2型糖尿病患者血清瘦素、NSF-1与血脂的关系研究

目的 研究2型糖尿病患者血清瘦素、NSF-1、载脂蛋白及血脂水平的相关性.方法 选择2016年6月至2017年1月我院收治的2型糖尿病患者64例作为观察组,于同期选择在我院健康体检的健康人群58例为对照组,抽取两组晨起空腹静脉血,比较两组血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白A1、载脂蛋白E、瘦素、摄食抑制因子-1水平,并采用Pearson相关分析以上指标的相关性.结果 观察组与对照组血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白E、瘦素、摄食抑制因子-1水平差异具有统计意义(P＜0.05),载脂蛋白A1比较无统计学差异.血清总胆固醇与甘油三酯、低密度脂蛋白胆固醇、载脂蛋白E呈正相关(r =0.341,P＜0.001;r=0.836,P＜0.001;r =0.337,P＜0.001),与摄食抑制因子-1呈负相关(r=-0.303,P＜0.001).甘油三酯与载脂蛋白E呈显著正相关(r =0.678,P＜0.001),低密度脂蛋白胆固醇与瘦素呈明显负相关(r=-0.266,P＜0.001),高密度脂蛋白胆固醇与载脂蛋白A1呈明显正相关(r=0.335,P＜0.001),载脂蛋白A1与载脂蛋白E呈显著正相关(r=0.318,P＜0.001).结论 2型糖尿病患者存在血脂代谢异常情况,且与血清载脂蛋白、瘦素、摄食抑制因子-1之间存在一定相关性.     

6～13岁肥胖儿童血清瘦素与胰岛素、血脂的关系及意义

为了探讨6～13岁儿童血中瘦素(Leptin)与体重指数(BMI)、胰岛素(INS)、甘油三酯(TG)、总胆固醇(TC)的关系及意义.对118名(男64名,女54名)6～13岁学龄期儿童(正常非肥胖儿童56名,肥胖或超体重儿童62例)血中Leptin进行测定,并与BMI、Insulin、TG和TC进行了相关性研究.结果显示:①肥胖或超体重儿童各项观察指标均明显高于非肥胖儿童(P＜0.001或P＜0.01);且两组同性别间均有肥胖或超体重儿童各项观察指标,均明显高于非肥胖儿童(P＜0.001或P＜0.05);②同组中男女间比较:两组均有女童Leptin值显著高于男童(P＜0.001或P＜0.05),BMI仅有肥胖或超体重组中女童显著高于男童(P＜0.001),各组中其余的观察指标均无明显差异(P＞0.05);③Leptin与BMI、Insulin和TG均存在明显正相关(P=0.001).表明Leptin 水平可随性别、BMI和血脂水平等因素作用而发生相应变化,如能研究和使用提高Leptin受体效应的药物,可能对防治肥胖有一定的帮助.     

多囊卵巢综合征高雄激素血症患者瘦素水平的检测及评价

目的探讨多囊卵巢综合征高雄激素血症进行患者瘦素(Leptin)水平及其与睾酮(T)、体重指数(BMI)的关系.方法采用放射免疫分析法(RIA)检测53例PCOS患者血清瘦素水平,其中非肥胖组PCOS患者36例,正常对照30例;肥胖组PCOS患者17例,正常对照20例.结果肥胖组及非肥胖组PCOS高雄激素血症患者血清瘦素水平均明显高于相当体重指数的正常对照组,有显著差异(p均＜0.01);两组瘦素水平分别与其睾酮水平进行相关性分析,均显著正相关(r=0.51,p＜0.01和r=0.58,p＜0.01);非肥胖组PCOS患者血清瘦素水平与其BMI相关分析显示,无相关性;肥胖组PCOS患者血清瘦素水平与其BMI进行相关分析,显著正相关(p=0.56,p＜0.01).结论高瘦素血症是PCOS患者的内分泌特征之一,PCOS高雄激素血症的形成与高瘦素水平有关;超重或肥胖的PCOS高雄激素血症患者存在瘦素抵抗现象.     

