腓骨移植治疗肢体侵袭性骨肿瘤和恶性骨肿瘤

目的：比较游离腓骨或吻合血管腓骨移植治疗切除四肢侵袭性骨肿瘤或恶性骨肿瘤后引起的长段骨缺损的临床疗效。方法：对１８例吻合血管移植及４例游离腓骨移植术的病例术后，采用ＥＣＴ、彩色多普勒血管超声检查、Ｘ线照片检查及随访，时间为术后２～１２年，移植骨最长达２６ｃｍ。结果：侵袭性骨肿瘤和恶性骨肿瘤１８例，肿瘤切除后用吻合血管腓骨移植重建缺损，１５例桡骨远端骨巨细胞瘤患者作游离腓骨移植重建缺损，结果前者愈合良好，移植骨片与受骨接合牢固，游离腓骨移植则愈合较差。结论：吻合血管腓骨移植可一期重建因骨肿瘤或骨恶性肿瘤广泛切除后造成的６ｃｍ以上的骨缺损，其优越性远远超过游离腓骨移植。     

Rigid bridging of massive femur defect using double vascularized fibula graft with hydroxyapatite

The presence of large and massive segmental defects of the diaphyseal bone following tumor resection is a significant problem for orthopedic surgeons. Double or folded free vascularized fibula graft (FVFG) is used in massive femur defects and is considered to be a reliable reconstructive procedure. However, folded or double fibula grafts cannot prevent stress fractures. Here, a novel surgical procedure for bridging of massive femur defects using double FVFG and hydroxyapatite with autogenous bone grafts to prevent stress fractures is reported.     

Femoral head osteonecrosis: why choose free vascularized fibula grafting

Osteonecrosis of the femoral head is a disease in which bone death occurs and usually progresses to articular incongruity and subsequent osteoarthritis. To delay the process of the disease and the conversion to total hip arthroplasty, many surgical techniques have been described. Core decompression, nonvascularized autologous bone grafts, porous tantalum implant procedure, and various osteotomies have been used for the management of early precollapse stage osteonecrosis of the femoral head. However, none of these procedures is neither entirely effective nor can obtain predictable results. With the progress of microsurgery, the implantation of a free vascularized fibula graft to the necrotic femoral head has provided the most consistently successful results. Although the procedure is technically demanding, there is growing recognition that the use of free vascularized fibula graft may improve patient quality of life by functional improvement and pain alleviation. The success of the procedure is related to decompression of the femoral head, excision of the necrotic bone, and addition of cancellous bone graft with osteoinductive and osteoconductive properties, which augments revascularization and neoosteogenesis of the femoral head. Free vascularized fibula graft, especially in younger patients, is a salvaging procedure of the necrotic femoral head in early precollapse stages. In postcollapse osteonecrosis, the procedure appears to delay the need for total hip arthroplasty in the majority of patients. The purpose of this review article is to update knowledge about treatment strategies in femoral head osteonecrosis and to compare free vascularized fibula grafting to traditional and new treatment modalities.     

不同侧带血管蒂腓骨移植修复胫骨长段缺损的疗效比较

目的　比较健侧与患侧带血管蒂腓骨移植修复胫骨长段缺损的疗效。方法　 1987年～ 1997年对 14例取健侧和 10例取患侧带血管蒂腓骨移植修复胫骨长段缺损的患者进行 3～ 13年随访。参照 Enneking系统对患肢进行功能评价 ,以正常肢体功能的百分数表示 ;对移植腓骨的转归 ,参照国际挽救肢体讨论会上制定的“同种及带血管骨移植放射学评价方法”进行评价。结果　取健侧带血管腓骨移植的患肢功能平均恢复 80 .7% ,移植腓骨平均愈合时间为 14周 ;骨折 1例 ,再手术后肢体短缩 2 .5 cm ;延迟愈合 1例 ;平均 4 3周后移植腓骨明显增粗 ,弃拐行走。取患侧带血管蒂腓骨移位的患肢功能平均恢复 6 8.3% ,移位腓骨平均愈合时间为 17周 ;骨折 3例 ,再手术后 2例肢体短缩分别为 2 cm和 4 cm,另 1例术后感染 ,骨吸收、关节功能严重障碍而截肢 ;延迟愈合 2例 ;平均4 9周后移位腓骨明显增粗 ,弃拐行走。两组患肢功能比较有统计学意义 (P<0 .0 5 )。结论　带血管腓骨移植是修复胫骨长段缺损的好方法。选择健侧带血管蒂腓骨移植 ,有利于移植腓骨正常愈合 ,患肢功能较好的早日恢复     

