高压氧辅助治疗严重手外伤的疗效观察

目的：探讨高压氧（hyperbaric oxygen, HBO）辅助治疗严重手外伤的临床疗效。方法对我院2008年10月—2011年6月收治的48例严重手外伤患者,随机分为高压氧辅助治疗组（高压氧组）和传统治疗组（对照组）,术后平均随访1.5年,根据全国手功能评定具体方案中断指再植功能评定标准进行两组手功能恢复状况的评价。结果高压氧治疗组功能评定结果明显优于传统治疗组。结论高压氧辅助治疗严重手外伤可明显提高术后再植手指的成活率,改善手部功能。     

术前高压氧治疗对肝硬化门静脉高压症病人的影响

目的 研究术前高压氧（HBO）治疗对肝硬化门静脉高压病人的作用,并探讨其机理。方法 选取肝硬化门静脉高压病人12例接受HBO治疗。观察肝功指标、内毒素和NO水平、肠粘膜通透性、网状内皮系统功能及血流动力学指标在HBO前后变化;另设正常对照组8例,比较两组间肠粘膜通透性、网状内皮系统功能的差异。结果 （1）与正常秩序正常组相比,肝硬化组的肠粘膜通透性增高,而网状内皮系统吞噬功能降低,且内毒素与肠粘膜通透性呈正相关（r＝0．504,P＝0．012）。（2）HBO治疗后,病人的肝功改善;网状内皮系统功能恢复,内毒素、NO较前下降;脾脏厚度、门静脉宽度及门静脉血流量减少。（3）统计分析发现NO与内毒素、脾脏厚度及门静脉血流速度呈正相关（r1＝0．597,P1＝0．000;r2＝0．472,P2＝0．027;r3＝0．463,P3＝0．030）,与门静脉血流速度呈负相关（r＝－0．443,P＝0．030）。结论 HBO能改善肝硬化病人的肝脏功能,改善门静脉高压和高动力循环状态。其作用机理可能与改善肝脏供氧,增加网状内皮系统功能,减少血中内毒素及NO有关。     

高压氧在手外科创伤中的应用

目的探讨高压氧在手外科常见创伤中的应用与临床效果。方法2002年3月～2005年12月对手外科常见创伤:断指再植术后血管危象、肢体顽固性溃疡、手部骨折、肢体压砸伤等按常规治疗组和高压氧治疗组进行观察。结果断指再植术后血管危象常规治疗组和高压氧治疗组无明显差异(t检验,P>0.05);肢体顽固性溃疡、手部骨折、肢体压砸伤等的常规治疗组和高压氧治疗组差异有显著性(t检验,P<0.05)。结论高压氧在手外科常见创伤中合理选择应用,可以取得较好的临床效果。     

Effects of hyperbaric oxygen therapy on rabbit skeletal muscle during extremity lengthening

Introduction  Extremity lengthening through distraction osteogenesis is limited by the surrounding skeletal muscle and neurovascular structures rather than the bone itself. The purpose of this study is to evaluate the effects of hyperbaric oxygen therapy on skeletal muscle during distraction osteogenesis. Materials and methods  Twenty New Zealand white rabbits were randomly divided into two groups. Right tibia of all rabbits was distracted at a rate of 0.125 mm per 6 h (0.5 mm/day) for 10 days with circular external fixator. Experimental group rabbits (N = 10) underwent 2.5 ATA hyperbaric oxygen therapy for 2 h everyday for 20 days, control group rabbits (N = 10) did not receive any corresponding treatment. Skeletal muscle perfusion was evaluated with scintigraphy before and after the distraction period. Serum CPK, LDH and AST levels were measured before and after the distraction period. All animals were killed on the 27th day. The right tibias of all animals were removed and tibialis posterior muscle was harvested for histopathologic and histomorphometric assessment with light and electron microscopy. Results  Skeletal muscle perfusion was decreased in the control group in comparison with pre-distraction level (P = 0.008). However, no significant decrease was observed in the experimental group (P = 0.678). There were no statistical differences in serum CPK, LDH and AST levels between groups (P = 0.340, P = 0.077, P = 0.796). The mean area of the muscle fibers was measured as 398.66 ± 9.16 μ² in the experimental group and 349.44 ±5.76 μ² in the control group (P = 0.000) with light microscopy. Mild fibrosis was observed in connective tissue component of muscle tissue in control group. An average of 26 myofibrils (20–32) was counted in a 16-cm² unit area in experimental group and 50 myofibrils (35–65) in the control group with electron microscopy. Enlargement in the sarcoplasmic reticulum, degenerative changes in nuclear cytoplasm and increase in myofibril diameter were observed in the control group, which was not observed in the experimental group Conclusion  Results of this study suggest that HBO treatment alleviates the detrimental effects of distraction on skeletal muscles and preserves its ultrastructure.     