肥胖儿童血清高敏C反应蛋白、瘦素、可溶性瘦素受体和胰岛素的水平及意义

目的探讨肥胖儿童血清高敏C反应蛋白、瘦素、可溶性瘦素受体及胰岛素的水平变化及临床意义。方法对64例12岁肥胖儿童进行血清高敏C反应蛋白（high-sensitivity C-reactive pro-tein,hs-CRP）、瘦素（leptin,Lp）、可溶性瘦素受体（soluble leptin receptor,sLR）及胰岛素（Insulin,INS）的水平测定,与48例健康体检儿童进行对照比较。其中,血清Lp、INS采用放射免疫分析法（RIA）测定,sLR采用酶联免疫吸附试验法检测,hs-CRP采用电化学发光免疫法测定。结果肥胖儿童组血清hs-CRP、Lp、INS水平及BMI均显著高于对照组（均P〈0.01）,sLR水平低于对照组（P〈0.05）;相关性分析显示肥胖儿童血清hs-CRP水平与Lp、INS、BMI之间均呈显著性正相关性（r=0.575,P〈0.01;r=0.504,P〈0.01;r=0.685,P〈0.01）,与sLR呈显著性负相关性（r=-0.339,P〈0.01）;Lp与INS、BMI之间呈显著性正相关性（r=0.352,P〈0.01;r=0.503,P〈0.01）,与sLR呈显著性负相关性（r=-0.467,P〈0.01）,sLR与BMI呈显著性负相关性（r=-0.398,P〈0.01）。结论肥胖儿童已存在炎症状态的改变及瘦素、胰岛素抵抗,且三方面密切相关。对这些血清学指标的检测,有助于儿童肥胖状态的监控和治疗。     

瘦素与多囊卵巢综合征的相关分析

目的探讨血清中瘦素（Leptin）水平与多囊卵巢综合征（PCOS）的关系。方法采用免疫化学发光法检测68例PCOS患者和32例正常妇女血清中的廋素、性激素水平,同时进行糖耐量及胰岛素释放试验。结果 PCOS组血清瘦素水平明显高于对照组（P〈0.05）;PCOS组与对照组相比,除E2水平无显著性差异（P〈0.05）外,其余各项LH、T、PRL、FSH、A4差异显著（P〈0.05）;PCOS组中非肥胖与肥胖组间,除了T、A4差异显著（P〈0.05）外,其余指标差异均无统计学意义（P〈0.05）;PCOS组中瘦素与FINS（r=0.726,P〈0.01）、IR（r=0.631,P〈0.01）、AUC（r=0.518,P〈0.01）、ISI（r=0.663,P〈0.05）均呈正相关关系。结论瘦素可能参与PCOS的发生、发展,并与胰岛素抵抗、高胰岛素血症密切相关。     

健康成年女性内生雌激素的变化与脂类代谢关系的探讨

目的:研究健康成年女性内生雌激素的变化对脂类代谢的影响,为雌激素替代治疗(ERT)提供参考.方法:选择健康体检育龄妇女387例,年龄(21～50)岁,测定雌激素(E2)、孕激素(P)、载脂蛋白A-Ⅰ(apoA-Ⅰ)、载脂蛋白B(apoB)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、脂蛋白a[LP(a)].并从中选取40例自愿者作月经周期中自体早排卵期(EF)和黄体期(LUT)对照.结果:月经周期中雌激素的周期性波动,会影响到脂类代谢,选取EF、LUT作配对比较,发现内生雌激素水平对apoA-Ⅰ、apoB、apoA-Ⅰ/apoB、HDL-C、LDL-C、LDL-C/HDL-C、TC、TC/HDL-C、TG有影响,对LP(a)无影响,其中LDL-C、LDL-C/HDL-C、TC/HDL-C水平在LUT均比EF明显低(P＜0.05).结论:健康成年女性月经周期中内生雌激素的波动对脂类代谢有影响,虽然对于多数脂类影响不显著,但对在绝经期前女性进行脂类检测和药物治疗监测时,对测定结果处于临界水平的标本,需将其考虑为重要影响因素之一,不注意这些波动可能会影响治疗和诊断.随年龄增长呈周期性变化的雌激素水平有下降趋势,脂类:TC、TG、LDL-C、apoB随年龄增长有增长趋势,作为心血管疾病的危险因素之一,是一个较长的渐进过程.     

