.05). There was no significant correlation between efficacy and age or sex (p > 0.05).

Conclusion: PDL is an effective and safe therapeutic modality for managing vascular anomalies in Chinese patients. We determined that differentiating and identifying IH subtypes prior to treatment could be a useful parameter for predicting therapeutic results. Lesion colour, sites, and hypertrophic changes in PWS are relevant therapeutic factors. PDL parameters and techniques differ according to the various vascular anomalies to achieve optimal results.     

Angioma serpiginosum: dermoscopy for diagnosis, pulsed dye laser for treatment

Angioma serpiginosum is a rare benign vascular disorder, characterized clinically by multiple minute, red to purple, grouped macules in serpiginous and gyrate patterns and histopathologically by ectatic dilatation of capillaries. Patients can undergo unnecessary hematological tests, because the condition can be confused with chronic purpuric dermatoses. An 18-year-old man with angioma serpiginosum of his left arm was evaluated by dermoscopy and treated with pulsed dye laser. Numerous small, relatively well-demarcated, round to oval red lagoons were determined with dermoscopy, and approximately 75% of the area of his lesion disappeared after four sessions of pulsed dye laser. Our case supports the hypothesis that dermoscopy is beneficial in the diagnosis of angioma serpiginosum and that pulsed dye laser is effective in the treatment of this disorder.     

Treatment of molluscum contagiosum with a pulsed dye laser: Pilot study with 19 children

Background: Molluscum contagiosum is a common, self‐limiting viral disease of childhood caused by a poxvirus. Often the children themselves and their parents desire treatment for cosmetic reasons or because of pruritus. Laser therapy offers another option to the traditional methods of treatment. Methods: 19 children aged between 2 and 13 years (median:6) with molluscum contagiosum were treated in a prospective, non‐randomized pilot study with the flashlamp pumped pulsed dye laser (wave length:585 nm, pulse duration 0,45 ms, spot size 7 mm, energy density 6–7 J/cm²). Results: All patients tolerated the laser treatment well. In 84.3% one laser treatment led to total remission. In 10.5% a further laser session was necessary and one patient was treated three times to achieve total remission. Conclusions: Treatment of molluscum contagiosum with the flashlamp pulsed dye laser is a safe and efficient treatment modality.     

To test or not to test: A study examining the return rates of rosacea patients treated with a pulsed dye laser

Pulsed dye laser (PDL) is an effective treatment option for erythematotelangiectatic rosacea. The use of a test spot allows patients to experience the procedure on a small area prior to further treatment. The purpose of this study was to elucidate whether the use of a no charge test spot influenced return rates for further PDL treatment. Data were obtained retrospectively using International Classification of Diseases (ICD)-10 codes for rosacea. Sixty charts were identified: 26 patients initially received a PDL test area free of charge, whereas 34 patients initially underwent full PDL treatment. Patients who experienced the test spot laser treatment had a lower return rate compared to those that directly underwent full PDL treatment. However, this difference was not statistically significant (Fisher’s exact test p = 0.2883). Future studies evaluating and identifying factors that influence PDL return rates are needed.

Abbreviations: ETR: Erythematotelangiectatic rosacea; PDL: pulsed dye laser; ICD: International classification of diseases