高压氧环境下颈椎牵引治疗神经根型颈椎病

目的评估高压氧环境下颈椎牵引治疗神经根型颈椎病的临床疗效。方法将2013年6月至2013年12月于广州市番禺区南村医院门诊就诊的78例神经根型颈椎病患者随机分为两组,治疗组（n=39）采用高压氧环境下颈椎牵引治疗,对照组（n=39）单纯行颈椎牵引治疗。根据中医病证诊断疗效标准评价1个疗程后的治疗效果,同时采用视觉模拟量表（VAS）评分判定患者疼痛症状的缓解程度,依据颈椎功能障碍指数（NDI）观察颈椎功能障碍的改善情况。对两组中临床疗效评估为治愈的患者进行为期6个月的随访,了解其复发情况。结果 1个疗程结束后对照组总有效率80%（31/39）,治疗组总有效率97%（38/39）,两组比较,差异有统计学意义（P〈0.05）;两组治疗1个疗程后VAS评分、NDI均较治疗前明显改善,治疗组治疗后VAS评分、NDI均优于对照组（P〈0.05）;6个月随访时对照组复发率为2/11,治疗组复发率为10%（2/21）,两组比较,差异无统计学意义（P〉0.05）。结论高压氧环境有助于提高牵引治疗神经根型颈椎病的近期临床疗效。     

高压氧治疗重症颅脑损伤26例临床分析

目的探讨高压氧对重型颅脑损伤患者的治疗效果。方法对26例重型颅脑损伤患者进行常规加高压氧治疗,21例进行常规治疗,比较两组的疗效。结果高压氧组显效21例,无效5例。常规组显效11例,无效10例。两组差异有统计学意义(P0.05)。结论早期给予高压氧治疗,可明显提高重型颅脑损伤患者治愈率和生存质量。     

高压氧对人前列腺癌细胞株小鼠荷瘤模型作用的研究

目的 为评估高压氧治疗前列腺癌放疗后出血性膀胱炎的安全性,探讨高压氧对体内前列腺癌细胞生长的影响. 方法 采用人前列腺癌PC-3细胞株皮下接种构建小鼠荷瘤模型(n=40),随机分组,实验组(n=20)每周连续进行5次200 kPa高压氧暴露,共20次,对照组(n=20)常压常氧条件下饲养.连续4周观察2组移植瘤生长体积的变化,免疫组织化学方法分析2组瘤体组织相关病理学特征,包括瘤体微血管密度(CD34)、瘤细胞增殖(Ki-67蛋白)以及瘤细胞凋亡(p53、p27蛋白)等指标. 结果 肿瘤接种后第28天,实验组移植瘤体积为(425.8±13.9)mm3,对照组为(433.6±12.8)mm3,2组比较差异无统计学意义(P>0.05);实验组移植瘤微血管密度及Ki-67、p53、p27蛋白表达的阳性率分别为69.7±9.5、(55.2±6.7)%、(31.2±5.3)%、(80.4±5.7)%,对照组分别为77.15±8.7、(50.65±7.3)%、(30.5±4.7)%、(85.3±6.4)%,2组比较差异均无统计学意义(P>0.05). 结论 高压氧对于前列腺癌细胞生长无促进作用,临床应用高压氧治疗因前列腺癌放射治疗引起的出血性膀胱炎患者可能是安全的.     

