补骨脂注射液联合卤米松乳膏治疗成人寻常型银屑病疗效观察

目的 观察补骨脂注射液联合卤米松乳膏治疗成人寻常型银屑病的临床疗效与安全性.方法 将94例寻常型银屑病患者随机分为补骨脂组和联合组,补骨脂组46例,肌注补骨脂注射液;联合组48例,肌注补骨脂注射液和外用卤米松乳膏,1个月后判定疗效.结果 补骨脂组治疗前后的PASI评分分别为(12.45±2.63),(4.08±0.96),联合组为(13.17±2.84),(2.57±0.88),两组治疗前后评分差异有显著性(P均<0.001);补骨脂组有效率为58.70%,联合组有效率为79.17%,两组有效率差异有显著性(P<0.05);两组均无严重不良反应.结论 补骨脂注射液联合卤米松乳膏治疗寻常型银屑病安全有效,不良反应少.     

复方甘草酸苷注射液联合复方氟米松软膏治疗寻常性银屑病的疗效观察及护理体会

目的:观察复方甘草酸苷(美能)注射液联合复方氟米松软膏治疗寻常性银屑病的疗效及护理体会.方法:将60例寻常性银屑病患者随机分为两组,治疗组用美能注射液联合复方氟米松软膏治疗,对照组用美能注射液联合艾洛松软膏治疗,观察时间为4周.结果:治疗4周时两组患者有效率分别为76.67％和56.67％,差异有显著性(P＜0.05).结论:复方甘草酸苷注射液联合复方氟米松软膏是一种安全有效的治疗寻常性银屑病的方法.正确的饮食、皮损护理、心理护理、健康教育及出院指导,有利于患者增加治疗信心、积极配合治疗,保持乐观情绪.     

白芍总苷联合复方氟米松软膏治疗寻常性银屑病疗效观察

目的评价白芍总苷联合复方氟米松软膏治疗寻常性银屑病的临床疗效。方法将2014年2月至2015年1月在解放军第九十一中心医院接受治疗的60例寻常性银屑病患者按治疗顺序分为两组,每组30例。对照组给予复方氟米松软膏治疗,观察组给予白芍总苷联合复方氟米松软膏治疗,均治疗30 d,对比两组的各项临床指标。结果治疗30 d后,观察组PASI评分,TNF-α、IL-2指数均明显低于对照组(P<0.05);观察组IL-4、IL-10指数,总有效率均高于对照组(P<0.05)。结论白芍总苷联合复方氟米松软膏治疗寻常性银屑病临床优势明显,值得推广应用。     

复方氟米松软膏联合UVB治疗寻常型银屑病的临床疗效观察

目的观察外涂氟米松软膏联合UVB照射治疗寻常型银屑病的疗效和安全性。方法治疗组于患处外涂氟米松软膏,每天2次,行UVB全身照射,隔日1次。对照组于患处外涂氟米松软膏,每天2次。结果治疗组有效率88.00%,对照组有效率60.00%,治疗组复发率19.05%,对照组复发率88.89%。结论复方氟米松软膏联合UVB照射治疗寻常型银屑病安全、有效,值得临床推广。     

补骨脂注射液联合窄谱UVB治疗寻常型银屑病疗效观察与护理

目的 评价补骨脂注射液联合窄谱UVB治疗寻常性银屑病的疗效.方法 选择60例寻常型银屑病住院患者,随机分为治疗组和对照组,每组30例,均给予5%葡萄糖注射液250 mL加入10%葡萄糖酸钙注射液20 mL及维生素C3.0g静滴,每天1次;窄谱UVB治疗隔日一次.治疗组添加每天肌注补骨脂注射液2 mL.疗程均为21天.结果 治疗组治疗前PASI评分为12.12±2.61,治疗后2.87±0.92,有效率为80.0%;对照组治疗前PASI评分为12.08±3.07,治疗后4.68±0.73,有效率为53.3%;两组有效率比较差异有统计学意义(P＜0.05).结论 补骨脂注射液联合窄谱UVB治疗寻常型银屑病疗效好,不良反应少.     

