The study of effect of tea polyphenols on microsatellite instability colorectal cancer and its molecular mechanism

Introduction  

Tea polyphenol has been shown to have anti-colorectal cancer and anti-gene mutation effects, although the mechanism of inhibition of microsatellite instability (MSI) colorectal cancer is not known.     

Humoral immune response to MUC5AC in patients with colorectal polyps and colorectal carcinoma

Background  

MUC5AC is a secreted mucin aberrantly expressed by colorectal polyps and carcinoma. It has been hypothesized that aberrant expression of MUC5AC in colorectal carcinoma tissues increased the overall survival of patients with colorectal carcinoma. The present study investigates the incidence of naturally occurring MUC5AC antibodies in the sera of normal individuals, patients with colonic polyps and patients with advanced colorectal carcinoma. A second aim was to determine the relationship of MUC5AC antibody with the prognosis of colorectal carcinoma.     

Treatment of benign colorectal strictures by temporary stenting with self-expanding stents

Background  

The application of stents in benign colorectal strictures is considered controversial. The aim of the present study was to assess effectiveness and complications associated with colorectal stent placement in benign colorectal disease.     

Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival

Background  

The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer patients with and without liver metastases, we investigated PTEN expression in primary colorectal cancer and colorectal cancer liver metastases.     

Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature

Purpose  

The aim of this study is to review published literature regarding a possible role of human papillomavirus (HPV) infection in colorectal cancer in order to understand if HPV infection plays an active role in colorectal carcinogenesis and to highlight evidences and pitfalls of published studies.     

Optimal use of adjuvant chemotherapy in stage II colorectal cancer

Background and objective  

The prognosis of stage II colorectal cancer varies. Whether or not to perform adjuvant chemotherapy on patients with stage II colorectal cancer is a controversial issue. The aims of this study were to identify relevant risk factors for the prognosis of stage II colorectal cancer and to evaluate the need for adjuvant chemotherapy.     

Microsatellite instability screening should be done for right-sided colon cancer patients less than 60 years of age

Background and aims  

Microsatellite analysis is a screening tool used for the identification of Lynch syndrome. We evaluated the occurrence of high-frequency microsatellite instability (MSI-H) in 160 patients with colorectal cancer ≤60 years old to determine if these individuals should be routinely tested for microsatellite instability.     

Is <Emphasis Type="Italic">KRAS</Emphasis> Mutation Associated with Interval Colorectal Cancers?

Background  

Colorectal cancers diagnosed in the interval after a complete colonoscopy may occur due to rapid tumor growth. Interval colorectal cancers are associated with microsatellite instability (MSI).     

Management of lower gastrointestinal bleeding after colorectal resection and stapled anastomosis

Background  

Although limited haematochezia with the first bowel movement is frequent in patients undergoing colorectal resection, postoperative life-threatening lower gastrointestinal bleeding is very rare. The purpose of this study was to review our results in the management of this complication.     

Determinants of short- and long-term outcome in patients undergoing simultaneous resection of colorectal cancer and synchronous colorectal liver metastases

Purpose  

The optimal surgical strategy for patients presenting with colorectal liver metastases has yet to be determined. Short- and long-term outcomes must be considered if simultaneous resection of primary and liver metastases is to gain acceptance. We examine the prognostic value of patient and tumour characteristics in predicting short- and long-term outcomes following simultaneous resection for synchronous disease.     

Adherence to colorectal cancer screening guidelines in Canada

Background  

To identify correlates of adherence to colorectal cancer (CRC) screening guidelines in average-risk Canadians.     

Colorectal surgeons and biomedical scientists improve lymph node harvest in colorectal cancer

Background  

The aim of this study was to review lymph node retrieval from colorectal cancer resections.     

Tissue detection of natural killer cells in colorectal adenocarcinoma

Background  

Natural killer (NK) cells represent a first line of defence against a developing cancer; however, their exact role in colorectal cancer remains undetermined. The aim of the present study was to evaluate the expression of CD16 and CD57 [immunohistochemical markers of natural NK cells] in colorectal adenocarcinoma.     

Radioembolization and systemic chemotherapy improves response and survival for unresectable colorectal liver metastases

Purpose  

To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases.     

Pleiotrophin is a potential colorectal cancer prognostic factor that promotes VEGF expression and induces angiogenesis in colorectal cancer

Purpose  

Pleiotrophin (PTN) is an important developmental secretory cytokine expressed in many types of cancer and involved in angiogenesis and tumor growth; however, the significance of PTN expression in colorectal cancer (CRC) has not been established.     

Association between age and synchronous liver metastasis in female colorectal cancer patients

Purpose  

The purpose of this study is to investigate the relationship between age and synchronous liver metastasis in female colorectal cancer patients.     

Impact of obesity on surgical and oncological outcomes in the management of colorectal cancer

Introduction  

Obesity is an established risk factor for colorectal cancer, particularly in males, and may negatively impact on oncologic outcomes. The aim of this study was to examine the impact of body mass index (BMI) on mortality and morbidity, tumour pathology, and overall survival in a consecutive cohort of Irish colorectal cancer patients treated with curative intent.     

Anti-mitogenic and apoptotic effects of 5-HT1B receptor antagonist on HT29 colorectal cancer cell line

Purpose  

There is lack of evidence about impact of 5-HT receptors on colorectal cancers. The current study was designed to investigate the role of serotonin and its receptors in colorectal cancer cell line and tissues.     

Clinicopathological features of colorectal cancer in patients under 40 years of age

Objective  

The aim was to identify the clinical factors and tumour characteristics that predict survival in patients younger than 40 years with colorectal adenocarcinoma.     

Externalization of Saw-Tooth Architecture in Small Serrated Polyps Implies the Presence of Methylation of <Emphasis Type="Italic">IGFBP7</Emphasis>

Introduction  

Serrated polyps have been considered to be precursors of colorectal cancer with microsatellite instability. However, the biological and/or morphological changes which occur during the course of serrated polyp to cancer remain to be elucidated.