高压氧对兔耳创面模型早期瘢痕组织形成的影响

目的 通过观察高压氧对兔耳创面愈合及瘢痕形成的影响,以探讨在临床中应用高压氧防治早期瘢痕的可行性.方法 选取新西兰白兔16只建立兔耳增生性瘢痕模型,每只兔左耳4个创面,右耳4个创面,共128个,随机分为高压氧组与对照组2组,每组8只,64个创面.高压氧组术后立即开始高压氧处理,2个大气压,吸氧60 min,每日1次,疗程以创面愈合为准.期间观察记录创面愈合情况以及兔耳瘢痕大小、厚度、颜色、硬度.待创面全部愈合后,切取创面进行HE染色,Masson染色和苦味酸天狼星红染色,行病理学观察、检测及分析.结果 高压氧组愈合时间为(16.7±1.8)d;对照组为(20.2±2.3)d,差异有统计学意义(P＜0.05).高压氧组瘢痕增生发生率较对照组低,实验组发生率为(38/64,59.4％),对照组发生率为(52/64,81.2％),差异有统计学意义(P＜0.05).光镜下观察,高压氧组真皮层较对照组薄,成纤维细胞数量较少,胶原较疏松,排列较整齐,胶原结节和漩涡状结构少.瘢痕增生指数,高压氧组为3.48±0.94,对照组为4.65 ±0.76,差异有统计学意义(P＜0.01).成纤维细胞密度,高压氧组为186.5±27.3,对照组为246±41.6,差异有统计学意义(P＜0.05).胶原纤维面密度,高压氧组为(31.42±5.36)％,对照组为(43.62±7.36)％,差异有统计学意义(P＜0.05).Ⅰ型和Ⅲ型胶原含量,高压氧组分别为(71.42±5.36)％和(28.58±5.36)％,对照组为(62.46±7.32)％和(37.54±7.32)％,差异有统计学意义(P＜0.05).Ⅰ型和Ⅲ型胶原比例,高压氧组为2.499,对照组为1.664,高压氧组比例更为接近正常皮肤Ⅰ型和Ⅲ型胶原约4∶1的比例.结论 高压氧可促进创面愈合,并对兔耳早期增生性瘢痕有较明显的抑制作用.     

Accuracy of a peristaltic finger-type infusion pump during hyperbaric oxygen therapy

PURPOSE: To evaluate the accuracy of a peristaltic finger-type pump during hyperbaric oxygen therapy (HBO). METHODS: Using two examples of one type of infusion pump, we evaluated its accuracy at 2 ATA (atmospheres absolute) by measuring the actual volumes pumped at given time points (flow rate) and comparing these data with the corresponding data obtained at 1 ATA. RESULTS: There was no significant difference in flow rates between 2 and 1 ATA. In terms of accuracy, the present pump was superior to the syringe pump tested in our previous study. Under our conditions, the ambient pressure might have acted equally on the inlet and outlet sides of the infusion line, which may explain the lack of effect of 2 ATA on flow rates. This is not the case with a syringe pump, and the difference in flow-generating mechanisms may help explain the different results obtained in our two studies. CONCLUSION: The present type of pump could be used during HBO (at 2 ATA) with the same accuracy as at 1 ATA. Whether the ambient pressure can affect pump input and output (peristaltic-pump infusion line) or only pump output (syringe type) may determine whether accuracy suffers under HBO conditions.     

Effects of hyperbaric oxygen therapy on caustic esophageal injury in rats

Background/purpose

Caustic esophageal burn is a serious problem in pediatric surgery. Even though many clinical and experimental studies had been performed, the complication rate could not be reduced to a satisfying level. In this study, the authors evaluated the effects of hyperbaric oxygen (HBO) therapy in caustic esophageal burn in rats.

Methods

Rats were divided into 4 groups, and caustic burn at the distal esophagus was created by applying 50% NaOH for 3 minutes in all groups. The first and third groups did not receive HBO therapy. HBO therapy was applied to the second group for 2 days and to the fourth group for 28 days. To evaluate the effects of short-term HBO therapy, the first 2 groups were compared for ulceration, inflammation, and submucosal vascular thrombosis after 2 days. The third and fourth groups were compared for the long-term effects of HBO therapy. Rats in these groups were killed after 28 days and compared for the collagen content, weight, and mortality rate.

Results

In the second group, which received 2 days of HBO therapy, ulcer depth and vascular thrombosis were significantly lower than these in the first group (P = .022 and P = .020, respectively). The fourth group, which received 4 weeks of HBO therapy, had a significantly reduced mortality rate, weight loss, and collagen score and hydroxyproline level if compared with the third group (P = .035; P = .016; P = .028; and P = .033, respectively).

Conclusions

These results indicate that HBO therapy is useful in caustic esophageal burn both in short-term and long-term use.     

