不同原因急性肺损伤患者细胞因子及糖皮质激素水平的临床研究

目的：探讨内、外源性急性肺损伤（ALI）患者血清肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）、白介素-6（IL-6）及糖皮质激素（GCs）水平的临床意义。方法：将45例ALI患者分为A组、B组,检测两组及20例对照组血清TNF-α、IL-1β、IL-6及GCs水平,进行APACHEⅡ评分。结果：A组血清TNF-α、IL-1β、IL-6水平高于B组及对照组。两组GCs与APACHEⅡ评分无统计学差异。结论：不同原因ALI患者血清细胞因子水平存在差异。     

超滤量的血液滤过对全身炎症反应的影响

目的研究高流量血液滤过(HVHF)对全身炎症反应综合征(SIRS)患者炎症介质水平和预后的影响。方法对ICU内31例SIRS患者接收血液滤过治疗,随机分为超滤量60ml·kg-1·h-1的HVHF组(15例)和超滤量35ml·kg-1·h-1的连续性静脉静脉血液滤过(CVVH)组(16例),每次血液滤过治疗时间不少于24h。分别于血液滤过前(T0)、滤过12h(T1)及24h(T2)抽取静脉血检测肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6、IL-8,并观察SIRS指标和APACHEⅡ评分。结果 T1时,HVHF组TNF-α、IL-6水平显著下降且低于CVVH组(P<0.05);T2时两组TNF-α、IL-6下降均不明显。两组的IL-8在治疗24h中均缓慢下降。两组治疗后SIRS指标和APACHEⅡ评分均显示明显改善,HVHF组的存活率明显高于CVVH组(P<0.05)。结论 HVHF降低SIRS患者炎症介质的效果较CVVH更为明显。     

炎性细胞因子与心力衰竭的相关性研究

目的探讨肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）与慢性心力衰竭（CHF）的关系。方法采用放射免疫分析法（RIA）和酶联免疫吸附法（ELISA）测定血清TNF-α、IL-6、IL一10的含量。结果心功能Ⅳ级组患者血清TNF-α、IL-6、IL-10含量显著高于对照组和心功能Ⅱ、III级组（P〈0．05）,心功能Ⅲ级患者的TNF-α、IL-6、IL．10水平显著高于心功能Ⅱ级患者和对照组（P〈0．05）。CHF组血清TNF-α和IL-6水平与LVEF呈负相关（r=-0．755,-0．751）。CHF组血清IL-10水平与LVEF呈正相关（r=0．476）。结论TNF-α、IL-6、IL-10水平与CHF发生发展密切相关。     

子宫内膜异位症患者腹腔液和血清白细胞介素-6、肿瘤坏死因子-α水平变化

目的 通过检测子宫内膜异位症（EMS）患者腹腔液和血清白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）水平,探讨其在EMS发病机制中的作用. 方法 采用酶联免疫吸附双抗体夹心法（ELISA）检测60例EMS患者（Ⅰ、Ⅱ期34例,Ⅲ、Ⅳ期26例）及30例对照组（同期非EMS患者）腹腔液和血清IL-6、TNF-α水平. 结果 EMS患者腹腔液和血清IL-6、TNF-α水平明显高于对照组（P＜0.01）,且Ⅲ、Ⅳ期EMS患者腹腔液及血清IL-6、TNF-α水平明显高于Ⅰ、Ⅱ期（P＜0.01）. 结论 EMS患者腹腔液和血清IL-6、TNF-α在EMS的发生、发展中均起着重要的作用.     

自拟宣肺升降方对COPD急性发作期伴炎性反应综合征患者炎性反应的影响

目的分析自拟宣肺升降方对慢性阻塞性肺疾病急性发作期(AECOPD)伴炎性反应综合征(SIRS)患者的影响。方法将240例AECOPD伴SIRS患者随机分为研究组与对照组各120例。对照组患者入院后均按照2010年慢性阻塞性肺疾病诊治指南给予积极的抗生素控制感染、解除支气管痉挛、化痰等综合处理。研究组在对照组治疗基础上加用自拟宣肺升降方治疗。治疗前及治疗后第5天晨空腹静脉血测血清C反应蛋白(CRP)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平的变化,并同日评估患者当日急性生理和慢性健康状况评分Ⅱ(APACHEⅡ)及肺功能,比较2组差异。结果治疗前2组FEV1/FVC及FEV1(%)和CRP、IL-β、TNF-α、APACHEⅡ评分差异无统计学意义(P>0.05)。治疗后2组FEV1/FVC及FEV1(%)高于治疗前,血清CRP、IL-β和TNF-α水平低于治疗前,APACHEⅡ评分低于治疗前,且研究组优于对照组,差异均有统计学意义(P>0.05)。结论自拟宣肺升降方对AECOPD伴SIRS患者具有改善肺功能水平作用,分析其机制与自拟宣肺升降方抑制血清中CRP、IL-1β及TNF-α水平有关。     