带血管蒂腓骨移植(位)治疗胫骨骨髓炎并骨缺损

目的 探讨带血管蒂腓骨移植治疗胫骨骨髓炎并骨缺损的效果。方法 1990～2001年对36例胫骨骨髓炎并骨缺损的患者采用健侧(19例)和患侧(17例)带血管蒂腓骨移植(位)治疗，术后随访1～11年。参照Enneking系统对患肢进行功能评价，以正常肢体功能的百分数表示，对移植腓骨的转归，参照国际挽救肢体讨论会上制定的“同种及带血管骨移植放射学评价方法”进行评价。结果 取健侧腓骨移植的患肢功能平均恢复86％，移植腓骨平均愈合时间为15周；骨髓炎复发1例，骨折及骨延迟愈合2例，平均41周移植骨明显变粗；取患侧腓骨移位的患肢功能平均恢复78％，移植腓骨平均愈合时间为16周；骨髓炎复发1例，骨折及骨延迟愈合3例，平均43周移植骨明显变粗；两组患肢功能恢复比较有统计学意义(P=O．041)。结论 带血管蒂腓骨移植(位)是治疗胫骨骨髓炎并骨缺损的较好方法，健侧腓骨移植功能恢复优于患侧。     

Vascularized bone grafts for congenital pseudarthrosis of the tibia

Eight vascularized fibula grafts and two vascularized rib grafts were used for the treatment of 10 Boyd's Type II congenital pseudarthrosis of the tibia. All but one vascularized fibula graft united within 4 months. The two vascularized rib grafts did not unite until receiving a conventional bone graft. Nine spontaneous fractures were seen in four patients; all were subsequently treated successfully with cast or conventional bone graft. Corrective osteotomies were done in two patients. Follow-up averaged 8 years and 5 months (range, 5 years and 1 month to 14 years and 4 months). Average age at end of follow-up was 13 years and 6 months (range, 7 years and 10 months to 20 years and 4 months). After bony union was achieved, shortening of the affected leg averaged 3.8 centimeters, flexion deformity averaged 20 degrees, and valgus deformity averaged 24 degrees. In three patients, whose leg discrepancy averaged 4.9 centimeters, the leg was lengthened at an average patient age of 13 years and 9 months (age range, 11 years and 7 months to 15 years and 2 months). The resulting limb length discrepancy averaged 2.2 centimeters. Vascularized bone grafting is a reliable technique for achieving bony union in congenital pseudarthrosis of the tibia. Residual shortening may be corrected later by limb lengthening. © 1997 Wiley-Liss, Inc. MICROSURGERY 17;459–469 1996     

Vascularized fibular graft in infected tibial bone loss

Background:

The treatment options of bone loss with infections include bone transport with external fixators, vascularized bone grafts, non-vascularized autogenous grafts and vascularized allografts. The research hypothesis was that the graft length and intact ipsilateral fibula influenced hypertrophy and stress fracture. We retrospectively studied the graft hypertrophy in 15 patients, in whom vascularized fibular graft was done for post-traumatic tibial defects with infection.

Materials and Methods:

15 male patients with mean age 33.7 years (range 18 - 56 years) of post traumatic tibial bone loss were analysed. The mean bony defect was 14.5 cm (range 6.5 – 20 cm). The mean length of the graft was 16.7 cm (range 11.5 – 21 cm). The osteoseptocutaneous flap (bone flap with attached overlying skin flap) from the contralateral side was used in all patients except one. The graft was fixed to the recipient bone at both ends by one or two AO cortical screws, supplemented by a monolateral external fixator. A standard postoperative protocol was followed in all patients. The hypertrophy percentage of the vascularized fibular graft was calculated by a modification of the formula described by El-Gammal. The followup period averaged 46.5 months (range 24 – 164 months). The Pearson correlation coefficient (r) was worked out, to find the relationship between graft length and hypertrophy. The t-test was performed to find out if there was any significant difference in the graft length of those who had a stress fracture and those who did not and to find out whether there was any significant difference in hypertrophy with and without ipsilateral fibula union. The Chi square test was performed to identify whether there was any association between the stress fracture and the fibula union. Given the small sample size we have not used any statistical analysis to determine the relation between the percentage of the graft hypertrophy and stress fracture.

