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密蒙花黄酮类化合物的分离和鉴定 总被引:35,自引:0,他引:35
从密蒙花(Buddleia officinalis Maxim)的花蕾中分离得到8个黄酮类化合物,其小3个甙元:刺槐素(acacetin,1),芹菜素(apigenin,2),木犀草素(luteolin,3);5个甙:密蒙花新甙(neobudofficide,4),蒙花甙(linarin=acaciin,5),木犀草素7-O-芸香糖甙(6),木犀草素-7-O-葡萄糖甙(7),秋英甙(cosmosiin,8)。化合物4为新化合物,用化学和波谱法确定其结构为5.7-二羟基-4'-甲氧基黄酮-7-O-α-L-吡喃鼠李糖基-(1→2)-[α-L-吡喃鼠李糖基-(1→6)]-β-D-吡喃葡萄糖甙,除化合物1和5以外,其它化合物均为首次从密蒙花中得到。 相似文献
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胀果甘草中2个新的二氢黄酮甙 总被引:3,自引:0,他引:3
从胀果甘草(Glycyrhizia inflata Bat.)根茎的95%醇提取部分经HPLC分得两个新的二氢黄酮二糖链甙,经化学和波谱分析,将其结构分别确定为甘草素-7-O-β-D-呋喃芹糖-4′-O-β-D-吡喃葡萄糖甙(liquiritigenin-7-O-β-D-apiofuranosyl)-4′-O-β-D-glucopyranoside(I)和甘草素-7-O-β-D-(3-O-乙酰基)呋喃芹糖-4′-O-β-D-吡喃葡萄糖-甙[liquiritigenin-7-O-β-D-(3-O-acetyl)-apiofuranosyl-4′-O-β-D-glucopyra-noside](I)。 相似文献
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紫花八宝化学成分的研究 总被引:5,自引:0,他引:5
从景天科紫花八宝[Hylotelepium mingjinianum (S.H.Fu)H.oh的]干燥全草中分得12个化合物,经光谱(UV,IR,MS和NMR)解析和化学分析鉴定其结构。其中两个为新黄酮甙,分别是3,5,7,8,4'-五羟基黄酮-7-O-β-D-葡萄糖醛酸甙(3,5,7,8,4’-pentahydroxyflavone-7-O-β-D-giucuronide,xT)和3,5,7,8,4'-五羟基黄酮-8-O-α-D-2"-O-(2-甲基丁酰)葡萄糖醛酸甙[3,5,7,8,4’-petalhydroxyfl-avone-8-O-α-D-2"-O-(2-methylbutanoyl)glucuronide,xII]。XI和XII分别命名为紫花八宝甙甲(mingji-nianuronideA)和紫花八宝甙乙(mingiinianutonideB)。十个已知物(1~X)为正三十三烷、木栓酮、β-谷甾醇、胡萝卜甙、原儿茶酸、没食子酸、槲皮素、槲皮素-3-O-α-L-鼠李糖甙、槲皮素-3-O-β-D-葡萄糖甙和山奈素-7-O-α-L-鼠李糖甙。 相似文献
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蛇毒中鞣花酸类及三萜类成分研究 总被引:11,自引:0,他引:11
自蛇毒(Duchesnea indica Fock)全草中分离出6个化合物,其中,2个为新化合物,分别命名为蛇莓甙A(duchesideA)和蛇莓甙B(duchesideB),经化学及光谱(UV,1R,1HNMR,13CNMR,NOEDS和MS)分析确定,蛇莓甙A的结构为3'-O-甲基-鞣花酸-4-O-β-D-吡喃木糖甙(Ⅰ),蛇莓甙B的结构为3'-O-甲基-鞣花酸-4-O-α-L-呋喃阿拉伯糖甙(Ⅱ)。另外4个化合物为已知三萜类化合物:3β-羟基-乌苏烷-12-烯-28-羧酸(Ⅲ),2α,3β,19α-三羟基-乌苏烷-12-烯-28-羧酸(Ⅳ),2α,3β,19α-三羟基-乌苏烷-12-烯-28-羧酸-28-O-β-D-吡喃葡萄糖甙(Ⅴ),2α,3α,19α-三羟基-乌苏烷-12-烯-28-羧酸-28-O-β-D-吡喃葡萄糖甙(Ⅵ)。其中化合物Ⅳ,Ⅴ和Ⅵ为首次从该属植物中分离得到。 相似文献
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山野豌豆黄酮类化学成分的研究 总被引:9,自引:0,他引:9
自山野豌豆(Vicia amoena Fisch.)全草的乙醇提取物中分得6个化合物,经波谱和化学分析鉴定其中一个为新的黄酮甙,命名为山野豌豆甙(amoenin A3),其余5个化合物为槲皮素(quercetin D2)、山奈酚(kaempferol D1)、槲皮素-3-O-α-L-鼠李糖甙(quercetin-3-O-α-L-rhamnosideC1)、槲皮素-3-O-β-D-葡萄糖甙(quercetin-3-O-β-D-glucosideC2)、山柰酚-3,7-O-α-L-二鼠李糖甙(kaempferol-3,7-O-α-L-dirhamnoside A2)。以上黄酮类化合物均为首次从山野豌豆中分得。 相似文献
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薤白甙J,K和L的结构 总被引:9,自引:0,他引:9
进一步用HPLC自小根蒜(Allium macrostemon Bunge)鳞茎中分得两种新的呋甾皂甙,薤白甙J(1)和薤白甙L(III),以及I的甲基化人工产物薤白甙K(II)。经过化学降解和光谱(1H-NMR,13C-NMR和FAB-MS等)分析,确定其结构分别为:(25R)-26-O-β-D-吡喃葡萄糖基-22-羟基-5β-呋甾-2β,3β,26-三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(I);(25R)-26-O-β-D-吡喃葡萄糖基-22-甲氧基-5β-呋甾-2β,3β,26-.三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(II)和(25R)-26-O-β-D-吡喃葡萄糖基-5β-呋甾-20(22)-烯-26β,3β,26-三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(III)。 相似文献
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山苦瓜中三萜及甾体成分的研究 总被引:6,自引:0,他引:6
从葫芦科植物山苦瓜(Momordica dioica)干燥块根中分离鉴定出5个三萜及甾体化合物:α-菠甾醇硬脂酸酯(I),α-菠甾醇 3-O-β-D-吡喃葡萄糖甙(II),3β-羟基-23-氧-齐墩果-12-烯-28-酸-3-O-β-D-吡喃葡萄糖醛酸甙(II),3β-羟基-23-氧-齐墩果-12-烯-28-酸-3-O-β-D-吡喃葡萄糖甙(IV)和3β,23-二羟基齐墩果-12-烯-28-酸-3-O-β-D-吡喃葡萄糖甙(V)。其中,成分II为一新化合物。 相似文献
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苦绳的甾体成分 总被引:3,自引:0,他引:3