血糖控制对2型糖尿病患者载脂蛋白A水平的影响

目的 观察分析2型糖尿病患者载脂蛋白A（apoA）水平变化与血糖控制状态关系及其可能的影响机制。方法 采用自动生化仪检测213名2型糖尿病患者血浆总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、载脂蛋白A（apoA）、载脂蛋白B（apoB），用离子交换高效液相色谱分析法测定糖化血红蛋白（HbAlc），比较其与血脂指标的相关性。结果 两组HDL-C水平差异无统计学意义[（1．26±0．45）mmol／L vs （1．13±0．35）mmol／L，P〉0．05]；控制满意组apoA水平显著高于非满意组[（1．16±0．31）g／L vs （0．98±0．32）g／L，P〈0．01]，apoB／apoA显著低于非满意组（P〈0．05）。TC、TG、LDL、VLDL水平两组差异无统计学意义（P〉0．05）。直线相关分析显示apoA与HbAlc、FBG呈显著负相关（r=-0．30，P〈0．01；r=-0．24，P〈0．01）：apoA与HDL、TC呈显著正相关（r=0．74，P〈0．01；r=0．39，P〈0．01）。结论 2型糖尿病患者血糖控制状态显著影响apoA水平，这可能是HDL功能紊乱的重要原因。     

Lp（a）、apoB/apoA1及HOMA-IR在2型糖尿病与糖耐量受损患者中的变化及意义

目的探讨2型糖尿病（T2DM）、糖耐量受损（IGT）患者脂蛋白（a）[Lp（a）]、载脂蛋白A1（apoA1）、载脂蛋白B（apoB）和稳态模型的胰岛素抵抗指数（HOMA-IR）的变化及其相互间的关系和意义。方法测定24例2型糖尿病患者（T2DM组）、22例糖耐量受损患者（IGT组）和36例健康成人（正常对照组）的Lp（a）、apoA1、apoB等血脂指标,同时检测T2DM组和IGT组的空腹血糖、空腹胰岛素并计算HOMA-IR,分析T2DM及IGT患者血脂指标的变化及其与HOMA-IR的关系。结果 T2DM组、IGT组与正常对照组比较Lp（a）、apoB、apoB/apoA1显著升高（P〈0.01）,apoA1显著降低（P〈0.05）;T2DM组与IGT组之间的差异有统计学意义,且两组间apoB、apoB/apoA1与HOMA-IR有显著的相关性（P〈0.05）。结论 Lp（a）、apoB、apoB/apoA1等血脂指标与T2DM的发生发展有关,且apoB、apoB/apoA1与胰岛素抵抗显著相关,在CV危险评估、病情与治疗监测等方面有重要的应用价值。     

Leptin基因甲基化与糖尿病的相关性研究

目的 探讨瘦素基因启动子区甲基化及蛋白表达与糖调节受损(impaired glucose regulation,IGR)以及2型糖尿病(type 2 diabetes mellitus,T2DM)的相关性.方法 采用甲基化特异性PCR对不同血糖水平的个体进行Leptin基因启动子区甲基化检测.用双抗体夹心ABC-酶联免疫吸附法检测血液标本中的瘦素蛋白表达量.结果 与正常对照组(59.2％)相比,T2DM和IGR组Leptin基因的甲基化率偏低(分别为31.5％和43.6％),差异具有统计学意义(x2分别为22.499,5.109,P值均＜0.05).T2DM与IGR组相比甲基化率偏低(x2=3.962,P＜0.05),差异具有统计学意义.患者的瘦素含量相对于正常人均偏高,但仅T2DM组与正常人差异具有统计学意义(q=6.81,P＜0.01).直线回归分析提示,瘦素含量随DNA甲基化程度的降低有增高的趋势,两者呈显著负相关(r=-0.95,P＜0.01).结论 Leptin基因启动子区甲基化与瘦素代谢紊乱可能参与糖尿病的发生和发展.检测IGR和T2DM患者Leptin基因启动子区的甲基化状态和基因蛋白表达,对于早期干预、延缓病程具有一定的参考价值.     