Results:

Graft union occurred in all patients in a mean time of 3.3 months, at both ends. At a minimum followup of 24 months the mean hypertrophy noted was 63.6% (30 – 136%) in the vascularized fibular graft. Ten stress fractures occurred in seven patients. The mean duration of the occurrence of a stress fracture in the graft was 11.1 months (2.5 – 18 months) postoperatively. The highest incidence of stress fractures was when the graft hypertrophy was less than 20%. The incidence of stress fractures reduced significantly after the graft hypertrophy exceeded 20%.

Conclusion:

In most cases hypertrophy of the vascularized fibular graft occurs in response to mechanical loading by protected weight bearing, and the amount of hypertrophy is variable. The presence or absence of an intact fibula has no bearing on the hypertrophy or incidence of stress fracture. The length of the fibular graft has no bearing on the hypertrophy or stress fracture.     

Combining free vascularized fibula graft and the Ilizarov external fixator: recent approaches to congenital pseudarthrosis of the tibia

The present study compares a recent approach for congenital pseudarthrosis of the tibia, combining a free vascularized fibula graft and an Ilizarov external fixator. Between 1984 and 1993, seven vascularized fibula grafts were performed. In the first six cases, casts or unilateral external fixators were applied, and five of these cases were complicated by fractures of the graft, necessitating secondary procedures or long-term immobilization. The mean follow-up was 12.1 years. Five patients can now walk unassisted, and one uses a brace only outdoors. On average, a brace was required for 18 months. In the recent Ilizarov external fixator case, the fixator was removed after 4 months and a brace was unnecessary at 10 months. There was no leg-length discrepancy, severe ankle deformity, or fracture of the grafted fibula 7 years postoperatively. Combining a free vascularized fibula graft with an Ilizarov external fixator is recommended for this condition.     

Free vascularized fibula grafts for salvage of failed oncologic long bone reconstruction and pathologic fractures

Vascularized bone grafts, particularly the free fibula transfer, have incited revolutionary changes in the field of skeletal reconstruction. In no place has this been more evident than in oncologic reconstruction. The free vascularized fibula graft has been used to good effect for primary long‐bone reconstruction, long‐bone allograft complication salvage, and pathologic fracture salvage of the long bones. Although many of these procedures often entail significant complications, limb salvage has been made possible in a majority of patients using transfers of free vascularized fibula grafts. The purpose of this review is to critically evaluate the technique of onlay free vascularized fibula grafts for salvage of allograft complications and pathologic fractures of the long bones. This will be accomplished by reviewing the problem of allograft complications and pathologic fractures, the current treatment modalities available, the outcomes of these treatments, and future directions of treatment for this particular problem. © 2009 Wiley‐Liss, Inc. Microsurgery, 2009.     

吻合血管腓骨游离移植在股骨头缺血性坏死中的应用

目的探讨用吻合血管的腓骨游离移植对股骨头缺血性坏死的应用效果. 方法 2000年10月～2002年2月,对26例(31髋)股骨头缺血性坏死采用了吻合血管的腓骨游离移植治疗并进行随访观察.获随访的21例(25髋)随访时间为6～18个月,平均12个月.根据患髋术前Steinberg分期:Ⅱ期,5髋;Ⅲ期,8髋;Ⅳ期,12髋. 结果 21例(25髋)中各期患者的Harris评分在术后均有不同程度的提高.其中疼痛症状明显缓解,术后患者能恢复正常日常生活和工作.随访的X线片显示,18髋的股骨头上出现了不同程度的改善,6髋未出现明显的改变,1髋恶化. 结论吻合血管的腓骨游离移植是治疗股骨头缺血性坏死的一种有效方法,能够阻止或延缓病情的发展.     

