Placental Isoferritin Levels in Pregnant Patients with Systemic Lupus Erythematosus and/or Antiphospholipid Syndrome

PROBLEM: Low serum placental isoferritin (PLF), an immunosuppressive cytokine-like protein, was found in women with underlying placento-vascular dysfunction, such as intrauterine growth retardation and preeclamptic toxemia. The possible contribution of this placental product in the assessment of pregnant patients with either systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) was investigated. METHOD OF STUDY: Seventy-five healthy pregnant women used as controls and 25 preselected pregnant patients with either SLE and/or APS were enrolled in the study. Study patients were in remission during conception and all patients agreed to give 5 ml of venous blood at midgestation. The samples were frozen and analyzed retrospectively. After delivery, pregnancy outcomes were gathered from hospital records. RESULTS: Seventeen (68%) women had uneventful pregnancies and deliveries (normal) whereas 8 (32%) showed pathologic obstetric outcomes. Mean midgestational serum PLF levels were similar in the control and normal outcome groups (87 U/ml), whereas significantly lower levels (37 U/ml) were measured in the pathologic outcome group. Using a cutoff level of 10 U/ml, 85% from the normal outcome group and 15% from the pathologic outcome group were above this threshold level, with 60% specificity and 100% sensitivity. CONCLUSIONS: These preliminary data suggest that PLF values may reflect placento-vascular functions. These may represent a predictive biomarker for developing obstetric complications in pregnant women with either SLE and/or APS.     

PIH患者测定血清cTnI和Mb的临床意义

目的:探讨妊娠高血压综合征(PIH)与心肌损伤的关系.方法:采用化学发光法测定39例PIH患者血清肌钙蛋白I(cTnI)和肌红蛋白(Mb)及39例正常孕妇血清cTnI和Mb的含量.结果:PIH伴蛋白尿组血清cTnI和Mb显著高于PIH不伴蛋白尿组及正常妊娠组(P＜0.05),且随病情加重其值升高,PIH不伴蛋白尿组与正...     

不同治疗时机行宫颈环扎术对宫颈机能不全患者的 疗效及妊娠结局的影响研究

目的 总结不同治疗时机开展宫颈环扎术对于宫颈机能不全患者的治疗效果和妊娠结局所产生的影响,为临床选择恰当的手术时机提供参考。方法 回顾性分析2016年1月~2017年1月我院收治的100例宫颈机能不全患者的临床资料,根据治疗时机分为研究组和对照组,每组50例。研究组患者采用紧急手术治疗,对照组择期进行手术治疗,比较两组患者的妊娠结局和对产妇与新生儿所产生的影响。结果 研究组足月生产产妇多于对照组,晚期流产（20.00% vs 60.00%）与宫内感染率（18.00% vs 62.00%）低于对照组,差异有统计学差异（P＜0.05）,研究组早产率对于对照组,组间差异无统计学差异（P＞0.05）;两组患者住院时间、孕周延长时间以及新生儿评分对比,差异无统计学意义（P＞0.05）。结论 临床中对于宫颈机能不全患者需要在孕早期开展择期宫颈环扎术治疗,但是对于孕中期患者需要开展紧急手术治疗,提高术后的监测措施,促进改善妊娠结局。