子宫内膜异位症患者血清IL-6、IL-8与TNF-α的水平变化

目的 探讨子宫内膜异位症（EMS）患者血清白细胞介索6（IL-6）、白细胞介素8（IL-8）、肿瘤坏死因子α（TNF-α）的水平变化及临床意义.方法 应用酶联免疫吸附法（ELISA）测定50例EMS患者（Ⅰ～Ⅱ期22例、Ⅲ～Ⅳ期28例）手术前后血清IL-6、IL-8与TNF-α的水平,并与35例非子宫内膜异位症（对照组）患者作比较.结果 EMS组患者血清IL-6、IL-8与TNF-α的水平均高于对照组（P＜0.05）;EMS组Ⅲ～Ⅳ期患者血清中IL-6、IL-8与TNF-α水平高于Ⅰ～Ⅱ期患者（P＜0.05）;手术后其水平下降,与术前比较差异有统计学意义（P＜0.05）,术后与对照组比较差异无统计学意义（P＞0.05）.结论 EMS患者血清中IL-6、IL-8与TNF-α水平明显增高,它们与EMS的发生发展密切相关,检测EM患者IL-6、IL-8与TNF-α水平对病情和预后判断均有重要的临床意义.     

急性胰腺炎患者血清部分细胞因子水平的变化

目的探讨急性胰腺炎（AP）患者血清肿瘤坏死因子-α（TNF—α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、血小板活化因子（PAF）、血管紧张素-Ⅱ（AGT-Ⅱ）的水平变化。方法60例AP患者分为重症急性胰腺炎（SAP）组30例,轻型急性胰腺炎（MAP）组30例,另选健康对照组30例。应用ELISA法和放射免疫法测定血清TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ比较观察三组间的水平变化。结果SAP组（急性期,恢复期）和MAP组（急性期,恢复期）TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ水平均明显高于健康对照组（均P〈0．01）;SAP组急性期TNF-α、IL-6、IL-8、PAF、AGT—Ⅱ水平均明显高于MAP组（均P〈0．05）;SAP组和MAP组恢复期TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ水平均明显低于急性期（均P〈0．05）;SAP组死亡者TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ水平均明显高于生存者（均P〈0．05～0．01）。结论TNF-α、IL-6、IL-8、与SAP的病情严重程度及预后密切相关,SAP组AGT-Ⅱ水平升高较MAP组明显。     

炎性细胞因子在膝骨关节炎中的表达及与高敏 C反应蛋白和红细胞沉降率的相关性

目的 探讨膝骨关节炎（KOA）患者血清和关节液中炎性细胞因子白细胞介素（IL）-1β、肿瘤坏死因子 （TNF）-α、IL-6 的表达特点及其与高敏 C 反应蛋白（hs-CRP）和红细胞沉降率（ESR）的相关性。方法 收集 85 例 KOA 患者和 80 例健康对照者（HC）的外周血标本,收集 25 例 KOA 患者的关节液标本。采用酶联免疫吸附试验 （ELISA）检测血清和关节液中IL-1β、TNF-α、IL-6水平,采用胶乳免疫比浊法检测血清hs-CRP水平,采用全自动动 态血沉仪检测ESR。Pearson相关分析KOA患者血清和关节液IL-1β、TNF-α、IL-6与血清hs-CRP及ESR的相关性。 结果 KOA患者各组血清IL-1β、TNF-α、IL-6与健康对照组相比表达水平均升高（均P＜0.01）,且其表达水平随着 病情严重程度的增加而升高;KOA患者关节液中IL-1β、TNF-α、IL-6表达水平高于血清（均P＜0.05）;KOA患者各组 血清 hs-CRP、ESR 均高于 HC 组（均 P＜0.01）;KOA 患者血清 IL-1β、TNF-α、IL-6 水平与 hs-CRP（r 分别为 0.489、 0.426、0.389）、ESR（r分别为0.348、0.423、0.394）均呈正相关（均P＜0.05）;KOA患者关节液IL-1β、TNF-α、IL-6表达 水平与血清 hs-CRP（r 分别为 0.547、0.644、0.511）、ESR（r 分别为 0.564、0.579、0.589）均呈正相关（均 P＜0.01）。结 论 炎性细胞因子IL-1β、TNF-α、IL-6与hs-CRP、ESR检测可能成为辅助KOA早期诊断、病情及预后评估的潜在血 清学标志物。     

血必净注射液对重症肺炎患者血清中白细胞介素-6、白细胞介素-10和肿瘤坏死因子-α影响的研究

目的：探讨血必净注射液对重症肺炎患者炎症因子的影响。方法：将126例患者采用随机双盲试验设计分为治疗组和对照组。对照组给予常规抗感染、祛痰、机械通气、对症支持治疗,治疗组在此基础上加用血必净注射液100ml静脉滴注、2次／d,疗程为14d。比较2组患者血清中白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）水平,并进行急性肺损伤评分、多器官功能障碍综合征评分（MODS评分）和全身炎症反应综合征评分（SIRS评分）。结果：治疗7d和14d后,治疗组患者IL-6、TNF-α、肺损伤评分、MODS评分和SIRS评分比对照组明显下降（P〈0．05）;2组患者治疗前后及2组间IL-10水平比较均无明显差异。结论：血必净注射液可抑制炎症因子释放,显著改善重症肺炎患者预后。     

