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Understanding health‐related quality of life in adult women with metastatic cancer who have dependent children 下载免费PDF全文
Eliza M. Park MD Allison M. Deal MS Justin M. Yopp PhD Teresa Edwards MA Samuel J. Resnick MS Mi‐Kyung Song PhD Zev M. Nakamura MD Donald L. Rosenstein MD 《Cancer》2018,124(12):2629-2636
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A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites 下载免费PDF全文
Chantal Quinten MSc Francesca Martinelli MSc Corneel Coens MSc Mirjam A. G. Sprangers PhD Jolie Ringash MD Carolyn Gotay PhD Kristin Bjordal PhD Eva Greimel PhD Bryce B. Reeve PhD John Maringwa PhD Divine E. Ediebah MSc Efstathios Zikos MSc Madeleine T. King PhD David Osoba MD Martin J. Taphoorn PhD Henning Flechtner PhD Joseph Schmucker‐Von Koch PhD Joachim Weis PhD Andrew Bottomley PhD 《Cancer》2014,120(2):302-311
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Epstein JB Beaumont JL Gwede CK Murphy B Garden AS Meredith R Le QT Brizel D Isitt J Cella D 《Cancer》2007,109(9):1914-1922
BACKGROUND: Quality-of-life instruments that measure specific functional consequences of mucositis are needed to assess the efficacy of therapeutic interventions targeted against mucositis and to guide patient care. The authors undertook a prospective, multicenter, observational study to assess the validity, reliability, and feasibility of a new instrument, the Oral Mucositis Weekly Questionnaire-Head and Neck Cancer (OMWQ-HN). The OMWQ-HN is a patient-reported outcome questionnaire that measures the symptoms of mucositis, including mouth and throat soreness (MTS), and their impact on patient well-being and function. METHODS: The OMWQ-HN, along with the Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN), was administered 5 times over an approximately 6-week period to patients with head and neck cancer (HNC) who were receiving radiation therapy with or without chemotherapy. Information on supportive care measures also was collected. RESULTS: Seventy-five patients were enrolled and completed 93% of scheduled assessments (100% at baseline). The OMWQ-HN demonstrated good test-retest reliability (correlation coefficient, 0.80-0.89). Cross-sectional analyses to assess validity showed that OMWQ-HN scores were different across levels of pain, with those in the worst pain category reporting the highest OMWQ-HN scores. Strong correlations were observed between OMWQ-HN and FACT-HN. Patients experienced increases in MTS, which corresponded with a steady decline in function. MTS scores were highest in the patients who were taking opioid analgesics, suggesting that mucositis pain continued despite standard pain therapy. CONCLUSIONS: The current results indicated that the OMWQ-HN is a valid, reliable, and feasible instrument for assessing the impact of mucositis on patients who are receiving radiation therapy with or without chemotherapy for HNC. 相似文献
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Patient‐reported outcomes enhance the survival prediction of traditional disease risk classifications: An international study in patients with myelodysplastic syndromes 下载免费PDF全文
Fabio Efficace PhD Francesco Cottone PhD Gregory Abel MD MPH Pasquale Niscola MD PhD Gianluca Gaidano MD PhD Franck Bonnetain PhD Amelie Anota PhD Giovanni Caocci MD Angel Cronin MS Luana Fianchi MD Massimo Breccia MD Reinhard Stauder MD Uwe Platzbecker MD Giuseppe A. Palumbo MD PhD Mario Luppi MD PhD Rosangela Invernizzi MD Micaela Bergamaschi MD Lorenza Borin MD Anna Angela Di Tucci MD Huiyong Zhang MD Mirjam Sprangers PhD Marco Vignetti MD Franco Mandelli MD 《Cancer》2018,124(6):1251-1259
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Objectives: Recent reviews suggest that the routine use of patient‐reported outcome measures (PROMs) in cancer clinics improves the processes of care but not patient outcomes such as quality of life or satisfaction. We set out to identify future strategies for (1) interventions to impact patient outcomes and (2) trials to identify treatment effects. Methods: MEDLINE and PsycINFO were systematically searched to identify reports of relevant randomized controlled trials. Intervention and trial designs were compared and contrasted along the parameters identified by previous reviews and the rationales reported in each article. Results were cross‐referenced with evidence for impact to develop recommendations. Results: Six articles were identified. Evidence for impact on patient outcomes was limited. Interventions varied according to the PROMs used, the frequency, content and presentation of feedback, and the training offered to medical teams. Trials varied in their unit of randomization, outcome measures, control of contamination, monitoring of PROM use, and length of follow‐up. Our analysis identified the need for future interventions to ensure that PROM data are used to optimum effect and for trials to control for contamination and monitor use of PROMs to link this with outcomes. Conclusions: Future interventions should motivate and equip health professionals to use PROM data in managing patients, train patients in self‐efficacy, use more specific PROMs in clinic, improve the interpretability of feedback for both medical staff and patients, and monitor the use of PROMs to intervene when problems arise. Future trials should use a cluster‐randomized design to control for contamination and enable systems‐based interventions. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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The effects of cancer and racial disparities in health‐related quality of life among older Americans: A case‐control,population‐based study 下载免费PDF全文
Laura C. Pinheiro MPH Stephanie B. Wheeler PhD Ronald C. Chen MD MPH Deborah K. Mayer PhD RN AOCN FAAN Jessica C. Lyons MS Bryce B. Reeve PhD 《Cancer》2015,121(8):1312-1320
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Elting LS Keefe DM Sonis ST Garden AS Spijkervet FK Barasch A Tishler RB Canty TP Kudrimoti MK Vera-Llonch M;Burden of Illness Head Neck Writing Committee 《Cancer》2008,113(10):2704-2713
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The risk, severity, and patient‐reported outcomes of radiation‐induced mucositis among head and neck cancer patients were prospectively estimated.METHODS.