从苦绳(Dregea sinensis Hemsl.)中分离到两个新化合物∶苦绳甙元乙(dresigeninB,1)和苦绳甙I(dresiosideI,2)。经光谱和化学反应确定其结构为∶20-O-(2-甲基丁酰基) 托曼托甙元[20-O-(2-methylbutyryl)-tomentogenin]和二氢肉珊瑚甙元3-O-β-D-吡喃黄夹糖基(1-4)-β-D-吡喃夹竹桃糖基(1-4)-β-D-吡喃磁麻糖甙[dihydrosarcostin 3-O-β-D-thevetopyranosyl(1-4)-β-D-oleandropyranosyl(1-4)-β-D-cymaropyranoside]。 相似文献
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黄芩甙元及其苄基衍生物的制备与抗人免疫缺陷病毒实验研究 总被引:19,自引:0,他引:19
Baicalein (1) was prepared from baicalin by acid hydrolysis with yield of 24%. 5, 6-Dibenzyl-7-hydroxyl-flanone (4) and 6-benzyl-5, 7-dihydroxyl-flanone (5) were obtained by using different benzylating agents, and then hydrolyzing those benzylated compounds. The total yield of (4) and (5) were 5.9% and 5%, respectively. Both 4 and 5 were less effective than baicalien on inhibition of HIV-1 RT in vitro. 相似文献
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目的:基于假病毒技术探究黄芩苷抗HIV-1活性作用.方法:利用HIV-1骨架质粒NL4-3 mCherry Luciferase、HIV-1包膜蛋白质粒pCMV-VSV-G和人胚肾细胞HEK-293T构建HIV-1假病毒药物筛选体系,并对该体系进行优化和安全性验证.测定黄芩苷对293T细胞活性、HIV-1假病毒活性、H... 相似文献
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Jiang-Miao Hu Ji-Jun Chen Hong Yu You-Xing Zhao Jun Zhou 《Journal of Asian natural products research》2008,10(7):647-651
Two novel bibenzyl trigonopols A (1) and B (2), together with seven known compounds, gigantol (3), tristin (4), moscatin (5), hircinol (6), naringenin (7), 3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-ol (8), and ( - )-syringaresinol (9), have been isolated from the stems of Dendrobium trigonopus, of which compounds 6, 8, and 9 were isolated for the first time from this species. The structures of two new compounds were elucidated as threo-22-(17-hydroxyl-9-(3-hydroxyl-4-methoxy-phenethyl)-13,16,18-trimethoxy-21H-benzo[c]chromen-21-yl)ethane-22, 23-diol (1) and 9-(4-hydroxyl-3-methoxy-phenethyl)-17-(21-hydroxyl-20-methoxy-phenyl)chroman-11, 16-diol (2) on the basis of spectroscopic methods. Trigonopol A was found to exhibit antiplatelet aggregation activity in vitro with 67.55% inhibitory ration at 1.4337 x 10(- 3) M. 相似文献
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Two novel bibenzyl trigonopols A (1) and B (2), together with seven known compounds, gigantol (3), tristin (4), moscatin (5), hircinol (6), naringenin (7), 3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-ol (8), and ( - )-syringaresinol (9), have been isolated from the stems of Dendrobium trigonopus, of which compounds 6, 8, and 9 were isolated for the first time from this species. The structures of two new compounds were elucidated as threo-22-(17-hydroxyl-9-(3-hydroxyl-4-methoxy-phenethyl)-13,16,18-trimethoxy-21H-benzo[c]chromen-21-yl)ethane-22, 23-diol (1) and 9-(4-hydroxyl-3-methoxy-phenethyl)-17-(21-hydroxyl-20-methoxy-phenyl)chroman-11, 16-diol (2) on the basis of spectroscopic methods. Trigonopol A was found to exhibit antiplatelet aggregation activity in vitro with 67.55% inhibitory ration at 1.4337 x 10(- 3) M. 相似文献
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Radhe Shyam Bahare Swastika Ganguly Kiattawee Choowongkomon Supaporn Seetaha 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2015,23(1)