Glasgow Coma Scale, brain electric activity mapping and Glasgow Outcome Scale after hyperbaric oxygen treatment of severe brain injury

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Prediction of neurologic outcome in patients with spinal cord injury by using hyperbaric oxygen therapy

The effectiveness of hyperbaric oxygen therapy (HBO) in predicting neurological recovery in patients with spinal cord injury was evaluated. HBO has been used to treat spinal cord injury, but HBO does not appear to greatly alter the neurological outcome. This is the first report of the use of HBO as a diagnostic tool to evaluate neurological recovery after spinal cord injury. The study group consisted of 22 patients, aged 21–73 years, with spinal cord injuries. The effect of HBO was evaluated on admission and categorized as one of four grades (excellent, good, fair, or poor). The neurological status was evaluated on admission and at the time of follow-up, according to Frankel grade and the American Spinal Injury Association (ASIA) motor score. Correlations between the HBO effect and Frankel grade recovery and correlations between the HBO effect and recovery rate of the ASIA motor score were evaluated. The recovery in Frankel grade from admission to the final follow-up became better as the effectiveness of HBO increased (r = 0.445; P = 0.0414). The Frankel grade (r = 0.036; P = 0.871) and ASIA motor score (r = 0.029; P = 0.893) on admission did not correlate with the recovery in Frankel grade. There was a significant correlation between the HBO effect and the recovery rate of the ASIA motor score (r = 0.586; P = 0.0072), but this correlation was weaker than that for the ASIA motor score on admission (r = 0.752; P = 0.0006). We conclude that HBO can be employed to assess the status of spinal cord function recovery after spinal cord injury. Received: January 27, 2001 / Accepted: May 11, 2001     

不同高压氧预处理方案对兔脊髓缺血再灌注损伤的影响

目的 探讨不同高压氧预处理方案对兔脊髓缺血再灌注损伤的影响.方法 新西兰大白兔45只,月龄4～5月,体重2.0～2.5 kg,随机分为5组:假手术组(S组,n=5)开腹剥离左肾动脉下段腹主动脉但不阻断血流,20 min后关腹;脊髓缺血再灌注组(IR组,n=10)采用左肾动脉下段腹主动脉阻断法建立脊髓缺血再灌注损伤模型,缺血20 min后恢复灌注;不同方案高压氧预处理组(H_(1～3)组,n=10)分别接受连续5 d(H_1组)、10 d(H_2组)或20 d(H_3组)高压氧预处理(2.5 ATA,吸入氧浓度100%),1h/d,末次高压氧预处理结束后24 h时,建立脊髓缺血再灌注模型.再灌注48 h时,采用修正Tarlov评分,评价后肢运动功能.然后取L_5脊髓节段,分别行HE、TUNEL和nuoro-Jade B染色,计数脊髓正常神经元、凋亡神经元和变性神经元.结果 与S组比较,IR组后肢运动功能评分和脊髓前角正常神经元计数降低(P<0.01);与IR组比较,H_1组和H_2组后肢运动功能评分和脊髓前角正常神经元计数升高,凋亡神经元计数和变性神经元计数降低(JP<0.01),H_3组各指标差异无统计学意义(P>0.05);H_1组和h_2组各指标比较差异无统计学意义(P>0.05);与H_1组和H_2组比较,H_3组后肢运动功能评分和脊髓前角正常神经元计数降低,凋亡神经元计数和变性神经元计数升高(P<0.01).结论 连续5 d或10 d高压氧预处理(2.5 ATA,吸入氧浓度100%)可减轻脊髓缺血再灌注损伤;而连续20 d高压氧预处理无神经保护作用.     