妊高征患者胎盘组织中瘦素mRNA表达与NO含量的测定及临床研究

目的检测正常妊娠、妊高征妇女胎盘组织中瘦素mRNA的表达及与一氧化氮含量的关系,探讨瘦素在妊高征发病中的作用.方法用逆转录-聚合酶链技术(RT-PCR)测定38例正常妊娠妇女、62例妊高征妇女分娩时胎盘组织中瘦素mRNA表达水平;用硝酸还原酶法测定胎盘组织NO的含量.结果(1)正常晚孕及妊高征妇女胎盘瘦素mRNA表达水平分别为:0.139±0.12、0.603±0.287(其中轻、中、重度妊高征胎盘瘦素水平分别为:0.145±0.056、0.38±0.122、0.75±0.199).(2)妊高征组胎盘瘦素水平明显高于正常晚孕组,差异有显著性(P＜0.01),妊高征患者胎盘瘦素水平随病情加重而升高;重、中、轻度之间差异均有显著性(P＜0.01、P＜0.05).(3)妊高征胎盘组织中NO含量低于正常晚孕妇女,差异有显著性(P＜0.05);重度妊高征患者胎盘NO含量明显低于中度、中度低于轻度,差异有显著性(P＜0.01、P＜0.05),(4)妊高征胎盘瘦素mR-NA表达与NO含量呈负相关(r=-0.6294,P＜0.01),与收缩压、舒张压、平均动脉压、尿蛋白呈正相关(r=0.547,0.377,0.45,0.517;P=0.015,0.015,0.020,0.040),重度妊高征组与新生儿体重呈负相关(r=-0.447,P=0.018).结论胎盘瘦素mRNA表达水平在妊高征组中明显升高,随着妊高征病情加重,胎盘瘦素mRNA表达逐渐增加;同时,胎盘组织中NO含量在妊高征妇女中明显降低,胎盘瘦素mRNA表达与胎盘组织中NO含量呈负相关.因此,瘦素可能与妊高征发病有关,可望成为妊高征病情发展的检测指标之一.     

2型糖尿病患者血清瘦素水平及临床意义

目的：观察2型糖尿病（DM2）患者血清瘦素（leptin）水平及其与肥胖、血糖、血脂的关系。方法：采用放射免疫分析（RIA）测定42例DM2患者和38例正常对照组的血清leptin水平。结果：DM2组血清leptin水平明显高于对照组（P〈0．01）;血清leptin与体重指数（BMI）、血清胰岛素（INS）、总胆固醇（TC）、甘油三酯（TG）、脂蛋白LDL-C呈正相关。结论：DM2患者的高leptin血症与肥胖、血脂异常及胰岛素抵抗（IR）密切相关。     

Comparison of leptin protein levels in Prader-Willi syndrome and control individuals

Prader-Willi syndrome (PWS) is characterized by early childhood obesity, mental deficiency, hypogonadism, hypotonia, hypopigmentation, short stature, small hands and feet, and a characteristic face. It is the most common genetic cause of obesity and obesity is the most significant health problem for PWS patients. Ob protein (leptin), which is produced by adipose tissue, is thought to play a significant role in obesity; thus, unusually low plasma leptin levels, or relative loss of sensitivity to leptin in PWS subjects, could be an important factor in their obesity. We measured plasma leptin levels in 19 obese and 14 non-obese PWS patients [mean body mass index (BMI) 37.2 and 22.0, respectively] and compared these levels to those of 28 obese controls (mean BMI 35.5) and 16 non-obese control individuals (mean BMI 21.6). The mean plasma leptin concentration (ng/ml) for obese PWS subjects was 33.4 and 23.6 for non-obese PWS subjects. Obese control leptin was 36.2 ng/ml and non-obese control was 9.9. Among the control groups, leptin levels in females were significantly higher than those in males; the obese males and females had significantly higher leptin than their respective non-obese counterparts. These differences did not hold true for the PWS subjects. Leptin levels in obese PWS males and females were similar, and the same was true of the non-obese PWS males and females. The differences between obese and non-obese PWS subjects of both sexes were small and not significant. Comparing control groups with their PWS counterparts revealed no significant differences, with one exception: circulating plasma leptin levels in non-obese PWS males were nearly five times higher than in non-obese control males with similar BMI. This difference may reflect a more female pattern of fat distribution and hypogonadism, which are characteristic of PWS males. Leptin levels in PWS patients were not obviously correlated with the chromosome 15 finding seen in the patients. Am. J. Med. Genet. 75:7–12, 1998. © 1998 Wiley-Liss, Inc.     

