多层螺旋CT技术和临床应用新进展

多层螺旋CT是CT史上的重要进展,在扫描范围、时间及空间分辨率三方面的技术指标均较前显著提高;在数据后处理方面引入了多种后处理方法,使得容积数据得以充分和优化显示。因此,使CT的临床应用和诊断效果均有新的进展。     

The impact of HIV infection on the clinical presentation of severe malnutrition in children at QECH

A study was undertaken in a central nutritional rehabilitation unit (NRU) in southern Malawi to assess the impact of HIV infection on clinical presentation and case fatality rate. The HIV seroprevalence for 250 severely malnourished children over 1 year of age was 34.4% and the overall mortality was 28%. HIV infection was significantly more associated with marasmus (62.2%) than with kwashiorkor (21.7%) [p<0.0001]. Clinical and radiological features were not helpful in distinguishing HIV infected from non HIV infected children. The in-hospital case fatality rate was significantly higher for HIV infected children (38.4%) compared to severely malnourished children without HIV infection (22.7%) [p<0.05]. Though HIV infection contributes to the high mortality experienced in NRU''s in Malawi, we argue that more remediable contributing factors still need to be addressed.     

A case of associated thyrotoxicosis and phaeochromocytoma. A diagnostic problem

A case of phaeochromocytoma and thyrotoxicosis occurring in the same patient is described, in which the similarity between the signs and symptoms produced by the two conditions delayed full diagnosis until post mortem. The mechanisms involved in the production of these signs and symptoms are discussed.     

The impact of advanced technology on critical care. Dilemmas in the making

Advanced technology has enhanced our ability to diagnose and treat critically ill patients, thereby assisting in prolonging life for many. However, its high cost has been prohibitive, and it may impose more burdens than benefits on some patients. Although technological advances have accelerated social change, many have also fuelled legal and ethical concerns. Consequently, the rationale for the use of advanced technology in the care of critically ill patients should be clear and ethically justified.     

蛋白质芯片技术的研究及应用现状

随着蛋白质组学研究的不断深入,蛋白质芯片技术作为一种高通量、微型化、自动化的蛋白质分析技术应运而生并得到广泛应用.现对这一技术的基本原理、分类及应用现状进行介绍,并探讨其目前存在的问题和发展前景.     

认知障碍诊治新进展解析

随着对痴呆认识的不断深入、诊治手段的不断更新,既往沿用的ICD-10及DSM-Ⅳ的痴呆诊断标准已不能满足临床需求.2010年国际认知障碍组着手制定并推出DSM-V认知障碍诊断标准供全球讨论借鉴,国际对痴呆的治疗也不再拘泥于乙酰胆碱酯酶抑制剂及NMDA受体拮抗剂,而针对疾病病因和病理生理机制进行深入探索,新的痴呆治疗药物已进入临床试验中.     

胰腺癌早期诊断的蛋白组学研究进展

肿瘤早期诊断的蛋白组学研究是近来国内外研究的热点。本文综述了胰腺癌早期蛋白质组的改变在胰腺癌早期诊断的作用,为胰腺癌的早期诊断提供科学手段。