危重症患者血清肿瘤坏死因子-α、白细胞介素-6及白细胞介素-10变化的研究

目的探讨危重症患者的血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）的变化，为判断危重症患者病情的严重程度提供新的客观指标。方法41例危重症患者中好转或治愈30例为存活组，死亡11例为死亡组，健康体检者20例为对照组。患者入住ICU后第1、7天清晨空腹抽取静脉血3ml，对照组抽空腹静脉血3ml，应用双抗体夹心酶联免疫吸附法检测血清中TNF-α、IL-6和IL-10的浓度。同时按急性生理和慢性健康评分系统（APACHEⅢ评分）方法进行危重症评分。结果危重症患者早期血清中促炎因子TNF-α、IL-6及抗炎因子IL-10的浓度均较对照组明显升高，存活组和死亡组与对照组比较均有统计学意义；TNF-α、IL-6、IL-10及APACHEⅢ评分四项指标两两之间呈显著性相关（P〈0．05）。结论促炎因子TNF-α、IL-6和抗炎因子IL-10在危重症患者中起重要作用，决定患者的预后。TNF-α、IL-6和IL-10浓度同APACHEⅢ评分一样可作为危重症预警的价值参数。     

Inflammatory fibroblasts in cancer

The association between inflammation and cancer has been studied widely. Indeed, the tumor microenvironment is influenced by inflammatory cells and affects tumor progression, tumor growth, and the survival of cancer cells. Also, the tumor microenvironment is essential to invasion and metastasis of cancer. Fibroblasts, immune cells, the extracellular matrix and other various components all constitute the tumor stroma, ordinarily referred to as the ‘reactive stroma’. Cancer-associated fibroblasts (CAFs), which are activated fibroblasts and one of the components of the tumor microenvironment, are associated with cancer progression, invasiveness and metastasis, and their functional contributions to these processes are beginning to emerge. CAFs mediate tumor-promoting inflammation through various signaling pathways. Epithelial–mesenchymal transition is a process for producing mesenchymal cells during invasion and metastasis of cancer cells. Fibroblasts have been identified as a key player in this mechanism. In the present review, we summarize the relationships between fibroblasts, inflammatory response, the tumor microenvironment and cancer progression. This review provides useful information for the development of cancer prevention and treatment therapies through controlling the inflammatory responses.     

Inflammatory aspects of depression

A bidirectional relation between depression and natural immunity has been identified: depressive episodes are associated to a relative immunodeficiency, conversely inflammatory activity has been implicated in the development of depressive symptoms and in the pathophysiology of depression. Depression has been associated with a decrease in the number and activity of NK lymphocytes and hence patients with depression may show immunodeficiency towards intracellular microorganisms and tumors. Paradoxically, depression is sometimes accompanied by an inflammatory state, developed from the peripheral stimuli (atopy) or central stimuli (chronic stress) and mediated by proinflammatory cytokines (IL-6, TNF and IL-1). These cytokines can play a role in the pathophysiology of depression and of various diseases, supporting the hypothesis that many chronic diseases are individual manifestations of a common proinflammatory denominator.     

Inflammatory biomarkers and statins

The concept of atherosclerosis as an inflammatory disorder has led to the exploration of new pathogeneses of this disease. In this regard, the levels of several inflammatory molecules are frequently increased in subjects at high risk of developing an acute coronary event. With a simple analysis we can characterize the circulating levels of a marker and its therapeutic modulation with various drugs. In this review we have analyzed different inflammatory markers currently used, such as C-reactive protein (CRP), CD40 ligand, adhesion molecules and chemokines, and their possible modulation by therapeutic intervention with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Moreover, in the future, new technologies will allow us to discover new markers, or sets of them, that could indicate the direction to be taken in the prevention and treatment of cardiovascular diseases.     

Inflammatory arthritis in the elderly

The three most common inflammatory arthritic conditions affecting the elderly are reviewed, along with current information about the various treatments.     

炎症性肠病与肿瘤

癌变是炎症性肠病(IBD)最严重的并发症之一.IBD相关的肿瘤与散发性肿瘤的临床特点并不完全相同.重视相关危险凶素,凭借内镜新技术,IBD相关肿瘤的早期诊断将有助丁提高患者的牛活质量和牛存机会.为提高对IBD相关肿瘤的认识及重视,本文就IBD相关肿瘤的发病情况、临床特点及危险冈素等作一综述.     

Inflammatory mediators and beta-adrenoceptor function

In this study the, in vitro, influence of arachidonic acid metabolites on human beta-adrenoceptors was investigated. Incubation of normal human pulmonary membranes with PAF, LTB4 and LTC4 affected pulmonary beta-adrenoceptor properties, as was shown in radioligand binding studies. The same mediators were able to induce a decreased lymphocyte cAMP synthesis. It is concluded that beta-adrenoceptor deficiencies, that can be demonstrated in peripheral lung tissue of COLD patients, may result from pathological processes such as inflammation.