Prevalence of obesity and hyperinsulinemia: its association with serum lipid and lipoprotein concentrations in healthy individuals from Maracaibo,Venezuela

The aim of this study was to analyse the prevalence of obesity and hyperinsulinemia and their association with lipid profile alterations on apparently healthy individuals from Maracaibo, Venezuela. We evaluated 306 men and 41 women, ages ranging from 33 to 65 years. All subjects underwent cardiovascular evaluation and laboratory examination after 10-12 h fasting, for glycaemia, total cholesterol, TG, VLDL-C, LDL-C and HDL-C as well as insulin. Seventy-four percent of men and 56.1% of women showed obesity (BMI > 25 Kg/m2). Men showed high concentrations of TG (48.3%), total cholesterol (40.2%), VLDL-C (48.3%) and LDL-C (33.9%) and low HDL-C levels (48%). The most frequent alteration on the lipid profile in women was high total cholesterol (46%) and LDL-C (51.2%). Men had significantly higher insulin concentrations than women (p < 0.005). After they were classified as obese or non obese, the obese subjects (men and women) showed higher prevalence of lipid profile alterations and insulin concentrations than non obese. The insulin concentration in obese men correlated with BMI, TG, VLDL-C and HDL and, in women with BMI, TG and VLDL-C. In conclusion, a high percentage of men and women in this study showed obesity and this obesity, specially in men, was strongly associated with lipid profile alterations and high insulin concentrations both well known cardiovascular risk factors.     

Triglyceride Is a Useful Surrogate Marker for Insulin Resistance in Korean Women with Polycystic Ovary Syndrome

Purpose

To evaluate lipid profiles and liver enzymes as surrogate markers used for recognizing insulin resistance in Korean women with polycystic ovary syndrome (PCOS).

Materials and Methods

458 women with PCOS were divided into two groups: non-obese with a body mass index (BMI)<25.0 kg/m² and obese with a BMI≥25.0 kg/m². Anthropometric measures and blood sampling for hormone assay, liver enzymes, lipid profiles and 75 g oral glucose tolerance test were performed. Insulin resistance was defined as homeostasis model assessment of insulin resistance (HOMA-IR)≥2.5. Areas under the receiver operating characteristic (ROC) curves were used to compare the power of serum markers. Multiple linear regression analysis was used to evaluate the contribution of each confounding factor for HOMA-IR.

Results

In non-obese and obese groups, the ROC curve analyses demonstrated that the best marker for insulin resistance was triglyceride (TG), with the areas under the ROC curve of 0.617 and 0.837, respectively. Low-density lipoprotein cholesterol (LDL-C) was the significant marker for insulin resistance with areas under the ROC curve of 0.698 in obese group, but not significant in non-obese group. TG and LDL-C were significantly associated with HOMA-IR in both non-obese and obese PCOS women by multiple linear regression analysis. The optimal cut-off points of TG≥68.5 was a marker for predicting insulin resistance in non-obese PCOS patients and TG≥100.5 in obese group.

Conclusion

TG can be used as a useful marker for insulin resistance in Korean women with PCOS, especially for obese patients.     

非酒精性脂肪性肝病与血尿酸水平测定及其临床意义

目的 探讨非酒精性脂肪性肝病（NAFLD）与血尿酸水平的关系。方法 选取在我院常规体检的2666例成人,其中经腹部彩超诊断为脂肪肝者为NAFLD组共603例,无脂肪肝者为非NAFLD组共2063例。根据BMI将其分为肥胖组290例及非肥胖组2376例。回顾性分析研究对象的年龄、血压、UA、FBG、TC、TG、LDL、GDL等临床指标。结果 NAFLD组的年龄、收缩压、舒张压、UA、FBG、TC、TG、LDL均高于非NAFLD组,差异具有统计学意义（P＜0.05）;而NAFLD组的HDL水平低于非NAFLD组,差异具有统计学意义（P＜0.05）。肥胖组的年龄、收缩压、舒张压、UA、FBG、TC、TG、LDL均高于非肥胖组,差异具有统计学意义（P＜0.05）;而肥胖组的HDL水平低于非肥胖组,差异具有统计学意义（P＜0.05）。在肥胖组中,血尿酸水平与是否发生NAFLD无明显相关关系（r=0.095,P=0.107）,而在非肥胖组中,血尿酸水平与是否发生NAFLD呈正相关关系（r=0.229,P=0.000）。结论 在非肥胖人群中,高尿酸血症可作为NAFLD的独立危险因素,为临床上NAFLD的治疗提供一定的实用价值。     

Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study

We evaluated the levels of some inflammatory adipocytokines in 363 obese and 365 non-obese subjects. We measured: body mass index (BMI), waist circumference (WC), fasting plasma glucose, fasting plasma insulin (FPI), homeostasis model assessment (HOMA) index, blood pressure, lipid profile, retinol binding protein-4 (RBP-4), vaspin, omentin-1, leptin, interleukin-6 (IL-6), visfatin, resistin, adiponectin (ADN), adipsin, tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (Hs-CRP). We observed higher BMI, WC, FPI, HOMA index, TC, LDL-C, RBP-4, leptin, IL-6, adipsin, Hs-CRP, vaspin, resistin and TNF-α levels, and lower visfatin, and ADN levels in obese compared to non-obese subjects. Higher WC correlated with lower ADN and visfatin levels, and higher vaspin levels. Higher HOMA index correlated with higher resistin, adipsin, RBP-4, and leptin concentrations, while higher leptin levels correlated with higher TNF-α, Hs-CRP, and IL-6 concentration, and lower ADN values. We confirmed obese subjects’ predisposition to develop dysmetabolic disease and hormonal dysfunctions.     

肥胖患者血清瘦素、C-肽和外周脂肪组织中瘦素受体水平的变化分析

目的 :通过对肥胖及伴有 2型糖尿病患者瘦素、C -肽及外周脂肪组织leptin受体表达的研究 ,进一步探讨肥胖及肥胖伴 2型糖尿病患者发生发展的机制。方法 :用放射免疫分析和放射配基结合实验的方法 ,对 91例受检者 (其中肥胖 38例 ,超重 2 3例 ,正常对照 30例 )外周脂肪组织leptin受体的密度及血清中的瘦素、C -肽水平进行检测。结果 :随着BMI的增加 ,瘦素受体密度肥胖组和超重组与正常组比较差异十分显著(p <0 0 1) ,肥胖组与超重组比较有显著性差异 (p <0 0 1) ;而受体与瘦素结合的能力 (Kd值 )没有显著性差异(p >0 0 5 )。三组间的Kd值无差异。从散点分布图可以看出体重指数越大其leptin受体的密度就越小 ,BMI与Bmax相关性 (r=- 0 70 ,p<0 0 1) ;在超重和肥胖伴有 2型糖尿病患者 ,血清中的瘦素和C -肽水平肥胖组比超重组明显升高 ,二者的比值有明显差异 (p <0 0 1) ;血清C -肽增高幅度比瘦素明显 ;血清C -肽水平与体重指数呈正相关。结论 :单纯性肥胖及肥胖伴 2型糖尿病患者血清瘦素、C -肽水平及外周脂肪组织中leptin受体的密度的变化与BMI密切相关 ,肥胖病人所并发的 2型糖尿病与瘦素抵抗和胰岛素抵抗密切相关     

利拉鲁肽对首诊2型糖尿病患者血糖、血脂及T细胞亚群的影响

目的 探讨利拉鲁肽治疗首诊超重或肥胖2型糖尿病患者的效果及其对T细胞亚群的影响。方法 选取2018年2月~2019年6月我院收治的72例确诊为2型糖尿病超重或肥胖患者,采用随机数字表法分为对照组和研究组,每组36例。对照组予以常规治疗,研究组在对照组基础上加用利拉鲁肽治疗,比较两组治疗前后血糖水平（FPG、BPG、HbA1c）、空腹胰岛素+C肽、餐后2h胰岛素+C肽水平、BMI、血脂（HDL-C、LDL-C、VLDL-C、TC、TG）以及CD4+、CD4+/CD8+水平。结果 治疗后,研究组FPG、BPG、HBA1c水平低于对照组（P＜0.05）,空腹胰岛素、餐后2h胰岛素和空腹C肽、餐后2h C肽水平高于对照组（P＜0.05）;研究组BMI水平低于对照组（P＜0.05）;研究组TG、TC、LDL-C、VLDL-C水平低于对照组,HDL-C水平高于对照组（P＜0.05）;研究组CD4+、CD4+/CD8+高于对照组（P＜0.05）。结论 利拉鲁肽可调节CD4+T细胞亚群平衡,改善胰岛素β细胞功能并降低胰岛素抵抗,可更好控制2型糖尿病患者血糖水平,改善血脂水平,降低体质量。