磺缺乏区影响学龄儿童智商水平的非磺元素及其复合效应

在碘缺乏区７－１４岁学龄儿童智商水平、甲肿调查的基础上对高中低智商水平的３组人群进行尿碘、甲状腺功能及尿、发样中Ｆ、ＳＣＮ、Ｚｎ、Ｃｕ、Ｆｅ、Ｃａ、Ｍｇ、Ｓｅ、Ｍｎ９指标水平检测，研究碘缺乏区影响学龄儿童智商水平的非碘元素及其复合效应。结果表明：高、中、低智商水平的３组人群之间在Ｚｎ、Ｃｕ、Ｃａ、Ｍｇ４元素水平上存在显著或极显著性差异，高智商组４元素水平高于低智商组人群。但存在地区性差异，茅山地区     

心律失常与血清硒、锰、锌、铜、铁变化的关系

本文对１０４例各种心律失常病人和１００例健康人分别进行血清硒（Ｓｅ）、锰（Ｍｎ）、锌（Ｚｎ）、铜（Ｃｕ）、铁（Ｆｅ）测定。结果发现：①心律失常组血清Ｓｅ、Ｍｎ、Ｚｎ、Ｆｅ含量明显降低，而血清Ｃｕ则升高。②心律失常患者Ｓｅ／Ｃｕ、Ｓｅ／Ｍｎ、Ｓｅ／Ｚｎ、Ｓｅ／Ｆｅ比值显著减低，而Ｃｕ／Ｆｅ比值增高。③在心律失常病人中，以房颤患者血清Ｓｅ降低和血清Ｃｕ增高最为明显。④病程≥５年患者血清Ｓｅ、Ｚｎ降低及血清铜增高比病程＜５年者更为显著。提示：心律失常对人体内Ｓｅ、Ｍｎ、Ｚｎ、Ｃｕ、Ｆｅ的变化密切相关，但其确切因果关系有待进一步探讨。     

克山病病区与非病区有关物质的微量元素对比分析

从克山病病区中的发病村、非发病村及非病区村分别采人发、羊毛、粮、土壤、水、岩石测定Ｓｅ、Ａｓ、Ｍｏ、Ｃｕ、Ｚｎ、Ｆｅ、Ｍｎ、Ｓｒ、Ｂａ、Ｃａ、Ｍｇ、Ｋ、Ａｌ、Ｐ、Ｃｏ、Ｎｉ、Ｖ、Ｃｒ、Ｐｂ、Ｃｄ、Ｔｉ、Ｆ等元素，并作对比分析。结果表明：不能肯定单纯某一种或几种元素的缺乏或增加导致克山病。     

老年缺血性脑血管病患者血清矿物元素的变化及其临床意义

目的探讨老年缺血性脑血管病患者血清矿物元素的变化及其临床意义。方法使用电感耦合等离子体直读光谱仪测定了８０例老年缺血性脑血管病病人及６１例健康对照的血清矿物元素含量。结果缺血性脑血管病组Ｍｇ、Ｃｄ、Ａｌ显著升高，Ｃａ、Ｚｎ、Ｃｏ、Ｆｅ显著降低。缺血性脑血管病发病与血清Ｃｕ、Ｃｏ、Ｚｎ、Ｃｃｄ、Ｍｇ等水平异常有关。结论观察血清Ｃｕ／Ｚｎ、Ｃｄ／Ｚｎ具有更显著的统计学意义。     

新疆拜城县重病区与中病区内外环境无机元素含量的调查

本文于１９９３年４月调查了新疆拜城县重病区查尔齐农场中与中病区赛里木乡的饮水，土壤，粮食，学龄儿童头发中Ｚｎ，Ｃｕ，Ｍｎ，Ｃａ，Ｌｉ，Ｓｅ６种元素无机元素的含量。结果表明，重病区小麦中Ｃａ的含量显著高于中病区（Ｐ〈０．０５），重病区饮水及小麦中Ｍｎ的含量显著低于中病区（Ｐ〈０．０５）。这些结果揭示重病区查尔齐与中病区赛里木乡的病情相比较，除缺碘较为严重这一主要原因之外，高Ｃａ，低Ｍｎ也可能与查尔齐     