复方甘草酸苷联合多烯磷脂酰胆碱治疗伴肝损害的寻常型银屑病

目的:探讨复方甘草酸苷联合多烯磷脂酰胆碱治疗伴肝损害的寻常型银屑病的疗效。方法:62例患者随机分为2组。对照组30例,予复方甘草酸苷注射液静滴,同时外用复方氟米松软膏及尿素乳膏。治疗组32例,在对照组的基础上加用多烯磷脂酰胆碱注射液静滴。2组治疗后观察疗效。结果:治疗组临床有效率(78.13%)高于对照组(53.33%);治疗组治疗后PASI评分(5.92±3.63)低于对照组(8.10±4.22);2周后治疗组血清ALT(69.03±30.08),AST(67.47±22.34)均低于对照组ALT(84.93±31.93),AST(83.2±37.89);差异均有统计学意义(P<0.05)。结论:复方甘草酸苷联合多烯磷脂酰胆碱治疗伴肝损害的寻常型银屑病的临床疗效优于单用复方甘草酸苷。     

复方氟米松软膏治疗银屑病的近期临床疗效观察

目的 评价复方氟米松软膏外用治疗斑块状银屑病的近期疗效. 方法 对符合入选标准的69例斑块型银屑病患者,采用随机数字法将肢体左或右侧的靶皮损分为治疗组和对照组,治疗组给予复方氟米松软膏外用,2次/d,4周为1个疗程.对照组给予复方丙酸氯倍他索软膏外用,方法及疗程同治疗组.结果 64例完成实验,治疗组 D14、D28时SSRI为0.65±0.21与0.91±0.32;痊愈率D14为35.94%,D28为60.94%;总有效率D14为92.19%,D28为93.75%;与对照组相比均无统计学差异(P>0.05). 结论复方氟米松与复方丙酸氯倍他索在治疗稳定期寻常型银屑病时疗效相仿,均具有较好的临床疗效.     

补骨脂注射液联合窄谱中波紫外线治疗寻常型银屑病疗效观察

目的:观察补骨脂注射液联合窄谱紫外线治疗寻常型银屑病的临床疗效及安全性。方法:选择127例寻常型银屑病住院患者,随机分为三组,三组均外用丁酸氢化可的松软膏,2次/日,A组每天肌注补骨脂注射液2mL,B组采用窄谱紫外线照射每周3次;C组补骨脂注射液联合窄谱紫外线治疗。三组疗程均为30天。结果:治疗后C组有效率为74.42%,明显高于A组、B组(P<0.05)。结论:补骨脂注射液联合窄谱紫外线治疗寻常性银屑病安全、有效。     

复方氟米松软膏联合他扎罗汀乳膏治疗斑块型银屑病疗效观察

目的观察评价复方氟米松软膏联合他扎罗汀乳膏治疗斑块型银屑病的疗效及安全性。方法随机选取经临床和病理确诊的斑块型银屑病患者75例,并随机分为治疗组45例和对照组30例,两组间年龄、性别、病情严重程度差异无统计学意义。治疗组给予复方氟米松软膏外涂,1次/d,他扎罗汀乳膏,1/次晚;对照组用同样方法给予复方氟米松软膏外涂,2次/d。两组于治疗前及治疗2周、4周后分别进行银屑病面积和严重指数(PASI)评分,数据采用x2检验进行统计学分析,对比观察两组疗效、愈后的复发率,并观察治疗期间的不良反应。结果2、4周后两组患者皮损均有明显好转,其中治疗组有效率分别为57.8%、88.9%,对照组分别为63.3%、66.7%,4周后两组间差异有统计学意义(P<0.05),治疗组疗效优于对照组。两组在治疗期间均未发现明显不良反应。结论他扎罗汀乳膏联合复方氟米松软膏治疗斑块型银屑病疗效好。     

斑块状银屑病两药联合治疗效果分析

目的观察他扎罗汀乳膏联合复方氟米松软膏治疗斑块状银屑病的疗效和安全性。方法68例患者随机分为治疗组和对照组,治疗组36例外用他扎罗汀乳膏与复方氟米松软膏,对照组32例单独外用他扎罗汀乳膏,两组疗程均为8周。结果治疗组有效率86.1％,对照组为56.3％,两组有效率经统计学分析,差异有统计学意义（P〈0.05）。结论他扎罗汀乳膏联合复方氟米松软膏治疗斑块状银屑病的疗效好,安全性好。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.