共查询到19条相似文献,搜索用时 93 毫秒
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本文介绍日本学者对雷公藤属植物倍半萜类化学成分的研究概况。从日本产雷公藤叶中分离出11个新的倍半萜类化合物,从中国东北雷公藤(黑蔓)中分离出一个新的倍半萜类生物碱。 相似文献
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目的 为深入研究八角属植物萜类成分和开发其药理活性提供参考。方法 总结2011年至2021年全球八角属植物中萜类成分的新化合物和药理活性研究进展。结果 八角属植物主要含有挥发油、萜类、黄酮类、木脂素、有机酸等化学成分。其中,萜类新化合物有80多个,以结构复杂、类型繁多的倍半萜类为主,具有抗柯萨奇病毒B3型、抗乙型肝炎病毒、抗菌、抗氧化、抗炎、营养神经、抑制细胞毒性等多种药理活性。结论 倍半萜类化合物为八角属植物萜类成分的主要成分,其抗病毒、营养神经、抗炎、抑制细胞毒性、抗菌、抗氧化等药理活性有待开发。 相似文献
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中国吉林栽培西洋参挥发油成分的新近研究 总被引:2,自引:0,他引:2
本文用气相色谱-质谱-计算机联用装置分离分析了吉林栽培西洋参挥发油中的化学成分及相对含量,鉴定出37种化合物。其中倍半萜类化合物有26种,约占总挥发油的75%,为西洋参挥发油中的主要成分。同时探讨了倍半萜类及皂甙的可能生合成途径。 相似文献
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Tomaszewski P Kubiak-Tomaszewska G Łukaszkiewicz J Pachecka J 《Acta poloniae pharmaceutica》2008,65(3):319-329
In the human genome 684 alleles of CYP genes, and additionally 30 complete CYP pseudogenes, have been identified. So far 388 isoforms of 58 human CYP isoenzymes have been described at the phenotypic level. The molecular forms of many CYP isoenzymes responsible for drug biotransformation show a differentiated degree of specific catalytic activity - from increased, through normal and decreased to various extent, to trace or even absent. Depending on the homo- or heterozygous genotype, a broad palette of phenotypic forms may be present, differentiated in respect to biotransformation dynamics of specific drugs. The progress of molecular biology with particular consideration of genotyping and DNA microarray technologies has created a basis for the dynamic progress of pharmacogenetics, allowing fast and sensitive determination of the individual pharmacogenetic profile, encompassing a large set of CYP alleles extended by allelic variants of genes encoding other enzymes participating in drug metabolism. The possibility to evaluate the pharmacogenetic profile of patients together with the increasing knowledge about the mechanisms of inhibition, repression and also induction of enzymes participating in biotransformation of xenobiotics and endogenous compounds create increasing possibilities of elaborating optimal individualized pharmacotherapeutic strategies. 相似文献
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地胆草的化学成分和药理作用研究进展 总被引:2,自引:0,他引:2
地胆草 Elephantopus scaber Linn.为菊科地胆草属植物,产于美洲、亚洲、非洲等地区及我国的南方诸省,具有清热解毒、消肿利尿之功效,用于治疗感冒、胃肠炎、扁桃体炎、咽喉炎、结膜炎、肾炎水肿、疖肿等。地胆草含有倍半萜、三萜、黄酮等成分,近年来从中发现的倍半萜内酯类成分因具有强大抗肿瘤活性而备受关注。为了更好的发掘、利用地胆草资源,该文综述了其化学成分和药理作用研究进展。 相似文献
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南蛇藤属植物化学成分及活性研究进展 总被引:5,自引:1,他引:4
南蛇藤属植物在我国分布广泛,近年来从中分得了多种β-二氢沉香呋喃型倍半萜和friedlane等型三萜,其中一些具有昆虫拒食、抗肿瘤和细胞毒活性。本文综述了近10年来从南蛇藤属植物中分得的化学成分及其活性的研究进展。 相似文献
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Xiuling Zhang Qing-Yu Zhang Dazhi Liu Ting Su Yan Weng Guoyu Ling Ying Chen Jun Gu Boris Schilling Xinxin Ding 《Drug metabolism and disposition》2005,33(10):1423-1428
Despite recent progress in the identification and characterization of numerous nasal biotransformation enzymes in laboratory animals, the expression of biotransformation genes in human nasal mucosa remains difficult to study. Given the potential role of nasal biotransformation enzymes in the metabolism of airborne chemicals, including fragrance compounds and therapeutic agents, as well as the potential interspecies differences between laboratory animals and humans, it would be highly desirable to identify those biotransformation genes that are expressed in human nasal mucosa. In this study, a global gene expression analysis was performed to compare biotransformation enzymes expressed in human fetal and adult nasal mucosa to those expressed in liver. The identities of a list of biotransformation genes with apparently nasal mucosa-selective expression were subsequently confirmed by RNA-polymerase chain reaction (PCR) and DNA sequencing of the PCR products. Further quantitative RNA-PCR experiments indicated that, in the fetus, aldehyde dehydrogenase 6 (ALDH6), CYP1B1, CYP2F1, CYP4B1, and UDP glucuronosyltransferase 2A1 are expressed preferentially in the nasal mucosa and that ALDH7, flavin-containing monooxygenase 1, and glutathione S-transferase P1 are at least as abundant in the nasal mucosa as in the liver. The nasal mucosal expression of CYP2E1 was also detected. These findings provide a basis for further explorations of the metabolic capacity of the human nasal mucosa for xenobiotic compounds. 相似文献
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The genus Artemisia is one of the largest and most widely distributed genera of the family Compositae. One type of the mainly active metabolites found in the Artemisia plants is sesquiterpenoids with extensive biological activities, including anti-inflammatory, immunomodulatory, anti-tumour, antimalarial, antinociceptive, antimicrobial and other activities. In this review, wecomprehensively summarized the progressconcerning the phytochemistry and biological activities of sesquiterpenoids obtained from the Artemisiaspecies from 2010 to July 2016. Furthermore,several future research perspectives and development of sesquiterpenoids as potential therapeutic agents were discussed as well. 相似文献
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目的对Acanthella属海绵的化学成分及其生物活性进行综述。方法通过综述国内外相关文献,归纳总结了该属海绵的研究概况。结果从该属海绵中已分离鉴定110个化合物,主要为含有异腈基、异硫氰酸酯和甲酰胺等含氮基团的倍半萜、二萜类化合物。这类化合物具有抗疟、抗虫、抗污损、抗肿瘤、抗菌等多样的生物活性。结论为Acanthella属海绵的化学成分及生物活性的进一步研究提供依据。 相似文献
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4-(p-Chlorophenylthio)butanol (W-2719) is absorbed, metabolized and excreted when administered orally to human volunteers. The butyrate (W-2718) and the acetate (W-2683) metabolites were found in plasma with W-2683 being the major biotransformation product and detectable seven days after administration with an apparent half-life of 33.2 h. p-Chlorothiophenol appeared to be the major biotransformation product in urine and was detectable through day 6. As in plasma, the other major biotransformation product was W-2683, which was again detectable through day 7 and had a t 1/2 in urine of 40.8 h. The minor metabolite found in urine was W-2718. No W-2719 was found in either plasma or urine after oral administration. 相似文献