A validated, patient‐reported questionnaire (OMDQ), the FACT quality of life (QOL), and the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scales were used to measure mucositis (reported as mouth and throat soreness), daily functioning, and use of analgesics. Patients were studied before radiotherapy (RT), daily during RT, and for 4 weeks after RT.RESULTS.
Contrary to previous reports, the risk of mucositis was virtually identical in the 126 patients with oral cavity or oropharynx tumors (99% overall; 85% grade 3‐4) compared with 65 patients with tumors of the larynx or hypopharynx (98% overall; 77% grade 3‐4). The mean QOL score decreased significantly during RT, from 85.1 at baseline to 69.0 at Week 6, corresponding with the peak of mucositis severity. The mean functional status score decreased by 33% from 18.3 at baseline to 12.3 at Week 6. The impact of mucositis on QOL was proportional to its severity, although even a score of 1 or 2 (mild or moderate) was associated with a significant reduction in QOL (from 93.6 at baseline to 74.7 at Week 6). Despite increases in analgesic use from 34% at baseline to 80% at Week 6, mean mucositis scores exceeded 2.5 at Week 6.CONCLUSIONS.
Mucositis occurs among virtually all patients who are undergoing radiation treatment of head and neck cancers. The detrimental effects on QOL and functional status are significant, and opioid analgesia provides inadequate relief. Preventive rather than symptom palliation measures are needed. Cancer 2008. © 2008 American Cancer Society. 相似文献13.
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Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health‐related quality of life in patients with spinal metastases 下载免费PDF全文
Anne L. Versteeg MD Arjun Sahgal MD Laurence D. Rhines MD Daniel M. Sciubba MD James M. Schuster MD PhD Michael H. Weber MD PhD Peter Pal Varga MD Stefano Boriani MD Chetan Bettegowda MD PhD Michael G. Fehlings MD PhD Michelle J. Clarke MD Paul M. Arnold MD Ziya L. Gokaslan MD Charles G. Fisher MD MHSc AOSpine Knowledge Forum Tumor 《Cancer》2018,124(8):1828-1838
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Quality of patient‐reported outcome reporting across cancer randomized controlled trials according to the CONSORT patient‐reported outcome extension: A pooled analysis of 557 trials 下载免费PDF全文
Andrea Pusic MD Yeliz Cemal MD Jane Yanagawa MD Marc Jacobs MSc Andrea la Sala PhD Valentina Cafaro MSc Katie Whale MSc Jonathan Rees MD for the European Organization for Research Treatment of Cancer Quality‐of‐Life Group 《Cancer》2015,121(18):3335-3342
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Patient‐Reported Outcomes and Early Discontinuation in Aromatase Inhibitor‐Treated Postmenopausal Women With Early Stage Breast Cancer 下载免费PDF全文
Kunal C. Kadakia Claire F. Snyder Kelley M. Kidwell Nicholas J. Seewald Todd C. Skaar Zereunesay Desta James M. Rae Julie L. Otte Janet S. Carpenter Anna M. Storniolo Daniel F. Hayes Vered Stearns N. Lynn Henry 《The oncologist》2016,21(5):539-546
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Jolie Ringash MD Heather‐Jane Au MD Lillian L. Siu MD Jeremy D. Shapiro MD Derek J. Jonker MD John R. Zalcberg MD Malcolm J. Moore MD Andrew Strickland MD Rami Kotb MD Mark Jeffery MD Thierry Alcindor MD Siobhan Ng MD Muhammad Salim MD Sabe Sabesan MD Jay C. Easaw MD Jenny Shannon MD Fabyolla El‐Tahche PhD Ian Walters MD Dongsheng Tu PhD Christopher J. O'Callaghan DVM NCIC Clinical Trials Group Australasian Gastrointestinal Trials Group 《Cancer》2014,120(2):181-189
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David E. Victorson Jennifer L. Beaumont Sarah K. Rosenbloom Daniel Shevrin David Cella 《Psycho-oncology》2011,20(9):977-983
Background: Owing to the spectrum of symptoms, side effects, and concerns in clinically advanced prostate cancer (PC), effective symptom assessment is imperative. In line with recent regulatory guidance on the development of patient‐reported outcomes, we undertook a multistep/multistudy approach to develop and test a new symptom index (NCCN FACT‐Prostate Symptom Index‐17 that can be used to examine the effectiveness of noncurative treatments in advanced PC. Methods: This included significant input from two waves of expert medical providers (n=66 and 11, respectively) and two waves of patient engagement and testing (n=50 and 24, respectively). The resulting 17‐item symptom index for advanced PC was then divided into sets or categories based on whether the symptoms are predominantly disease or treatment related. Results: Preliminary reliability estimates suggest good internal consistency (α=0.86) and relationships with expected outside validity criteria are moderate to strong. Conclusions: This new tool may help clinicians and researchers quickly target and measure important symptoms and concerns in advanced PC, leading to increased knowledge of treatment effectiveness of noncurative therapies and improvements in the quality of patient care. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献