不同压力高压氧治疗对大鼠神经病理性痛的影响

目的 探讨不同压力高压氧治疗(HBO)对大鼠神经病理性痛的影响.方法 成年雄性SD大鼠24只,采用随机数字表法,将其分为4组(n=6):假手术组(S组)、神经病理性痛组(NP组)、2.O标准大气压高压氧治疗组(HBO2.0组)、2.5标准大气压高压氧治疗组(HBO2.5组).将HBO2.0组和HBO2.5组大鼠置于高压氧舱,以10 kPa/min的速率向舱内匀速加压直至目标压力并保持60 min.然后以10 kPa/min的速率匀速减压至正常大气压.从术后1d开始高压氧治疗,连续5d,1次/d.S组和NP组单纯放入氧舱100 min而不接受治疗.于出高压氧舱后即刻(T0)、1 h(T1)和2 h(T2)时测定机械缩足反应阈(MWT)和热缩足反应潜伏期(TWL).结果 与S组比较,NP组MWT降低,TWL缩短(P＜0.05).与NP组比较,HBO2.0组和HBO2.5组高压氧治疗期间T1时MWT升高,TWL延长(P＜0.05),T2时MWT和TWL差异无统计学意义(P＞0.05).HBO2.0组和HBO2.5组间各时点MWT和TWL比较差异无统计学意义(P＜0.05).结论 不同压力高压氧治疗均可减轻大鼠神经病理性痛,但压力改变不影响镇痛效果.     

高压氧对脊髓损伤肌张力控制的队列研究

目的:探讨高压氧(hyperbaric oxygenation,HBO)对脊髓损伤(spinal cord injury,SCI)肌张力增高患者的治疗效果。方法:选择2009年3月至2011年4月脊髓损伤肌张力增高患者80例作为研究对象,男49例,女31例;年龄17～60岁,平均(34.12±6.61)岁;病程14～30d,平均(20.16±5.08)d。按就诊顺序、是否愿意同时进行高压氧治疗分成治疗组和对照组。其中治疗组40例,在运动康复训练和巴氯芬药物治疗的基础上,加用HBO治疗。治疗压力为2ATA;治疗方案为:面罩吸氧20min,休息5min,反复3个循环为1次,每日1次,10d为1个疗程,共治疗6个疗程。对照组40例,只进行运动康复训练和巴氯芬药物治疗,疗程同治疗组。两组均按国际通用修订的Ashworth评分(modified ash worth scale,MAS)方法分别于治疗3个疗程和6个疗程时对肌张力进行评估。结果:治疗3个疗程时对肌张力的控制,治疗组有效5例,显效0例;对照组有效4例,显效0例。治疗6个疗程时对肌张力的控制,治疗组有效24例,显效5例;对照组有效14例,显效2例。3个疗程时,治疗组与对照组疗效差异无统计学意义(P=0.508);6个疗程时治疗组疗效优于对照组(P<0.05)。结论:HBO对脊髓损伤肌张力增高患者有治疗作用,可作为一种常规辅助治疗方法,在临床上值得推广应用,但需要足够的疗程。     

高压氧下调低氧诱导因子对急性胰腺炎的影响

目的 观察高压氧(HBO)抑制低氧诱导因子(HIF)活化对急性胰腺炎(AP)的影响.方法 40只Wistar大鼠随机分为假手术组、AP组、吸氧组和HBO组,每组10只.造模后4 h,吸氧组和HBO组大鼠分别接受常压下吸氧治疗和HBO治疗90 min;造模后6 h检测大鼠体内氧代谢水平;以免疫组织化学、激光共聚焦显微镜和Western blot法分析胰腺组织中HIF活化及血管内皮生长因子(VEGF)表达情况,检测胰腺组织髓过氧化物酶(MPO)含量和主要脏器干湿重比,以血清TNF-α和胰腺组织病理学评分评估病情.结果 免疫组织化学证实,AP组、吸氧组和HBO组腺泡细胞及中性粒细胞内HIF活化进入细胞核,并伴有VEGF高表达;与AP组[PaO_2:(86.6±5.6)nnn Hg(1 mm Hg=0.133 kPa);SaO_2:87.7%±1.8%]和吸氧组[PaO_2:(86.6±5.6)mm Hg;SaO_2:91.2%4±2.5%]比较,HBO组[PaO_2:(369.1±67.6)mm Hg;SaO_2:99.6%±0.7%]大鼠体内氧代谢水平升高(P<0,05);胰腺组织中HIF、VEGF和MPO含量减少,胰腺及胰外脏器水肿减轻,血清TNF-α和胰腺组织病理学评分降低(P<0.05).结论 HIF可促进AP炎症反应,HBO可以通过抑制HIF活化改善AP病情.     