Free vascularized fibula transfer for stabilization of the thoracolumbar spine. A case report

Anterior strut grafting for kyphosis has become an accepted procedure. High stresses are placed across these grafts, however, and it would seem advisable to use a living bone graft that could remodel in response to these stresses, rather than an avascular graft of fibula or rib such as is commonly employed. This case report demonstrates the use of a free, vascularized living bone graft in the treatment of a post-traumatic kyphosis, with successful subsequent incorporation into the anterior fusion mass.     

M?glichkeiten und Ergebnisse der (freien) vaskularisierten Knochentransplantation im Handbereich

The vascularized bone transplantation or graft is a modern and successful treatment concept in segmental bone loss. Faster healing and higher union rates were shown in several studies. Using vascularized bone grafts, the adaption in mechanical conditions as well as stability are improved. The indications, however, must be critically considered in order to obtain an optimal result. Reconstruction of the bone defect should be performed as quickly as possible after the trauma, infection, or tumor resection. Amputation should always remain the method of last choice. Depending on the existing bone defect, there are various possible donor sites, e.g., fibula, scapula, ulna, femur, and hip bone. The advantages and disadvantages of each donor site has to be thoroughly discussed prior to the operation to assure an optimal postoperative result. In view of these issues, vascularized bone grafts should be performed in microvascular specialized plastic or hand surgery centers.     

Free vascularized fibula grafts in surgery of the upper limb

Twenty patients with intractable diseases in the upper extremity were treated using free vascularized fibula grafts. There were 13 men and seven women. Three patients had traumatic bone defects, five had post-traumatic nonunions, two had congenital pseudoarthroses, seven had defects after tumor resection, and three had other lesions. The reconstructed sites were the humerus in two patients, the radius and/or ulna in 17, and the metacarpal and phalangeal bones in one. The length of the bone defect ranged from 3 to 18 cm (mean: 8.4 cm). Follow-up periods ranged from 6 to 204 months. No patient required additional bone grafts. The mean period required to obtain radiographic bone union was 4.4 months. There were no cases with fractures of the grafted bone, but malunion occurred in four cases. The vascularized fibula graft is indicated in patients with large bone defects or intractable nonunions in the humerus, radius, and/or ulna.     

Fractured coracoid with anterior shoulder dislocation and greater tuberosity fracture--report of a bilateral case

We treated 23 patients with recalcitrant posttraumatic humeral shaft nonunion with vascularized bone grafts (fibula 10, femur 10 and scapula 3). 21/23 patients healed primarily. Venous thrombosis in the graft necessitated postoperative thrombectomy in 2 patients. Complications at the donor site were trivial. We used a vascularized fibular graft in patients with a large bone defect and with poor intrinsic stability of the nonunion site and a corticoperiosteal femoral graft in atrophic nonunion without a substantial bone defect. The scapula graft is easy to transfer to the surgical neck of the humerus on its pedicle.     

Recalcitrant posttraumatic nonunion of the humerus: 23 patients reconstructed with vascularized bone graft: 23 patients reconstructed with vascularized bone graft

We treated 23 patients with recalcitrant posttraumatic humeral shaft nonunion with vascularized bone grafts (fibula 10, femur 10 and scapula 3). 21/23 patients healed primarily. Venous thrombosis in the graft necessitated postoperative thrombectomy in 2 patients. Complications at the donor site were trivial. We used a vascularized fibular graft in patients with a large bone defect and with poor intrinsic stability of the nonunion site and a corticoperiosteal femoral graft in atrophic nonunion without a substantial bone defect. The scapula graft is easy to transfer to the surgical neck of the humerus on its pedicle.     

Recalcitrant posttraumatic nonunion of the humerus: 23 patients reconstructed with vascularized bone graft

We treated 23 patients with recalcitrant posttraumatic humeral shaft nonunion with vascularized bone grafts (fibula 10, femur 10 and scapula 3). 21/23 patients healed primarily. Venous thrombosis in the graft necessitated postoperative thrombectomy in 2 patients. Complications at the donor site were trivial. We used a vascularized fibular graft in patients with a large bone defect and with poor intrinsic stability of the nonunion site and a corticoperiosteal femoral graft in atrophic nonunion without a substantial bone defect. The scapula graft is easy to transfer to the surgical neck of the humerus on its pedicle.     

