太田痣952例临床分析

目的：对重庆及邻近地区太田痣患者进行回顾性临床分析：方法：总结952例太田痣患者的临床资料，并在性别、发病时间、临床分型、皮损颜色等方面进行统计学比较。结果：太田痣患者的男女性别之比为1：2．5．先天发病占56％，后天发病出现儿童早期及青少年期两个发病高峰。少数患者可与鲜红斑痣(0．53％)、伊藤痣(0.32％）等并发，有家族史者占0．84％。以Ⅱ、Ⅲ型最多见，Ⅳ型最少．皮损颜色可有褐色、青灰、黑褐、蓝紫色的变化，皮损面积大小与颜色无明显相关性。结论：太田痣在性别、发病时间、临床轻重分型上具有分布特征。     

太田痣患者352例生活质量评估及影响因素分析

目的探讨太田痣(nevus of Ota)对患者生活质量的影响及其影响因素。方法使用皮肤病生活质量指数调查表(dermatology life quality index,DLQI)调查352例太田痣患者的生活质量,单因素、多因素分析影响生活质量的因素。结果太田痣患者生活质量轻度、中度受影响者分别占45.17%和47.16%,其余7.67%患者对生活质量重度影响;单因素分析显示性别、发病年龄、皮损呈单/双侧分布、居住地、受教育程度、工作学习状态、皮损部位、皮损面积以及黏膜是否受累有统计学意义(P0.05);多元回归分析显示性别、皮损面积、发病年龄是影响太田痣患者生活质量的主要因素(P0.05,OR1)。结论太田痣对绝大多数患者生活质量有着轻、中度影响,女性、皮损面积大、发病较晚是影响太田痣患者生活质量的主要因素。     

太田痣的发病机制及激光治疗进展

太田痣又可称眼上腭部褐青色痣、眼真皮黑素细胞增多症,是临床较常见的一种色素性疾病,严重影响患者的心理健康。虽然目前对其发病机制的研究仍处于初始阶段,但调Q激光治疗太田痣的疗效被大众所认可。本文对太田痣的发病机制和激光治疗太田痣的新进展以及影响疗效的一些因素进行总结,为提高治愈率和减少副作用提供借鉴。     

Q开关Nd：YAG激光治疗太田痣的疗效和不良反应观察

随着激光在医学领域的广泛应用与发展 ,应用Ｑ开关的脉冲式激光代替传统的ＣＯ2 激光、冷冻和手术等治疗太田痣已被越来越多的美容医师认可 ,但仍存在一些并发症[1 ] 。为了进一步观察Ｑ开关Ｎｄ :ＹＡＧ激光 (Ｑ开关掺钕镱铝石榴石激光 )治疗太田痣的疗效及安全性 ,现将我所 1999年 4月～ 2 0 0 1年 8月应用这一技术治疗的2 0 0例太田痣进行总结 ,报告如下。1　临床资料2 0 0例太田痣患者 ,男 5 1例 ,女 149例 ,男女之比为 1:2 .92 ,就诊年龄 4个月～46岁。发病年龄 :出生时既有者 93例(4 6 .5 0 %) ,出生后发病者 10 7例(5 3.5 0 %)。分型…     

483例儿童花斑癣回顾性分析

目的总结及分析儿童花斑癣患者的临床特点,比较与成人花斑癣的异同点.方法就诊于我院皮肤科门诊的花斑癣患者认真填写问卷调查表,内容包括:性别、年龄、发病年龄,病程、皮损部位、诱因、发病季节、家族史.并进行真菌学检查.结果儿童花斑癣患者共483例,其中男286例,占59.2%,女197例,占40.8%.年龄15天至12岁.所有患儿面部发病207例,占42.9%,其中发生于前额的共143例,占面部发病的69.1%.多汗患儿405例,占83.9%.有家族史38例,占7.9%.所有患儿均采用1%联苯苄唑乳膏外用,治疗2周以上,447例患儿通过治疗后得到有效的临床症状改善及病原学疗效,总有效率为92.5%.结论儿童花斑癣同成人花斑癣比较有不同的临床特点,发病因素与成人不尽相同,且在诊断上需与儿童面部色素减退性皮肤病进行鉴别.     

太田痣临床分析及其中青少年患者社交心理调查分析

目的 了解太田痣患者在性别、发病时间、临床轻重程度等方面的特征,并了解该病对青少年患者社交心理的影响.方法 总结553例太田痣患者的临床资料,并在性别、发病时间、临床分型、皮损颜色等方面进行统计学比较;并对其中299例13～25岁青少年患者进行社会交往倾向及苦恼感受的评估.结果 太田痣发病男女性别之比为1:2.31;先天发病占54.25%,后天发病出现儿童早期及青少年期两个发病高峰;以Ⅱ、Ⅲ型最多见,Ⅳ型最少;皮损颜色可有褐色、青灰、黑褐、蓝紫色的变化;患者的焦虑分量表分、回避分量表分均明显高于正常组(P<0.01),其中女性各项得分明显高于男性.结论 太田痣在性别、发病时间、临床轻重分型上具有分布特征,太田痣影响了患者的社交心理,使其具有回避社会交往的倾向及身临其境时的苦恼感受.     

