健康教育干预对提高癫痫儿童相关生活质量的研究

目的对健康教育和心理干预提高癫痫儿童的相关生活质量进行研究。方法采用癫痫患者生活质量量表-31(QOLIE-31)对49例癫痫患儿进行评估。对49例患儿进行健康教育、心理干预,并于干预前、干预后6个月,9个月分别进行生活质量量表-31的评估。结果干预治疗后癫痫儿童的相关生活质量评分比干预前有明显提高(P<0.05)。综合干预治疗后癫痫儿童的生活质量明显改善。结论综合干预治疗能促进癫痫儿童相关生活质量的提高。     

癫痫儿童的心理障碍及干预效果分析

目的研究癫痫儿童的心理状态及干预治疗效果。方法应用癫痫患儿生活质量量表对84例癫痫患儿进行心理评估,并通过癫痫科普知识讲座和个别咨询相结合的方法对本组患儿进行心理干预。结果67%患儿存在心理障碍,主要表现为对发作及药物副作用的担忧,生活满意度低下,情绪及精力差,认知功能及社会能力低下,生活质量低于正常儿童;干预后患儿心理状态明显改善,各项指标前后比较差异显著(P<0.01)。结论癫痫患儿存在心理障碍,抗癫痫药物和心理治疗不能相互替代,只有二者的综合治疗才是有效控制发作、改善患儿心理状态、提高患儿生活质量的根本途径。     

癫痫全身性强直阵挛发作儿童健康相关生活质量的研究

目的 探讨癫痫全身性强直阵挛发作儿童的生活质量及其影响因素。方法 采用美国癫痫儿童生活质量量表，对60例癫痫大发作患儿进行心理评估，并分析其影响因素。结果 癫痫全身性强直-阵挛发作儿童存在心理、行为障碍，其生活质量明显低于正常儿童；就诊年龄、起病年龄、病程等均影响患儿的生活质量。结论 癫痫儿童存在心理障碍．对癫痫儿童应采用综合治疗措施才能有效控制发作，提高其生活质量。     

癫痫患儿生活质量及其影响因素的研究

目的用新的生活质量量表研究癫痫患儿的生活质量并探讨其影响因素.方法用量表对71例符合标准的癫痫患儿的生活质量进行评估.结果癫痫患儿的生活质量明显低下,总评得分为63.13±18.89.发作频率、发作担忧及抑郁情绪与患儿生活质量呈负相关,相关系数分别为-0.42、-0.25和-0.45,而记忆功能与患儿生活质量呈正相关,相关系数为0.84.结论癫痫患儿的生活质量明显低下,对癫痫患儿进行药物治疗并辅以心理治疗、健康教育,能提高癫痫患儿的生活质量.     

癫痫患儿的生活质量及其影响因素

目的 研究癫痫儿童的生活质量的状况,并分析影响其生活质量的相关因素.方法 应用新的癫病儿童生活质量量表,对83例癫痫儿童进行生活质量的评估,探讨影响因素并与正常儿童进行比较.结果 癫痫儿童的生活质量明显低于正常儿童,尤其是情绪状况、社会功能及认知功能.癫痫患儿的生活质量与疾病的严重程度、长期用药、自我感知及家庭因素等相关.结论 癫痫患儿的生活质量明显低下,综合治疗是提高患儿生活质量的有效途径.     

癫痫患儿生活质量及其影响因素的研究

目的用新的生活质量量表研究癫痫患儿的生活质量并探讨其影响因素。方法用量表对71例符合标准的癫痫患儿的生活质量进行评估。结果癫痫患儿的生活质量明显低下,总评得分为63. 13±18. 89。发作频率、发作担忧及抑郁情绪与患儿生活质量呈负相关,相关系数分别为-0. 42、-0. 25和-0. 45,而记忆功能与患儿生活质量呈正相关,相关系数为0. 84。结论癫痫患儿的生活质量明显低下,对癫痫患儿进行药物治疗并辅以心理治疗、健康教育,能提高癫痫患儿的生活质量。     

护理干预对癫痫患儿适应性行为的影响

目的探讨癫痫患儿可能存在的心理问题,改善其生活的质量。方法选择癫痫患儿42例,采用Achenbach儿童行为量表（CBCL）、儿童适应行为评定量表（SAB）等一系列标准化评定工具,对患者进行测试评定,并观察护理干预对患者适应性行为的影响。结果通过观察和测量,发现特发性癫痫患儿E量表均分显著降低（P〈0．01）,CBCL测试均分显著增高（P〈0．01）,癫痫惠儿独立因子和社会自制因子均分明显低于健康儿童（P〈0．01,P〈0．05）。针对癫痫患儿存在的不同程度心理行为问题,对患儿实施护理干预,改善了癫痫患儿的适应性行为。结论护理干预可对患者进行心理疏导,从而使癫痫患儿回归社会,提高患者生活质量。     

综合护理干预对围绝经期妇女影响的研究

目的探讨综合护理干预对围绝经期妇女健康的影响。方法对110例围绝经期妇女实施健康教育、心理干预、用药指导及饮食运动指导等综合护理干预措施,6个月后应用症状自评量表、WHO生存质量测定量表等评估综合干预效果。结果 110例围绝经期妇女主要症状和心理状态得到改善,生活质量明显提高,与干预前比较差异有统计学意义（P〈0.05）。结论对围绝经期妇女实施综合护理干预措施,可显著减轻症状,改善心理状态,提高生活质量。     

抽动障碍儿童生活质量量表测试结果分析

评估抽动儿童的生活质量。方法：采用儿少生活质量问卷（ISLQ）对31例抽动障碍儿童的生活质量进行检查评定，并与正常学龄儿童进行对比，结果：患儿组的生活质量明显低于正常组。结论：除合理的药物治疗外，应对患儿进行包括心理干预的综合治疗。     

心理行为干预对学龄期癫痫儿童自我概念水平及生活质量的影响

目的：探讨心理行为干预对学龄期癫痫儿童自我概念水平和生活质量的影响。方法选择100例学龄期癫痫儿童为研究对象,就患者随机分为对照组和干预组,各50例。对照组患者接受门诊医生随访治疗与检查,干预组患者在对照组的基础上给予心理行为干预措施。比较2组患者的自我概念水平和生活质量。结果干预前2组总体自我概念和6个分量表得分比较差异无统计学意义,干预后6个月,干预组总体焦虑、智力与学校、自我概念以及躯体外貌、合群分量表得分显著高于对照组（P<0.05）,行为、幸福与满足分量表得分在2组干预后组间比较差异无统计学意义。干预后6个月,干预组患者生活质量评分显著优于对照组（P<0.05）。结论心理行为干预能有效提高学龄期癫痫儿童自我概念水平,显著提高生活质量,可以在临床中推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.