西咪替丁抗疟作用的研究 Ⅳ.感染疟原虫小鼠血清4种元素含量比较

应用ＩＣＰ－４００型等离子原子发射光谱仪检测感染伯氏疟原虫氯喹敏感株（Ｐ．ｂＣＱＳ）、抗性株（Ｐ．ｂＣＱＲ）和约氏疟原虫氯喹敏感株（Ｐ．ｙＣＱＳ）小鼠血清的Ｚｎ、Ｃｕ、Ｆｅ、Ｃａ４种元素含量。结果显示：与正常组比较，３株虫感染组中，Ｃｕ的含量均明显增高（Ｐ＜０．００１），Ｃａ的含量均明显降低（Ｐ＜０．００１）；Ｚｎ值在Ｐ．ｂＣＱＳ组显著降低；Ｆｅ值在Ｐ．ｙＣＱＳ组中显著增高。Ｐ．ｂＣＱＳ组与Ｐ．ｂＣＱＲ组在西咪替丁及氯喹作用下，元素变化有组间差异。     

西咪替丁抗疟作用的研究：Ⅳ.感染疟原虫小鼠血清4种元素含？…

应用ＩＣＰ－４００型等离子原子发射光谱仪检测感染伯氏疟原虫氯喹敏感株（Ｐ．ｂＣＱＳ）、抗性株（Ｐ．ｂＣＱＲ）和约氏疟原虫氯喹敏感株（Ｐ．ｙＣＱＳ）小鼠血清的Ｚｎ、Ｃｕ、Ｆｅ、Ｃａ４种元素含量。结果显示：与正常组比较，３株虫感染组中，Ｃｕ的含量均明显增高（Ｐ〈０．００１），Ｃａ的含量均明显降低（Ｐ〈０．００１）；Ｚｎ值在Ｐ．ｂＣＱＳ组显著降低；Ｆｅ值在Ｐ．ｙＣＱＳ组中显著增高．Ｐ．ｂＣＱＳ组与Ｐ．ｂ     

原子发射光谱法测定不同产地六味地黄丸中六种微量元素

用原子反射光谱法对三种产地的六味地黄丸中所含的Ｆｅ、Ｃｕ、Ｚｎ、Ｍｎ、Ｃａ、Ｍｇ六种微量元素进行测定。分析结果表明，产地不同，丸药中微量元素含量也不同。     

大骨节病区和常硒及低硒非病区儿童发铜锌锰铁含量测定

采用原子吸收光谱法测定了大骨节病区、常硒非病区和低硒非病区儿童发Ｃｕ、Ｚｎ、Ｍｎ、Ｆｅ含量。结果表明，低硒非病区组儿童发Ｃｕ、Ｚｎ、Ｍｎ、Ｆｅ含量与常硒非病区组无明显差异（Ｐ＞０．０５），大骨节病区组儿童除发Ｃｕ含量与常硒、低硒非病区无显著性差异（Ｐ＞０．０５）外，发Ｚｎ、Ｍｎ、Ｆｅ含量均明显高于常硒、低硒非病区组（Ｐ＜０．０１或０．０５），大骨节病区组儿童硒以外某些微量元素状况与常硒、低硒非病区     

沙依瓦克病人体中无机元素及饮用水卫生学的调查报告

本文报告了应用微分电位溶出法和示波极谱法检测８例沙依瓦克病人与同病区２４例健康人的血清，尿液，头发，以及病区饮用水中Ｃａ，Ｐ，Ｍｇ，Ｚｎ，Ｃｕ，Ｍｎ，Ｓｅ，Ｉ，Ｆ含量，以国家标准卫生检验方法对病区饮用水的ｐＨ值进行检测和卫生细菌学检查，用ＣＹＢＲ法做尿液粘多糖定性试验。检测结果：（１）血清Ｃａ，Ｐ，Ｍｇ含量略高于健康水平（Ｐ〈０．０５）。（２）尿液Ｉ含量在正常值低限。（３）头发Ｃａ，Ｐ，Ｍｇ含量略     