调Q激光治愈太田痣后复发病例分析

目的:研究调Q激光治愈太田痣后复发情况,了解复发可能存在的原因.方法:对经治愈的1 510 例太田痣患者进行随访,对24例复发的太田痣病例进行回顾性分析.结果:太田痣复发患者中,女性居多,均为育龄期妇女,大部分复发前有妊娠史,另一部分患者复发前有过度日晒史.男性患者中,复发前有过度日晒病史.女性患者复发率较男性高,差异具有统计学意义.Ⅲ型太田痣复发率最高,各型复发率相比差异均有统计学意义.初次就诊并开始治疗的年龄大多数在青少年时期,治愈后平均经过6.5 年出现复发.复发患者再次治疗仍有效.结论:复发是太田痣激光治疗后的一个并发症,其发生与性激素、日晒及治疗次数不足有关.     

白癜风患者215例临床分析

目的：总结白癜风患者的临床特点和发病诱因.方法：对确诊的白癜风患者进行问卷设计和调查,用SPSS 11.5软件包进行统计分析.结果：资料完整的215例白癜风患者中男98例,女117例;平均发病年龄18.76±7.43岁;最常见的受累部位为上肢（54.42%）;伴发疾病中以甲状腺疾病最常见（5.58%）;有家族史者占13.02%,有家族史患者发病年龄为14.6±4.31岁,无家族史为25.09±5.45岁（P〈0.001）,两者间有显著性差异;春夏季发病最常见;25.58%的患者可发现诱因,其中常见的诱因包括精神因素 （43.64%）和皮肤损伤（56.36%）.结论：本地区白癜风好发于青少年,有家族史患者发病年龄早于无家族史患者,上肢为最常见的好发部位,可能与精神因素和皮肤外伤、日晒伤有关.     

白癜风2 008例临床分析

目的：总结及分析白癜风患者的临床特点及意义，探讨白癜风发病机理。方法：对2008例白癜风门诊患者进行认真填写问卷调查表，对各种可能涉及的因素进行统计分析。结果：白癜风主要发生于青少年，5－10岁为发病高峰，该年龄段占发病总数的近18．4％。泛发者占34．4％，神经节段型占7．0％，有阳性家族史者占7．4％，合并自身免疫性疾病者占11．2％，晕痣占6．3％。结论：（1）目前的观察尚未能提出有意义的诱发因素；（2）有阳性家族史者符合多基因遗传规律；（3）白癜风并非完全后天发病，少数出生时即可发生。     

太田痣与颧部褐青色痣皮肤共聚焦激光扫描成像特征分析

目的探讨太田痣、颧部褐青色痣在皮肤共聚焦激光扫描显微镜(RCM)成像中的特征。方法由经验丰富的临床医师对面部色素斑进行诊断,选取未经治疗的20例太田痣和25例颧部褐青色痣,上述病例均未合并其他色素异常性皮肤病;应用RCM对上述病例患者皮损进行成像并存储、分析,所有患者皮损周围正常皮肤作为对照。结果与周围正常皮肤相比,所有患者(100%)皮损处表皮、真表皮交界处均未见色素颗粒增加;12例太田痣(60%)和18颧部褐青色痣患者(72%)真皮浅中层可见散在条索状或者团块状黑素颗粒沉积,8例太田痣(40%)和7颧部褐青色痣患者(28%)真皮中未查及黑素颗粒沉积。结论 RCM成像结果表明:单纯的太田痣和颧部褐青色痣的表皮、真表皮交界处均无色素异常,两者色素颗粒沉积均在真皮,RCM成像有助于太田痣、颧部褐青色痣的诊断。     

太田痣合并鲜红斑痣3例

报告3例太田痣合并鲜红斑痣，3例患者均为先天发病，第1例为面部双侧太田痣合并躯干部大片鲜红斑痣，组织病理和电镜显示真皮中可见色素细胞；第2例为面部双侧同时太田痣合并鲜红斑痣；第3例为右侧面部太田痣合并颈部、下颌部鲜红斑痣。     

Malignant melanoma in a Hispanic male with nevus of Ota.