短节段椎弓根钉内固定联合高压氧治疗急性脊柱损伤对脊柱形态和功能的影响

目的：探讨短节段椎弓根钉内固定联合高压氧治疗急性脊柱骨折的效果及对脊髓功能恢复的影响。方法：将2017年2月至2020年3月收治的96例急性脊柱骨折患者分为联合组与对照组,每组48例。两组患者均采用短节段椎弓根钉内固定治疗,其中联合组术后给予高压氧治疗。记录两组患者手术时间、手术出血量、切口长度等一般手术情况,观察手术前后脊柱形态功能,美国脊柱损伤协会（Ameraican Spinal Injury Assiciation,ASIA）神经功能分级,血清炎症因子,日常生活活动能力的差异。结果：两组患者的手术时间、手术出血量、切口长度比较差异无统计学意义（P>0.05）。术前及术后1周、6个月患者的伤椎前缘高度比和Cobb角组间比较差异无统计学意义（P>0.05）;两组术后1、6个月的伤椎前缘高度比较术前明显改善（P<0.05）,Cobb角较术前明显减小（P<0.05）。术后1 d两组患者的血清白细胞介素-6(interleukin-6,IL-6),白细胞介素-8(interleukin-8,IL-8)和肿瘤坏死因子（tumor necrosis factor-α,...     

高压氧治疗急性氯气中毒5例临床分析

目的观察高压氧治疗急性氯气中毒的疗效。方法对5例急性氯气中毒患者在内科常规治疗的同时,根据患者中毒的程度,给予不同次数的高压氧治疗。结果 5例急性氯气中毒患者治疗效果明显,均痊愈出院。结论高压氧可以作为辅助治疗急性氯气中毒的一种有效的方法。     

高压氧对皮肤磨削术后创面愈合的影响

目的探讨高压氧治疗在面部瘢痕皮肤磨削术后创面愈合中的作用。方法将行面部瘢痕皮肤磨削术患者32例（痤疮后凹陷性瘢痕20例,外伤后条索状线性瘢痕12例）．随机分为两组：16例为高压氧治疗组,于术后第1天开始给予高压氧干预,每日1次,连续6d;另外16例作为对照组．只给予常规术后换药处理,换药程序与高压氧治疗组相同,观察高压氧治疗组与对照组在磨削术后创面换药天数及愈合时间上的差异。结果16例磨削创面进行高压氧治疗后创面愈合较快,平均换药时间为（4．0±1．2）d,平均愈合时间为（11．0±2．8）d,无创面感染。对照组16例磨削创面愈合较慢,平均换药时间为（5．0±1．6）d,平均愈合时间为（16．0±3．1）d,无创面感染。两组患者以供皮区创面内层敷料完全自然翘起,可轻易揭除。揭除的时间为判定愈合标准,两组愈合时间比较差异有统计学意义（P〈O．05）,换药天数差异无统计学意义（P〉O．05）。结论面部瘢痕皮肤磨削术后行高压氧治疗可以促进磨削区创面愈合,缩短愈合时间。     

高压氧对大鼠缺血再灌注损伤肾FasL和半胱氨酸蛋白酶3表达的影响

目的 研究高压氧(HBO)对大鼠缺血再灌注损伤(IRI)肾细胞凋亡相关基因(FasL)和细胞凋亡执行蛋白半胱氨酸蛋白酶3(caspase-3)表达的影响,并探讨其作用机制.方法 健康SD雄性大鼠随机分为假手术组(n=8)、IRI组(n=8)和IRI+HBO组(n=8).采用夹闭双侧肾动脉方法建立IRI模型.IRI+HBO组分别在再灌注后lh、24 h、48 h给予HBO处理,末次HBO后取双肾组织测定各组大鼠肾组织匀浆超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量 ;采用实时荧光定量PCR和免疫组织化学染色方法分别测定肾组织FasL mRNA、caspase-3蛋白表达.结果 与假手术组比较,IRI组SOD活性下降(P＜0.05),MDA含量升高(P＜0.05),经HBO治疗后SOD活性升高(P＜0.05),MDA含量降低(P＜0.05).FasL mRNA、caspase-3蛋白在假手术组呈低水平表达,而在IRI组表达显著上调(P＜0.01),IRI+HBO组表达较IRI组显著下调(P＜0.01).结论 大鼠肾缺血损伤后随着再灌注时间延长FasL mRNA 、caspase-3蛋白表达显著上调.早期HBO治疗后可以使FasL mRNA、caspase-3蛋白表达明显下调,抑制细胞凋亡,保护肾脏.