The long term fate of the fibula when used as an intraosseous graft

The long term fate of the fibula in an intra-osseous site is still a matter of debate. Since the procedure of free fibular grafting for neglected femoral neck fractures was routinely done at our institute, we were able to observe the serial changes in 37 cases with an average 8.9 years follow-up. Graft incorporation was not consistent in the 4 to 10-year postoperative period, but in cases with more than 10 years follow-up, a major portion of the graft got incorporated into the host bone. A classification system for the incorporated grafts is suggested. The presence of avascular necrosis seems to initially hinder graft incorporation, but if the bone revascularises, graft incorporation proceeds at a comparable rate. This study shows that cortical bone gets well incorporated into host cancellous bone and helps to reconstitute the neck in cases of femoral neck nonunions.     

Reconstruction of large posttraumatic skeletal defects of the forearm by vascularized free fibular graft

Vascularized bone graft is most commonly applied for reconstruction of the lower extremity; indications for its use in the reconstruction of the upper extremity have expanded in recent years. Between 1993-2000, 12 patients with segmental bone defects following forearm trauma were managed with vascularized fibular grafts: 6 males and 6 females, aged 39 years on average (range, 16-65 years). The reconstructed site was the radius in 8 patients and the ulna in 4. The length of bone defect ranged from 6-13 cm. In 4 cases, the fibular graft was harvested and used as a vascularized fibula osteoseptocutaneous flap. To achieve fixation of the grafted fibula, plates were used in 10 cases, and screws and Kirschner wires in 2. In the latter 2 cases, an external skeletal fixator was applied to ensure immobilization of the extremity. The follow-up period ranged from 10-93 months. Eleven grafts were successful. The mean period to obtain radiographic bone union was 4.8 months (range, 2.5-8 months). Fibular grafts allow the use of a segment of diaphyseal bone which is structurally similar to the radius and ulna and of sufficient length to reconstruct most skeletal defects of the forearm. The vascularized fibular graft is indicated in patients with intractable nonunions where conventional bone grafting has failed or large bone defects, exceeding 6 cm, are observed in the radius or ulna.     

The use of postoperative bone scintigraphy to predict graft retention

BACKGROUND: Osteonecrosis of the femoral head commonly occurs in patients aged under 50 years. Because of a high rate of complications associated with joint replacement surgery in this population, surgical techniques, such as vascularized fibular grafting, have been devised in an attempt to salvage the femoral head. The purpose of this study was to investigate the use of bone scintigraphy to predict graft retention after vascularized fibular grafting for osteonecrosis of the hip. METHODS: We evaluated single photon emission computed tomography images from 104 subjects whose hips were treated with vascularized fibular grafts between 1994 and 2000. We compared the signal intensity of the graft with the intensity of the ipsilateral proximal femoral diaphysis and assigned a score of 1 if less than diaphysis, 2 if equal to diaphysis and 3 if greater than diaphysis. We defined graft failure as conversion to or on the waiting list for total hip arthroplasty. RESULTS: Thirty percent of hips failed treatment (n = 31, mean graft survival 34.9 mo), while 70% of grafts were retained (n = 73, mean follow-up 56.6 mo). Bone scan scores were significantly lower in the failed group (mean 7.1, range 6-12), compared with the retained group (mean 8.5, range 6-18; p = 0.03). Logistic regression demonstrated that a bone scan score > 6 was associated with graft retention (p = 0.028), with an odds ratio of 3.08 (range 1.13-8.40). CONCLUSION: These results suggest that having a well-perfused graft in the early postoperative period improves the chances of graft retention in the future.     

带血管骨移植治疗股骨头无菌性坏死进展

股骨头无菌性坏死是骨科临床较常见的疾病，如能早期做出诊断（股骨头塌陷前），可采用钻芯减压（植骨或不植骨）、截骨、以及带或不带血管的骨移植治疗，尽力保存髋关节功能。局部带蒂骨移植与和游离带血管的骨移植能将带血运的骨组织植入股骨头骨坏死区，除用健康骨组织替代坏死骨外，还重建了股骨头新的血供来源。经5年观察，对各期患者治疗成功率为80％。应用游离带血管的骨移植治疗股骨头无菌性坏死，可获得较高的成功率。