Nevus of Ota is uncommon in the non-Oriental population. We report a case of malignant melanoma with metastasis to the genitourinary tract in a Hispanic male with nevus of Ota. Thirty-six prior cases of nevus of Ota with malignant melanoma reported in the English language are reviewed. Sixty-eight percent were women; 76% were Caucasians. Metastatic disease was reported in 16%. Three patients had liver metastases. Our case was the first involving the genitourinary tract. All but one patient with metastatic disease died within 1 month of presentation. Despite the increased frequency of nevus of Ota in the Japanese, only 4 cases of malignant melanoma have been reported. Nevus of Ota would appear to be a risk factor for developing malignant melanoma in the Caucasian population.     

Late-onset nevus of Ota

We report a patient with a type IB nevus of Ota whose lesion did not appear until she was thirty years old. To our knowledge, this represents the oldest age of a patient at clinical onset of nevus of Ota. The diagnosis, implications, and treatment of nevus of Ota are reviewed.     

Successful treatment of a patient with multicolored nevus of Ota using a combination of 1064 and 532 nm Q-switched Nd:YAG lasers

ABSTRACT

Nevus of Ota (NO) is a hamartoma of dermal melanocytes usually presents as unilateral blue, gray or brown macules or patches. It can impose a high burden of cosmetic and psychological disturbances in affected individuals. Q-Switched lasers appear to be an effective treatment for this kind of dermal melanocytosis. Multicolored Ota nevus is a rare variant of this kind of nevus and its treatment may be more challenging compared with unicolor lesions. Herein we report a 21-year-old woman with a multicolored nevus of Ota (blue and brown), which showed a dramatic response to a combination of 1,064 nm and 532 nm Q-Switched Nd:YAG lasers. We also discuss different aspects of the Q-switched laser application of Ota nevus treatment. We also focus on laser combination therapy to treat the nevus of Ota.     

Nevus of Ota and choroid melanoma

A 59-year-old patient presented with metastatic uveal melanoma that developed in a nevus of Ota. The nevus of Ota or oculodermal melanocytosis contains an increased number of dermal melanocytes in the distribution of the ophthalmic and maxillary divisions of the trigeminal nerve. Malignant transformation arising in a nevus of Ota may occur in all anatomical sites influenced by the nevus. Most often the choroid is involved. Although the nevus of Ota is rare in Caucasians, associated melanoma is more common than in Asians or black people. The dermatologist should be aware of this problem and aim at an interdisciplinary management of these patients.     

太田痣并发伊藤痣和鲜红斑痣

报告2例太田痣并发伊藤痣及鲜红斑痣.2例患者均为先天发病,例1为左侧面部太田痣并发双侧肩部、背部、腰部、臀部和上肢伊藤痣及左面颈部、左背部鲜红斑痣:例2为左侧面部太田痣并发肩背部伊藤痣及面部、躯干和四肢多处鲜红斑痣.     

Nevus of ota with nevus of Ito--report of a case with cataract

A 53-year-old Japanese male patient with both nevus of Ota and nevus of Ito developed cataract of the eye ipsilateral to the side of the nevi. In this patient, cataract might have appeared in a close pathogenetic relationship with nevus of Ota.     

Bilateral naevus of Ota: a rare manifestation in a Caucasian

The naevus of Ota (naevus fusculocoeruleus ophthalmomaxillaris) was first described by the Japanese dermatologist M. T. Ota in 1939. It has a reported incidence of 0.2% to 1% in the Japanese population. It usually occurs in the skin innervated by the first or second branch of the trigeminal nerve. The naevus comprises dermal melanocytes and is congenital or acquired during adolescence. Commonly associated lesions include scleral melanocytosis and other ocular manifestations as well as lesions of the tympanic membrane, oral and intranasal mucosa and leptomeninges. Diseases associated with Ota's naevus in rare cases are open-angle glaucomas and melanoma. The naevus of Ota in Europeans is a rare manifestation. We report the very rare case of a bilateral naevus of Ota associated with enoral melanocytosis in a white European person.     

Unilateral Nevus of Ota with Bilateral Nevus of Ito and Palatal Lesion: A Case Report with a Proposed Clinical Modification of Tanino's Classification

Nevus of Ota and nevus of Ito are rare dermal melanocytoses. Nevus of Ota may be very rarely associated with the nevus of Ito and other extra cutaneous features. Both nevi are similar in all respect apart from the area of distribution. Bilateral distribution of nevus of Ito is seldom reported in the literature. A 24-year-old male patient reported with nevus of Ota of the right side of his face since his infancy and nevus of Ito on both shoulder regions since early childhood. He had bluish lesions on the right side of his hard palate. Systemic examination was normal. Relevant laboratory investigations were non contributory. The histopathological examination of the skin from the affected areas showed the presence of elongated dendritic dermal melanocytes. The present case is the first report of an association of bilateral nevus of Ito with nevus of Ota and palatal lesions. Tanino classified Nevus of Ota into four groups. As both the nevi are similar in all respect except the area of distribution, a minor modification of the existing Tanino''s classification to incorporate the nevus of Ito into the classification for the Ota''s nevus may be appropriate.