Studies on the mechanism of action of the bipyridine milrinone on the heart

Summary Milrinone is a positive inotropic and vasodilator agent when tested in experimental animals and in human heart-failure patients. It is generally believed that milrinone acts by inhibiting phosphodiesterase IV, thus increasing cyclic AMP, [Ca^{+ +}]_i and cardiac contractile force and relaxation. Maximal force produced by milrinone is greater when single-dose response curves are compared to cumulative dose-response curves. In vitro, milrinone produces a tachyphylaxis, the extent of which is both dose- and time-dependent. Recovery of tachyphylaxis is both dose- and time-dependent and is not influenced by inhibitors of protein or RNA synthesis. There is a specific cross-tachyphylaxis between milrinone and amrinone, theophylline, papaverine, and Bay K8644. This tachyphylaxis may explain the low maximal contractile response of the cumulative dose-response observed in isolated tissues. Milrinone increased cyclic AMP in dog and guinea pig cardiac muscle. As previously shown by Endoh et al. [17], milrinone in low doses produced a biphasic effect on cyclic AMP. The early increase (first 60–70 s) in cyclic AMP shows a good correlation with contractile force changes. If cyclic AMP is determined at maximal contractile force this correlation was poor. Here we also present instances where the increase in cyclic AMP after milrinone (determined at maximal effect) does not correlate with the contractile response. The cross-tachyphylaxis of milrinone with Bay K8644 suggests that milrinone has an action on the sarcolemmal Ca⁺⁺ channels. Bay K8644 suppresses the positive inotropic effect of catecholamines by 50%, but not the cyclic AMP response. The inotropic effect of milrinone, in contrast to norepinephrine is highly sensitive to [Ca⁺⁺]₀, stimulation rate, and [K⁺]₀. In this respect milrinone behaves more like Bay K8644. We postulate that the main inotropic action of milrinone is due to a sarcolemmal effect. The early cyclic AMP production described could be in the sarcolemmal compartment and this may explain some of the similarities of milrinone’s actions with those of Bay K8644. The tachyphylaxis observed with the inotropic effect of milrinone does not extend to the decreases in relaxation time. This and other findings to be discussed suggest that the positive inotropic and reduction in relaxation time by milrinone depend on different mechanisms, possibly through differential compartmentalization of cyclic AMP.     

锌对心肌保护作用机理的探讨

应用电镜、电子示踪技术和立体计量测试法，从形态学上观察异丙基肾上腺素对心肌膜系统的影响及锌的保护作用，同时应用标准玻璃微电极技术和微机实时分析方法，研究异丙基肾上腺素致心肌损伤及锌对心肌保护作用的机理。实验结果表明：异丙基肾上腺素可引起心肌细胞膜系统损伤，此时心肌细胞的去极化和复极化过程均发生改变；经锌前处理后，心肌损伤程度明显减轻，心肌细胞的复极化过程得到明显改善。锌对心肌的保护作用，主要是通过阻断心肌细胞膜慢通道、减少平台期钙离子内流、防止细胞内钙超载来实现。     

Study on the Compression Effect of Clothing on the Physiological Response of the Athlete

The study aimed to analyze whether the high compression of unique, tight-fitting sportswear influences the clothing physiology comfort of the athlete. Three specific sportswear with different compression were tested on four subjects while they were running on a treadmill with increasing intensity. The compression effect of the sportswear on the body of the test persons, the temperature distribution of the subjects, and the intensity of their perspiration during running were determined. The results indicate that the compression effect exerted by the garments significantly influences the clothing physiology comfort of the athlete; a higher compression load leads to more intense sweating and higher skin temperature.